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市場調查報告書
商品編碼
1284233
2028 年癌症疫苗市場預測——按產品類型、技術、應用、最終用戶和地區進行的全球分析Cancer Vaccines Market Forecasts to 2028 - Global Analysis By Product Type, Technology, Application, End users and By Geography |
根據Stratistics MRC,2022年全球癌症疫苗市場規模將達到75億美元,預測期內以16.7%的複合年增長率增長,2028年將達到189.5億美元,預計將達到美元。
癌症疫苗是被視為生物反應調節劑的藥物。 這種生物反應調節劑通過提高人體免疫系統抗癌能力發揮作用。 有兩種類型的癌症疫苗:治療性和預防性。 預防性癌症疫苗用於預防健康人的癌症。 另一方面,癌症患者接受治療性癌症疫苗以增強免疫力來對抗癌症。 從兒童到成人,癌症疫苗都可以通過靜脈滴注進行接種。
據世界癌症研究基金會(WCRF)統計,2020年全球約有1810萬癌症患者,其中男性930萬,女性880萬。
這個市場的特點是默克公司和葛蘭素史克公司等行業參與者非常關注新型疫苗的推出。 然而,缺乏產品批准和新疫苗管道中治療適應症的不平衡引發了人們對巨大市場缺口的擔憂。 此外,致力於開發新型癌症疫苗的中小型生物技術公司和學術機構正在努力獲得資金和投資。 因此,正在採用鼓勵合作的新商業模式來進入國際市場,並將尖端的新產品推向市場。 因此,許多從事預防和治療疫苗研發的中型免疫治療公司現在都與業內知名公司合作,進行臨床試驗以評估疫苗的安全性和有效性。
癌症是世界上主要的死亡原因之一,是一種複雜且異質性強的疾病。 治療性癌症疫苗針對的是癌細胞而不是疾病的根本原因,而預防性癌症疫苗則致力於增強人體對疾病的自然防禦能力。 此外,這些疫苗是一種免疫療法,只有少數癌症類□□型獲得了全球產品批准。 一些癌症類型(結直腸癌、乳腺癌、非霍奇金淋巴瘤)根據分子亞型進一步細分。 此外,根據癌症的部位和階段,即使在同一腫瘤內,特定標誌物的表達方式也不同。 除了癌症疫苗,還需要更精確的治療來改善這些癌症的預後。 一種新的腫瘤預防和治療方法是個性化或精準醫療。 有可能針對腫瘤中的促癌因子並以影響其環境的方式改變治療。
PDAC(胰腺導管腺癌)是一種常見的胰腺癌,目前尚無治愈方法。 BioNTech 開發的 PDAC 疫苗的 1 期臨床試驗數據已經發布。 由 BioNTech 開發的 mRNA 疫苗用於將新抗原遺傳密碼傳遞給患者的細胞。 該代碼告訴細胞產生新抗原,即癌細胞產生的蛋白質。 這些蛋白質用於幫助免疫系統直接攻擊腫瘤。
由於開發癌症疫苗的成本高且製造疫苗所需的時間長,預計在預測期內市場發展將受到限制。 此外,在即將推出的疫苗管線中,缺乏產品批准和治療適應症的不平衡威脅著市場的巨大缺口。
2020 年 1 月 30 日,世界衛生組織 (WHO) 宣布 COVID-19 疫情為全球關注的突發公共衛生事件。 全球共有 210 個國家/地區受到 COVID-19 的影響。 隨著幾個受 COVID-19 影響的國家關閉,以及在 COVID-19 大流行之後生病的醫護人員增加,導致短缺,製造和銷售癌症疫苗的公司被迫將影響降至最低
CreaVax 預計將在預測期內顯著擴張。 一種基於自體樹突狀細胞的癌症疫苗,使用患者的外周血單核細胞 (PBMC) 在用腫瘤裂解物和 KLH 致敏後成熟為樹突狀細胞(匙孔血藍蛋白)。 Creagene 推出了 Creavax,一種治療腎細胞癌的疫苗。 CreaVax 對肝細胞癌的療效目前正在 III 期臨床試驗中進行研究。
成人疫苗細分市場佔據了最大的市場份額。 此外,世界各地的許多研究人員正在進行深入研究,以開發有效的候選疫苗,以實現潛在的治療策略。 例如,2022 年 3 月,馬裡蘭州的 Northwest Biotherapeutics 將在其位於英國索斯頓的新製造工廠推出第一種具有先進療法的個性化樹突狀細胞藥物,用於治療膠質母細胞瘤病例。我們將宣布,我們將開始出於同情的原因生產癌症疫苗。
北美的收入份額最高。 在預測期內推動市場的因素包括癌症發病率上升、研究支出增加、市場進入者增加臨床試驗以及癌症疫苗的監管批准。 例如,美國癌症協會預測,2021 年美國將有 608,570 例癌症死亡和 190 萬例新癌症病例。 與此同時,預計到 2022 年將有近 190 萬美國人被診斷出患有癌症。 乳腺癌將成為 2018 年最常見的癌症診斷,估計影響 287,850 名女性和 2,710 名男性。 前列腺癌是男性最常見的癌症診斷,也是第二大最常見的癌症診斷。
歐洲市場預計將顯著增長。 這是由癌症疫苗需求增加、癌症患病率上升、歐洲癌症協會和該地區新興市場參與者對研究的支持增加等因素推動的。這被認為是由於其對疫苗市場的積極影響.
2022 年 6 月,生物技術公司 Treos Bio Limited 宣布了 Polypepi 1018 與 F. Hoffmann-La Roche AG 的 pd-l1 抑製劑聯合用於治療轉移性結直腸癌的第 2 期臨床試驗。宣布試驗中的第一位患者已經服藥了。
2020年10月,處於臨床階段的生物製藥公司Vaccibody AS與羅氏集團成員Genentech合作,開髮用於治療癌症的基於DNA的個性化新抗原疫苗(DNA癌症疫苗)。宣布它已經簽訂了一項全球許可和合作協議,用於開發和商業化
2020 年 6 月,UbiVac, Inc. 和 Bristol-Myers Squibb 公佈了 UbiVac 的在研產品 DPV-001 聯合免疫療法治療晚期三陰性乳腺癌的安全性、耐受性和初步結果。宣佈建立臨床試驗合作夥伴關係以評估它的功效。
According to Stratistics MRC, the Global Cancer Vaccines Market is accounted for $7.50 billion in 2022 and is expected to reach $18.95 billion by 2028 growing at a CAGR of 16.7% during the forecast period. Cancer vaccines are drugs that are thought of as biological response modifiers. These biological response modifiers work by boosting the body's immune system's capacity to combat cancer. There are two different kinds of cancer vaccines: therapeutic and preventative. In order to prevent cancer in healthy individuals, preventive cancer vaccines are used. In order to boost their immune systems ability to combat the disease, cancer patients receive therapeutic cancer vaccines. Children and adults alike can receive cancer vaccines intravenously .
According to statistics published by the World Cancer Research Fund (WCRF), there were about 18.1 million cancer cases worldwide in 2020, of which 9.3 million were males and 8.8 million females.
The market is characterized by a significant focus on the introduction of novel vaccines by industry players like Merck & Co., Inc., GSK plc, and others. However, a sizable market gap is feared due to a lack of product approvals and an imbalance of therapeutic indications in the pipeline for new vaccines. Additionally, small and mid-size biotech businesses as well as academic institutions working to develop novel cancer vaccines are having trouble finding funding and investments. Therefore, new business models that encourage collaboration are being adopted so that these players can access international markets and provide the market with cutting-edge new products. As a result, a number of mid-sized immunotherapy players involved in the research and development of prophylactic and therapeutic vaccines are now working with well-known companies in the industry to carry out clinical trials to gauge the safety and effectiveness of vaccines.
Cancer, one of the leading causes of death worldwide, is a complex and heterogeneous disease. Therapeutic cancer vaccines target the cancer cells rather than the disease's underlying cause, whereas preventive cancer vaccines work to bolster the body's natural defenses against the disease. Additionally, these vaccines are a form of immunotherapy that only has a small number of cancer types for which they have received global product approval. Based on their molecular subtypes, some cancer types (colon, breast, and non-Hodgkin's lymphoma) have even more detailed classifications. Additionally, the location or stage of the cancer affects how certain markers are expressed within the same tumor. In order to improve the prognosis for these cancer types, more precise treatment methods are required in addition to cancer vaccines. A new approach to prevention and treatment in oncology is personalized or precision medicine. It may alter treatment in ways that target the tumor's oncogenic drivers and influence its environment.
PDAC, or pancreatic ductal adenocarcinoma, is a common form of pancreatic cancer for which there are no curative therapies. Data from the first phase of a clinical trial for BioNTech's PDAC vaccine against PDAC was made public. The mRNA vaccination developed by BioNTech is used to deliver the genetic code for the neoantigen to the patient's cells. The code instructs the cells to produce the neoantigens, proteins created by cancer cells. These proteins are produced to help the immune system attack the tumor directly.
Market growth is anticipated to be constrained during the forecast period due to the high cost of developing cancer vaccines and the prolonged time required for vaccine manufacturing. Additionally, a sizable market gap is threatened by a lack of product approvals and an imbalance of therapeutic indications in the pipeline of upcoming vaccines.
On January 30, 2020, the World Health Organization (WHO) declared the COVID-19 outbreak a public health emergency of global concern. A total of 210 countries around the world have been impacted by COVID-19. Due to closures in several COVID-19-affected countries and an increase in the number of sick healthcare workers following the COVID-19 pandemic, which resulted in a shortage, companies that manufacture and distribute cancer vaccines have only been minimally impacted by COVID-19.
CreaVax is expected to expand significantly during the forecast period. The patient's peripheral blood mononuclear cells (PBMC) are used to make the autologous dendritic cell-based cancer vaccine, which is sensitized with tumor lysate and KLH before maturing into dendritic cells (Keyhole Limpet Hemocyanin). Creagene released Creavax, a therapeutic vaccine for renal cell carcinoma. The effectiveness of CreaVax in the treatment of hepatocellular carcinoma is currently being studied in a Phase III clinical trial.
The adult vaccine market segment had the largest market share. Additionally, a large number of researchers around the world are conducting in-depth research to develop efficient vaccine candidates to realize potential therapeutic strategies. For instance, Northwest Biotherapeutics of Maryland will announce in March 2022 the start of production of the first personalized dendritic cell-based cancer vaccine at its new production facility in Sawston, UK, using advanced therapy medicinal products for the treatment of a glioblastoma case on compassionate grounds.
The largest revenue share came from North America. The factors driving the market during the forecast period include the rising incidence of cancer, rising research expenditures, an increase in clinical trials by industry participants, and regulatory approvals for cancer vaccines. For instance, the American Cancer Society predicts that in 2021 there will be 608,570 cancer deaths in the United States and an estimated 1.9 million new cancer cases. In contrast, the number of Americans who will receive a cancer diagnosis in 2022 will be close to 1.9 million. Breast cancer will be the most common cancer diagnosis in 2018, affecting an estimated 287,850 women and 2,710 men. The most frequent cancer diagnosis in men and the second most frequent overall is prostate cancer.
Europe's market is expected to grow significantly. This can be attributed to factors such as the rising demand for cancer vaccines, the rising incidence of cancer, the increase in support for research studies from cancer societies across Europe, and emerging market players in the area, all of which have a positive impact on the market for dendritic cell cancer vaccines.
Some of the key players in Cancer Vaccines market include Aduro Biotech Inc., Advaxis Inc., Amgen Inc., Argos Therapeutics, Astellas Pharma Inc., Astrazeneca Plc., Batavia Bioservices, Bristol-Myers Squibb Company, Csl Limited, Dandrit Biotech, Dynavax Technologies Corporation, Generex Biotechnology Corporation, Immunocellular Therapeutics, Ltd, Merck & Co., Inc., Sanpower Corporation, Sanpower Group Co. Ltd. And Vaccinogen, Inc.
In June 2022, Treos Bio Limited, a biotechnology company, announced the first patient dosed in a phase 2 trial of polypepi1018 in combination with pd-l1-inhibitor manufactured by F. Hoffmann-La Roche AG for the treatment of metastatic colorectal cancer.
In October 2020, Vaccibody AS, a clinical-stage biopharmaceutical company, announced its worldwide license and collaboration agreement with Genentech, Inc., a member of the Roche Group, for the development and commercialization of DNA-based individualized neoantigen vaccines (DNA cancer vaccines) for the treatment of cancers.
In June 2020, UbiVac, Inc. announced a clinical trial collaboration with Bristol Myers Squibb to evaluate the safety, tolerability, and preliminary efficacy of UbiVac's investigational product, DPV-001, in combination with Immunotherapy for Advanced Triple Negative Breast Cancer.