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再生醫學細胞療法

市場調查報告書

商品編碼

1737200

CAR-T細胞療法市場（按目標抗原、治療應用和地區）：未來預測（2026-2032）

Car T Cell Therapy Market By Targeted Antigen (CD 19, HER1, BCMA, CD33), Therapeutic Application (Acute Lymphocytic Leukemia, Colorectal Cancer, Chronic Lymphocytic Leukemia, Hepatocellular Carcinoma) & Region for 2026-2032

出版日期: 2025年05月09日 | 出版商:

Verified Market Research | 英文 202 Pages | 商品交期: 2-3個工作天內

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簡介目錄

CAR-T細胞療法市場評估（2026-2032）

癌症發生率不斷上升，尤其是白血病和淋巴瘤等骨髓惡性腫瘤，而CAR-T細胞療法正是有效標靶治療這些疾病的標靶。此外，基因編輯技術和定製藥物的進步將使治療更加精準有效，預計到2024年，這類癌症的市場規模將達到369億美元，到2032年將達到1,916億美元。

腫瘤學研究資金的增加和監管部門的積極核准正在加速這些治療方法的開發和商業化。患者對創新療法的需求以及 Kymriah 和 Yescarta 等早期 CAR-T 細胞療法的成功進一步推動了市場擴張，預計 2026 年至 2032 年的複合年成長率約為 63.82%。

CAR-T細胞療法市場定義/概述

CAR-T細胞療法是一種免疫療法，透過基因改造患者的T細胞來表達嵌合體抗原受體(CAR)，使其能夠更有效地靶向和攻擊癌細胞。其主要用於治療白血病、淋巴瘤和多發性骨髓瘤等骨髓惡性腫瘤。此治療方法已顯示出良好的療效，尤其適用於對先前治療方法未產生反應的患者。 CAR-T細胞療法的未來發展方向包括：擴大對固體癌的應用；提高安全性和有效性；降低治療成本；以及透過新型生產和輸送系統提高可及性。

癌症發生率的上升會推動CAR-T細胞治療市場的發展嗎？

癌症發生率的上升是推動CAR-T細胞療法市場發展的關鍵因素。隨著全球癌症發生率的上升，對創新有效治療方法的需求也日益成長。根據世界衛生組織 (WHO) 預測，到2040年，癌症確診人數將達到2,950萬，其中白血病和淋巴瘤等骨髓惡性腫瘤將發揮關鍵作用。癌症負擔的日益加重推動了人們對CAR-T細胞療法的興趣和投資，該療法提供個人化的治療方案，並在臨床試驗中顯示出良好的療效。

有鑑於新型癌症治療的迫切需求，各國政府和醫療機構正在推動CAR-T細胞療法的研究和核准。 2024年3月，FDA加快了針對多種癌症的新型CAR-T細胞療法的核准流程，彰顯了其致力於擴大患者獲得這些創新療法的管道的承諾。此外，隨著研發投入的加大以及生技公司和研究機構的通力合作，CAR-T細胞療法產業預計將大幅擴張。隨著癌症發生率的上升以及對更優治療方法的持續需求，預計到2030年，全球CAR-T細胞療法市場規模將達到380億美元。

細胞激素釋放症候群（CRS）等副作用的增加是否會阻礙CAR-T細胞治療市場的成長？

細胞激素釋放症候群 (CRS) 是 CAR-T 細胞療法常見且嚴重的副作用，其發生率不斷上升可能會阻礙市場擴張。當 CAR-T 細胞在輸注過程中過度激活，釋放大量發炎細胞激素時，就會發生 CRS，這會導致高燒、低血壓、呼吸問題，嚴重時會導致器官衰竭。 CRS 的不可預測性和嚴重性引起了醫療專業人員、患者和監管機構的擔憂，影響了公眾對 CAR-T 細胞療法的認知和接受度。治療 CRS 需要精心護理，包括使用托珠單抗和皮質類固醇等免疫抑制藥物，這可能會增加本已很高的治療費用，並進一步限制患者獲得治療的機會。

慢性鼻竇炎 (CRS) 早期檢測和管理的進步有助於降低風險。研發部門正在開發更安全、更不容易引發 CRS 的下一代 CAR-T 細胞療法。此外，監測和應對 CRS 的臨床指南也在不斷發展，緩解了一些擔憂。然而，持續存在嚴重副作用的可能性仍然是更廣泛市場成長的障礙，尤其是在醫療基礎設施低度開發且加護治療昂貴的地區。

The increasing incidence of cancer, particularly hematologic malignancies such as leukemia and lymphoma, which CAR T-cell treatments efficiently target. Furthermore, advances in gene-editing technology and customized medicine are allowing for more precise and effective therapies is fuelling the USD 36.9 Billion in 2024 and reaching USD 191.6 Billion by 2032.

Rising funding for oncology research, along with favorable regulatory approvals, is accelerating the development and commercialization of these therapies. Patient demand for innovative treatments and the success of early CAR T therapies, such as Kymriah and Yescarta, are further fueling market expansion is grow at a CAGR of about 63.82% from 2026 to 2032.

Car T Cell Therapy Market: Definition/ Overview

CAR T-cell treatment is a type of immunotherapy in which a patient's T-cells are genetically modified to express chimeric antigen receptors (CARs), allowing them to more effectively target and attack cancer cells. Its main applications are to treat blood malignancies such as leukemia, lymphoma, and multiple myeloma. The therapy has produced promising outcomes, particularly in individuals who have not responded to previous therapies. The future of CAR T-cell therapy includes expanding its application to solid tumors, improving safety and efficacy, lowering treatment costs, and increasing accessibility through novel manufacturing and delivery systems.

Will Growing Prevalence of Cancer Propelling the CAR T Cell Therapy Market?

The rising incidence of cancer is a crucial element driving the CAR T-cell treatment market. As cancer rates climb around the world, there is an increased desire for innovative and effective therapies. According to the World Health Organization (WHO), cancer diagnoses are anticipated to reach 29.5 million by 2040, with hematologic malignancies like leukemia and lymphoma playing a significant role. This growing burden has sparked increased interest and investment in CAR T-cell treatments, which provide individualized therapy choices and have demonstrated encouraging results in clinical trials.

Governments and healthcare organizations recognize the critical need for novel cancer medicines and are thus promoting the research and approval of CAR T-cell treatments. In March 2024, the FDA hastened the clearance process for new CAR T therapies targeting several cancer types, demonstrating a commitment to expanding patient access to these innovative treatments. Furthermore, with large investments in research and development, as well as joint efforts between biotech businesses and research institutes, the CAR T-cell treatment industry is predicted to expand dramatically. The global CAR T-cell therapy market is expected to reach $38 billion by 2030, owing to the increasing frequency of cancer and the continued need for better treatments.

Will Rising Side Effects of Cytokine Release Syndrome (CRS) Hinder the Growth of the CAR T Cell Therapy Market?

Rising incidence of cytokine release syndrome (CRS), a common and serious side effect of CAR T-cell therapy, may impede market expansion. CRS arises when CAR T-cells become over-activated during infusion, resulting in a huge release of inflammatory cytokines that can induce high fevers, low blood pressure, respiratory problems, and, in severe cases, organ failure. The unpredictability and severity of CRS have created concerns among healthcare practitioners, patients, and regulatory agencies, influencing public perception and uptake of CAR T-cell therapy. Managing CRS necessitates careful care, including the use of immunosuppressive medicines such as tocilizumab and corticosteroids, which might increase the already high treatment expenses, further limiting patient accessibility.

Advances in CRS early identification and management techniques are helping to reduce dangers. Researchers are developing next-generation CAR T-cell therapies that are designed to be safer and less likely to cause CRS. Furthermore, clinical guidelines for monitoring and responding to CRS are evolving, which may allay some concerns. However, the continuous potential of severe side effects remains a barrier to broader market growth, particularly in places with underdeveloped healthcare infrastructure or where intensive care is too expensive.

Category-Wise Acumens

Will Rising Demand of CD19 Antigen Propel the CAR T Cell Therapy Market?

The growing demand for CD19-targeted CAR T-cell treatments is likely to greatly boost the market. CD19 is a well-known antigen for treating B-cell malignancies, specifically acute lymphocytic leukemia (ALL) and diffuse large B-cell lymphoma (DLBCL). The success of CD19-targeted therapies such as Kymriah (Novartis) and Yescarta (Gilead/Kite) has led to widespread acceptance, with the CD19 sector dominating the market. In June 2023,Gilead Sciences announced substantial rise in Yescarta sales, citing increased demand in the United States and Europe as more treatment centers accept the drug. The continuous success of these medicines has confirmed CD19 as a key market growth driver.

For instance, in April 2024, the US FDA granted Kymriah expedited permission to treat a broader group of patients with relapsed or refractory ALL, increasing access to the medication. This regulatory support demonstrates the increasing awareness of CD19 treatments' efficacy. Furthermore, continued research to increase safety and efficacy, combined with excellent clinical outcomes, ensures that the increasing demand for CD19-targeted medicines will continue to drive the CAR T-cell therapy industry.

The fastest-growing segment, is BCMA (B-cell maturation antigen), which is gaining popularity due to its efficacy in treating multiple myeloma. With novel BCMA-targeted medicines such as Abecma entering the market, this segment is projected to expand rapidly in the future years.

Will Rising Usage Acute Lymphatic Leukemia (ALL) Therapies Fuel the CAR T Cell Therapy Market?

The increasing use of CAR T-cell treatments for acute lymphatic leukemia (ALL) is likely to drive market expansion. Kymriah (Novartis), a CAR T-cell therapy licensed for pediatric and young adult patients with relapsed or refractory ALL, has demonstrated extraordinary success in attaining remission in many situations when previous treatments have failed. In May 2023, Novartis reported a surge in demand for Kymriah due to its success in treating ALL, particularly among younger patients. As the first FDA-approved CAR T-cell therapy, Kymriah has established a strong precedent, encouraging additional investment and research into ALL-targeted medicines, which is likely to drive market growth.

In March 2024, the European Medicines Agency (EMA) upgraded Kymriah's permission to treat a broader range of ALL patients, making it more accessible throughout Europe. This regulatory support, combined with continued advances in ALL treatments, sets the sector for rapid expansion. With greater patient awareness, better clinical outcomes, and regulatory support, the adoption of CAR T-cell treatments for ALL will continue to drive the overall CAR T-cell therapy market.

Chronic lymphocytic leukemia (CLL) is the fastest-growing segment, owing to increased research and clinical studies involving CAR T-cell therapy. As treatment options for CLL improve, this market is likely to rise substantially, reflecting increased demand and the development of more effective medicines.

Country/Region-wise

Will Rising Adoption of Advanced Therapies in North America Drive the CAR T Cell Therapy Market?

The increasing use of improved therapeutic alternatives and a supportive regulatory framework. The American Cancer Society estimates that 1.9 million new cancer cases would be diagnosed in 2023, offering a large potential patient pool for CAR T cell therapy. In March 2024, the United States Food and Drug Administration (FDA) authorized two additional CAR T cell therapies for treating certain types of blood malignancies, increasing the total number of CAR T cell products approved in the United States to nine. In January 2024, Bristol Myers Squibb announced a 45% year-over-year rise in sales of its CAR T cell therapy medicines, totaling USD 1.2 Billion in revenue. The National Cancer Institute has also in 2024, it will increase its financing for cell therapy research by 25%, with USD 500 Million set aside particularly for CAR T cell therapy development and clinical trials.

According to a Cell & Gene Therapy Catapult analysis, the number of CAR T cell therapy clinical studies in North America grew by 35% in 2023 compared to 2022, with over 500 trials currently underway. Furthermore, the Centers for Medicare & Medicaid Services reported that insurance coverage for CAR T cell therapies expanded by 30% in 2023, improving access to these treatments. These developments, coupled with increasing success rates in clinical trials and growing physician acceptance, indicate that North America will continue to lead the global CAR T cell therapy market growth.

Will Increasing Healthcare Infrastructure in Asia Pacific Propel the CAR T Cell Therapy Market?

The growing healthcare infrastructure in Asia-Pacific is expected to boost the CAR T-cell treatment market significantly. Many countries, including China and India, are investing considerably in improving their healthcare systems, which includes the construction of advanced treatment facilities and increased access to cutting-edge therapies. For instance, in April 2024, the Chinese government announced a significant financial commitment to support oncology research and increase access to CAR T-cell therapy in rural areas. This investment is likely to increase the availability of novel treatments, making them more accessible to a larger patient population and boosting the growth of the CAR T-cell therapy market in the area.

Furthermore, the Asia-Pacific market is seeing greater collaboration between local biotech businesses and multinational pharmaceutical corporations, which is helping to improve the development and marketing of CAR T cell therapies. Gilead Sciences established a partnership with a top Chinese biotech firm in February 2024 to develop and commercialize CAR T-cell medicines specifically for the Asian market. The goal of this collaboration is to speed the commercialization of CAR T-cell therapeutics by using the region's developing healthcare infrastructure and expertise. According to Verified Market Research, the CAR T-cell therapy market is expected to grow at a compound annual growth rate (CAGR) of more than 63.82% between 2024 and 2031, owing to infrastructure improvements and strategic partnerships, highlighting the region's potential in this rapidly evolving market.

Competitive Landscape

The competitive landscape of the CAR T-cell therapy market is characterized by the presence of emerging biotechnology firms and smaller pharmaceutical companies focusing on innovative therapies. These players often collaborate with academic institutions and research organizations to develop novel treatments. They also benefit from partnerships with larger companies for funding and commercialization. With advancements in gene editing and manufacturing processes, these smaller firms are gaining traction by addressing unmet clinical needs, targeting diverse cancer types, and optimizing the safety and efficacy of CAR T-cell therapies.

Some of the prominent players operating in the CAR T cell therapy market Include:

CARsgen Therapeutics, Ltd.

Novartis International AG

Pfizer, Inc.

Kite Pharma, Inc.

Legend Biotech

Juno Therapeutics.

Latest Developments

In March 2024, Bristol Myers Squibb announced positive clinical trial findings for Abecma, a CAR T-cell treatment targeting multiple myeloma. According to the business, the medication displayed significant efficacy in patients with relapsed and refractory disease, indicating that it has the potential to gain broader market acceptability.

In January 2024, Celgene reported positive findings from a Phase II clinical trial of their CAR T-cell treatment for ALL. The trial demonstrated a high overall remission rate, highlighting the potential of CAR T treatments in both juvenile and adult populations.

1 INTRODUCTION OF GLOBAL CAR T-CELL THERAPY MARKET

1.1 Overview of the Market
1.2 Scope of Report
1.3 Assumptions

2 EXECUTIVE SUMMARY

3 RESEARCH METHODOLOGY OF VERIFIED MARKET RESEARCH

3.1 Data Mining
3.2 Validation
3.3 Primary Interviews
3.4 List of Data Sources

4 GLOBAL CAR T-CELL THERAPY MARKET OUTLOOK

4.1 Overview
4.2 Market Dynamics
- 4.2.1 Drivers
- 4.2.2 Restraints
- 4.2.3 Opportunities
4.3 Porters Five Force Model
4.4 Value Chain Analysis

5 GLOBAL CAR T-CELL THERAPY MARKET, BY TARGETED ANTIGEN

5.1 Overview
5.2 CD19
5.3 HER1
5.4 BCMA
5.5 CD33

6 GLOBAL CAR T-CELL THERAPY MARKET, BY THERAPEUTIC APPLICATION

6.1 Overview
6.2 Acute Lymphocytic Leukemia
6.3 Colorectal Cancer
6.4 Chronic Lymphocytic Leukemia
6.5 Hepatocellular Carcinoma

7 GLOBAL CAR T-CELL THERAPY MARKET, BY GEOGRAPHY

7.1 Overview
7.2 North America
- 7.2.1 U.S.
- 7.2.2 Canada
- 7.2.3 Mexico
7.3 Europe
- 7.3.1 Germany
- 7.3.2 U.K.
- 7.3.3 France
- 7.3.4 Rest of Europe
7.4 Asia Pacific
- 7.4.1 China
- 7.4.2 Japan
- 7.4.3 India
- 7.4.4 Rest of Asia Pacific
7.5 Rest of the World
- 7.5.1 Latin America
- 7.5.2 Middle East and Africa

8 GLOBAL CAR T-CELL THERAPY MARKET COMPETITIVE LANDSCAPE

8.1 Overview
8.2 Company Market Ranking
8.3 Key Development Strategies

9 COMPANY PROFILES

9.1 CARsgen Therapeutics, Ltd
- 9.1.1 Overview
- 9.1.2 Financial Performance
- 9.1.3 Product Outlook
- 9.1.4 Key Developments
9.2 Novartis International AG
- 9.2.1 Overview
- 9.2.2 Financial Performance
- 9.2.3 Product Outlook
- 9.2.4 Key Developments
9.3 Pfizer, Inc.
- 9.3.1 Overview
- 9.3.2 Financial Performance
- 9.3.3 Product Outlook
- 9.3.4 Key Developments
9.4 Kite Pharma, Inc
- 9.4.1 Overview
- 9.4.2 Financial Performance
- 9.4.3 Product Outlook
- 9.4.4 Key Developments
9.5 Legend Biotech
- 9.5.1 Overview
- 9.5.2 Financial Performance
- 9.5.3 Product Outlook
- 9.5.4 Key Developments
9.6 Juno Therapeutics
- 9.6.1 Overview
- 9.6.2 Financial Performance
- 9.6.3 Product Outlook
- 9.6.4 Key Developments