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市場調查報告書
商品編碼
1797895
全球卡路里限制模擬物市場:預測至 2032 年—按產品類型、劑型、分銷管道、應用、最終用戶和地區進行分析Caloric Restriction Mimetics Market Forecasts to 2032 - Global Analysis By Product Type, Formulation Type, Distribution Channel, Application, End User and By Geography |
根據 Stratistics MRC 的數據,全球卡路里限制模擬物市場預計在 2025 年達到 13.4 億美元,到 2032 年將達到 28.7 億美元,預測期內的複合年成長率為 11.5%。
熱量限制模擬物 (CRM) 是一種能夠模擬熱量限制的正面效應的物質,例如提高新陳代謝、增強抗壓性和延長壽命,而無需顯著減少熱量攝取。它們的作用標靶是受熱量限制影響的類似分子通路,例如AMP活化蛋白激酶 (AMPK)、Sirtuin活化以及雷帕黴素靶點 (mTOR) 的抑制。此外,在臨床前研究中,亞精胺、二甲雙胍和白藜蘆醇等 CRM 已顯示出延長壽命和降低老齡化性疾病風險的良好效果。模擬熱量限制引起的細胞和代謝變化的 CRM 干預措施正在被研究,以期促進健康老化並預防慢性疾病。
美國國立衛生研究院 (NIH) 發表的一項人體研究發現,適度(約 30%)的熱量限制會引起骨骼肌的轉錄轉變,從與生長相關的途徑轉向維持和修復過程,類似於在長壽囓齒動物中看到的效果,這表明熱量限制的益處在不同物種之間具有很強的保留性。
健康長壽意識
預防性醫療保健服務、穿戴式健康追蹤器以及日益普及的訊息,鼓勵消費者採取更積極主動的方式來維護健康。這種「長壽思維」已從專門的健康和健身活動演變為普遍性的鍛煉,激發了人們對長期生活品質干預措施的興趣。 CRM 非常適合這一趨勢,因為它提供了一種與生活方式相容、非侵入性的方式,無需劇烈的飲食改變即可獲得卡路里限制的好處。此外,這種意識在都市區和健身群體中尤其強烈,在那些願意儘早投資預防性健康措施的年輕消費者中也特別明顯。
對健康人的影響有限
CRM 的主要缺點之一是其對健康個體的影響尚不清楚。儘管許多物質,例如亞精胺、二甲雙胍和白藜蘆醇,在動物研究和代謝紊亂患者中顯示出顯著的健康益處,但關於這些影響對健康個體的影響程度,證據尚不明確。一些研究表明,與老化、發炎和代謝健康相關的生物標記僅發生了輕微變化,這讓人懷疑其在沒有潛在疾病的情況下作為預防措施的潛力。這使得公司很難在不做出不切實際的宣傳的情況下向廣大受眾推廣 CRM,並且可能會在獲得更可靠、更清晰的健康人群長期研究數據之前,抑制消費者的熱情。
世界各地對長壽科學的興趣日益濃厚
長壽研究領域正在迅速擴展,其研究重點從單純治療與老齡化相關的疾病轉向積極延長壽命。隨著CRM的分子通路研究深入,CRM已成為熱門話題,學術界、研究機構和生技公司也越來越關注減緩生物老化過程的介入措施。此外,消費者對新型干涉措施的接受度以及商業性和學術投資也受益於這種認知的提升。隨著人們關注的重點從“活得更長”轉向“活得更長壽、更健康”,CRM已佔據有利地位,能夠充分利用市場對科學支持的長壽產品的購買意願。
與其他抗衰老策略的競爭
CRM並非長壽市場上唯一的競爭對手。替代療法,例如高級胜肽、抗衰老化合物、生酮飲食、NAD+增強劑、幹細胞療法和禁食療法,正日益普及。許多此類治療方法效果更顯著、更立竿見影,因此對消費者更具吸引力。例如,運動和禁食方案免費且得到良好支持,有可能超越CRM。此外,CRM必須不斷突顯其獨特的價值提案、安全性和有效性,從而在眾多競爭解決方案中脫穎而出。
新冠疫情對卡路里限制模擬物 (CRM) 市場產生了許多影響。封鎖和生產延誤最初擾亂了供應鏈、原料採購和臨床研究時間表。然而,這場危機也提高了人們對 CRM 能夠發揮作用的三個關鍵領域的認知:免疫力、慢性病管理和預防保健。隨著消費者越來越注重健康,並尋求干預措施來增強代謝韌性、降低對老齡化相關感染疾病的易感性,人們對 CRM 和其他促進長壽的補充劑的興趣也日益濃厚。此外,儘管實體零售受到限制,但疫情推動的電商蓬勃發展使 CRM 品牌能夠觸及更多消費者,部分抵消了早期的市場挫折。
預計片劑和膠囊市場在預測期內將佔據最大佔有率
預計片劑和膠囊細分市場將在預測期內佔據最大市場佔有率,這得益於其易用性、精準劑量和廣泛的消費者接受度。這種劑型能夠穩定地遞送生物活性物質,例如亞精胺、二甲雙胍類似物和白藜蘆醇,而這些物質可能會受到光照和濕度等環境條件的影響。藥片和膠囊尤其受到臨床患者和預防性用藥者的青睞,因為它們便於攜帶、保存期限長,並且易於融入日常營養補充方案。此外,成熟的生產技術、可擴展的生產能力和明確的監管途徑進一步增強了它們相對於粉末、液體製劑或功能性混合物的優勢,所有這些都有利於快速商業化和全球廣泛分銷。
預計預測期內候選藥物(治療)部分將以最高的複合年成長率成長。
在精準醫療和長壽科學快速發展的推動下,候選藥物(治療性藥物)領域預計將在預測期內呈現最高成長率。此領域專注於開發經臨床驗證的新型藥物,透過針對mTOR抑制、AMPK刺激和sirtuin活化等途徑,模擬熱量限制帶來的細胞和代謝益處。製藥和生物技術公司正在大力投資臨床前和臨床試驗,以確立CRM作為治療方法與老齡化相關的疾病、代謝紊亂和慢性發炎的有效方法。強勁的專利機會、不斷成長的老年人口以及不斷上漲的醫療成本推動了需求。此外,隨著監管核准的推進,治療性CRM有望使健康老齡化成為一項共同的醫療目標。
預計北美將在預測期內佔據最大的市場佔有率,這得益於其強勁的生物技術和製藥行業、先進的醫療基礎設施以及消費者對長壽和預防保健的高度認知。大量的研發支出、強大的臨床試驗生態系統以及鼓勵創新 CRM 的創建和行銷的有利法律規範都是該地區的優勢。人口快速老化和文明病的增加進一步刺激了需求。此外,北美廣泛使用膳食補充劑、機能性食品和抗衰老療法,加上電子商務的普及,使其成為 CRM 創新和市場收益的主要中心。
預計亞太地區在預測期內將呈現最高的複合年成長率,這得益於中國、日本、韓國和印度等國家日益增強的健康意識、快速的都市化以及不斷成長的可支配收入。文明病的發病率上升以及人們對健康老齡化的認知不斷增強,推動了對先進治療和預防補充劑的需求。此外,該地區還受益於不斷擴大的製藥和營養保健品生產能力、政府鼓勵的生物技術研究項目以及蓬勃發展的電子商務行業,這些行業提供了更便捷的 CRM 獲取途徑。亞太地區人口老化問題嚴重,再加上重視長壽的文化,正在推動市場大幅擴張。
According to Stratistics MRC, the Global Caloric Restriction Mimetics Market is accounted for $1.34 billion in 2025 and is expected to reach $2.87 billion by 2032 growing at a CAGR of 11.5% during the forecast period. Caloric Restriction Mimetics (CRMs) are substances that, without requiring a substantial calorie reduction, replicate the positive effects of caloric restriction, such as increased metabolism, increased resilience to stress, and prolonged lifespan. Similar molecular pathways impacted by calorie restriction, such as AMP-activated protein kinase (AMPK), sirtuin activation, and inhibition of the mechanistic target of rapamycin (mTOR), are the targets of their action. Moreover, in preclinical studies, CRMs such as spermidine, metformin, and resveratrol have demonstrated encouraging outcomes for extending life expectancy and lowering the risk of age-related illnesses. Potential interventions for healthy aging and the prevention of chronic diseases are being investigated by CRMs, which mimic the cellular and metabolic alterations brought on by calorie restriction.
According to a human study published via the NIH, moderate (~30%) caloric restriction induced a transcriptional shift in skeletal muscle from growth-related pathways to maintenance and repair processes. Crucially, this involved down-regulation of the IGF-1/insulin/FOXO signaling axis-mirroring effects seen in long-lived rodents and suggesting strong conservation of CR benefits across species.
Awareness of health and longevity
Preventive health services, wearable health trackers, and increased information availability have made consumers more proactive in preserving their health. This "longevity mindset" has evolved from a specialized wellness movement to a popular one, with increasing interest in long-term quality of life-improving interventions. CRMs are a suitable fit for this trend because they provide a lifestyle-compatible, non-invasive way to benefit from calorie restriction without requiring drastic dietary changes. Additionally, this awareness is particularly high among younger consumers who are prepared to make early investments in preventive health measures, as well as in urban areas and fitness communities.
Limited effectiveness in healthy people
The unknown effect of CRMs on otherwise healthy people is one of their primary drawbacks. Even though a number of substances, including spermidine, metformin, and resveratrol, have shown significant health benefits in animal studies or in patients with metabolic disorders, there has been mixed evidence regarding how well these benefits translate to healthy humans. Some trials have shown only slight changes in biomarkers associated with aging, inflammation, or metabolic health, which raises questions about their potential as a preventive measure in the absence of underlying disease. This makes it challenging for businesses to advertise CRMs to a wide audience without making unrealistic claims, and it might also stifle customer excitement until more solid, lucid data from long-term research in healthy populations becomes available.
Growing interest in longevity science worldwide
The field of longevity research is expanding quickly as it moves from merely treating age-related illnesses to actively prolonging life expectancy. CRMs are a key topic of interest because of their thoroughly researched molecular pathways, and conferences, research institutes, and biotech companies are focusing more and more on interventions that slow the biological aging process. Furthermore, consumer receptivity to new interventions and commercial and academic investment are both benefiting from this growing awareness. As the emphasis shifts from "living longer" to "living healthier for longer," CRMs can capitalize on a market that is open to purchasing longevity products with scientific support.
Competition from other anti-aging strategies
There are other competitors in the longevity market besides CRMs. Alternatives such as advanced peptides, senolytic compounds, ketogenic diets, NAD+ boosters, stem cell therapies, and intermittent fasting are becoming more and more well-liked. Customers find many of these interventions more appealing because of their more obvious or instantaneous results. For instance, exercise routines and fasting protocols are free and well-supported, and they may eventually eclipse CRMs. Moreover, CRMs must constantly set themselves apart from the competition due to the abundance of competing solutions by showcasing their unique value propositions, safety, and efficacy.
The COVID-19 pandemic had a mixed effect on the market for Caloric Restriction Mimetics (CRM). Lockdowns and manufacturing slowdowns initially caused supply chains, raw material sourcing, and clinical research timelines to be disrupted. But the crisis also raised awareness of immunity, chronic disease management, and preventive health-three important areas where CRMs can be helpful. Interest in CRMs and other longevity-promoting supplements increased as consumers grew more health-conscious and looked for interventions to enhance metabolic resilience and lessen age-related susceptibility to infections. Additionally, despite physical retail limitations, the pandemic's spike in e-commerce allowed CRM brands to reach a larger audience, partially offsetting early market setbacks.
The pills and capsules segment is expected to be the largest during the forecast period
The pills and capsules segment is expected to account for the largest market share during the forecast period, propelled by their ease of use, accurate dosage, and broad consumer recognition. This format enables the stable delivery of bioactive substances that can be affected by environmental conditions like light and moisture, such as spermidine, metformin analogs, and resveratrol. Particularly well-liked by patients in clinical settings as well as those using them for preventive health, pills and capsules are portable, have a long shelf life, and blend in easily with daily supplement regimens. Moreover, their dominance over powders, liquids, or functional blends is further reinforced by proven manufacturing techniques, scalable production capacities, and well-defined regulatory pathways, all of which facilitate quick commercialization and extensive worldwide distribution.
The drug candidates (therapeutics) segment is expected to have the highest CAGR during the forecast period
Over the forecast period, the drug candidates (therapeutics) segment is predicted to witness the highest growth rate, propelled by rapid developments in precision medicine and longevity science. This section concentrates on creating new, clinically proven substances that mimic the cellular and metabolic advantages of calorie restriction by focusing on pathways such as mTOR inhibition, AMPK stimulation, and sirtuin activation. In order to establish CRMs as viable therapies for age-related illnesses, metabolic disorders, and chronic inflammation, pharmaceutical and biotech companies are making significant investments in preclinical and clinical trials. Demand is being driven by strong patent opportunities, growing geriatric populations, and rising healthcare costs. Additionally, therapeutic CRMs have the potential to make healthy aging a common medical objective as regulatory approvals move forward.
During the forecast period, the North America region is expected to hold the largest market share, driven by its robust biotechnology and pharmaceutical industries, sophisticated healthcare infrastructure, and high levels of consumer awareness regarding longevity and preventive health. Significant R&D expenditures, a strong clinical trial ecosystem, and advantageous regulatory frameworks that encourage the creation and marketing of innovative CRMs are all advantages for the region. Demand has been further accelerated by the rapidly aging population and the rising prevalence of lifestyle-related disorders. Furthermore, North America is positioned as the primary center for CRM innovation and market revenue due to the extensive use of dietary supplements, functional foods, and anti-aging therapies-as well as the robust penetration of e-commerce.
Over the forecast period, the Asia-Pacific region is anticipated to exhibit the highest CAGR, driven in nations like China, Japan, South Korea, and India by growing health consciousness, fast urbanization, and rising disposable incomes. The demand for both advanced therapeutics and preventive supplements is being driven by rising rates of lifestyle-related diseases and growing awareness of healthy aging. Additionally, the region gains from growing pharmaceutical and nutraceutical manufacturing capacities, encouraging government programs for biotechnology research, and a flourishing e-commerce industry that facilitates the accessibility of CRMs. Asia-Pacific is positioned for remarkable market expansion due to its sizable and aging population and cultural emphasis on longevity.
Key players in the market
Some of the key players in Caloric Restriction Mimetics Market include Cayman Chemical Company, E. Merck KG, Archer Daniels Midland Company (ADM), Hangzhou DayangChem Co. Ltd, DSM Nutritional Products, Chengdu Yazhong, Evolva Holding, Lonza Group, Biodor Holding AG, Laurus Labs Inc, Sabinsa Corporation, Calico Life Sciences, Tokyo Chemical Industry (TCI), Sirtris Pharmaceuticals and InterHealth Inc.
In February 2025, Archer Daniels Midland (ADM), a global food processing and nutrition company, has officially opened a new facility at Lagos Free Trade Zone (LFZ), Nigeria. The expansion marks a major milestone in ADM's strategy to strengthen its presence in Africa and enhance its ability to serve customers and partners in the region.
In October 2024, Lonza has expanded its drug product (DP) services offering by adding a new facility for quality control and bioanalytics at its DPS site in Basel (CH) to support its global DP capacity increase. The expansion includes 6000m2 of state-of-the-art labs and office space to support early and late-stage clinical and commercial DP QC.
In October 2024, Sabinsa Corporation and Postbiotics, Inc. announced a multinational distribution agreement (including the USA, Canada, European Union, and other significant markets (including India and Japan) for the dietary supplement and functional food ingredient PoZibio(R) for age-related digestive health conditions including Leaky Gut Syndrome (LGS).
Note: Tables for North America, Europe, APAC, South America, and Middle East & Africa Regions are also represented in the same manner as above.