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市場調查報告書
商品編碼
1445546
移植物抗宿主疾病(GvHD)市場評估:按疾病類型、藥物類別、給藥途徑、最終用戶和地區劃分的機會和預測(2017-2031)Graft versus Host Disease Assessment, By Disease Type, By Drug Class, By Route of Administration, By End-user, By Region, Opportunities and Forecast, 2017-2031F |
全球移植物抗宿主疾病 (GvHD) 市場規模將從 2023 年的 29.9 億美元增至 2031 年的 61 億美元,2024-2031 年預測期間複合年增長率為 9.51%。預計將增長至9000萬美元。
由於器官移植和幹細胞移植等移植需求的增加、技術進步、政府舉措以及人工智慧的整合等因素,GvHD 市場正在不斷增長。 移植需求的不斷增加正在推動 GvHD 的流行,並加速對治療方案的需求。 患者正在尋找更可靠、無麻煩和一流的方法來管理移植後症狀。 此外,政府也大力投資研發,將最好的技術推向市場。 許多新進展正在幫助接受移植手術的患者恢復得更快、更好。
GvHD 盛行率增加
由於幹細胞移植的增加,GvHD 市場正在顯著擴大。 幹細胞移植是治療多種免疫學和血液學問題的一種強大的新方法。 然而,隨著移植手術的增多,GvHD的盛行率也在增加。 幹細胞移植已成為多種疾病的常見治療方法。 有使用病人幹細胞的自體移植和使用捐贈者幹細胞的同種異體移植。 再生障礙性貧血和嚴重複合型免疫缺陷(SCID)等非惡性疾病以及白血病、淋巴瘤和骨髓瘤等血液惡性腫瘤的治療都受益於這些療法。 隨著越來越多人接受幹細胞移植,發生 GvHD 的風險也會增加。 除了傳統用途之外,醫生和研究人員正在研究支持實體器官移植、自體免疫疾病移植和再生醫學的應用。 隨著移植手術的多樣化,面臨 GvHD 風險的患者數量不斷增加,對有效 GvHD 治療的需求進一步增加。
政府措施
對 GvHD 治療的生產和批准的持續監管支持是市場成長的關鍵驅動力之一。 GvHD 研究、臨床研究和有前景藥物的商業化得到了政府和私營部門的大力資助。 政府已採取主動與該領域的研究中心、醫療專業人員和研究機構合作。
技術進步
GvHD 治療技術正在以驚人的速度發展,這主要歸功於醫療技術的進步。 由於醫療技術的進步,診斷GvHD的能力已大大提高。 利用基因組定序、生物標記識別和高解析度成像,醫療保健專業人員可以高精度檢測 GvHD。 醫療技術的進步使得專門針對 GvHD 患者的需求而設計的針對性治療成為可能。 GvHD 有前景的治療方法包括免疫調節藥物、生物製劑和單株抗體。 基於這些免疫學特徵的精確定製藥物提供了危害較小、更好的疾病控制方法。
本報告調查了全球移植物抗宿主疾病(GvHD) 市場,並提供了市場定義和概述、市場規模趨勢和預測、各個細分市場和地區的詳細分析、產業結構和市場成長。它總結了以下分析:影響因素、案例研究、競爭格局、主要公司概況。
Global graft versus host disease market is projected to witness a CAGR of 9.51% during the forecast period 2024-2031, growing from USD 2.99 billion in 2023 to USD 6.19 billion in 2031. The graft versus host disease (GvHD) market is experiencing growth due to factors such as rising demand for transplants, such as organ transplants or stem cell transplants, advancements in technology, government initiatives, and the integration of AI. Increasing demand for transplantations has boosted the prevalence of GvHD, which, in turn, has accelerated the demand for treatment options. Patients are looking for a more reliable, hassle-free, and best possible approach to deal with the symptoms that come after the transplantations. Furthermore, the government is also spending significant amounts on research and development to bring out the best possible techniques in the market. Many new advancements are helping faster and better recovery of patients after undergoing transplantation procedures.
Results from a phase 2 study (NCT02867384) presented during the 2023 ASH Annual Meeting showed that using obinutuzumab (Gazyva) to enhance B-cell depletion significantly reduced the need for corticosteroids and increased relapse-free survival in patients with steroid-requiring chronic GvHD undergoing well-matched hematopoietic stem cell transplant.
Rising Prevalence of GvHD
The market for GvHD is expanding significantly due to the rising use of stem cell transplants. A potent new technique for treating several immunological and hematological problems is stem cell transplantation. However, the prevalence of GvHD has increased in tandem with the growth in transplant procedures. Stem cell transplants have become a common therapy option for a variety of illnesses. They can be performed autologously, using the patient's stem cells, or allogeneically, using donor stem cells. Treatments for non-malignant conditions, including aplastic anemia and severe combined immunodeficiency (SCID), as well as hematological malignancies like leukemia, lymphoma, and myeloma, are both benefiting from this rising use. There is a growing risk of developing GvHD as more individuals receive stem cell transplantation. Beyond the conventional applications, physicians and researchers are investigating solid organ transplant support, autoimmune disease transplantation, and regenerative medicine applications. The demand for efficient GvHD treatments is being further driven by the expansion of the patient pool at risk of developing GvHD due to the diversity of transplant procedures.
In the United States, 42% of patients had developed chronic (cGvHD) within three years following allogenic HCT; 66% of those impacted by cGvHD had acute GvHD prior, per an Elsevier paper from June 2021.
Government Initiatives
Ongoing support by regulatory bodies toward the production and approval of GvHD medicines is acting as one of the main market drivers of flourishing growth. Research, clinical studies, and the commercialization of promising medicines related to GvHD are receiving significant funding from the government and private sectors. The government is taking initiatives to collaborate with research centers, healthcare professionals, and institutes that deal with this sector. According to the Australian government's Department of Health and Aged Care, new medications are now available for treating esophageal cancer, chronic rhinosinusitis, and GvHD. The new and upgraded medications, which will be covered under the Pharmaceutical Benefits Scheme (PBS), include Opdivo (nivolumab), Jakavi (ruxolitinib), and Nucala (mepolizumab).
Technological Advancements
The treatment techniques for GvHD are expanding at an impressive rate, mostly due to the ongoing progress in medical technology. The ability to diagnose GvHD has greatly improved due to developments in healthcare technologies. Using genome sequencing, biomarker identification, and high-resolution imaging, medical professionals can detect GvHD with high accuracy. Early detection is essential because it enables timely action, which may stop the illness from getting worse. Targeted therapies that are specifically designed to meet the needs of patients with GvHD are now possible due to advancements in medical technology. Promising therapies for GvHD include immunomodulatory medications, biologics, and monoclonal antibodies. These precisely tailored immunological profile-based medicines provide a less harmful and more successful means of controlling the illness.
The development of cellular and gene treatments is one of the biggest developments in the treatment of GvHD. GvHD may be treated with chimeric antigen receptor T-cell (CAR-T) therapy, which targets the immune cells that cause the illness. CRISPR-Cas9 and other gene editing methods show promise for precisely modifying immune cells to prevent or treat GvHD. Innovative medical technology makes these state-of-the-art treatments possible. Treatment has been transformed by the combination of telemedicine and remote monitoring technology, especially when it comes to GvHD. Improved GvHD management and patient outcomes are a result of this accessibility, which also improves patient compliance and overall quality of care. Big data analytics and artificial intelligence (Al) are being utilized to help with GvHD early detection and prevention. Large-scale datasets can be analyzed by machine learning algorithms, which can then spot patterns and risk factors that human clinicians could miss. With the use of this technology, medical professionals can anticipate future GvHD consequences, personalize treatment regimens, and make better decisions.
Research studies from Michigan Medicine, the Children's Hospital of Philadelphia, and Penn Medicine are paving the road for novel gene therapy treatments for blood disorders like sickle cell anemia. A patient still needs chemotherapy and the transplantation of their own corrected cells even after gene therapy corrects the mutation in their cells. However, it is possible to genetically modify blood stem cells in the bone marrow during a single therapy.
Corticosteroids are Dominating the Global Market
Tyrosine kinase inhibitors, corticosteroids, monoclonal antibodies, and other pharmaceuticals make up the product segment of this market. Due to the increasing number of research studies and the rising prevalence of the target disease, the corticosteroid segment retained the biggest share in 2023. Furthermore, the corticosteroid segment is anticipated to grow over the forecast period due to increased research and development efforts focused on corticosteroids and their combinations for the treatment of GvHD in patients undergoing hematopoietic cell transplantation (HCT). Corticosteroids help in managing the immune system and can also limit the activity of donated T-cells in the host's body. It even helps to reduce inflammation caused after the transplant, which regulates the blood pressure well. As of June 2022, an open-label, multicenter, two-arm randomized trial was conducted to evaluate the efficacy of corticosteroids alone or in combination with Ruxolitinib for newly identified high-risk acute gene therapy-related heart failure or dysfunction. It has been observed that roughly 50% of instances of acute graft-versus-host disease (aGvHD) respond to corticosteroid first-line therapy.
North America to Dominate GvHD Market
The North American region is expected to hold a significant market size due to its well-established healthcare infrastructure, ongoing research and development activities, and a growing number of transplant procedures. An increasing number of transplants performed in North America is accelerating market opportunities in the region. Between January 2022 and June 2022, 20,663 transplant procedures were performed in the United States, according to statistics provided by the Organ Procurement and Transplantation Network, which is supervised by the US Department of Health and Human Services and updated in July 2022. Due to the immunological-mediated reactions that take place between the recipients' and donors' adaptive immune systems, the rise in transplant cases may raise demand for therapies for GvHD, which would ultimately spur market demand.
Future Market Scenario (2024 - 2031F)
The growing need to address a variety of symptoms that occur post transplantation processes can fuel the market of GvHD. Increasing number of organ transplantations and the use of new types of inhibitors are also driving market expansion.
The advent of new and improved technologies, well researched drugs, gene editing techniques, and the integration of AI have enabled high accuracy and precision, which, in turn, is anticipated to increase market share in the upcoming years.
Personalised treatment strategies that target genetic alterations and pathways are becoming more and more popular as precision medicine gains traction. AI has also enhanced early detection for any possible indications that further helps the treatment as well as ensure market expansion.
Global regulatory bodies are building frameworks to speed up the development of specialized transplantation departments, which is also driving the expansion of the GvHD market worldwide.
Key Players Landscape and Outlook
There are several significant players in the competitive graft versus host disease market. Currently, the market is dominated by a few dominant players, such as Merck & Co., Inc, Novartis AG, Astellas Pharma Inc., Astra Zeneca PLC, Bayer AG, Boehringer Ingelheim International Gmbh, Abott Inc., Bristol Myers Squibb, Pfizer Inc., F. Hoffmann-La Roche Ltd, Novartis AG, Elli Lilly and Company, etc. These companies are governing the market share because of their consistent efforts toward R&D, technological advancements, and reliable quality.
Jakavi (ruxolitinib), approved by the European Commission (EC) in May 2022, is intended to treat individuals with acute or chronic GvHD who are 12 years of age or older and do not respond well to corticosteroids or other systemic therapy.
The EQUATOR project, a major Phase III clinical trial of itolizumab in patients with aGvHD, was started by Equillium Inc. in March 2022. When used in conjunction with corticosteroids, itolizumab versus placebo will be evaluated for both safety and efficacy as first-line therapy for aGvHD in this randomized, double-blind study.
All segments will be provided for all regions and countries covered
Companies mentioned above DO NOT hold any order as per market share and can be changed as per information available during research work.