硼酸親和性和層析法市場規模、佔有率和成長分析：按產品類型、應用、最終用戶、方法和地區分類 - 產業預測，2026-2033年

2024 年全球硼酸親和性和層析法市場價值為 4.72 億美元，預計到 2025 年將成長至 2033 年的 10.1671 億美元，在預測期（2026-2033 年）內複合年成長率為 8.9%。

全球硼酸親和性和層析法市場專注於以樹脂為基礎的技術，這些技術能夠選擇性地捕捉生物分子，特別是糖蛋白和糖複合物，包括順式二醇。市場成長的驅動力在於生物製藥（尤其是單株抗體）需求的不斷成長，這些產品需要高純度純化以滿足嚴格的監管要求。隨著產業逐漸摒棄傳統的蛋白A層析法，人們的關注點轉向了能夠維持天然糖鏈結構以實現精確糖工程的硼酸鹽介質。隨著生物製程製程向連續發展，穩健的在線純化至關重要，而硼酸親和性和柱具有結合速度快、易於再生等優點。隨著製造商加強對自動化和生產規模的投資，樹脂供應商正在開發更先進、高容量的載體，從而促進市場滲透、加快法規核准，並推動生物製藥領域的創新應用。

全球硼酸親和性和層析法市場成長要素

對能夠維持產品完整性的高選擇性純化平台的需求，正在推動全球硼酸親和性和層析法市場的成長。治療性蛋白質和抗體生產商正擴大利用這項技術，因為它能夠精確結合順式二醇，並簡化下游製程。隨著產業優先考慮快速進入市場和成本效益，硼酸親和性和層析法在研發和商業應用領域的應用都在不斷擴展。此外，不斷成長的生物製藥研發管線也進一步推動了對此方法的需求，使其成為早期研發和大規模生產環境中關鍵純化難題的理想解決方案。

全球硼酸親和性和層析法市場面臨的限制因素

硼酸配體的製備及其與高純度載體基質的可靠結合需要多個精細步驟、專用試劑和嚴格的品質保證。這種複雜性導致材料成本遠高於傳統層析法介質，為小規模實驗室和新興生物技術公司帶來了巨大的經濟挑戰。當資金被分配給關鍵研究舉措時，對這些先進親和性和樹脂的投資可能會被推遲或限制。因此，高成本阻礙了許多相關人員採用這項技術，儘管其具有顯著的技術優勢，但仍抑制了整體市場成長。

硼酸親和性和層析法的全球市場趨勢

受高純度單株抗體和高糖基化蛋白需求不斷成長的推動，全球硼酸親和性和層析法市場正經歷顯著成長。隨著生技製藥企業日益重視下游製程的效率，硼酸親和性和層析法正成為選擇性捕捉聚醣、提高純化效率和確保產品均一性的重要工具。將這些樹脂整合到連續純化平台是關鍵的市場趨勢，可降低批間差異，並滿足產業對穩健製程的需求。該技術與生物製藥研發的創新追求相契合，有助於企業遵守嚴格的監管標準，並在快速變化的環境中增強競爭優勢。

目錄

介紹

• 調查目的
• 市場定義和範圍

調查方法

• 研究過程
• 二級資料和一級資料的方法
• 市場規模估算方法

執行摘要

• 全球市場展望
• 市場主要亮點
• 細分市場概覽
• 競爭環境概述

市場動態及展望

• 總體經濟指標
• 促進者和機會
• 抑制因素和挑戰
• 供給面趨勢
• 需求面趨勢
• 波特的分析和影響

關鍵市場分析

• 關鍵成功因素
• 影響市場的因素
• 主要投資機會
• 生態系測繪
• 2025年市場魅力指數
• PESTLE分析
• 監理情勢

全球硼酸親和性和層析法市場規模：依產品類型分類

• 硼酸親和性和樹脂
• 硼酸親和性和柱
• 硼酸親和性盒

全球硼酸親和性和層析法市場規模：依應用分類

• 糖蛋白的純化
• 聚醣分析
• 生物標記研究
• 藥物發現

全球硼酸親和性和層析法市場規模：依最終用戶分類

• 製藥和生物技術公司
• 學術研究機構
• 受託研究機構

全球硼酸親和性和層析法市場規模：依方法分類

• 分析層析法
• 製備層析法

全球硼酸親和性和層析法市場規模：按地區分類

• 北美洲
  • 美國
  • 加拿大
• 歐洲
  • 德國
  • 西班牙
  • 法國
  • 英國
  • 義大利
  • 其他歐洲國家
• 亞太地區
  • 中國
  • 印度
  • 日本
  • 韓國
  • 其他亞太國家
• 拉丁美洲
  • 墨西哥
  • 巴西
  • 其他拉丁美洲國家
• 中東和非洲
  • 海灣合作理事會國家
  • 南非
  • 其他中東和非洲國家

競爭資訊

• 前五大公司對比
• 主要公司2025年的市場定位
• 主要市場公司採取的策略
• 近期市場趨勢
• 企業市場占有率分析，2025 年
• 主要公司的完整公司簡介
  • 公司詳情
  • 產品系列分析
  • 按細分市場進行企業市佔率分析
  • 銷售收入年比比較（2023-2025 年）

主要公司簡介

• Cytiva
• Merck KGaA
• Bio-Rad Laboratories, Inc.
• Tosoh Corporation
• Thermo Fisher Scientific Inc.
• Agilent Technologies, Inc.
• Danaher Corporation
• Sartorius AG
• Repligen Corporation
• Purolite Corporation
• Sepax Technologies, Inc.
• GenScript Biotech Corporation
• Kaneka Corporation
• Avantor, Inc.
• Biotage AB
• YMC Co., Ltd.
• Pall Corporation
• Shimadzu Corporation
• GL Sciences Inc.
• Waters Corporation

結論與建議

Global Boronate Affinity Chromatography Market size was valued at USD 472.0 Million in 2024 and is poised to grow from USD 514.01 Million in 2025 to USD 1016.71 Million by 2033, growing at a CAGR of 8.9% during the forecast period (2026-2033).

The Global Boronate Affinity Chromatography market focuses on a resin-based technology adept at selectively capturing cis-diol-containing biomolecules, especially glycoproteins and glycoconjugates. The market's growth is fueled by the rising demand for biologics, particularly monoclonal antibodies, which necessitate high-purity purification compliant with stringent regulatory requirements. Transitioning from traditional protein A chromatography, industry interest has shifted towards boronate media to preserve native glycan structures for precise glyco-engineering. With the evolution towards continuous bioprocessing, robust inline purification is essential, and boronate affinity columns provide rapid binding kinetics and ease of regeneration. As manufacturers invest in automation and scale-up production, resin suppliers are developing advanced, higher-capacity media, thereby enhancing market reach, easing regulatory acceptance, and promoting innovative applications in biopharma.

Top-down and bottom-up approaches were used to estimate and validate the size of the Global Boronate Affinity Chromatography market and to estimate the size of various other dependent submarkets. The research methodology used to estimate the market size includes the following details: The key players in the market were identified through secondary research, and their market shares in the respective regions were determined through primary and secondary research. This entire procedure includes the study of the annual and financial reports of the top market players and extensive interviews for key insights from industry leaders such as CEOs, VPs, directors, and marketing executives. All percentage shares split, and breakdowns were determined using secondary sources and verified through Primary sources. All possible parameters that affect the markets covered in this research study have been accounted for, viewed in extensive detail, verified through primary research, and analyzed to get the final quantitative and qualitative data.

Global Boronate Affinity Chromatography Market Segments Analysis

Global boronate affinity chromatography market is segmented by product type, application, end user, technique and region. Based on product type, the market is segmented into Boronate Affinity Resins, Boronate Affinity Columns and Boronate Affinity Kits. Based on application, the market is segmented into Glycoprotein Purification, Glycan Analysis, Biomarker Research and Drug Discovery. Based on end user, the market is segmented into Pharmaceutical & Biotechnology Companies, Academic & Research Institutes and Contract Research Organizations. Based on technique, the market is segmented into Analytical Chromatography and Preparative Chromatography. Based on region, the market is segmented into North America, Europe, Asia Pacific, Latin America and Middle East & Africa.

Driver of the Global Boronate Affinity Chromatography Market

The demand for high-selectivity purification platforms that maintain product integrity is driving growth in the global boronate affinity chromatography market. Manufacturers of therapeutic proteins and antibodies are increasingly utilizing this technology due to its ability to provide precise binding to cis-diols, which streamlines downstream processing. As the industry prioritizes rapid market entry and cost efficiency, the adoption of boronate affinity chromatography is expanding across both research and commercial applications. Additionally, the increasing pipeline of biologics further propels the demand for this method, establishing it as a preferred solution for critical purification challenges in early-stage development and large-scale production settings.

Restraints in the Global Boronate Affinity Chromatography Market

The production of boronate ligands and their secure attachment to high-purity support matrices entails several meticulous steps, requiring specialized reagents and rigorous quality assurance. This complexity elevates the costs of materials considerably beyond those associated with traditional chromatography media, posing financial challenges for smaller laboratories and emerging biotech firms. When funding is directed toward essential research initiatives, the investment in these advanced affinity resins may be postponed or restricted. As a result, the high costs can discourage many from adopting this technology, hindering its overall market growth despite its significant technical benefits.

Market Trends of the Global Boronate Affinity Chromatography Market

The Global Boronate Affinity Chromatography market is witnessing significant growth driven by the expanding demand for high-purity monoclonal antibodies and advanced glyco-engineered proteins. As biopharmaceutical manufacturers increasingly prioritize streamlined downstream processing, boronate affinity chromatography emerges as an essential tool for selective glycan capture, enhancing purification efficiency and product consistency. The integration of these resins into continuous purification platforms is a key market trend, reducing batch variability and supporting industry demands for robust processes. This technology aligns with the pursuit of innovation in biologics development, facilitating compliance with stringent regulatory standards and fostering competitive advantages in a rapidly evolving landscape.

Table of Contents

Introduction

• Objectives of the Study
• Market Definition & Scope

Research Methodology

• Research Process
• Secondary & Primary Data Methods
• Market Size Estimation Methods

Executive Summary

• Global Market Outlook
• Key Market Highlights
• Segmental Overview
• Competition Overview

Market Dynamics & Outlook

• Macro-Economic Indicators
• Drivers & Opportunities
• Restraints & Challenges
• Supply Side Trends
• Demand Side Trends
• Porters Analysis & Impact
  • Competitive Rivalry
  • Threat of Substitute
  • Bargaining Power of Buyers
  • Threat of New Entrants
  • Bargaining Power of Suppliers

Key Market Insights

• Key Success Factors
• Market Impacting Factors
• Top Investment Pockets
• Ecosystem Mapping
• Market Attractiveness Index 2025
• PESTEL Analysis
• Regulatory Landscape

Global Boronate Affinity Chromatography Market Size by Product Type & CAGR (2026-2033)

• Market Overview
• Boronate Affinity Resins
• Boronate Affinity Columns
• Boronate Affinity Kits

Global Boronate Affinity Chromatography Market Size by Application & CAGR (2026-2033)

• Market Overview
• Glycoprotein Purification
• Glycan Analysis
• Biomarker Research
• Drug Discovery

Global Boronate Affinity Chromatography Market Size by End User & CAGR (2026-2033)

• Market Overview
• Pharmaceutical & Biotechnology Companies
• Academic & Research Institutes
• Contract Research Organizations

Global Boronate Affinity Chromatography Market Size by Technique & CAGR (2026-2033)

• Market Overview
• Analytical Chromatography
• Preparative Chromatography

Global Boronate Affinity Chromatography Market Size & CAGR (2026-2033)

• North America (Product Type, Application, End User, Technique)
  • US
  • Canada
• Europe (Product Type, Application, End User, Technique)
  • Germany
  • Spain
  • France
  • UK
  • Italy
  • Rest of Europe
• Asia Pacific (Product Type, Application, End User, Technique)
  • China
  • India
  • Japan
  • South Korea
  • Rest of Asia-Pacific
• Latin America (Product Type, Application, End User, Technique)
  • Mexico
  • Brazil
  • Rest of Latin America
• Middle East & Africa (Product Type, Application, End User, Technique)
  • GCC Countries
  • South Africa
  • Rest of Middle East & Africa

Competitive Intelligence

• Top 5 Player Comparison
• Market Positioning of Key Players, 2025
• Strategies Adopted by Key Market Players
• Recent Developments in the Market
• Company Market Share Analysis, 2025
• Company Profiles of All Key Players
  • Company Details
  • Product Portfolio Analysis
  • Company's Segmental Share Analysis
  • Revenue Y-O-Y Comparison (2023-2025)

Key Company Profiles

• Cytiva
  • Company Overview
  • Business Segment Overview
  • Financial Updates
  • Key Developments
• Merck KGaA
  • Company Overview
  • Business Segment Overview
  • Financial Updates
  • Key Developments
• Bio-Rad Laboratories, Inc.
  • Company Overview
  • Business Segment Overview
  • Financial Updates
  • Key Developments
• Tosoh Corporation
  • Company Overview
  • Business Segment Overview
  • Financial Updates
  • Key Developments
• Thermo Fisher Scientific Inc.
  • Company Overview
  • Business Segment Overview
  • Financial Updates
  • Key Developments
• Agilent Technologies, Inc.
  • Company Overview
  • Business Segment Overview
  • Financial Updates
  • Key Developments
• Danaher Corporation
  • Company Overview
  • Business Segment Overview
  • Financial Updates
  • Key Developments
• Sartorius AG
  • Company Overview
  • Business Segment Overview
  • Financial Updates
  • Key Developments
• Repligen Corporation
  • Company Overview
  • Business Segment Overview
  • Financial Updates
  • Key Developments
• Purolite Corporation
  • Company Overview
  • Business Segment Overview
  • Financial Updates
  • Key Developments
• Sepax Technologies, Inc.
  • Company Overview
  • Business Segment Overview
  • Financial Updates
  • Key Developments
• GenScript Biotech Corporation
  • Company Overview
  • Business Segment Overview
  • Financial Updates
  • Key Developments
• Kaneka Corporation
  • Company Overview
  • Business Segment Overview
  • Financial Updates
  • Key Developments
• Avantor, Inc.
  • Company Overview
  • Business Segment Overview
  • Financial Updates
  • Key Developments
• Biotage AB
  • Company Overview
  • Business Segment Overview
  • Financial Updates
  • Key Developments
• YMC Co., Ltd.
  • Company Overview
  • Business Segment Overview
  • Financial Updates
  • Key Developments
• Pall Corporation
  • Company Overview
  • Business Segment Overview
  • Financial Updates
  • Key Developments
• Shimadzu Corporation
  • Company Overview
  • Business Segment Overview
  • Financial Updates
  • Key Developments
• GL Sciences Inc.
  • Company Overview
  • Business Segment Overview
  • Financial Updates
  • Key Developments
• Waters Corporation
  • Company Overview
  • Business Segment Overview
  • Financial Updates
  • Key Developments

Conclusion & Recommendations