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市場調查報告書
商品編碼
1856968
全球神經退化性疾病市場:預測至 2032 年—按分子類型、適應症、藥物類別、給藥途徑、最終使用者和地區進行分析Neurodegenerative Disease Market Forecasts to 2032 - Global Analysis By Molecule Type (Small-Molecule Drugs, Biologics and Cell & Gene Therapies), Indication, Drug Class, Route of Administration, End User and By Geography |
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根據 Stratistics MRC 的數據,預計到 2025 年,全球神經退化性疾病市場規模將達到 644 億美元,到 2032 年將達到 1,189 億美元,預測期內複合年成長率為 9.15%。
神經退化性疾病是指一組以神經細胞結構和功能逐漸喪失為特徵的疾病,最終導致神經細胞逐漸死亡。這些疾病會影響大腦和神經系統,損害認知、運動和感覺功能。常見的例子包括阿茲海默症、帕金森氏症、亨廷頓氏症和肌萎縮性側索硬化症(ALS)。其根本原因通常涉及異常蛋白質累積、基因突變、氧化壓力和粒線體功能障礙。由於神經細胞無法有效再生,這些疾病通常會發展為慢性病,並隨著時間的推移而惡化。由於其複雜性和缺乏有效治療方法,神經退化性疾病為醫學和社會帶來了重大挑戰。
生物標記和診斷技術的進步
研究人員正在開發體液和影像生物標記,以識別阿茲海默症、帕金森氏症和肌萎縮側索硬化症(ALS)的早期病理。人工智慧和機器學習的結合正在提高診斷準確性和疾病分層能力。製藥公司正在利用生物標記來最佳化試驗設計和治療標靶。伴隨診斷在精準神經病學研發管線中正變得越來越普遍。這些能力正在推動早期療育和個人化醫療領域的創新。
複雜疾病生物學與異質性
許多疾病的病因複雜,涉及遺傳、環境和發炎等多種因素。疾病進展在個體間差異很大,這使得臨床試驗終點和治療效果的評估變得複雜。臨床前研究因缺乏經過驗證的動物模型和轉化生物標記而受阻。監管機構要求提供在異質人群中療效和安全性的有力證據。這些挑戰持續阻礙藥物研發和平台規模化應用。
醫療保健支出和意識不斷提高
各國政府正在資助國家失智症戰略和老化相關研究計畫。旨在消除認知衰退和神經系統疾病污名化的宣傳活動正在進行中。醫院正在擴大記憶診所和神經復健中心,以滿足日益成長的需求。對數位醫療和遠端監測的投資正在支持長期護理和疾病管理。這些趨勢正在推動預防、診斷和治療創新領域的發展。
資源匱乏地區診斷途徑有限
許多地區缺乏訓練有素的神經科、影像基礎設施和分子檢測能力。農村和醫療服務不足的人面臨診斷延遲和專科診療機會有限的問題。 PET掃描、腦脊髓液檢測和基因檢測的費用和可近性仍然是新興市場的障礙。轉診途徑分散和公眾認知度低進一步損害了醫療品質。這些限制因素持續阻礙全球神經退化領域的公平性和治療效果。
疫情擾亂了全球神經退化患者的臨床試驗、診斷和長期照護。封鎖和資源重新分配減緩了患者獲得治療和疾病監測的速度。然而,疫情後的復甦策略強調神經科照護的韌性和數位轉型。遠端醫療、遠距認知評估和數位生物標記已在老年族群中廣泛應用。疫情期間,民眾對神經系統健康的關注度有所提高,這影響了政策和研究重點。這些轉變正在加速對基礎設施、技術創新和以患者為中心的護理模式的投資。
預計在預測期內,阿茲海默症細分市場將成為最大的細分市場。
由於阿茲海默症領域將佔據最大的市場佔有率。製藥公司已推出針對澱粉樣蛋白和Tau蛋白病理的單株抗體和疾病修正治療。隨著人口老化,對早期檢測和風險分層的投資正在增加。與數位認知工具和體液生物標記的整合正在改善篩檢和監測。各國政府正在資助失智症研究和護理協調計畫。
預計細胞和基因治療領域在預測期內將達到最高的複合年成長率。
隨著治療方法在罕見和進行性神經退化性疾病中的應用日益廣泛,細胞和基因治療領域預計將在預測期內呈現最高的成長率。研發人員正利用病毒載體、幹細胞和基因編輯平台來恢復神經元功能並阻止疾病進展。監管機構正在為突破性療法提供快速審查和有條件核准。對生產規模化和遞送平台的投資正在提高治療的準備度和可負擔性。生物技術公司、醫院和支付方之間的夥伴關係正在支持治療的可及性和報銷模式。
在預測期內,北美預計將佔據最大的市場佔有率,這主要得益於其先進的研究基礎設施、積極的監管參與以及人口老化趨勢。美國和加拿大擁有眾多領先的神經病學中心、臨床試驗網路和患者權益組織。美國食品藥物管理局(FDA)的快速通道和突破性療法認定等項目為創新和市場准入提供了支持。對生物標記開發和精準神經病學的投資正在推動平台擴張。領先的生物技術公司和學術機構的存在進一步鞏固了其市場領導地位。
預計亞太地區在預測期內將呈現最高的複合年成長率,這主要得益於醫療現代化、人口老化和政策改革的共同推動。中國、日本、印度和韓國等國家正在擴大都市區地區神經系統疾病診斷和治療的覆蓋範圍。政府支持的計畫正在推動失智症篩檢、公眾意識提升和基礎設施建設。區域生物技術公司正在推出針對特定族群適應症的細胞和基因療法。公共和私人醫療系統對經濟實惠且擴充性的解決方案的需求日益成長。這些趨勢正在推動整個神經退化性疾病生態系統的區域性成長。
According to Stratistics MRC, the Global Neurodegenerative Disease Market is accounted for $64.4 billion in 2025 and is expected to reach $118.9 billion by 2032 growing at a CAGR of 9.15% during the forecast period. Neurodegenerative disease refers to a group of disorders characterized by the progressive loss of structure or function of neurons, leading to their gradual death. These conditions affect the brain and nervous system, impairing cognitive, motor, and sensory functions. Common examples include Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis (ALS). The underlying causes often involve abnormal protein accumulation, genetic mutations, oxidative stress, and mitochondrial dysfunction. As neurons cannot regenerate efficiently, these diseases are typically chronic and worsen over time. Neurodegenerative diseases pose significant medical and social challenges due to their complexity and lack of curative treatments.
Advances in biomarker & diagnostic technology
Researchers are developing fluid-based and imaging biomarkers to identify early-stage pathology in Alzheimer's, Parkinson's, and ALS. Integration with AI and machine learning is improving diagnostic accuracy and disease stratification. Pharmaceutical companies are using biomarkers to optimize trial design and therapeutic targeting. Companion diagnostics are gaining traction across precision neurology pipelines. These capabilities are propelling innovation in early intervention and personalized care.
Complex disease biology & heterogeneity
Many conditions involve multifactorial pathogenesis, including genetic, environmental, and inflammatory components. Disease progression varies widely across individuals, complicating trial endpoints and treatment response. Lack of validated animal models and translational biomarkers slows preclinical research. Regulatory bodies require robust evidence for efficacy and safety in heterogeneous populations. These challenges continue to hinder drug development and platform scalability.
Rising healthcare spending & awareness
Governments are funding national dementia strategies and aging-related research programs. Public campaigns are improving awareness and reducing stigma around cognitive decline and neurological disorders. Hospitals are expanding memory clinics and neurorehabilitation centers to meet rising demand. Investment in digital health and remote monitoring is supporting long-term care and disease management. These trends are fostering growth across prevention, diagnosis, and therapeutic innovation.
Limited diagnostic access in low-resource settings
Many regions lack trained neurologists, imaging infrastructure, and molecular testing capabilities. Rural and underserved populations face delays in diagnosis and limited access to specialized care. Cost and availability of PET scans, CSF assays, and genetic testing remain barriers in emerging markets. Fragmented referral pathways and low public awareness further degrade care quality. These constraints continue to hamper equity and outcomes across global neurodegenerative ecosystems.
The pandemic disrupted clinical trials, diagnostics, and long-term care for neurodegenerative patients worldwide. Lockdowns and resource reallocation delayed therapy access and disease monitoring. However, post-pandemic recovery strategies have emphasized resilience and digital transformation in neurology care. Telemedicine, remote cognitive assessments, and digital biomarkers gained traction across aging populations. Public awareness of neurological health increased during the crisis, influencing policy and research priorities. These shifts are accelerating investment in infrastructure, innovation, and patient-centric care models.
The alzheimer's disease segment is expected to be the largest during the forecast period
The alzheimer's disease segment is expected to account for the largest market share during the forecast period due to its high prevalence, diagnostic complexity, and therapeutic innovation. Pharmaceutical firms are launching monoclonal antibodies and disease-modifying therapies targeting amyloid and tau pathology. Investment in early detection and risk stratification is rising across aging populations. Integration with digital cognitive tools and fluid biomarkers is improving screening and monitoring. Governments are funding dementia research and care coordination programs.
The cell & gene therapies segment is expected to have the highest CAGR during the forecast period
Over the forecast period, the cell & gene therapies segment is predicted to witness the highest growth rate as curative approaches gain traction across rare and progressive neurodegenerative conditions. Developers are using viral vectors, stem cells, and gene editing platforms to restore neuronal function and halt disease progression. Regulatory bodies are offering expedited review and conditional approvals for breakthrough therapies. Investment in manufacturing scale-up and delivery platforms is improving readiness and affordability. Partnerships between biotech firms, hospitals, and payers are supporting access and reimbursement models.
During the forecast period, the North America region is expected to hold the largest market share due to its advanced research infrastructure, regulatory engagement, and aging demographics. The United States and Canada host major neurology centers, clinical trial networks, and patient advocacy organizations. FDA programs such as Fast Track and Breakthrough Therapy Designation are supporting innovation and market entry. Investment in biomarker development and precision neurology is driving platform expansion. Presence of leading biotech firms and academic institutions is reinforcing leadership.
Over the forecast period, the Asia Pacific region is anticipated to exhibit the highest CAGR as healthcare modernization, aging populations, and policy reform converge. Countries like China, Japan, India, and South Korea are scaling neurology diagnostics and therapy access across urban and rural regions. Government-backed programs are supporting dementia screening, public awareness, and infrastructure development. Regional biotech firms are launching cell and gene therapies tailored to population-specific indications. Demand for affordable and scalable solutions is rising across public and private healthcare systems. These trends are accelerating regional growth across neurodegenerative disease ecosystems.
Key players in the market
Some of the key players in Neurodegenerative Disease Market include AbbVie Inc., Amneal Pharmaceuticals LLC, Boehringer Ingelheim GmbH, F. Hoffmann-La Roche Ltd., Merck & Co., Inc., Novartis AG, Pfizer Inc., Teva Pharmaceutical Industries Ltd., UCB S.A., Biogen Inc., Eli Lilly and Company, Johnson & Johnson, Eisai Co., Ltd., Lundbeck A/S and Denali Therapeutics Inc.
In January 2025, AbbVie exercised its first opt-in under the collaboration with Capsida Biotherapeutics, securing rights to a gene therapy program for neurodegenerative diseases. The decision followed promising primate data showing effective delivery of AbbVie's therapeutic payload to the brain using Capsida's engineered AAV capsids, while minimizing off-target effects in the liver and dorsal root ganglia.
In September 2023, Amneal launched IPX203 in the U.S. following FDA approval for Parkinson's disease. The extended-release formulation demonstrated superior "on-time" versus immediate-release carbidopa-levodopa in Phase 3 trials, offering improved symptom control and dosing convenience for patients with advanced Parkinson's.
Note: Tables for North America, Europe, APAC, South America, and Middle East & Africa Regions are also represented in the same manner as above.