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1812313

甲羥戊酸市場－全球產業規模、佔有率、趨勢、機會和預測，按應用（製藥和生物技術產業、化妝品產業、萜烯生產等）、按地區和競爭細分，2020-2030 年

Mevalonic Acid Market- Global Industry Size, Share, Trends, Opportunity, and Forecast, Segmented By Application (Pharmaceutical & Biotechnology Industry, Cosmetic Industry, Terpene Production, Others), By Region and Competition, 2020-2030F

出版日期: 2025年09月14日 | 出版商:

TechSci Research | 英文 180 Pages | 商品交期: 2-3個工作天內

價格

簡介目錄

2024 年全球甲羥戊酸市值為 5.1235 億美元，預計到 2030 年將達到 6.6425 億美元，預測期內的複合年成長率為 4.12%。全球甲羥戊酸 (MVA) 市場是特種化學品和生命科學領域的利基市場，但具有重要的戰略意義。雖然與大宗化學品相比，其整體產量較小，但該市場具有高價值密度、嚴格的純度要求和強大的智慧財產權 (IP) 障礙。甲羥戊酸及其更穩定的衍生物甲羥戊酸內酯是甲羥戊酸途徑中的關鍵代謝物，甲羥戊酸途徑是生產異戊二烯類化合物（如膽固醇、類固醇激素、輔酶 Q、類胡蘿蔔素、維生素 K2 中間體和用於藥物、營養保健品、香精和香料的多種萜類化合物）的基本生化途徑。它作為上游中間體的作用使其成為一種多功能的構建塊，其純度和雜質控制直接影響下游產品的產量和法規遵從性。

市場概況
預測期	2026-2030
2024年市場規模	5.1235億美元
2030年市場規模	6.6425億美元
2025-2030年複合年成長率	4.12%
成長最快的領域	製藥和生物技術產業
最大的市場	亞太

市場成長主要得益於製藥、營養保健品以及香精香料 (F&F) 領域日益成長的應用。在製藥和生物技術產業，MVA 被視為類固醇 API、萜類候選藥物以及脂質組學研究的研究和生產中間體。營養保健品產業將 MVA 用作維生素 K2 和輔酶 Q 等高價值補充劑的前體，這得益於消費者對功能性保健產品的需求。在香精香料產業，生物基 MVA 路線支持「天然等同」的宣稱，並有助於開發新型萜類香料分子。此外，代謝工程和發酵技術的進步提高了產量，提高了成本效率，並實現了永續的生物基採購，進一步支持了市場應用。

儘管有這些機遇，市場仍面臨諸多限制。生產經濟性對發酵產量和純化損失敏感，而穩定性問題（例如吸濕性和酸-內酯平衡）則需要專門的處理和經過驗證的分析方法。供應商數量有限，高監管和智慧財產權壁壘阻礙了新進入者。需求也集中在少數高價值客戶群中，使得市場容易受到專案延期或取消的影響。此外，遵守cGMP、REACH和FDA等全球監管架構的要求也增加了生產的複雜性和成本。

關鍵市場促進因素

不斷擴大的製藥和生物技術研發正在推動全球甲羥戊酸市場的發展

主要市場挑戰

生產成本高

主要市場趨勢

技術進步

The Global Mevalonic acid Market was valued at USD 512.35 Million in 2024 and is expected to reach USD 664.25 Million by 2030 with a CAGR of 4.12% during the forecast period. The global mevalonic acid (MVA) market is a niche but strategically significant segment within specialty chemicals and life sciences. Although overall production volumes are small compared with commodity chemicals, the market is characterized by high value density, stringent purity requirements, and strong intellectual property (IP) barriers. Mevalonic acid, and its more stable derivative mevalonolactone, is a key metabolite in the mevalonate pathway-a fundamental biochemical route for producing isoprenoids such as cholesterol, steroid hormones, coenzyme Q, carotenoids, vitamin K2 intermediates, and numerous terpenoids used in pharmaceuticals, nutraceuticals, flavors, and fragrances. Its role as an upstream intermediate makes it a versatile building block where purity and impurity control directly impact yields and regulatory compliance for downstream products.

Market Overview
Forecast Period	2026-2030
Market Size 2024	USD 512.35 Million
Market Size 2030	USD 664.25 Million
CAGR 2025-2030	4.12%
Fastest Growing Segment	Pharmaceutical & Biotechnology Industry
Largest Market	Asia-Pacific

Market growth is primarily driven by increasing applications across pharmaceuticals, nutraceuticals, and the flavors & fragrances (F&F) sector. In the pharmaceutical and biotechnology industries, MVA is valued as a research and production intermediate for steroidal APIs, terpenoid-based drug candidates, and lipidomics studies. The nutraceutical sector uses MVA as a precursor for high-value supplements such as vitamin K2 and coenzyme Q, benefiting from consumer demand for functional health products. In the F&F industry, biobased MVA routes support "natural-identical" claims and enable the development of new terpenoid fragrance molecules. Moreover, advances in metabolic engineering and fermentation technologies have enhanced production yields, improved cost efficiency, and enabled sustainable biobased sourcing, further supporting market adoption.

Despite these opportunities, the market faces several constraints. Production economics are sensitive to fermentation yields and purification losses, while stability issues-such as hygroscopicity and the acid-lactone equilibrium-require specialized handling and validated analytical methods. The supplier base is limited, with high regulatory and IP barriers deterring new entrants. Demand is also concentrated among a small group of high-value customers, making the market vulnerable to project delays or cancellations. Furthermore, compliance with global regulatory frameworks such as cGMP, REACH, and FDA requirements adds to production complexity and cost.

Key Market Drivers

Expanding Pharmaceutical & Biotechnology R&D Is Driving the Global Mevalonic Acid Market

The global mevalonic acid (MVA) market is experiencing steady growth, largely fueled by the rapid expansion of pharmaceutical and biotechnology research and development (R&D). In 2023, the pharmaceutical industry submitted 12,425 patent applications via the Patent Cooperation Treaty administered by the World Intellectual Property Organization (WIPO). As drug discovery programs intensify in therapeutic areas such as oncology, immunology, infectious diseases, metabolic disorders, and synthetic biology, there is a growing demand for high-purity mevalonic acid and its derivatives. These compounds are widely used as research reagents, pathway modulators, analytical standards, and bioprocess inputs. The increased adoption of MVA is also being driven by advances in isoprenoid engineering, the incorporation of mevalonate-pathway tools in high-throughput screening, and the use of isotope-labeled MVA in modern metabolomics workflows. Acc to IFPMA, the average time from clinical trial start to patient enrolment close increased by 26% from 2019 to 2023, highlighting the growing complexity of pharmaceutical R&D.

Mevalonic acid plays a critical role in the biosynthetic mevalonate pathway, which is essential for producing isoprenoids such as cholesterol, dolichols, ubiquinone (CoQ), and prenyl groups. Acting as a key intermediate, MVA sits at the pivotal point where HMG-CoA reductase converts HMG-CoA into MVA. This biochemical position makes it indispensable for experimental applications, including mechanism-of-action and rescue assays for statins and prenylation inhibitors, cancer biology studies, metabolic disease research, and synthetic biology projects aimed at producing high-value isoprenoids. Its utility also extends to targeted and untargeted metabolomics, where both native and isotope-labeled MVA serve as reference standards.

One of the primary factors driving market demand is the surge in pathway-focused screening and validation work. High-throughput screening (HTS) and CRISPR-based functional genomics increasingly target the mevalonate pathway, requiring MVA as a rescue agent to confirm on-target drug effects. This is especially relevant in oncology drug discovery, where researchers are investigating combination therapies that modulate prenylation and cholesterol biosynthesis. MVA is also critical for immunology research, particularly in immunometabolism studies, where supplementation or depletion experiments are used to understand immune cell behavior.

Synthetic biology has emerged as another major growth avenue for the MVA market. With the rise of microbial production of terpenoids and other isoprenoids for pharmaceuticals, nutritional supplements, and fragrances, engineered strains often rely on the mevalonate pathway for biosynthesis. In such applications, MVA and its lactone form are used in process development, analytical benchmarking, and metabolic flux optimization. This has created a steady source of demand from bioprocess development teams, contract development and manufacturing organizations (CDMOs), and synthetic biology start-ups.

The analytical sector is also boosting the demand for high-purity and isotope-labeled MVA. As metabolomics, lipidomics, and pathway analysis gain traction in both research and regulatory settings, there is a growing need for reliable standards with strict impurity profiles. Laboratories performing LC-MS and GC-MS analyses require MVA with consistent batch quality, detailed certificates of analysis, and extended stability data to meet good laboratory practice (GLP) and good manufacturing practice (GMP) standards.

Key Market Challenges

High Production Costs

One of the primary challenges restraining market expansion is the high production cost associated with mevalonic acid. The synthesis of mevalonic acid requires sophisticated technology, stringent quality control, and specialized raw materials, all of which contribute to elevated manufacturing expenses. These high costs impact pricing strategies, making it challenging for smaller manufacturers to compete effectively. Consequently, companies are forced to optimize production processes, invest in cost-efficient technologies, and negotiate better procurement contracts to maintain profitability.

Key Market Trends

Technological Advancements

The global mevalonic acid market is witnessing robust growth, largely fueled by continuous technological advancements in production processes, synthetic biology, and metabolic engineering. Mevalonic acid is a critical precursor in the biosynthesis of isoprenoids, compounds that find applications across pharmaceuticals, cosmetics, and agriculture. The increasing demand for high-purity, sustainable, and efficient production methods has positioned technological innovation as a key driver in expanding the market.

Traditional chemical synthesis methods for mevalonic acid often involve high costs, complex steps, and significant environmental impact due to the use of petrochemical feedstocks. To address these challenges, biotechnological approaches such as microbial fermentation are gaining prominence. Advances in metabolic engineering have enabled the development of engineered microbial strains capable of producing mevalonic acid at higher yields and lower production costs. These strains are designed to efficiently convert renewable feedstocks into mevalonic acid, thereby reducing reliance on fossil fuels and supporting environmentally sustainable production.

Synthetic biology has further accelerated market growth by allowing scientists to design and construct novel biological systems tailored for optimal mevalonic acid production. By fine-tuning metabolic pathways within microorganisms, researchers can minimize by-product formation and maximize the production of the desired compound. This approach not only improves the overall efficiency of the production process but also enhances scalability, which is critical for industrial applications.

The expansion of mevalonic acid applications has also been influenced by these technological advancements. In the pharmaceutical sector, mevalonic acid serves as a precursor for statins, a class of drugs extensively used to manage cholesterol levels. The cosmetic industry leverages mevalonic acid-derived compounds like squalene for their moisturizing, antioxidant, and anti-aging properties. Additionally, in agriculture and food industries, mevalonic acid contributes to the production of carotenoids, which function as natural colorants and antioxidants. These diversified applications are fueling demand and encouraging further research and development in the field.

Key Market Players

Sigma-Aldrich Chemicals Private Limited
Tlc Pharmaceutical Standards Ltd
Carbosynth Ltd.
Tocris Bioscience Corp.
TCI Chemicals
Cayman Chemical Company
Santa Cruz Biotechnology, Inc.
Adooq Bioscience LLC

Report Scope

In this report, Global Mevalonic Acid market has been segmented into the following categories, in addition to the industry trends, which have also been detailed below:

Mevalonic Acid Market, By Application:

Pharmaceutical & Biotechnology Industry
Cosmetic Industry
Terpene Production
Others

Mevalonic Acid Market, By Region:

North America
United States
Mexico
Canada
Europe
France
Germany
United Kingdom
Spain
Italy
Asia-Pacific
China
India
South Korea
Japan
Australia
South America
Brazil
Argentina
Colombia
Middle East & Africa
South Africa
Saudi Arabia
UAE

Competitive landscape

Company Profiles: Detailed analysis of the major companies present in Global Mevalonic Acid market.

Available Customizations:

With the given market data, TechSci Research offers customizations according to a company's specific needs. The following customization options are available for the report:

1. Product Overview

2. Research Methodology

3. Executive Summary

4. Disruptions: Conflicts, Pandemics, and Trade Barriers

5. Impact of Russia-Ukraine War Crisis on Global Mevalonic Acid Market

6. Voice of Customer

7. Global Mevalonic Acid Market Outlook

7.1. Market Size & Forecast
- 7.1.1. By Value & Volume
7.2. Market Share & Forecast
- 7.2.1. By Application (Pharmaceutical & Biotechnology Industry, Cosmetic Industry, Terpene Production, Others)
- 7.2.2. By Region
- 7.2.3. By Company (2024)
7.3. Product Market Map

8. North America Mevalonic Acid Market Outlook

8.1. Market Size & Forecast
- 8.1.1. By Value & Volume
8.2. Market Share & Forecast
- 8.2.1. By Application
- 8.2.2. By Country
8.3. North America: Country Analysis
- 8.3.1. United States Mevalonic Acid Market Outlook
  - 8.3.1.1. Market Size & Forecast
    - 8.3.1.1.1. By Value & Volume
  - 8.3.1.2. Market Share & Forecast
    - 8.3.1.2.1. By Application
- 8.3.2. Mexico Mevalonic Acid Market Outlook
  - 8.3.2.1. Market Size & Forecast
    - 8.3.2.1.1. By Value & Volume
  - 8.3.2.2. Market Share & Forecast
    - 8.3.2.2.1. By Application
- 8.3.3. Canada Mevalonic Acid Market Outlook
  - 8.3.3.1. Market Size & Forecast
    - 8.3.3.1.1. By Value & Volume
  - 8.3.3.2. Market Share & Forecast
    - 8.3.3.2.1. By Application

9. Europe Mevalonic Acid Market Outlook

9.1. Market Size & Forecast
- 9.1.1. By Value & Volume
9.2. Market Share & Forecast
- 9.2.1. By Application
- 9.2.2. By Country
9.3. Europe: Country Analysis
- 9.3.1. France Mevalonic Acid Market Outlook
  - 9.3.1.1. Market Size & Forecast
    - 9.3.1.1.1. By Value & Volume
  - 9.3.1.2. Market Share & Forecast
    - 9.3.1.2.1. By Application
- 9.3.2. Germany Mevalonic Acid Market Outlook
  - 9.3.2.1. Market Size & Forecast
    - 9.3.2.1.1. By Value & Volume
  - 9.3.2.2. Market Share & Forecast
    - 9.3.2.2.1. By Application
- 9.3.3. United Kingdom Mevalonic Acid Market Outlook
  - 9.3.3.1. Market Size & Forecast
    - 9.3.3.1.1. By Value & Volume
  - 9.3.3.2. Market Share & Forecast
    - 9.3.3.2.1. By Application
- 9.3.4. Italy Mevalonic Acid Market Outlook
  - 9.3.4.1. Market Size & Forecast
    - 9.3.4.1.1. By Value & Volume
  - 9.3.4.2. Market Share & Forecast
    - 9.3.4.2.1. By Application
- 9.3.5. Spain Mevalonic Acid Market Outlook
  - 9.3.5.1. Market Size & Forecast
    - 9.3.5.1.1. By Value & Volume
  - 9.3.5.2. Market Share & Forecast
    - 9.3.5.2.1. By Application

10. Asia-Pacific Mevalonic Acid Market Outlook

10.1. Market Size & Forecast
- 10.1.1. By Value & Volume
10.2. Market Share & Forecast
- 10.2.1. By Application
- 10.2.2. By Country
10.3. Asia-Pacific: Country Analysis
- 10.3.1. China Mevalonic Acid Market Outlook
  - 10.3.1.1. Market Size & Forecast
    - 10.3.1.1.1. By Value & Volume
  - 10.3.1.2. Market Share & Forecast
    - 10.3.1.2.1. By Application
- 10.3.2. India Mevalonic Acid Market Outlook
  - 10.3.2.1. Market Size & Forecast
    - 10.3.2.1.1. By Value & Volume
  - 10.3.2.2. Market Share & Forecast
    - 10.3.2.2.1. By Application
- 10.3.3. South Korea Mevalonic Acid Market Outlook
  - 10.3.3.1. Market Size & Forecast
    - 10.3.3.1.1. By Value & Volume
  - 10.3.3.2. Market Share & Forecast
    - 10.3.3.2.1. By Application
- 10.3.4. Japan Mevalonic Acid Market Outlook
  - 10.3.4.1. Market Size & Forecast
    - 10.3.4.1.1. By Value & Volume
  - 10.3.4.2. Market Share & Forecast
    - 10.3.4.2.1. By Application
- 10.3.5. Australia Mevalonic Acid Market Outlook
  - 10.3.5.1. Market Size & Forecast
    - 10.3.5.1.1. By Value & Volume
  - 10.3.5.2. Market Share & Forecast
    - 10.3.5.2.1. By Application

11. South America Mevalonic Acid Market Outlook

11.1. Market Size & Forecast
- 11.1.1. By Value & Volume
11.2. Market Share & Forecast
- 11.2.1. By Application
- 11.2.2. By Country
11.3. South America: Country Analysis
- 11.3.1. Brazil Mevalonic Acid Market Outlook
  - 11.3.1.1. Market Size & Forecast
    - 11.3.1.1.1. By Value & Volume
  - 11.3.1.2. Market Share & Forecast
    - 11.3.1.2.1. By Application
- 11.3.2. Argentina Mevalonic Acid Market Outlook
  - 11.3.2.1. Market Size & Forecast
    - 11.3.2.1.1. By Value & Volume
  - 11.3.2.2. Market Share & Forecast
    - 11.3.2.2.1. By Application
- 11.3.3. Colombia Mevalonic Acid Market Outlook
  - 11.3.3.1. Market Size & Forecast
    - 11.3.3.1.1. By Value & Volume
  - 11.3.3.2. Market Share & Forecast
    - 11.3.3.2.1. By Application

12. Middle East and Africa Mevalonic Acid Market Outlook

12.1. Market Size & Forecast
- 12.1.1. By Value & Volume
12.2. Market Share & Forecast
- 12.2.1. By Application
- 12.2.2. By Country
12.3. MEA: Country Analysis
- 12.3.1. South Africa Mevalonic Acid Market Outlook
  - 12.3.1.1. Market Size & Forecast
    - 12.3.1.1.1. By Value & Volume
  - 12.3.1.2. Market Share & Forecast
    - 12.3.1.2.1. By Application
- 12.3.2. Saudi Arabia Mevalonic Acid Market Outlook
  - 12.3.2.1. Market Size & Forecast
    - 12.3.2.1.1. By Value & Volume
  - 12.3.2.2. Market Share & Forecast
    - 12.3.2.2.1. By Application
- 12.3.3. UAE Mevalonic Acid Market Outlook
  - 12.3.3.1. Market Size & Forecast
    - 12.3.3.1.1. By Value & Volume
  - 12.3.3.2. Market Share & Forecast
    - 12.3.3.2.1. By Application

13. Market Dynamics

13.1. Drivers
13.2. Challenges

14. Market Trends & Developments

14.1. Product Launches
14.2. Mergers & Acquisitions
14.3. Technological Developments

15. Competitive Landscape

15.1. Sigma-Aldrich Chemicals Private Limited
- 15.1.1. Business Overview
- 15.1.2. Financial Analysis (In case of listed companies)
- 15.1.3. Key Product Offerings
- 15.1.4. Recent Developments
- 15.1.5. Key Personnel/Contact Person Details
- 15.1.6. SWOT Analysis
15.2. Tlc Pharmaceutical Standards Ltd
15.3. Carbosynth Ltd.
15.4. Tocris Bioscience Corp.
15.5. TCI Chemicals Industry Co., Ltd.
15.6. Cayman Chemical Company
15.7. Santa Cruz Biotechnology, Inc.
15.8. Adooq Bioscience LLC