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市場調查報告書
商品編碼
1371999
2030 年人類胚胎幹細胞市場預測:按類型、來源、用途和地區分類的全球分析Human Embryonic Stem Cells Market Forecasts to 2030 - Global Analysis By Type (Totipotent Stem Cells, Pluripotent Stem Cells, Multipotent Stem Cells, Oligopotent Stem Cells, Unipotent Stem Cells and Other Types), Source, Application and By Geography |
根據Stratistics MRC的數據,2023年全球人類胚胎幹細胞市場規模為18億美元,預計在預測期內將以11.2%的年複合成長率成長,到2030年達到38億美元。
人類胚胎幹細胞是一種多功能細胞,由人類胚胎胚囊(通常是受精後 5 至 7 天)的內細胞團產生。這種細胞幾乎可以長成人體的任何細胞。它們不僅在人類早期發育中發揮重要作用,而且在再生醫學和研究中也具有巨大的應用潛力。為了確保使用人類胚胎幹細胞的療法的有效性和安全性,嚴格的品管程序以及對其製造和部署的安全性評估至關重要。
2022 年 8 月發表的一篇 DVC Stem報導證實,幹細胞治療帕金森氏症的目標是用健康、未分化的幹細胞取代受損的腦細胞。
人類胚胎幹細胞市場極大地受益於技術進步。這些進展顯著提高了人類胚胎幹細胞的功效、安全性和效用,使其成為潛在研究和治療應用更具吸引力的選擇。3D(3D)培養模型的發展使研究人員能夠更準確地重建人體內細胞的自然環境。因此,人類胚胎幹細胞已改善分化為用於再生治療的特定細胞類型。借助 CRISPR-Cas9 等技術創新,現在可以精確編輯 hESC 基因組,從而徹底改變了基因編輯領域。因此,上述所有要素都在推動市場成長。
探索胚胎幹細胞(ESC)治療潛力的研究與許多道德困境有關,包括殺死人類胚胎。由於缺乏適當的政府立法來規範胚胎幹細胞治療方法開發的支持,最終可能會在一定程度上限制市場的成長。由於該領域法律的複雜性,需要進一步的聯邦立法來幫助研究人員、科學家和製藥公司開發並加速胚胎幹細胞治療方法的商業化。
糖尿病、心血管疾病、神經系統疾病和自體自體免疫疾病等慢性疾病的罹患率不斷上升,增加了對有效治療方法的需求。這些疾病通常涉及永久性組織損傷,可以透過基於人類胚胎幹細胞的治療方法來治療。慢性疾病患者經常出現組織劣化和器官功能障礙,再生醫學技術利用它們來修復、替換和再生受損的組織和器官,從而解決慢性病的長期影響,是一種有用的資源。臨床研究已經開始確定使用人類胚胎幹細胞來治療某些慢性疾病的安全性和有效性。
免疫排斥會導致源自人類胚胎幹細胞的細胞療法失敗。如果接受者的免疫系統將移植的細胞識別為外來細胞,則移植的細胞可能會被攻擊和殺死,從而導致治療無效,並限制人類胚胎幹細胞治療的長期益處。益處可能有限。即使最初的植入是有效的,持續的免疫反應也會導致移植細胞逐漸流失,縮短治療效果的壽命,從而阻礙市場成長。
這場大流行擾亂了該研究所的研究項目,特別是幹細胞項目。一些研究機構的暫時關閉或縮減阻礙了人類胚胎幹細胞的研發和臨床試驗。此外,實驗室關閉、病患招募挑戰和安全問題減緩了這些臨床試驗的進展,並更加重視醫學研究和治療開發的安全性和有效性。因此,使用人類胚胎幹細胞的藥物將接受更徹底的安全評估,這可能會阻礙市場成長。
全能幹細胞領域是一種特殊類型的幹細胞,具有有利的生長潛力,因為人體內所有類型的細胞,包括胚胎外和胚胎組織,都可以由這些細胞形成。全能幹細胞與全能幹細胞的不同之處在於,全能幹細胞可以發展成除胚外組織外的所有體細胞。使用這些細胞的研究有助於了解全能幹細胞如何發展成不同的細胞類型。
幹細胞生物學研究領域預計在預測期內年複合成長率最高。各種類型的幹細胞也用於醫學。許多生物製藥公司最近對這些化合物進行了大量研究,這些化合物對多種疾病有大量的階段用途,包括癌症和神經系統疾病。隨著帕金森氏症和癌症等疾病發生率的增加,幹細胞生物學研究預計未來將進一步發展。由於這些原因,預計所研究的市場將在預測期內顯著成長。
除了政府對藥物研發、醫療保健投資以及在藥物研發技術開發的先進基礎設施方面取得進展的重視外,由於該地區多家公司擴大發展戰略,北美正在經歷快速成長。在預測期內佔據最大的市場佔有率。此外,藥物研究和相關臨床研究的嚴格法規規則預計將提振市場。在美國,生物製藥製造商正在推出生物製藥和生物相似藥產品,這是預計支持市場擴張的另一個要素。
由於歐洲對人類胚胎幹細胞用於研究和治療的使用有嚴格的法律法規,預計在預測期內複合年複合成長率最高。使用幹細胞開發和核准藥物受到國家法規機構和歐洲藥品管理局 (EMA) 的法規。例如,在歐洲,利用人類胚胎幹細胞治療多種疾病的臨床研究已經且目前正在進行中,包括脊髓損傷、心臟病和退化性疾病。這些臨床試驗的目的是評估基於幹細胞的治療的有效性和安全性。該地區學術機構、生物技術公司和醫療機構之間的合作很常見,以推進人類胚胎幹細胞的研究和實用化,從而推動市場發展。
According to Stratistics MRC, the Global Human Embryonic Stem Cells Market is accounted for $1.8 billion in 2023 and is expected to reach $3.8 billion by 2030 growing at a CAGR of 11.2% during the forecast period. The inner cell mass of a human embryo during the blastocyst stage, usually 5-7 days after conception, is when human embryonic stem cells, a kind of pluripotent stem cell, are generated. The amazing capacity of these cells to develop into almost any form of cell in the human body is well recognized. They have a tremendous potential for application in regenerative medicine and research in addition to playing a critical function in early human development. It is crucial to ensure the efficacy and security of human embryonic stem-based therapeutics, to produce and deploy them, rigorous quality control procedures and safety evaluations are essential.
According to the article from DVC Stem published in August 2022, it was observed that the goal of stem cell therapy for Parkinson's disease is to replace destroyed brain cells with healthy, undifferentiated stem cells.
The market for human embryonic stem cells has greatly benefited from technological improvements. With these developments, working with these cells has substantially improved in terms of effectiveness, safety, and usability, making them a more attractive alternative for research and possible therapeutic applications. Researchers can more accurately replicate the natural milieu of cells in the human body thanks to the development of three-dimensional (3D) culture models. As a result, human embryonic stem cells differentiation into certain cell types for regenerative therapy is improved. With the help of innovations like CRISPR-Cas9, the hESC genome may now be precisely edited, revolutionizing the field of gene editing. Hence all the above factors boost the market growth.
Studies looking into the therapeutic potential of embryonic stem cells (ESC) are linked to a number of moral dilemmas including the killing of human embryos. Lack of appropriate government laws that specify what can be supported in the development of therapies using embryo-based stem cells may eventually limit the market's growth to some extent. Federal laws are further necessary due to the complexity of the legislation in this field so that researchers, scientists, and pharmaceutical firms can develop ESC treatment and accelerate its commercialization.
There is a high demand for efficient therapies due to the rising prevalence of chronic diseases including diabetes, cardiovascular disease, neurological disorders, and autoimmune ailments. These diseases, which frequently include permanent tissue damage, may be treated using human embryonic stem cells -based therapy. Tissue deterioration and organ dysfunction are frequently seen in patients with chronic illnesses and are a useful resource for tackling the long-term effects of chronic illnesses because regenerative medicine techniques use them to repair, replace, or regenerate damaged tissues and organs. To determine the safety and effectiveness of human embryonic stem-based treatments for particular chronic conditions, clinical studies have been started.
Immune rejection may cause human embryonic stem cells-derived cell treatments to fail. Transplanted cells may be attacked and killed if the immune system of the recipient recognizes them as alien, making the therapy useless and it may limit the long-term advantages of therapy based on human embryonic stem cells. Even if the initial engraftment is effective, the persistent immune response may cause the transplanted cells to gradually disappear, decreasing the therapeutic effect's longevity thus hampering the market growth.
The pandemic interfered with laboratory research projects, particularly stem cell projects. The development of human embryonic stem cells research and clinical trials was hampered by the temporary closure or reduction of activities at several research organizations. Moreover, the progress of these trials was slowed down by site closures, challenges with patient recruiting, and safety worries and made safety and efficacy of medical research and therapy development even more important. This might result in human embryonic stem cells -based medicines receiving more thorough safety evaluations which hinder the market growth.
The totipotent stem cells segment is estimated to have a lucrative growth, as these are special kind of stem cell and all cell types in the human body, including extraembryonic and embryonic tissues, may be formed from these cells, which is extraordinary. They vary from pluripotent stem cells, though, in that the latter can develop into all bodily cell types except for extraembryonic tissues. Understanding how totipotent stem cells develop into distinct cell types can be aided by research employing these cells.
The stem cell biology research segment is anticipated to witness the highest CAGR growth during the forecast period, as these are living things that can develop into many kinds of cells. Various stem cell types are also employed in medical treatments. Numerous biopharmaceutical firms have recently conducted substantial research into these compounds, which have numerous uses at the clinical stage for a variety of disorders, including cancer and neurological ailments. Due to the growing frequency of disorders like Parkinson's disease, cancer, and others, stem cell biology research will see improved growth. The market under study is thus anticipated to see a significant growth rate throughout the projected period as a result of these reasons.
North America is projected to hold the largest market share during the forecast period owing to the growing government emphasis on drug discovery, healthcare investment, and advanced infrastructure for the development of technologies in drug discovery, as well as expanding development strategies used by several business verticals in the area. Furthermore, it is predicted that strict regulatory rules for medication research and related clinical studies would spur the market. The launch of biological and bio similar drugs by biopharmaceutical manufacturers in the US is another factor that is anticipated to fuel the market's expansion.
Europe is projected to have the highest CAGR over the forecast period, owing to stringent laws governing the use of human embryonic stem cells for both research and therapy. The creation and endorsement of stem cell-based medicines are regulated by national regulatory organizations and the European Medicines Agency (EMA). For instance, in Europe, human embryonic stem cells -based clinical studies have been carried out or are now being done for a range of illnesses, including spinal cord injury, heart disease, and degenerative diseases. The purpose of these trials is to assess the efficacy and safety of stem cell-based treatments. To advance human embryonic stem cells research and turn it into practical applications, partnerships between academic institutions, biotech firms, and healthcare facilities are typical in this region which encourages the market.
Some of the key players profiled in the Human Embryonic Stem Cells Market include: PeproTech Inc., Astellas Pharma Inc., Merck KGaA, Lineage Cell Therapeutics Inc., PromoCell GmbH, Thermo Fisher Scientific, ViaCyte, Inc., Takara Bio Inc., STEMCELL Technologies Inc, Cell Cure Neurosciences LTD, CellGenix GmbH, ESI BIO, Lonza, Kite Pharma, Cynata, Sumanas, Inc., LifeCell, International Stem Cell Corporation, Genea BioCells and Geron
In October 2023, Astellas Pharma Inc. and BioLabs Global, Incand Mitsui Fudosan, announced that they have agreed on a tri-party memorandum of understanding to enhance the life science ecosystem in Tsukuba and Kashiwa-no-ha, Japan, world-renowned science hubs.
In October 2023, Merck launches new collaboration with United Nations-Guided Global Initiative on ageing to support carers; new training course provides critical skills for unpaid family carers and coincides with European Carers Day and Family Caregiver awareness month in the U.S.
In September 2023, Thermo Fisher Scientific expands St. Louis manufacturing for complex biologic treatments for diseases ranging from cancers to auto immune conditions to rare genetic disorders.
In September 2023, Thermo Fisher Scientific Inc. the world leader in serving science, and the National Minority Quality Forum (NMQF), an independent not-for-profit research and education organization, announced a collaboration to help bring clinical research to historically underserved patient populations through NMQF's Alliance for Representative Clinical Trials (ARC).