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市場調查報告書
商品編碼
1722423
2025 年至 2033 年高通量篩選市場報告(按技術、產品和服務、應用、最終用戶和地區分類)High-throughput Screening Market Report by Technology, Products and Services, Applications, End User, and Region 2025-2033 |
2024年全球高通量篩選市場規模達271億美元。展望未來, IMARC Group預計到2033年市場規模將達到507億美元,2025-2033年期間的成長率(CAGR)為7.2%。 3D 細胞培養模型的採用率不斷提高、個人化醫療篩選檢測的需求不斷成長以及基於 CRISPR 的篩選技術的應用日益增多是推動市場成長的一些關鍵因素。
主要市場促進因素:擴大利用 HTS 來最大限度地縮短製造藥物所需的時間,這主要推動了市場的成長。此外,治療各種危及生命的疾病的新藥的開發也催化了對 HTS 技術的需求。
主要市場趨勢:將人工智慧 (AI) 和機器學習 (ML) 等先進技術與高通量篩選相結合,以促進自動化和快速資料處理,這是促進市場成長的重要趨勢之一。
地理格局:高通量篩選市場預測報告提供了基於地區的市場詳細細分和分析。其中包括北美、亞太地區、歐洲、拉丁美洲以及中東和非洲。由於高通量篩選的日益普及、研發支出的增加以及組合化學和基因組學領域的不斷進步等因素,預計北美將在高通量篩選市場中佔據相當大的市場佔有率。
競爭格局:一些領先的高通量篩選市場公司包括安捷倫科技公司、Aurora Biomed 公司、Axxam SpA、貝克曼庫爾特公司(丹納赫公司)、Bio-RAD Laboratories 公司、Charles River Laboratories International 公司、康寧公司、Luminex 公司(DiaSorin)、Perkinelmerature 公司、Sywise Group。
挑戰與機會:高通量篩選市場的挑戰包括資料管理的複雜性和對更多生理相關檢測模型的需求,而機會則在於自動化、人工智慧和器官晶片系統等先進技術,以實現更有效率和更具預測性的篩選過程。
不斷增加的HTS設施數量
治療各種危及生命的疾病的新藥的開發是推動市場成長的主要動力。此外,HTS 利用率的提高,最大限度地縮短了藥品製造所需的時間,也促進了市場的成長。除此之外,高通量篩選(HTS)設施數量的不斷增加也催化了高通量篩選市場的近期價格。這些中心的顯著優勢之一是研究人員、科學家、研究人員等之間的知識分享。例如,哥倫比亞基因組中心為整個哥倫比亞大學研究界的研究人員提供高品質的分子篩選服務。此外,美國國立衛生研究院 (NIH) 計畫的歐洲對應計畫 EU-open-screen 也為所有從事化學生物學的歐洲公司提供開放取用。高通量篩選(HTS)中心的聯合旨在提供有關藥物或標靶或整個過程的有用資訊。因此,開放取用為知識共享提供了更好的平台,有助於加速藥物開發過程,這可能會推動未來幾年高通量篩選市場佔有率的成長。
新分子的不斷開發
各種傳染病的盛行率不斷上升,促使新型分子和疫苗的開發,這反過來又為高通量篩選市場創造了積極的前景。此外,在藥物製造過程中對各種藥物和分子進行精確和快速篩選的需求不斷增加,導致自動化高通量篩選技術的應用日益廣泛。此外,各種製藥和生物公司擴大採用高通量篩選方法,因為它們具有高靈敏度、自動化、樣品最小化以及檢測低背景訊號的能力等各種優勢,這增強了高通量篩選市場的需求。根據美國國會預算辦公室 2021 年發布的資料,全球製藥業在 2020 年的研發支出接近 2,000 億美元,而 2019 年為 8,300 萬美元。同樣,丹納赫公司在 2021 年的研發投資為 17.42 億美元,而 2020 年為 13.48 億美元。此外,Bio-Rad Laboratories Inc. 在 2021 年的投資為 8.796 億美元,而 2020 年為 8.003 億美元。因此,公司在研發方面不斷增加的投資進一步提高了它們在高通量篩選檢測中採用創新技術的能力,從而增加了市場成長。
技術進步
近年來,高通量篩選 (HTS) 技術取得了重大進展,這得益於機器人、自動化、資料分析和小型化領域的持續創新。此外,自動化和機器人技術的進步正在大大提高 HTS 工作流程的速度和效率。自動化液體處理系統、讀板器和機器人平台現在可以高精度、高通量地執行重複性任務,從而減少了人工干預的需要。此外,各領先的生物技術公司也在投資研發活動,以引入改進的 HTS 方法,預計這將推動高通量篩選市場收入的成長。例如,2024 年 2 月,生命科學分析技術的全球領導者 SCIEX 在 SLAS 2024 上推出了 Echo MS+ 系統。該系統將專有的聲學噴射質譜技術和開放端口介面 (OPI) 採樣與 SCIEX ZenoTOF 7600 或 Triple Quad 6500+ 系統的功能相結合,透過擴展的強大高通量篩選工作流程提供精確的定性和定量結果。
高通量篩選市場概況表明,基於細胞的分析正擴大被各種製藥和生物技術公司使用。高通量篩選中的細胞分析利用活細胞作為化合物測試的生物讀數,能夠以高通量的方式評估候選藥物對細胞功能、活力和表現型的影響,通常用於藥物發現和毒性篩選。螢光成像板讀數儀檢測因其可見的結果和以最小體積進行測試的能力,已成為最常用的基於細胞的檢測方法。除此之外,超高通量篩選是最新技術,可在更短的時間內提高產量。大多數公司正處於從 2D 細胞培養到 3D 細胞培養的過渡階段,因為 3D 細胞在自然環境和其他細胞相關操作中進行測試時表現出更逼真的特性,有助於藥物設計和發現。
高通量篩選市場報告根據產品和服務提供了詳細的市場細分和分析。其中包括儀器、試劑和試劑盒以及服務。
高通量篩選依賴專門的儀器,例如自動液體處理器、平板讀取器和機器人平台。這些儀器能夠快速處理、分配和分析微孔板形式的樣品,從而提高篩選實驗的效率和吞吐量。而高通量篩選所使用的試劑和試劑盒則包括化合物庫、生化檢測試劑、螢光探針或酵素底物等檢測試劑。這些針對與自動化系統和微型化分析格式的兼容性進行了最佳化,從而可以針對特定的生物靶點或途徑篩選大型化合物庫。
目標識別和驗證涉及識別和驗證與疾病或生物過程有關的分子目標(例如蛋白質、基因或細胞通路)。透過基因組學、蛋白質組學和生物資訊學等各種方法,可以識別潛在目標並進行驗證,以確保其與進一步研究的相關性和可追溯性。而在初級和二級篩選中,會針對特定目標或生物測定對大量化合物庫進行測試,以識別出顯示出活性或調節作用的初始化合物。該方法涉及對命中化合物進行更詳細的表徵,以確認其活性、選擇性和效力。初步篩選和二次篩選通常包括劑量反應研究、反篩選和二次分析,以驗證命中結果並確定其優先順序以進行先導化合物最佳化和臨床前開發。
根據 IMARC 的高通量篩選市場統計數據,製藥公司和政府組織在研發 (R&D) 上的支出最近一直在增加,預計這將在預測期內推動市場成長。例如,全球領先的生命科學和診斷創新者丹納赫公司 (Danaher Corporation) 在 2021 年的研發投資為 17.42 億美元,而 2020 年為 13.48 億美元。此外,Bio-Rad Laboratories Inc. 在 2021 年的投資為 8.796 億美元,而 2020 年為 8.003 億美元。因此,製藥公司、生技公司和政府機構的巨額投資將繼續推動市場成長。
市場研究報告也對所有主要區域市場進行了全面分析,包括北美(美國和加拿大);歐洲(德國、法國、英國、義大利、西班牙、俄羅斯等);亞太地區(中國、日本、印度、韓國、澳洲、印尼等);拉丁美洲(巴西、墨西哥等);以及中東和非洲。
由於高通量篩選的日益普及、研發支出的增加以及組合化學和基因組學領域的不斷進步等多種因素,預計北美將在高通量篩選市場中佔據相當大的市場佔有率。除此之外,該地區知名市場參與者的存在也對高通量篩選市場前景產生了正面影響。例如,2021年8月,碧迪公司推出了一款全新的全自動高通量診斷系統,該系統採用機器人技術和樣本管理軟體演算法,為美國核心實驗室和其他中心實驗室的傳染病分子檢測自動化樹立了新標準。此次發布使得 BD Onclarity HPV 檢測試劑盒(具有擴展基因分型功能)可用於 BD COR 系統,供高通量實驗室用於處理美國大多數持續感染人類乳突病毒 (HPV) 的子宮頸癌篩檢樣本。
市場研究報告對競爭格局進行了全面的分析。也提供了所有主要公司的詳細資料。市場中的一些主要參與者包括:
(請注意,這只是關鍵參與者的部分列表,完整列表在報告中提供。)
2024 年 4 月:Gordian Biotechnology 推出高通量體內篩選平台,以發現治療方法並更好地預測與年齡相關的疾病的人類結果。
2024 年 4 月:Metrion Biosciences Limited 和 Enamine Ltd. 宣布,Metrion 已增強其高通量篩選 (HTS) 服務,並增加了對 Enamine 化合物庫的存取權限。
2024 年 2 月:生命科學分析技術的全球領導者 SCIEX 在 SLAS 2024 上推出了 Echo MS+ 系統。該系統將專有的聲學噴射質譜技術和開放端口介面 (OPI) 採樣與 SCIEX ZenoTOF 7600 或 Triple Quad 6500+ 系統的功能相結合,透過擴展的強大高通量篩選工作流程提供精確的定性和定量結果。
The global high-throughput screening market size reached USD 27.1 Billion in 2024. Looking forward, IMARC Group expects the market to reach USD 50.7 Billion by 2033, exhibiting a growth rate (CAGR) of 7.2% during 2025-2033. The increased adoption of 3D cell culture models, growing demand for personalized medicine screening assays, and rising application of CRISPR-based screening techniques are some of the key factors driving the market growth.
Major Market Drivers: The increasing utilization of HTS for minimizing the time required for manufacturing a drug is primarily driving the growth of the market. Furthermore, the development of new medicines for treating various life-threatening diseases is also catalyzing the demand for HTS techniques.
Key Market Trends: Integration of advanced technologies, such as artificial intelligence (AI) and machine learning (ML) with high-throughput screening to facilitate automation and fast data processing is one of the significant trends, augmenting the growth of the market.
Geographical Landscape: The high-throughput screening market forecast report has provided a detailed breakup and analysis of the market based on the region. This includes North America, Asia Pacific, Europe, Latin America, and Middle East and Africa. North America is expected to hold a significant market share in the high-throughput screening market owing to factors such as the increasing adoption of high-throughput screening, rising research and development expenditure, and the growing advances in combinatorial chemistry and the field of genomics.
Competitive Landscape: Some of the leading high-throughput screening market companies include Agilent Technologies Inc., Aurora Biomed Inc., Axxam S.p.A, Beckman Coulter Inc. (Danaher Corporation), Bio-RAD Laboratories Inc., Charles River Laboratories International Inc. Corning Incorporated, Luminex Corporation (DiaSorin), Perkinelmer Inc., Sygnature Discovery, Tecan Group Ltd., and Thermo Fisher Scientific, among many others.
Challenges and Opportunities: Challenges in the high-throughput screening market include data management complexities and the need for more physiologically relevant assay models, while opportunities lie in advancing technologies like automation, artificial intelligence, and organ-on-a-chip systems for more efficient and predictive screening processes.
Increasing Number of HTS Facilities
The development of new medicines for treating various life-threatening diseases is primarily driving the growth of the market. Furthermore, the rise in the utilization of HTS for minimizing the time required for manufacturing a drug is also contributing to the market growth. In addition to this, the escalating number of high-throughput screening (HTS) facilities is also catalyzing the high-throughput screening market's recent prices. One of the significant advantages of these centers is knowledge sharing among investigators, scientists, researchers, etc. For instance, the Columbia Genome Center offers high-quality molecular screening services for investigators throughout the Columbia University research community. Also, the European counterpart of the National Institutes of Health (NIH) program, known as EU-open-screen, provides open access to all European companies engaged in chemical biology. The association of high-throughput screening (HTS) centers is intended to provide useful information about the drug or target or the entire process. Thus, open access provides a better platform for knowledge sharing and can help accelerate the drug development process, which may drive the high-throughput screening market share in the coming years.
Rising Development of Novel Molecules
The rising prevalence of various infectious diseases is prompting the development of novel molecules and vaccines, which in turn is creating a positive outlook for the high-throughput screening market. Moreover, the escalating need for precise and quick screening of various drugs and molecules during the manufacturing of a drug is resulting in an increased adoption of automated high-throughput screening techniques. Furthermore, various pharmaceutical and biologic firms are increasingly adopting high-throughput screening methods on account of their various advantages, such as high sensitivity, automation, minimization of the sample, and the ability to detect low background signals, which is bolstering the high-throughput screening market demand. According to the data published by the Congressional Budget Office, in 2021, it was observed that pharmaceutical industries spent nearly US$ 200 Billion on research and development in 2020 globally, compared to US$ 83 Million in 2019. Similarly, Danaher Corporation invested US$ 1,742 Million in its research and development in 2021, as compared to US$ 1,348 Million in 2020. In addition, Bio-Rad Laboratories Inc. invested US$ 879.6 Million in 2021 as compared to US$ 800.3 Million in 2020. Thus, the increasing investment in research and development by the companies further increases their capabilities to adopt innovative technologies in high throughput screening assays, thereby increasing the market growth.
Technological Advancements
High-throughput screening (HTS) techniques have seen significant advancements in recent years, driven by the continuous innovations in robotics, automation, data analysis, and miniaturization. Moreover, advances in automation and robotics are extensively increasing the speed and efficiency of HTS workflows. Automated liquid handling systems, plate readers, and robotic platforms can now perform repetitive tasks with high precision and throughput, reducing the need for manual intervention. Additionally, various leading biotech companies are also investing in research and development activities to introduce improved HTS methods which are anticipated to propel the high-throughput screening market revenue. For instance, in February 2024, SCIEX, a global leader in life science analytical technologies, launched the Echo MS+ system at SLAS 2024. The system couples proprietary Acoustic Ejection Mass Spectrometry technology and Open Port Interface (OPI) sampling with the capabilities of either the SCIEX ZenoTOF 7600 or Triple Quad 6500+ system to deliver precise qualitative and quantitative results through an expanded panel of robust high-throughput screening workflows.
The high-throughput screening market overview indicates that cell-based assays are increasingly being used by various pharmaceutical and biotech companies. Cell-based assays in high-throughput screening utilize live cells as the biological readout for compound testing, enabling the evaluation of drug candidates' effects on cellular function, viability, and phenotype in a high-throughput manner, often employed in drug discovery and toxicity screening. Fluorometric imaging plate reader assays have become the most used cell-based assays owing to visible results and their ability to test with the smallest of volumes. Besides this, ultra-high-throughput screening is the latest technology and is used for increased output in less time. A majority of companies are in a transition phase from 2D-cell cultures to 3D-cell cultures as 3D cells show more lifelike properties while testing in the natural environment and other cell-related manipulations, aided for drug design and discovery.
The high-throughput screening market report has provided a detailed breakup and analysis of the market based on the products and services. This includes instruments, reagents and kits, and services.
High-throughput screening relies on specialized instruments, such as automated liquid handlers, plate readers, and robotic platforms. These instruments enable the rapid handling, dispensing, and analysis of samples in microplate formats, thereby increasing the efficiency and throughput of screening experiments. Whereas reagents and kits that are used in high-throughput screening include compound libraries, biochemical assays, and detection reagents such as fluorescent probes or enzyme substrates. These are optimized for compatibility with automated systems and miniaturized assay formats, allowing for the screening of large compound libraries against specific biological targets or pathways.
Target identification and validation involves identifying and validating molecular targets (such as proteins, genes, or cellular pathways) that are implicated in a disease or biological process. Through various methods, including genomics, proteomics, and bioinformatics, potential targets are identified and then validated to ensure their relevance and draggability for further investigation. Whereas in primary and secondary screening large libraries of compounds are tested against a specific target or biological assay to identify initial hits that show activity or modulation. This method involves a more detailed characterization of hit compounds to confirm their activity, selectivity, and potency. Primary and secondary screening typically includes dose-response studies, counter-screens, and secondary assays to validate hits and prioritize them for lead optimization and preclinical development.
According to high-throughput screening market statistics by IMARC, the spending on research and development (R&D) by both pharmaceutical companies and government organizations has been increasing recently, which is anticipated to drive market growth over the forecast period. For instance, Danaher Corporation, a leading global life sciences and diagnostics innovator, invested US$ 1,742 Million in its research and development in 2021, as compared to US$ 1,348 Million in 2020. In addition, Bio-Rad Laboratories Inc. invested US$ 879.6 Million in 2021 as compared to US$ 800.3 Million in 2020. Thus, the huge investment by pharmaceuticals, biotech firms, and government institutions will continue to drive the market growth.
The market research report has also provided a comprehensive analysis of all the major regional markets, which include North America (the United States and Canada); Europe (Germany, France, the United Kingdom, Italy, Spain, Russia, and others); Asia Pacific (China, Japan, India, South Korea, Australia, Indonesia, and others); Latin America (Brazil, Mexico, and others); and the Middle East and Africa.
North America is expected to hold a significant market share in the high-throughput screening market owing to various factors such as the increasing adoption of high-throughput screening, rising research and development expenditure, and the growing advances in combinatorial chemistry and the field of genomics. In addition to this, the presence of prominent market players in the region is also positively impacting the high-throughput screening market outlook. For instance, in August 2021, Becton, Dickinson, and Company launched a new, fully automated high-throughput diagnostic system using robotics and sample management software algorithms to set a new standard in automation for infectious disease molecular testing in core laboratories and other centralized laboratories in the United States. This launch made BD Onclarity HPV Assay with extended genotyping for the BD COR System available to the high-throughput labs for processing most cervical cancer screening specimens in the United States with persistent infection with human papillomavirus (HPV).
The market research report has provided a comprehensive analysis of the competitive landscape. Detailed profiles of all major companies have also been provided. Some of the key players in the market include:
(Please note that this is only a partial list of the key players, and the complete list is provided in the report.)
April 2024: Gordian Biotechnology introduced a high-throughput in vivo screening platform to discover therapies and better predict human outcomes for age-related diseases.
April 2024: Metrion Biosciences Limited and Enamine Ltd., announced that Metrion has enhanced its High Throughput Screening (HTS) services with the addition of access to Enamine's compound libraries.
February 2024: SCIEX, a global leader in life science analytical technologies, launched the Echo MS+ system at SLAS 2024. The system couples proprietary Acoustic Ejection Mass Spectrometry technology and Open Port Interface (OPI) sampling with the capabilities of either the SCIEX ZenoTOF 7600 or Triple Quad 6500+ system to deliver precise qualitative and quantitative results, through an expanded panel of robust high-throughput screening workflows.