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市場調查報告書
商品編碼
1371920
噬菌體療法的全球市場,到 2030 年的市場預測:按產品、類型、目標細菌、適應症、給藥途徑、給藥配銷通路、用途、最終用戶、地區進行全球分析Bacteriophage Therapy Market Forecasts to 2030 - Global Analysis By Product, Type, Targeted Bacteria, Disease Indication, Route of Administration, Distribution Channel, Application, End User and By Geography |
根據 Stratistics MRC 的數據,2023 年全球噬菌體治療市場規模為 4,659 萬美元,預計 2030 年將達到 8,090 萬美元,年複合成長率為 8.2%。
噬菌體是僅攻擊和殺死細菌的病毒。噬菌體是最常見的生物體,可以對抗和消滅具有多重抗藥性的細菌。當所有其他抗生素都失效時,噬菌體可以消除引起感染疾病的細菌,使醫護人員得以挽救生命。此外,噬菌體正在被研究作為抗生素的替代療法。這種治療方法使用病毒將遺傳物質注入細菌中,使它們能夠利用宿主的機器進行繁殖。
根據美國疾病管制與預防中心 (CDC) 的數據,歐洲每年約有 33,000 人受到抗生素抗藥性細菌感染疾病的影響。預計全球抗生素抗藥性將增加,對噬菌體產生巨大需求。
在人類醫學和農業中過度使用抗生素會產生嚴重後果,包括抗生素抗藥性增加。這種令人震驚的趨勢導致了抗生素抗藥性超級細菌的出現,並迫切需要噬菌體療法等替代療法。此外,噬菌體是天然存在的病毒,能夠靶向並消滅細菌,使其成為對抗這些抗藥性病原體的有前途的武器。研究人員正在研究如何使用噬菌體混合物和專門設計的噬菌體有效地瞄準和消除這些頑固的細菌菌株。
要讓法規相信噬菌體療法的安全性和有效性是很困難的。這是因為能夠提供足夠臨床證據的大規模隨機對照試驗並不多。然而,新治療方法的法規環境非常嚴格,需要大量的臨床資料,這使得獲得產品核准既耗時又昂貴。在克服這些挑戰的同時,開發人員還必須解決臨床試驗中使用的噬菌體製劑的一致性和品質問題。
快速增加的研發成本推動了噬菌體療法的創新。噬菌體工程、噬菌體文庫的創建以及噬菌體療法與免疫療法和抗生素等其他治療方法的結合都是活躍的研究主題。此外,這種動態環境不僅使治療工具箱多樣化,而且促進了對噬菌體生物學及其臨床應用的深入理解。
缺乏大規模、一流的臨床資料是噬菌體治療市場的最大威脅之一。由於噬菌體療法的臨床試驗相對較少,法規可能會推遲核准並增加開發成本。此外,法規機構核准新治療方法需要強力的臨床證據。對於開發商來說,適應新治療方法的法規環境可能既困難又耗時。
噬菌體治療市場受到了 COVID-19大流行的各種影響。雖然噬菌體和其他替代療法由於人們對感染疾病和抗生素抗藥性的日益關注而受到更多關注,但這場大流行也將更多的資源、注意力和研究工作集中在了 COVID-19 上。供應鏈問題推遲了噬菌體療法的臨床試驗和研究,並導致生產中斷。儘管如此,這場大流行病還是引起了人們對多種治療選擇的需求的關注,特別是醫療機構中持續存在的細菌威脅,以及在大流行後時代加速採用噬菌體療法治療抗生素抗藥性感染疾病的潛力。是。
尿道感染(UTI)領域佔據噬菌體治療市場的最大佔有率。每年,數百萬人患有尿道結石,這是最常見的細菌感染疾病之一。此外,由於導致尿道結石的抗生素抗藥性菌株數量不斷增加,噬菌體療法已成為有前途的選擇。噬菌體療法可有效針對特定的泌尿道致病細菌,尿道結石。尿道結石的複發性和抗生素在預防復發方面的限制進一步增加了基於噬菌體的治療方法在該市場的市場潛力。
在噬菌體治療市場,抗菌藥物的發現正以最高的年複合成長率成長。世界各地對抗生素抗藥性的擔憂日益增加,導致尋找新抗菌藥物的資金和研究不斷增加。噬菌體靶向並消滅抗生素抗藥性細菌的能力引起了藥物研發配合措施的極大興趣。此外,不斷探索噬菌體發現和創造新抗菌藥物的潛力是該市場快速成長的關鍵驅動力,是解決嚴重的抗藥性感染疾病問題的迫切需求的解決方案。
預計北美地區將擁有噬菌體療法最高的市場佔有率。造成這一優勢的因素有很多,包括強大的醫療基礎設施、抗生素抗藥性細菌引起的感染疾病發生率高、研發方面的大量投資以及支持性的法規環境。北美由於該地區生物技術和製藥行業的蓬勃發展以及噬菌體療法在臨床實踐中的使用不斷增加而引領市場。此外,透過學術機構、製藥公司和政府機構之間的合作,噬菌體療法在北美迅速擴張,目前佔據最大的市場佔有率。
在全球噬菌體治療市場中,亞太地區的年複合成長率最高。這種快速擴張是多種要素共同作用的結果,包括抗生素抗藥性感染疾病的流行、醫療保健行業的擴張以及公眾對噬菌體療法潛在優勢的認知不斷提高。亞太地區正在大力投資研發,重點是建立高效的生產技術和擴大臨床應用。此外,當地學術機構、外國製藥公司和當地生物技術公司之間的合作正在促進創新並擴大市場。
According to Stratistics MRC, the Global Bacteriophage Therapy Market is accounted for $46.59 million in 2023 and is expected to reach $80.90 million by 2030 growing at a CAGR of 8.2% during the forecast period. Bacteriophages are viruses that only attack and kill bacteria. They are among the most prevalent biological organisms capable of battling and eliminating bacteria with multiple drug resistances. Phages can eliminate the bacteria causing an infection when all other antibiotics have failed to treat it, enabling medical professionals to save a life. Additionally, bacteriophages are being investigated as an alternative to antibiotics. In this therapy, viruses are used to inject bacteria with their genetic material so that the bacteria can use the machinery of their hosts to grow.
According to the Centers for Disease Control and Prevention (CDC), antibiotic-resistant bacterial infections affect approximately 33 000 people in Europe each year. Antibiotic resistance is predicted to increase globally, creating considerable demand for bacteriophages.
The overuse and abuse of antibiotics in both human medicine and agriculture have serious consequences, including the rise in antibiotic resistance. Antibiotic-resistant superbugs have emerged as a result of this worrying trend, necessitating the urgent need for alternative therapies like bacteriophage therapy. Moreover, bacteriophages are naturally occurring viruses that target and destroy bacteria, making them a promising weapon against these pathogens that are drug-resistant. Researchers are investigating how to effectively target and get rid of these tough bacterial strains using phage cocktails and specially created phages.
It is difficult to persuade regulatory agencies of the safety and effectiveness of bacteriophage therapy because there aren't many large-scale, randomized controlled trials that can provide sufficient clinical evidence. However, it may take longer to get a product approved for the market and cost more money because of the strict regulatory environment for new therapies and the requirement for extensive clinical data. While overcoming these challenges, developers must also address issues with the consistency and quality of phage preparations used in clinical trials.
Innovation in bacteriophage therapy is accelerating as a result of the surge in R&D spending. Phage engineering, the creation of phage libraries, and the combination of phage therapy with other therapeutic modalities like immunotherapies or antibiotics are all topics of active research. Moreover, this dynamic environment encourages a deeper comprehension of phage biology and its clinical applications, in addition to diversifying the therapeutic toolbox.
Lack of large-scale, top-notch clinical data is one of the biggest threats to the bacteriophage therapy market. Because there have been relatively few clinical trials for bacteriophage therapy, regulatory agencies may delay approvals and raise development costs. Furthermore, regulatory agencies need strong clinical evidence to approve new therapies. It can be challenging and time-consuming for developers to navigate the regulatory environment for novel therapies.
The bacteriophage therapy market has been affected in different ways by the COVID-19 pandemic. Although bacteriophages and other alternative therapies have received more attention due to the increased focus on infectious diseases and antibiotic resistance, the pandemic has also focused more resources, attention, and research efforts on COVID-19. Due to supply chain issues, bacteriophage therapy clinical trials and research were delayed, and some production interruptions happened. Despite this, the pandemic brought attention to the need for a wider range of treatment options, which may hasten the adoption of bacteriophage therapy in the post-pandemic era, particularly for persistent bacterial threats in healthcare settings and antibiotic-resistant infections.
In the market for bacteriophage therapy, the urinary tract infections (UTIs) segment commands the largest share. Each year, millions of people experience UTIs, which are among the most prevalent bacterial infections. Moreover, bacteriophage therapy has become a promising alternative due to the rise in antibiotic-resistant strains that cause UTIs. It is a compelling option for both simple and complex UTIs due to its effectiveness in targeting particular uropathogenic bacteria. Further boosting the market potential for bacteriophage-based treatments in this market are the recurrent nature of UTIs and the limitations of antibiotics in preventing relapses.
In the market for bacteriophage therapy, antimicrobial drug discovery is growing at the highest CAGR. There has been an increase in funding and research into finding new antimicrobial agents as a result of the growing concern about antibiotic resistance around the world. The ability of bacteriophages to target and destroy bacteria that are resistant to antibiotics has attracted a lot of interest in drug discovery efforts. Furthermore, the ongoing investigation of bacteriophages potential for locating and creating novel antimicrobial remedies-solutions that are urgently required to address the mounting problem of drug-resistant infections-is the primary driver of this market's rapid growth.
The largest market share for bacteriophage therapy is anticipated to be in the North American region. A number of elements, such as a strong healthcare infrastructure, a high incidence of infections caused by bacteria resistant to antibiotics, significant investments in research and development, and a supportive regulatory environment, can be credited for this dominance. The region's thriving biotechnology and pharmaceutical sectors, along with the growing use of bacteriophage therapy in clinical settings, place North America as a market leader. Additionally, bacteriophage therapy has expanded more quickly in North America thanks to partnerships between academic institutions, pharmaceutical companies, and governmental organizations, where it now accounts for the largest market share.
In the global market for bacteriophage therapy, Asia-Pacific is growing at the highest CAGR. This rapid expansion is a result of a number of factors, including the heavy prevalence of infections that are resistant to antibiotics, the expanding healthcare industry, and growing public awareness of the potential advantages of bacteriophage therapy. With a focus on creating efficient production techniques and extending clinical applications, the Asia-Pacific region is seeing significant investments in research and development. Furthermore, collaborations between local academic institutions, pharmaceutical firms from abroad, and regional biotechnology companies are promoting innovation and expanding the market.
Some of the key players in Bacteriophage Therapy market include: InnoPhage Ltd, Eliava Biopreparations Ltd., Adaptive Phage Therapeutics, Inc, Nextbiotics, Armata Pharmaceuticals Inc., Enbiotix Inc., Eligo Bioscience SA, BiomX Ltd., Phagomed Biopharma GmbH, Intodeworld Inc., Phi Therapeutics, ContraFect Corporation, Locus Biosciences Inc., Intralytix Inc., PhagePro Inc., Pherecydes Pharma and TechnoPhage SA.
In May 2023, Adaptive Phage Therapeutics (APT), a clinical-stage biotechnology company pioneering the development of phage-based therapies to combat bacterial infections, is pleased to announce a collaboration and license agreement with the Israeli Phage Therapy Center (IPTC) of the Hebrew University of Jerusalem and Hadassah Medical Center. Researchers at the IPTC have discovered several phages that have exceptionally broad coverage against antibiotic resistant bacteria.
In January 2023, Armata Pharmaceuticals, Inc., a biotechnology company focused on pathogen-specific bacteriophage therapeutics for antibiotic-resistant and difficult-to-treat bacterial infections, today announced that it has closed a secured convertible credit agreement with Innoviva Strategic Opportunities LLC, a wholly-owned subsidiary of Innoviva, Inc, Armata's largest shareholder.
In July 2022, Micro biome firm BiomX is to continue collaborating with pharma giants Boehringer Ingelheim in a partnership that looks to identify biomarkers for inflammatory bowel disease (IBD). BiomX Ltd. The agreement, the second one between the two firms, uses BiomX's XMarker micro biome-based biomarker discovery platform to aid in identifying IBD-linked pathogenic bacterium. Additional agreement terms see BiomX receive research payments with Boehringer able to negotiate an exclusive right to biomarkers discovered under the collaboration.
Note: Tables for North America, Europe, APAC, South America, and Middle East & Africa Regions are also represented in the same manner as above.