全球患者來源異種移植模型市場規模（按癌症類型、組織來源、應用、地區、範圍和預測）

病患來源異種移植 (PDX) 模型市場規模及預測

2024 年，患者來源的異種移植 (PDX) 模型市場規模價值為 2.5896 億美元，預計 2024 年至 2031 年期間的複合年增長率為 16.60%，到 2031 年將達到 7.9482 億美元。 10萬美元。患者來源異種移植 (PDX) 模型是癌症研究和治療開發中複雜且非常有用的工具。該模型涉及將人類腫瘤組織直接植入免疫缺陷小鼠體內。與標準細胞系模型相比，PDX 模型保留了原始人類腫瘤的組織學和遺傳特徵，使其能夠更真實地複製患者體內的腫瘤行為。

PDX 模型在癌症研究中變得越來越重要，因為它們比傳統細胞系模型更能準確地描述實際惡性腫瘤。 PDX 模型最常見的用途之一是臨床前藥物開發和測試。透過將人類腫瘤組織直接移植到免疫缺陷小鼠體內，研究人員能夠保留患者腫瘤的組織學特徵、遺傳多樣性和異質性。

未來在癌症研究和個人化治療中使用患者來源異種移植 (PDX) 模型有可能改變對許多惡性腫瘤的理解和治療。 PDX 模型是將人類腫瘤組織移植到免疫缺陷小鼠體內，由於其能夠準確模擬人類腫瘤的複雜性和異質性，因此變得越來越有價值。

病患來源異種移植 (PDX) 模型的全球市場動態

影響全球病患來源異種移植 (PDX) 模型市場的關鍵市場動態

主要市場驅動因子

個人化治療需求日益增加

PDX 模型最重要的市場推動因素之一是向個人化治療的轉變。精準醫療尋求根據遺傳、生活方式和環境為個別患者提供個人化的治療方案。 PDX 模型涉及將人類腫瘤組織移植到免疫缺陷小鼠體內，忠實模擬人類癌症的生物學特徵，包括遺傳多樣性、異質性和微環境。

癌症研究的進展：

癌症研究的重大進展也推動了 PDX 模型產業的擴張。傳統的癌症模型，例如細胞系和基因工程小鼠，通常無法重現複雜的人類惡性腫瘤，因此在藥物開發中會出現很高的流失率。然而，PDX 模型提供了更準確的人類癌症生物學影像，並在臨床前研究中帶來更好的預後結果。

癌症發生率上升

全球癌症發生率的上升是 PDX 模型產業發展的另一個主要驅動力。根據世界衛生組織 (WHO) 的數據，癌症是全球主要死亡原因之一，預計 2020 年將導致約 1,000 萬人死亡。癌症發生率的上升推動了對更有效和客製化治療方案的需求，從而增加了對 PDX 模型的需求。

主要問題

可變性和可重複性

PDX 模型的主要問題之一是其固有的多變性和缺乏可重複性。許多因素會影響 PDX 模型的有效性，包括腫瘤的起源、植入方法和患者腫瘤的生物學。這些參數的變化會促使腫瘤發展模式和治療結果的顯著變化。

免疫系統的差異

在研究與免疫細胞相互作用的人類癌症時，在 PDX 模型中使用免疫缺陷小鼠會帶來很大的缺點，因為宿主的免疫系統會被消除。這些動物缺乏免疫系統，因此無法代表對腫瘤生長和藥物反應至關重要的免疫環境。

道德和後勤問題：創建和維護 PDX 模型帶來了一些道德和實際課題。創建 PDX 模型需要從患者身上獲取腫瘤樣本，這涉及侵入性手術，這對患者來說是一種負擔，並且會引發有關同意和處理人體組織的倫理問題。

主要趨勢：

增強個人化醫療客製化

PDX 模型最顯著的趨勢之一是其在個人化醫療中的應用日益廣泛。研究人員使用 PDX 模型來產生特定於患者的腫瘤模型，以便更好地預測個體對治療的反應。這種客製化需要將患者的腫瘤組織移植到免疫缺陷小鼠體內，使其發育並模仿原始腫瘤的異質性。

與基因組和組學資料的整合：

PDX 模型與基因組和組學資料的整合是另一個重要趨勢。高通量定序和分子分析技術的進步使研究人員能夠更深入地瞭解腫瘤的遺傳和分子特徵。 PDX 模型越來越多地用於驗證這些結果並探索基因改變和分子路徑如何影響藥物反應。

擴展到新的癌症類型和藥物聯合療法

目前明顯的趨勢是將 PDX 模型的使用範圍擴大到新型腫瘤類型和藥物組合。 PDX 模型先前用於治療乳癌和肺癌等特徵明確的疾病，現在用於治療更罕見、更具課題性的癌症，包括胰臟癌和腦癌。

目錄

第 1 章簡介

• 市場定義
• 市場區隔
• 研究方法

第 2 章執行摘要

• 主要發現 市場概況
• 市場亮點

第三章 市場概覽

• 市場規模與成長潛力
• 市場趨勢
• 市場推動因素
• 市場限制
• 市場機會
• 波特五力分析

第 4 章。

• 乳癌
• 肺癌
• 大腸癌
• 攝護腺癌

第 5 章。

• 實體腫瘤
• 血液系統惡性腫瘤

第 6 章 患者來源的異種移植 (PDX) 模型市場（按應用）

• 臨床前藥物開發
• 生物標記分析
• 精準醫療
• 毒性測試

第 7 章 區域分析

• 北美洲
• 美國
• 加拿大
• 墨西哥
• 歐洲
• 英國
• 德國
• 法國
• 義大利 亞太地區
• 中國
• 日本
• 印度
• 澳大利亞
• 拉丁美洲
• 巴西
• 阿根廷
• 智利
• 中東和非洲
• 南非
• 沙烏地阿拉伯
• 阿拉伯聯合大公國

第 8 章 市場動態

• 市場推動因素
• 市場限制
• 市場機會
• COVID-19 市場影響

第 9 章 競爭格局

• 大型公司
• 市佔率分析

第十章 公司簡介

• Crown Bioscience Inc
• WuXi AppTec
• Champions Oncology
• The Jackson Laboratory
• Charles River Laboratories International Inc
• Taconic Biosciences Inc
• Oncodesign Precision Medicine
• Inotiv Inc
• EPO Berlin-Buch GmbH
• Xentech

第 11 章 市場展望與機會

• 新興技術
• 未來市場趨勢
• 投資機會

第 12 章附錄

• 縮寫列表
• 來源與參考文獻

Patient Derived Xenograft (PDX) Models Market Size and Forecast

Patient Derived Xenograft (PDX) Models Market size was valued at USD 258.96 Million in 2024 and is projected to reach USD 794.82 Million by 2031, growing at a CAGR of 16.60% from 2024 to 2031. Patient-Derived Xenograft (PDX) models are a sophisticated and extremely useful tool in cancer research and therapeutic development. These models include transplanting human tumor tissue directly into immunocompromised mice. Compared to standard cell line models, PDX models preserve the histological architecture and genetic properties of the original human tumor making them highly realistic of the tumor's activity in the patient.

They are becoming increasingly important in cancer research as they provide a more accurate portrayal of actual malignancies than traditional cell line models. One of the most common applications for PDX models is preclinical drug development and testing. Researchers can preserve the patient's tumor's histological traits, genetic variety, and heterogeneity by directly implanting human tumor tissues into immunodeficient mice.

The future use of patient-derived xenograft (PDX) models in cancer research and personalized therapy has the potential to transform our understanding and treatment of many malignancies. PDX models which entail implanting human tumor tissues into immunodeficient mice are becoming increasingly valuable due to their ability to accurately imitate the complexity and heterogeneity of human tumors.

Global Patient Derived Xenograft (PDX) Models Market Dynamics

The key market dynamics that are shaping the global patient derived xenograft (PDX) Models market include:

Key Market Drivers:

Rising Demand for Personalized Treatment:

One of the most important market drivers for PDX models is the shift to personalized treatment. Personalized medicine seeks to personalize treatment solutions to individual patients based on their genetics, lifestyle, and environment. PDX models which entail implanting human tumor tissues into immunodeficient mice, closely mimic the biological properties of human cancers, such as genetic variety, heterogeneity, and the microenvironment.

Advancements in Cancer Research:

Significant advances in cancer research are also driving the expansion of the PDX models industry. Traditional cancer models such as cell lines and genetically engineered mice models, frequently fail to replicate the complexities of human malignancies resulting in high attrition rates in drug development. However, PDX models provide a more accurate picture of human cancer biology resulting in higher prognostic outcomes in preclinical studies.

Increasing Cancer Prevalence

: The global growth in cancer incidence is another major driver of the PDX models industry. According to the World Health Organization (WHO), cancer is one of the main causes of mortality globally accounting for nearly 10 million deaths in 2020. The rising incidence of cancer is driving the need for more effective and customized treatment options which is growing demand for PDX models.

Key Challenges:

Variability and Reproducibility

: One of the key concerns with PDX models is their inherent variability and lack of reproducibility. Numerous factors can influence the effectiveness of a PDX model including the origin of the tumor, the manner of implantation, and the biological properties of the patient's tumor. Variations in these parameters can cause major changes in tumor development patterns and treatment responses.

Immune System Differences

: Using immunodeficient mice in PDX models eliminates the host immune system which is a major disadvantage when investigating human cancers that interact with immune cells. Because these animals lack an immune system, they do not represent the immunological milieu which is critical for tumor growth and medication response.

Ethical and Logistical Concerns: The creation and maintenance of PDX models raises several ethical and practical issues. Creating PDX models necessitates the collecting of tumor samples from patients which includes invasive procedures that can be burdensome for patients and raise ethical concerns about consent and the handling of human tissues.

Key Trends:

Enhanced Customization for Personalized Medicine:

One of the most notable trends in PDX models is their growing usage in personalized medicine. Researchers are using PDX models to create patient-specific tumor models that can better predict individual responses to treatment. This customization entails implanting patient tumor tissues into immunodeficient mice which develop and mimic the original tumor's heterogeneity.

Integration with Genomic and Omics Data:

Integrating PDX models with genomic and omics data is another critical trend. Advances in high-throughput sequencing and molecular profiling have allowed researchers to get a better understanding of tumor genetics and molecular features. PDX models are increasingly being utilized to validate these results and investigate how genetic variants and molecular pathways influence medication responsiveness.

Expansion into Novel Cancer Types and Medication Combinations

: There is a noticeable trend of extending the use of PDX models to novel cancer types and medication combinations. PDX models which were previously utilized for well-characterized diseases like breast and lung cancer are now being used to treat rarer and more difficult cancers including pancreatic and brain tumors.

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Global Patient Derived Xenograft (PDX) Models Market Regional Analysis

Here is a more detailed regional analysis of the global patient derived xenograft (PDX) Models market:

North America:

In North America, the patient-derived xenograft (PDX) models market is dominant driven by increased oncology research and development activities as well as a growing emphasis on customized therapy. The region's global market leadership is supported by its advanced healthcare infrastructure, significant investment in research, and high cancer prevalence all of which drive demand for PDX models. The increasing expenditure on oncology research and development in North America is a major driver of the PDX model industry. According to the National Cancer Institute (NCI), the United States will invest nearly USD 7.5 Billion in cancer research in 2023 representing a significant increase over previous years.

Another significant factor is the growing emphasis on individualized medicine which is strongly aligned with the capabilities of PDX models. Personalized medicine seeks to personalize therapies to individual patients based on genetic, environmental, and lifestyle characteristics. PDX models are useful in this field because they allow researchers to investigate patient-specific cancers and test targeted medicines. The United States Food and Drug Administration (FDA) recognizes the importance of customized medicine, and in 2023, it approved a record number of personalized medicines reflecting the increased demand for models that can simulate unique patient reactions.

Asia Pacific:

The Patient Derived Xenograft (PDX) models market in Asia Pacific is expanding rapidly owing mostly to rising cancer incidence and the need for personalized therapy. China and Japan are the region's fastest-growing markets, due to massive investments in healthcare infrastructure and research. The increased incidence of cancer is a primary driver of the PDX models market in Asia Pacific. According to the World Health Organization (WHO), cancer is still the biggest cause of death in the region. In 2020, there are an anticipated 9.5 million new cancer cases and 5.4 million cancer deaths in Asia.

Another key factor is the increased emphasis on customized medicine which is rapidly gaining popularity in Asia Pacific. Personalized medicine seeks to customize treatments to individual genetic profiles, and PDX models play an important part in this effort by offering more realistic preclinical testing environments. The Japanese Ministry of Health, Labour, and Welfare announced that the government is heavily investing in customized medicine and genomics research with significant funds given to precision oncology efforts. This emphasis on individualized treatments drives up the need for PDX models which are critical for testing and validating innovative therapeutic approaches suited to individual patient's needs.

Global Patient Derived Xenograft (PDX) Models Market: Segmentation Analysis

The Global Patient Derived Xenograft (PDX) Models Market is segmented based on Type of Cancer, Source of Tissue, Application, and Geography.

Patient Derived Xenograft (PDX) Models Market, By Type of Cancer

• Breast Cancer
• Lung Cancer
• Colorectal Cancer
• Prostate Cancer

Based on the Type of Cancer, the Global Patient Derived Xenograft (PDX) Models Market is bifurcated into Breast Cancer, Lung Cancer, Colorectal Cancer, and Prostate Cancer. In the global patient derived xenograft (PDX) Models Market, breast cancer models are the dominant segment. This dominance is primarily due to the high incidence of breast cancer globally and its complex biology which necessitates extensive research for effective treatments. PDX models for breast cancer are crucial for understanding tumor heterogeneity, drug resistance, and developing personalized therapies.

Patient Derived Xenograft (PDX) Models Market, By Source of Tissue

• Solid Tumors
• Hematological Malignancies

Based on the Source of Tissue, the Global Patient Derived Xenograft (PDX) Models Market is bifurcated into Solid Tumors, and Hematological Malignancies. In the patient derived xenograft (PDX) models market, solid tumors are the dominant segment. This dominance is due to the high prevalence of solid tumors compared to hematological malignancies and the extensive research and development focus on these models. The demand for PDX models of solid tumors is driven by their relevance in drug discovery, personalized medicine, and cancer research.

Patient Derived Xenograft (PDX) Models Market, By Application

• Preclinical Drug Development
• Biomarker Analysis
• Precision Medicine

Based on the Application, the Global Patient Derived Xenograft (PDX) Models Market is bifurcated into Preclinical Drug Development, Biomarker Analysis, and Precision Medicine. In the global patient derived xenograft (PDX) models market, preclinical drug development is the dominant application. This dominance stems from the critical role PDX models play in evaluating the efficacy and safety of new drug candidates before clinical trials. PDX models which involve implanting human tumors into immunocompromised mice, provide a more accurate representation of human cancer compared to traditional cell lines.

Patient Derived Xenograft (PDX) Models Market, By Geography

• North America
• Europe
• Asia Pacific
• Rest of the World

Based on Geography, the Global Patient Derived Xenograft (PDX) Models Market is classified into North America, Europe, Asia Pacific, and the Rest of the World. In the patient derived xenograft (PDX) models market, North America holds the dominant position. This leadership is primarily due to advanced healthcare infrastructure, significant investment in research and development, and a high prevalence of cancer which drives demand for innovative cancer research models. The region's strong presence of leading pharmaceutical and biotechnology companies further supports this dominance by facilitating extensive research and clinical trials.

Key Players

• The "Global Patient Derived Xenograft (PDX) Models Market" study report will provide valuable insight with an emphasis on the global market. The major players in the market are
• Crown Bioscience, Inc., WuXi AppTec, Champions Oncology, The Jackson Laboratory, Charles River Laboratories International, Inc., Taconic Biosciences, Inc., Oncodesign Precision Medicine, Inotiv, Inc., EPO Berlin-Buch GmbH, Xentech.

Our market analysis also entails a section solely dedicated to such major players wherein our analysts provide an insight into the financial statements of all the major players, along with product benchmarking and SWOT analysis. The competitive landscape section also includes key development strategies, market share, and market ranking analysis of the above-mentioned players globally.

Global Patient Derived Xenograft (PDX) Models Market Key Developments

• In July 2022, GemPharmatech (GemPharmatech Co., Ltd.) announced that it has signed a strategic license deal with Charles River Laboratories, Inc. for the exclusive sale of their next-generation NOD CRISPR Prkdc Il2r gamma (NCG) mice lines in North America. Charles River will create foundation colonies, with commercially available versions starting in 2023.
• In April 2022, Professor Kamimura's research group at Niigata University developed a novel pancreatic cancer model in wild-type rats using the pancreas-targeted selective hydrodynamic gene delivery approach.

TABLE OF CONTENTS

1. Introduction

• Market Definition
• Market Segmentation
• Research Methodology

2. Executive Summary

• Key Findings
• Market Overview
• Market Highlights

3. Market Overview

• Market Size and Growth Potential
• Market Trends
• Market Drivers
• Market Restraints
• Market Opportunities
• Porter's Five Forces Analysis

4. Patient Derived Xenograft (PDX) Models Market, By Type of Cancer

• Breast Cancer
• Lung Cancer
• Colorectal Cancer
• Prostate Cancer

5. Patient Derived Xenograft (PDX) Models Market, By Source of Tissue

• Solid Tumors
• Hematological Malignancies

6. Patient Derived Xenograft (PDX) Models Market, By Application

• Preclinical Drug Development
• Biomarker Analysis
• Precision Medicine
• Toxicology Testing

7. Regional Analysis

• North America
• United States
• Canada
• Mexico
• Europe
• United Kingdom
• Germany
• France
• Italy
• Asia-Pacific
• China
• Japan
• India
• Australia
• Latin America
• Brazil
• Argentina
• Chile
• Middle East and Africa
• South Africa
• Saudi Arabia
• UAE

8. Market Dynamics

• Market Drivers
• Market Restraints
• Market Opportunities
• Impact of COVID-19 on the Market

9. Competitive Landscape

• Key Players
• Market Share Analysis

10. Company Profiles

• Crown Bioscience Inc
• WuXi AppTec
• Champions Oncology
• The Jackson Laboratory
• Charles River Laboratories International Inc
• Taconic Biosciences Inc
• Oncodesign Precision Medicine
• Inotiv Inc
• EPO Berlin-Buch GmbH
• Xentech

11. Market Outlook and Opportunities

• Emerging Technologies
• Future Market Trends
• Investment Opportunities

12. Appendix

• List of Abbreviations
• Sources and References