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市場調查報告書
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1811992

分析化學樣品製備市場-全球產業規模、佔有率、趨勢、機會和預測,按技術、產品、應用、最終用途、地區和競爭細分,2020-2030F

Analytical Chemistry Sample Preparation Market - Global Industry Size, Share, Trends, Opportunity, and Forecast, Segmented By Technique, By Product, By Application, By End Use, By End Use, By Region and Competition, 2020-2030F

出版日期: | 出版商: TechSci Research | 英文 187 Pages | 商品交期: 2-3個工作天內

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簡介目錄

2024 年全球分析化學樣品製備市場價值為 25.1 億美元,預計到 2030 年將達到 33.9 億美元,預測期內複合年成長率為 5.12%。

市場概況
預測期 2026-2030
2024年市場規模 25.1億美元
2030年市場規模 33.9億美元
2025-2030年複合年成長率 5.12%
成長最快的領域 耗材
最大的市場 北美洲

分析化學樣品製備市場在製藥、生物技術、食品飲料、環境檢測和法醫分析等各行各業中發揮著至關重要的作用。樣品製備是分析工作流程中至關重要的一步,確保複雜樣品得到妥善處理,從而實現準確可靠的測試。隨著分析技術的進步,對改進樣品製備方法的需求持續成長,推動了自動化、小型化和效率的創新。

分析樣品日益複雜,大大促進了對先進樣品製備技術的需求。在製藥和生物技術領域,FDA 和 EMA 等機構的嚴格監管要求,要求藥物開發和品質控制採用精確且可重複的樣品製備方法。此外,由於污染風險和監管準則的製定,人們對食品安全的關注度日益提高,這促使食品和飲料行業採用先進的樣品製備解決方案。環境監測中必須檢測微量污染物,因此也依賴先進的樣品製備工具進行可靠的分析。

近年來,自動化和高通量樣品製備系統日益受到關注,有助於實驗室提高效率並減少人為錯誤。固相萃取 (SPE)、液-液萃取 (LLE) 和蛋白質沉澱等技術正在不斷最佳化,以提高靈敏度和重現性。質譜和色譜技術的日益普及需要高純度樣品,這進一步推動了對增強樣品製備方法的需求。

關鍵市場促進因素

製藥和生物技術領域的擴張

主要市場挑戰

樣品製備成本高

主要市場趨勢

食品與環境安全日益重要

目錄

第 1 章:產品概述

第2章:研究方法

第3章:執行摘要

第4章:干擾:衝突、流行病與貿易壁壘

第5章:全球分析化學樣品製備市場展望

  • 市場規模和預測
    • 按價值
  • 市場佔有率和預測
    • 按技術(萃取、過濾、沉澱、離心、其他)
    • 依產品(試劑盒及試劑、耗材)
    • 依應用(HPLC、LC-MS、GC-MS、MALDI-ToF-MS、ICP-MS、NMR、其他)
    • 依最終用途(生物製藥和生物技術公司、學術和研究機構、合約研究組織、其他)
    • 按地區
    • 按公司分類(2024 年)
  • 市場地圖

第6章:北美分析化學樣品製備市場展望

  • 市場規模和預測
  • 市場佔有率和預測
  • 北美:國家分析
    • 美國
    • 墨西哥
    • 加拿大

第7章:歐洲分析化學樣品製備市場展望

  • 市場規模和預測
  • 市場佔有率和預測
  • 歐洲:國家分析
    • 法國
    • 德國
    • 英國
    • 義大利
    • 西班牙

第8章:亞太分析化學樣品製備市場展望

  • 市場規模和預測
  • 市場佔有率和預測
  • 亞太地區:國家分析
    • 中國
    • 印度
    • 韓國
    • 日本
    • 澳洲

第9章:南美洲分析化學樣品製備市場展望

  • 市場規模和預測
  • 市場佔有率和預測
  • 南美洲:國家分析
    • 巴西
    • 阿根廷
    • 哥倫比亞

第10章:中東和非洲分析​​化學樣品製備市場展望

  • 市場規模和預測
  • 市場佔有率和預測
  • MEA:國家分析
    • 南非
    • 沙烏地阿拉伯
    • 阿拉伯聯合大公國

第 11 章:市場動態

  • 驅動程式
  • 挑戰

第 12 章:市場趨勢與發展

  • 合併與收購(如有)
  • 產品發布(如有)
  • 最新動態

第 13 章:全球分析化學樣品製備市場:SWOT 分析

第 14 章:波特五力分析

  • 產業競爭
  • 新進入者的潛力
  • 供應商的力量
  • 顧客的力量
  • 替代產品的威脅

第 15 章:競爭格局

  • Merck KGaA
  • Thermo Fisher Scientific Inc.
  • Bio-rad Laboratories Inc.
  • Shimadzu Corporation
  • Agilent Technologies Inc.
  • PerkinElmer US LLC
  • Promega Corporation
  • Danaher Corporation
  • QIAGEN NV
  • Waters Corporation

第 16 章:策略建議

第17章調查會社について,免責事項

簡介目錄
Product Code: 27719

Global Analytical Chemistry Sample Preparation Market was valued at USD 2.51 Billion in 2024 and is expected to reach USD 3.39 Billion by 2030 with a CAGR of 5.12% during the forecast period.

Market Overview
Forecast Period2026-2030
Market Size 2024USD 2.51 Billion
Market Size 2030USD 3.39 Billion
CAGR 2025-20305.12%
Fastest Growing SegmentConsumables
Largest MarketNorth America

The Analytical Chemistry Sample Preparation Market plays a crucial role in various industries, including pharmaceuticals, biotechnology, food & beverage, environmental testing, and forensic analysis. Sample preparation is an essential step in analytical workflows, ensuring that complex samples are properly processed for accurate and reliable testing. As analytical techniques advance, the demand for improved sample preparation methods continues to rise, driving innovations in automation, miniaturization, and efficiency.

The growing complexity of analytical samples has significantly contributed to the increasing need for advanced sample preparation techniques. In the pharmaceutical and biotechnology sectors, stringent regulatory requirements from organizations such as the FDA and EMA necessitate precise and reproducible sample preparation methods for drug development and quality control. Additionally, the rising focus on food safety due to contamination risks and regulatory guidelines fuels the adoption of sophisticated sample preparation solutions in the food and beverage industry. Environmental monitoring, where pollutants must be detected at trace levels, also relies on advanced sample preparation tools for reliable analysis.

Automation and high-throughput sample preparation systems have gained traction in recent years, helping laboratories enhance efficiency and reduce human error. Technologies such as solid-phase extraction (SPE), liquid-liquid extraction (LLE), and protein precipitation are being optimized to improve sensitivity and reproducibility. The growing adoption of mass spectrometry and chromatography techniques, which require high-purity samples, further drives the need for enhanced sample preparation methods.

Key Market Drivers

Expansion of the Pharmaceutical and Biotechnology Sectors

The rapid expansion of the pharmaceutical and biotechnology sectors has significantly fueled the growth of the analytical chemistry sample preparation market. As drug discovery, development, and quality control processes become more sophisticated, the need for precise, accurate, and reproducible analytical techniques has increased. Sample preparation, a critical step in analytical chemistry, ensures that samples are suitable for analysis by removing contaminants, concentrating analytes, and improving detection limits. The increasing complexity of pharmaceutical formulations and biotechnological products has made advanced sample preparation techniques indispensable for ensuring compliance with stringent regulatory requirements.

One of the key drivers of this market growth is the increasing investment in pharmaceutical research and development (R&D). Pharmaceutical companies are continuously working on new drug molecules, biosimilars, and gene therapies, which require high-throughput and sensitive analytical techniques. Liquid chromatography, mass spectrometry, and spectroscopy rely heavily on well-prepared samples to deliver accurate results. Additionally, regulatory agencies such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) mandate rigorous quality control and analytical validation, further driving demand for advanced sample preparation solutions.

The biotechnology industry has also witnessed significant growth, particularly in the fields of personalized medicine, biologics, and cell and gene therapies. These advancements require precise analytical methodologies to characterize complex biomolecules, detect impurities, and ensure product consistency. Techniques such as solid-phase extraction (SPE), liquid-liquid extraction (LLE), and protein precipitation have become essential in the preparation of biological samples before analysis. The increasing focus on biomarker discovery, genomics, and proteomics has further necessitated innovative sample preparation methods capable of handling diverse biological matrices.

The rise in contract research organizations (CROs) and contract development and manufacturing organizations (CDMOs) has contributed to the growing demand for efficient sample preparation technologies. As pharmaceutical and biotechnology companies outsource analytical testing and drug development processes, CROs and CDMOs require robust sample preparation tools to ensure high-quality analytical data. Automation and miniaturization of sample preparation workflows have also gained traction, enabling higher throughput and reducing human error in laboratory settings. In addition to pharmaceutical and biotechnology applications, the expansion of analytical chemistry sample preparation is evident in the growing fields of forensic science, environmental testing, and food safety. However, the pharmaceutical and biotech sectors remain the primary drivers of market growth due to their ever-evolving analytical requirements. As drug pipelines expand and biopharmaceutical innovation accelerates, the demand for cutting-edge sample preparation solutions is expected to rise, making this market an essential component of modern analytical chemistry.

Key Market Challenges

High Costs of Sample Preparation

One of the primary challenges in the analytical chemistry sample preparation market is the high cost associated with sophisticated sample preparation techniques. Many modern methods, such as solid-phase extraction (SPE), liquid-liquid extraction (LLE), and advanced chromatographic techniques, require expensive consumables, reagents, and instrumentation. Laboratories, especially small-scale facilities and academic institutions, often struggle to afford these high-end technologies, limiting their adoption. Moreover, recurring expenses related to maintenance, calibration, and skilled personnel further add to the overall cost burden.

Key Market Trends

Growing Importance in Food and Environmental Safety

Another significant trend in the Analytical Chemistry Sample Preparation Market is its expanding role in food and environmental safety. According to the World Health Organization (WHO), an estimated 600 million people-approximately one in ten globally-suffer from foodborne illnesses each year, resulting in 420,000 fatalities annually. Governments and regulatory agencies worldwide are implementing stricter regulations to monitor contaminants in food products and environmental samples. Analytical techniques such as gas chromatography (GC), liquid chromatography (LC), and mass spectrometry (MS) require efficient sample preparation methods to detect trace levels of contaminants such as pesticides, heavy metals, and toxins. This growing need for accurate and efficient testing has led to increased adoption of advanced sample preparation technologies.

Key Market Players

  • Merck KGaA
  • Thermo Fisher Scientific Inc.
  • Bio-rad Laboratories Inc.
  • Shimadzu Corporation
  • Agilent Technologies Inc.
  • PerkinElmer U.S. LLC
  • Promega Corporation
  • Danaher Corporation
  • QIAGEN N.V.
  • Waters Corporation

Report Scope

In this report, the Global Analytical Chemistry Sample Preparation Market has been segmented into the following categories, in addition to the industry trends which have also been detailed below:

Analytical Chemistry Sample Preparation Market, By Technique:

  • Extraction
  • Filtration
  • Precipitation
  • Centrifugation
  • Others

Analytical Chemistry Sample Preparation Market, By Product:

  • Kits & Reagents
  • Instruments & Software
  • Consumables

Analytical Chemistry Sample Preparation Market, By Application:

  • HPLC
  • LC-MS
  • GC-MS
  • MALDI-ToF-MS
  • ICP-MS
  • NMR
  • Others

Analytical Chemistry Sample Preparation Market, By End Use:

  • Biopharmaceutical & Biotechnology Companies
  • Academic & Research Institutes
  • Contract Research Organizations
  • Others

Analytical Chemistry Sample Preparation Market, By Region:

  • North America
    • United States
    • Canada
    • Mexico
  • Europe
    • France
    • United Kingdom
    • Italy
    • Germany
    • Spain
  • Asia Pacific
    • China
    • India
    • Japan
    • Australia
    • South Korea
  • South America
    • Brazil
    • Argentina
    • Colombia
  • Middle East & Africa
    • South Africa
    • Saudi Arabia
    • UAE

Competitive Landscape

Company Profiles: Detailed analysis of the major companies present in the Global Analytical Chemistry Sample Preparation Market.

Available Customizations:

Global Analytical Chemistry Sample Preparation Market report with the given market data, TechSci Research offers customizations according to a company's specific needs. The following customization options are available for the report:

Company Information

  • Detailed analysis and profiling of additional market players (up to five).

Table of Contents

1. Product Overview

  • 1.1. Market Definition
  • 1.2. Scope of the Market
    • 1.2.1. Markets Covered
    • 1.2.2. Years Considered for Study
    • 1.2.3. Key Market Segmentations

2. Research Methodology

  • 2.1. Objective of the Study
  • 2.2. Baseline Methodology
  • 2.3. Key Industry Partners
  • 2.4. Major Association and Secondary Sources
  • 2.5. Forecasting Methodology
  • 2.6. Data Triangulation & Validation
  • 2.7. Assumptions and Limitations

3. Executive Summary

  • 3.1. Overview of the Market
  • 3.2. Overview of Key Market Segmentations
  • 3.3. Overview of Key Market Players
  • 3.4. Overview of Key Regions/Countries
  • 3.5. Overview of Market Drivers, Challenges, and Trends

4. Disruptions: Conflicts, Pandemics, and Trade Barriers

5. Global Analytical Chemistry Sample Preparation Market Outlook

  • 5.1. Market Size & Forecast
    • 5.1.1. By Value
  • 5.2. Market Share & Forecast
    • 5.2.1. By Technique (Extraction, Filtration, Precipitation, Centrifugation, Others)
    • 5.2.2. By Product (Kits & Reagents, Consumables)
    • 5.2.3. By Application (HPLC, LC-MS, GC-MS,MALDI-ToF-MS, ICP-MS, NMR, Others)
    • 5.2.4. By End Use (Biopharmaceutical & Biotechnology Companies, Academic & Research Institutes, Contract Research Organizations, Others)
    • 5.2.5. By Region
    • 5.2.6. By Company (2024)
  • 5.3. Market Map

6. North America Analytical Chemistry Sample Preparation Market Outlook

  • 6.1. Market Size & Forecast
    • 6.1.1. By Value
  • 6.2. Market Share & Forecast
    • 6.2.1. By Technique
    • 6.2.2. By Product
    • 6.2.3. By Application
    • 6.2.4. By End Use
    • 6.2.5. By Country
  • 6.3. North America: Country Analysis
    • 6.3.1. United States Analytical Chemistry Sample Preparation Market Outlook
      • 6.3.1.1. Market Size & Forecast
        • 6.3.1.1.1. By Value
      • 6.3.1.2. Market Share & Forecast
        • 6.3.1.2.1. By Technique
        • 6.3.1.2.2. By Product
        • 6.3.1.2.3. By Application
        • 6.3.1.2.4. By End Use
    • 6.3.2. Mexico Analytical Chemistry Sample Preparation Market Outlook
      • 6.3.2.1. Market Size & Forecast
        • 6.3.2.1.1. By Value
      • 6.3.2.2. Market Share & Forecast
        • 6.3.2.2.1. By Technique
        • 6.3.2.2.2. By Product
        • 6.3.2.2.3. By Application
        • 6.3.2.2.4. By End Use
    • 6.3.3. Canada Analytical Chemistry Sample Preparation Market Outlook
      • 6.3.3.1. Market Size & Forecast
        • 6.3.3.1.1. By Value
      • 6.3.3.2. Market Share & Forecast
        • 6.3.3.2.1. By Technique
        • 6.3.3.2.2. By Product
        • 6.3.3.2.3. By Application
        • 6.3.3.2.4. By End Use

7. Europe Analytical Chemistry Sample Preparation Market Outlook

  • 7.1. Market Size & Forecast
    • 7.1.1. By Value
  • 7.2. Market Share & Forecast
    • 7.2.1. By Technique
    • 7.2.2. By Product
    • 7.2.3. By Application
    • 7.2.4. By End Use
    • 7.2.5. By Country
  • 7.3. Europe: Country Analysis
    • 7.3.1. France Analytical Chemistry Sample Preparation Market Outlook
      • 7.3.1.1. Market Size & Forecast
        • 7.3.1.1.1. By Value
      • 7.3.1.2. Market Share & Forecast
        • 7.3.1.2.1. By Technique
        • 7.3.1.2.2. By Product
        • 7.3.1.2.3. By Application
        • 7.3.1.2.4. By End Use
    • 7.3.2. Germany Analytical Chemistry Sample Preparation Market Outlook
      • 7.3.2.1. Market Size & Forecast
        • 7.3.2.1.1. By Value
      • 7.3.2.2. Market Share & Forecast
        • 7.3.2.2.1. By Technique
        • 7.3.2.2.2. By Product
        • 7.3.2.2.3. By Application
        • 7.3.2.2.4. By End Use
    • 7.3.3. United Kingdom Analytical Chemistry Sample Preparation Market Outlook
      • 7.3.3.1. Market Size & Forecast
        • 7.3.3.1.1. By Value
      • 7.3.3.2. Market Share & Forecast
        • 7.3.3.2.1. By Technique
        • 7.3.3.2.2. By Product
        • 7.3.3.2.3. By Application
        • 7.3.3.2.4. By End Use
    • 7.3.4. Italy Analytical Chemistry Sample Preparation Market Outlook
      • 7.3.4.1. Market Size & Forecast
        • 7.3.4.1.1. By Value
      • 7.3.4.2. Market Share & Forecast
        • 7.3.4.2.1. By Technique
        • 7.3.4.2.2. By Product
        • 7.3.4.2.3. By Application
        • 7.3.4.2.4. By End Use
    • 7.3.5. Spain Analytical Chemistry Sample Preparation Market Outlook
      • 7.3.5.1. Market Size & Forecast
        • 7.3.5.1.1. By Value
      • 7.3.5.2. Market Share & Forecast
        • 7.3.5.2.1. By Technique
        • 7.3.5.2.2. By Product
        • 7.3.5.2.3. By Application
        • 7.3.5.2.4. By End Use

8. Asia Pacific Analytical Chemistry Sample Preparation Market Outlook

  • 8.1. Market Size & Forecast
    • 8.1.1. By Value
  • 8.2. Market Share & Forecast
    • 8.2.1. By Technique
    • 8.2.2. By Product
    • 8.2.3. By Application
    • 8.2.4. By End Use
    • 8.2.5. By Country
  • 8.3. Asia Pacific: Country Analysis
    • 8.3.1. China Analytical Chemistry Sample Preparation Market Outlook
      • 8.3.1.1. Market Size & Forecast
        • 8.3.1.1.1. By Value
      • 8.3.1.2. Market Share & Forecast
        • 8.3.1.2.1. By Technique
        • 8.3.1.2.2. By Product
        • 8.3.1.2.3. By Application
        • 8.3.1.2.4. By End Use
    • 8.3.2. India Analytical Chemistry Sample Preparation Market Outlook
      • 8.3.2.1. Market Size & Forecast
        • 8.3.2.1.1. By Value
      • 8.3.2.2. Market Share & Forecast
        • 8.3.2.2.1. By Technique
        • 8.3.2.2.2. By Product
        • 8.3.2.2.3. By Application
        • 8.3.2.2.4. By End Use
    • 8.3.3. South Korea Analytical Chemistry Sample Preparation Market Outlook
      • 8.3.3.1. Market Size & Forecast
        • 8.3.3.1.1. By Value
      • 8.3.3.2. Market Share & Forecast
        • 8.3.3.2.1. By Technique
        • 8.3.3.2.2. By Product
        • 8.3.3.2.3. By Application
        • 8.3.3.2.4. By End Use
    • 8.3.4. Japan Analytical Chemistry Sample Preparation Market Outlook
      • 8.3.4.1. Market Size & Forecast
        • 8.3.4.1.1. By Value
      • 8.3.4.2. Market Share & Forecast
        • 8.3.4.2.1. By Technique
        • 8.3.4.2.2. By Product
        • 8.3.4.2.3. By Application
        • 8.3.4.2.4. By End Use
    • 8.3.5. Australia Analytical Chemistry Sample Preparation Market Outlook
      • 8.3.5.1. Market Size & Forecast
        • 8.3.5.1.1. By Value
      • 8.3.5.2. Market Share & Forecast
        • 8.3.5.2.1. By Technique
        • 8.3.5.2.2. By Product
        • 8.3.5.2.3. By Application
        • 8.3.5.2.4. By End Use

9. South America Analytical Chemistry Sample Preparation Market Outlook

  • 9.1. Market Size & Forecast
    • 9.1.1. By Value
  • 9.2. Market Share & Forecast
    • 9.2.1. By Technique
    • 9.2.2. By Product
    • 9.2.3. By Application
    • 9.2.4. By End Use
    • 9.2.5. By Country
  • 9.3. South America: Country Analysis
    • 9.3.1. Brazil Analytical Chemistry Sample Preparation Market Outlook
      • 9.3.1.1. Market Size & Forecast
        • 9.3.1.1.1. By Value
      • 9.3.1.2. Market Share & Forecast
        • 9.3.1.2.1. By Technique
        • 9.3.1.2.2. By Product
        • 9.3.1.2.3. By Application
        • 9.3.1.2.4. By End Use
    • 9.3.2. Argentina Analytical Chemistry Sample Preparation Market Outlook
      • 9.3.2.1. Market Size & Forecast
        • 9.3.2.1.1. By Value
      • 9.3.2.2. Market Share & Forecast
        • 9.3.2.2.1. By Technique
        • 9.3.2.2.2. By Product
        • 9.3.2.2.3. By Application
        • 9.3.2.2.4. By End Use
    • 9.3.3. Colombia Analytical Chemistry Sample Preparation Market Outlook
      • 9.3.3.1. Market Size & Forecast
        • 9.3.3.1.1. By Value
      • 9.3.3.2. Market Share & Forecast
        • 9.3.3.2.1. By Technique
        • 9.3.3.2.2. By Product
        • 9.3.3.2.3. By Application
        • 9.3.3.2.4. By End Use

10. Middle East and Africa Analytical Chemistry Sample Preparation Market Outlook

  • 10.1. Market Size & Forecast
    • 10.1.1. By Value
  • 10.2. Market Share & Forecast
    • 10.2.1. By Technique
    • 10.2.2. By Product
    • 10.2.3. By Application
    • 10.2.4. By End Use
    • 10.2.5. By Country
  • 10.3. MEA: Country Analysis
    • 10.3.1. South Africa Analytical Chemistry Sample Preparation Market Outlook
      • 10.3.1.1. Market Size & Forecast
        • 10.3.1.1.1. By Value
      • 10.3.1.2. Market Share & Forecast
        • 10.3.1.2.1. By Technique
        • 10.3.1.2.2. By Product
        • 10.3.1.2.3. By Application
        • 10.3.1.2.4. By End Use
    • 10.3.2. Saudi Arabia Analytical Chemistry Sample Preparation Market Outlook
      • 10.3.2.1. Market Size & Forecast
        • 10.3.2.1.1. By Value
      • 10.3.2.2. Market Share & Forecast
        • 10.3.2.2.1. By Technique
        • 10.3.2.2.2. By Product
        • 10.3.2.2.3. By Application
        • 10.3.2.2.4. By End Use
    • 10.3.3. UAE Analytical Chemistry Sample Preparation Market Outlook
      • 10.3.3.1. Market Size & Forecast
        • 10.3.3.1.1. By Value
      • 10.3.3.2. Market Share & Forecast
        • 10.3.3.2.1. By Technique
        • 10.3.3.2.2. By Product
        • 10.3.3.2.3. By Application
        • 10.3.3.2.4. By End Use

11. Market Dynamics

  • 11.1. Drivers
  • 11.2. Challenges

12. Market Trends & Developments

  • 12.1. Merger & Acquisition (If Any)
  • 12.2. Product Launches (If Any)
  • 12.3. Recent Developments

13. Global Analytical Chemistry Sample Preparation Market: SWOT Analysis

14. Porters Five Forces Analysis

  • 14.1. Competition in the Industry
  • 14.2. Potential of New Entrants
  • 14.3. Power of Suppliers
  • 14.4. Power of Customers
  • 14.5. Threat of Substitute Products

15. Competitive Landscape

  • 15.1. Merck KGaA
    • 15.1.1. Business Overview
    • 15.1.2. Company Snapshot
    • 15.1.3. Products & Services
    • 15.1.4. Financials (As Reported)
    • 15.1.5. Recent Developments
    • 15.1.6. Key Personnel Details
    • 15.1.7. SWOT Analysis
  • 15.2. Thermo Fisher Scientific Inc.
  • 15.3. Bio-rad Laboratories Inc.
  • 15.4. Shimadzu Corporation
  • 15.5. Agilent Technologies Inc.
  • 15.6. PerkinElmer U.S. LLC
  • 15.7. Promega Corporation
  • 15.8. Danaher Corporation
  • 15.9. QIAGEN N.V.
  • 15.10. Waters Corporation

16. Strategic Recommendations

17. About Us & Disclaimer