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市場調查報告書
商品編碼
1871423
2021-2031年北美微電極陣列體外市場報告:範圍、細分、動態和競爭分析North America Microelectrode Array In Vitro Market Report 2021-2031 by Scope, Segmentation, Dynamics, and Competitive Analysis |
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2023 年北美微電極陣列體外市場價值約為 844 萬美元,預計到 2031 年將成長至 1,194 萬美元,在此期間的年複合成長率(CAGR) 為 4.4%。
神經科學研究需求不斷成長
神經科學研究領域對微電極陣列(MEA)日益成長的需求是北美市場的重要驅動力。這些陣列對於在神經元培養物上測試新藥至關重要,使研究人員能夠評估藥物對神經活動的影響並開發標靶療法。體外模型被用於研究一系列神經系統和神經精神疾病,包括阿茲海默症、帕金森氏症、癲癇和各種神經發育障礙。這些疾病的日益普遍導致了對微電極陣列系統需求的增加,該系統有助於研究與這些疾病相關的細胞和分子變化及其對神經功能的影響。
透過在體外細胞模型中使用微電極陣列,研究人員可以測量神經活動,並評估藥物化合物如何調節這種活動、恢復正常的神經網路功能或對抗疾病相關的異常。這項能力對於在研發早期階段識別有前景的候選藥物至關重要。隨著神經科學研究的不斷發展,Axion BioSystems、Multi Channel Systems 和 MaxWell Biosystems 等公司正在不斷創新並推出新產品以滿足這一需求。例如,Axion BioSystems 於 2024 年 4 月推出了 Maestro Volt,這是一款經濟高效的桌上型微電極陣列系統,專為通量要求較低的學術實驗室而設計。這款 6 孔設備適用於神經系統和心血管系統研究,具有方便用戶使用的控制功能和 Maestro 品牌一貫的高品質標準。
北美市場概覽
投資者對生產用於體外研究的高通量微電極陣列的公司越來越感興趣,這些微電極陣列對研究機構、製藥公司和生物技術行業至關重要。基於CMOS的微電極陣列、幹細胞研究、神經假體和體外毒理學測試等領域的創新正在推動對這些技術的需求。值得注意的是,2020年6月,喬治亞州立大學研究基金會從美國國家科學基金會獲得了1.9756億美元的資助,用於開發用於SARS-CoV-2和其他RNA病毒的微電極陣列感測器,這展現了這些技術在應對全球健康挑戰方面的巨大潛力。
美國環保署也認可微電極陣列是進行體外毒性測試的寶貴工具,尤其是在評估發育神經毒性方面,而發育神經毒性是新化學物質和藥物核准過程中面臨的重大挑戰。這種監管支持促使微電極陣列在藥物發現和疾病建模中的高通量篩選方面得到更廣泛的應用,因為研究人員正在尋求可靠的平台來即時監測細胞和組織活動。
微電極陣列在類器官等創新體外模型中的應用,推動了包括3D微電極陣列技術和高密度CMOS微電極陣列在內的先進技術的發展。例如,2023年1月,美國微電極陣列技術供應商BMSEED為其2D可拉伸微電極陣列(sMEA)申請了專利,該陣列已升級為3D版本,可用於對腦類器官和3D組織培養物進行電生理測量,尤其是在阿茲海默症研究中。這種3D-sMEA技術具有可調節的、嵌入電極的微腔,能夠貼合類器官的形狀,使研究人員能夠從完整類器官約80%的表面積上採集神經訊號。
市場區隔
北美體外微電極陣列市場按產品、應用和國家進行細分。按產品分類,市場分為傳統微電極陣列 (MEA)、多孔微電極陣列 (multiwell-MEA) 和 CMOS 微電極陣列 (CMOS-MEA),其中多孔微電極陣列在 2023 年佔據最大的市場佔有率。按應用分類,市場分為心肌細胞、神經和其他,其中心肌細胞應用領域也佔據領先的市場佔有率。按國家/地區分類,市場分為美國、加拿大和墨西哥,其中美國在 2023 年佔據市場主導地位。
關鍵參與者
北美微電極陣列體外市場的主要公司包括:Tucker Davis Technologies、SCREEN Holdings Co., Ltd.、Plexon Inc.、MaxWell Biosystems AG、Harvard Bioscience Inc.、Axion BioSystems Inc.、3Brain AG、NeuroNexus Technologies Inc.、MiElectrodepvic、TirkEED這些公司致力於開發創新解決方案,以滿足神經科學及相關領域日益成長的需求。
The North America microelectrode array in vitro market was valued at approximately US$ 8.44 million in 2023 and is projected to grow to US$ 11.94 million by 2031, reflecting a compound annual growth rate (CAGR) of 4.4% during this period.
Increasing Demand in Neuroscience Research
The rising demand for microelectrode arrays (MEAs) in neuroscience research is a significant driver of the North American market. These arrays are essential for testing new pharmaceuticals on neuronal cultures, allowing researchers to evaluate the impact of drugs on neural activity and develop targeted therapies. In vitro models are utilized to study a range of neurological and neuropsychiatric disorders, including Alzheimer's disease, Parkinson's disease, epilepsy, and various neurodevelopmental conditions. The growing prevalence of these disorders has led to an increased need for microelectrode array systems, which facilitate the examination of cellular and molecular changes associated with these diseases and their effects on neural functions.
By employing microelectrode arrays in in vitro cell models, researchers can measure neural activity and assess how drug compounds can modulate this activity, restore normal network function, or counteract disease-related abnormalities. This capability is crucial for identifying promising drug candidates early in the development process. As neuroscience research continues to expand, companies like Axion BioSystems, Multi Channel Systems, and MaxWell Biosystems are innovating and launching new products to meet this demand. For example, in April 2024, Axion BioSystems introduced the Maestro Volt, a cost-effective benchtop microelectrode array system designed for academic laboratories with lower throughput requirements. This 6-well device is suitable for both neurological and cardiovascular research, featuring user-friendly controls and high-quality standards associated with the Maestro brand.
North America Market Overview
Investors are increasingly interested in companies that manufacture high-throughput microelectrode arrays for in vitro research, which are essential for research institutions, pharmaceutical companies, and the biotechnology sector. Innovations in CMOS-based microelectrode arrays, stem cell research, neuroprosthetics, and in vitro toxicology testing are propelling the demand for these technologies. Notably, in June 2020, the Georgia State University Research Foundation received US$ 197.56 million from the US National Science Foundation to develop microelectrode array sensors for SARS-CoV-2 and other RNA viruses, showcasing the potential of these technologies to address global health challenges.
The US Environmental Protection Agency has also recognized microelectrode arrays as valuable tools for conducting in vitro toxicity tests, particularly for assessing developmental neurotoxicity, which poses significant challenges in the approval of new chemicals and drugs. Such regulatory support has led to increased use of microelectrode arrays for high-throughput screening in drug discovery and disease modeling, as researchers seek reliable platforms for real-time monitoring of cellular and tissue activity.
The adoption of microelectrode arrays in innovative in vitro models, such as organoids, has spurred the development of advanced technologies, including 3D microelectrode array technology and high-density CMOS-based microelectrode arrays. For instance, in January 2023, BMSEED, a US-based provider of microelectrode array technologies, filed a patent application for its 2D stretchable microelectrode array (sMEA) that has been enhanced into a 3D version, allowing for electrophysiological measurements from brain organoids and 3D tissue cultures, particularly in Alzheimer's research. This 3D-sMEA technology features adjustable pockets with embedded electrodes that conform to organoids, enabling researchers to capture neural signals from approximately 80% of the surface area of intact organoids.
Market Segmentation
The North America microelectrode array in vitro market is segmented by product, application, and country. In terms of product, the market is divided into classical MEA, multiwell-MEA, and CMOS-MEA, with the multiwell-MEA segment holding the largest market share in 2023. Regarding application, the market is categorized into cardiomyocytes, nerve, and others, with the cardiomyocytes segment also leading in market share. By country, the market is segmented into the US, Canada, and Mexico, with the US dominating the market in 2023.
Key Players
Leading companies in the North America microelectrode array in vitro market include Tucker Davis Technologies, SCREEN Holdings Co., Ltd., Plexon Inc., MaxWell Biosystems AG, Harvard Bioscience Inc., Axion BioSystems Inc., 3Brain AG, NeuroNexus Technologies Inc., MicroElectrodeDevices, Blackrock Microsystems, Inc., NMI Technologietransfer GmbH, and BMSEED. These companies are at the forefront of developing innovative solutions to meet the growing demands of neuroscience and related fields.