市場調查報告書
商品編碼
1139889
移植物抗宿主病市場:按產品類型,按治療類型,按最終用戶:2021-2031 年全球機會分析和行業預測Graft Versus Host Disease Market By Product Type, By Treatment Type, By End Use : Global Opportunity Analysis and Industry Forecast, 2021-2031 |
2021 年全球移植物抗宿主病市場價值為 29.686 億美元,到 2031 年將達到 103.753 億美元,預計 2022 年至 2031 年的複合年增長率為 13.5%。
移植物抗宿主病 (GVHD) 是異基因移植(骨髓移植)後可能發生的疾病。在GVHD中,捐贈的骨髓和外周血幹細胞將接受者的身體視為異物,捐贈的細胞和骨髓會攻擊身體。 GVHD 有兩種形式:急性移植物抗宿主病 (aGVHD) 和慢性移植物抗宿主病 (cGVHD)。
aGVHD 和 cGVHD 的病理生理學仍未完全了解。即損傷腸黏膜和肝臟等宿主組織的調理療法,激活供體T細胞對抗宿主抗原並隨後擴增克隆T細胞,白細胞介素-1(IL-1)和腫瘤壞死因子(TNFα)釋放炎症細胞毒性等細胞因子會導致進一步的宿主組織損傷。幾種機制有助於 cGVHD 的發展,包括供體來源的同種異體反應性 T 細胞、自身反應性 T 細胞和產生針對宿主的抗體的 B 細胞的持續存在,以及導致終末器官纖維化的慢性炎症機制。涉及。
儘管在移植後免疫抑制治療方面進行了數十年的研究和改進,移植物抗宿主病 (GVHD) 仍然是異基因造血幹細胞移植 (HSCT) 受者發病率和死亡率的重要原因。
COVID-19 大流行正在影響世界各地的各種企業。移植物抗宿主病市場也產生了重大影響。為了阻止 COVID-19 的傳播,世界各國政府都實施了嚴格的規定,包括關閉邊境、限制和嚴格的社會隔離措施。這些措施對全球經濟產生了重大影響,影響了各個行業。製藥和生物技術公司正在與世界各地的政府合作應對 COVID-19 疫情,從支持疫苗開發到規劃藥物供應鏈挑戰。目前大約有 115 種候選疫苗和 155 種分子在研發中。
COVID-19 的影響 COVID-19 大流行已經深刻改變了美國和全球的腎移植格局。大流行不僅對受者同種異體移植物和腎移植後的患者生存產生了不利影響,而且還影響了移植物的轉診和上市、器官捐贈率、器官採購和運送、等待名單死亡率以及移植醫學的其他方面。
隨著腎移植率的下降,器官獲取率也在下降。英國報告稱,轉診至 OPO 的器官減少了 39%。法國報告說,與往年相比,全死亡器官採購減少了 16%。其中一些下降是由於缺乏測試能力和 COVID-19 測試結果延遲、手術室的可用性有限、強制避免不必要的臨床活動以保護人員和防護設備以及該組織面臨的採購挑戰。
因此,由於移植手術數量的減少,COVID-19 對移植物抗宿主病市場的總體影響仍然是負面的。植入手術需要常規使用可重複使用的器械,並與患者密切接觸。這增加了疾病傳播的風險。
移植物抗宿主病的增加主要是由於同種異體移植的增加。疾病診斷率的提高和移植物抗宿主病治療產品的增加也是推動市場增長的因素。
根據器官採購和移植網絡的初步數據,2020 年,美國已故捐獻者的器官捐贈創下歷史新高。共有 12,587 人捐贈了一個或多個器官來拯救或改善他人的生命,比 2019 年增加了 6%。
此外,死者捐贈的大部分增加是由於捐贈者的表現低於傳統醫療標準。已故捐贈者最常見的年齡組是 50-64 歲。與 2019 年相比,該類別的 3,726 名捐助者增加了 7.9%。與腦死亡相比,死於心肺功能不全的人的捐贈顯著增加,有 3223 名心肺死亡後捐贈者(DCD 捐贈者),比 2019 年的總數增加了 18.6%。
根據器官捐獻統計,全國等待器官移植的人數為105988人,而每天等待器官移植的人死亡17人,預計2021年將進行40000例移植手術。完成了。
術後並發症,如計算生物學無法檢測到的過敏反應、不利的政府情景、設備的高初始和維護成本、缺乏標準化、缺乏熟練勞動力等,將在預測期內影響市場。預計成為增長的主要障礙。
移植物抗宿主病市場根據產品、診斷、類型、最終用途和地區進行細分。按產品劃分,它分為皮質類固醇、單克隆抗體、免疫抑製劑等。按類型分為急性期和慢性期。最終用途分為醫院藥房、零售藥房和在線藥房。
The global Graft Versus Host Disease Market was valued at $2,968.6 million in 2021, and is projected to reach $10,375.3 million by 2031, registering a CAGR of 13.5% from 2022 to 2031.
Graft versus host disease (GVHD) is a condition that might occur after an allogeneic transplant (bone marrow transplant). In GVHD, the donated bone marrow or peripheral blood stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body. There are two forms of GVHD: acute graft versus host disease (aGVHD) and chronic graft versus host disease (cGVHD).
The pathophysiology of aGVHD and cGVHD remains incompletely understood. One commonly quoted model suggests three distinct stages in the development of aGVHD: a conditioning regimen, which damages host tissues, including intestinal mucosa and liver; activation of donor T cells against host antigens & subsequent clonal T-cell expansion; and release of inflammatory cytokines such as interleukin 1 (IL-1) & tumor necrosis factor (TNFα), leading to further host tissue damage. Several mechanisms have been implicated in cGVHD pathogenesis, including persistence of donor-derived alloreactive T cells, autoreactive T cells, B cells producing antibodies against the host, and mechanisms of chronic inflammation leading to end organ fibrosis.
Despite decades of research and improvements in post-transplant immunosuppressive therapies, graft-versus-host disease (GVHD) remains a significant cause of morbidity and mortality in allogenic hematopoietic stem-cell transplant (HSCT) recipients.
The COVID-19 pandemic has had an impact on a variety of businesses around the world. The Graft Versus Host Disease Market had a significant impact as well. To halt the spread of COVID-19, governments around the world implemented harsh restrictions such as border locks, lockdowns, and tight social distancing measures. These measures had a significant impact on the global economy, affecting a variety of industries. Pharmaceutical and biotech companies together with governments around the globe work to address the COVID-19 outbreak, from supporting the development of vaccines to planning for medicine supply chain challenges. Currently, around 115 vaccine candidates and 155 molecules are in the R&D pipeline.
Impact of COVID-19: The COVID-19 pandemic has significantly changed the landscape of kidney transplantation in the U.S. and worldwide. In addition to adversely impacting allograft and patient survival in post kidney transplant recipients, the current pandemic has affected all aspects of transplant care, including transplant referrals and listing, organ donation rates, organ procurement and shipping, and waitlist mortality.
As kidney transplantation rates declined, so did organ procurement rates. The UK reported a 39% decrease in referrals of organs to OPOs. France reported a 16% decrease in all deceased organ procurement rates as compared to previous years. Part of these declines were due to procurement challenges faced by transplant programs and organizations, such as insufficient testing capabilities and delayed COVID-19 test results, limited operating room availabilities, and mandates for the avoidance of nonessential clinical activities to preserve personnel and protective equipment.
Therefore, the overall impact of COVID-19 remains negative on graft versus host disease market due to decline in number of transplantation procedure. The transplant procedure requires the routine use of reusable equipment with close contact with patients. This increases the risk of disease transmission.
Increase in number of grafts versus host disease, which arises predominantly due to rise in number of allogenic transplantations. Also, increase in disease diagnosis rate and increase in number of products available for the treatment of graft versus host disease are the factors fueling the growth of the market.
According to preliminary data from the Organ Procurement and Transplantation Network, in 2020 organ donation from deceased donors in the U.S. set an all-time record. A total of 12,587 people provided one or more organs to save and enhance the lives of others, representing an increase of six percent over 2019.
Moreover, much of the increase in deceased donation was made possible by donors representing less traditional medical criteria. The most common age range of deceased donors was 50 to 64. The 3,726 donors in this category increased by 7.9 percent over 2019. Donation increased significantly among individuals who died of cardiorespiratory failure as opposed to brain death; the 3,223 donors after cardiorespiratory death (DCD donors) increased by 18.6 percent over the total in 2019.
According to Organ Donation Statistics, 105,988 number of men, women, and children are on the national transplant waiting list, whereas 17 people die each day waiting for the organ transplant and an estimated 40,000 transplants were performed in 2021.
Complications such as allergic reactions, which cannot be detected by computational biology and other post-surgery complications, unfavorable government scenario, the high initial cost and maintenance costs of the instruments, lack of standardization, and shortage of skilled workforce are expected to be the significant restraints to market growth during the forecast period.
The graft versus host disease market is segmented on the basis of product, diagnosis, types, end use, and region. By product the market is segmented into corticosteroids, monoclonal antibodies, immunosuppressants and others. On the basis of type the segment is divided into acute and chronic. On the basis of end use the segment is divided into hospital pharmacies, retail pharmacies and online pharmacies.
Region-wise, it is analyzed across North America, Europe, Asia-Pacific, and LAMEA.
Some of the major companies that operate in the graft versus host disease market are AbbVie, Asahi Kasei, Bristol Myer Squibb, GlaxoSmithKline, Incyte Corporation, Medac GmbH, Merck & co., Novartis, Pfizer and Sanofi.
Key Benefits For Stakeholders
The study provides an in-depth analysis of the graft versus host disease market, and the current graft versus host disease market trends and future estimations to elucidate imminent investment pockets.
It presents a quantitative analysis of the market from 2022 to 2031 to enable stakeholders to capitalize on the prevailing market graft versus host disease market opportunity.
Extensive analysis of the market based on procedures and services assists to understand the trends in the graft versus host disease industry.
Key players and their strategies are thoroughly analyzed to understand the competitive outlook of the market.
Key Market Segments
By Product Type
By Treatment Type
By End Use
By Region