Product Code: RA100300
Oligonucleotide Synthesis Market (3rd Edition): Industry Trends and Global Forecasts, Till 2035 - Application Area (Research and Diagnostics, and Therapeutics), Type of Product Synthesized (Active Pharmaceutical Ingredients and Finished Dosage Forms), Type of Oligonucleotide Synthesized (Antisense, DNA, siRNA and Other Oligonucleotides), Scale of Operation (Clinical and Commercial), Therapeutic Area (Cardiovascular Disorders, Genetic Disorders, Liver Disorders, Rare Diseases, and Other Disorders), End-Users (Pharmaceutical / Biopharmaceutical Companies, Academic and Research Institutes, and Hospitals), Company Size (Small, Mid-sized, and Large and Very Large) and Key Geographical Regions (North America, Europe, Asia-Pacific and Rest of the World)
The Oligonucleotide Synthesis Market is valued at USD 4.8 billion in 2024 growing at a CAGR of 9.9% during the forecast period 2024-2035.
Oligonucleotides, commonly referred to as oligos, are short single-stranded segments of DNA or RNA molecules. Typically composed of 10-50 nucleotides, each oligonucleotide chain consists of a phosphate group, a sugar molecule (deoxyribose in DNA and ribose in RNA), and a nitrogenous base. The nitrogenous base can vary, with DNA containing adenine (A), cytosine (C), guanine (G), and thymine (T), while RNA includes adenine (A), cytosine (C), guanine (G), and uracil (U). These molecules play pivotal roles in genetic testing, molecular analysis, and various analytical procedures such as artificial gene synthesis and polymerase chain reactions (PCR). The approval of the first antisense oligonucleotide drug, Vitravene, has significantly expanded the applications of oligonucleotides beyond therapeutics, into research and diagnostics. Numerous preclinical and clinical studies have highlighted the potential of oligonucleotides as safe and effective treatment modalities, thanks to their unique characteristics like high target specificity and superior pharmacokinetic profiles.
Currently, more than 15 oligonucleotide-based therapies have received global approval. Recent examples include Amvuttra (2022), AMONDYS 45 (2021), Leqvio (2021), and Oxlumo (2020). Additionally, there are nearly 300 clinical studies investigating approximately 80 oligonucleotides for over 102 different indications across 14 therapeutic areas, targeting 66 different genes. Oligonucleotides are primarily manufactured using chemical synthesis methods like phosphoramidite synthesis and solid-phase synthesis, although these approaches pose challenges such as extended development timelines, purification issues, and regulatory compliance concerns. Consequently, many researchers and developers in the oligonucleotide synthesis market opt to outsource manufacturing to contract service providers with the requisite expertise and capabilities. Moreover, the global demand for oligonucleotides has surged, particularly post the COVID-19 pandemic, due to their widespread use in COVID-19 testing kits. Consequently, contract service providers are expanding their capacities and capabilities to meet this rising demand. Additionally, the growing pipeline of oligonucleotide-based drugs, promising clinical trial outcomes, and extensive research activities in the field are expected to create lucrative growth opportunities for custom/contract service providers in the foreseeable future.
Key Market Segments
Application Area
- Research and Diagnostics
- Therapeutics
Type of Product Synthesized
- Active Pharmaceutical Ingredients
- Finished Dosage Forms
Type of Oligonucleotide Synthesized
DNA
- siRNA
- Other Oligonucleotides
Scale of Operation
Therapeutic Area
- Cardiovascular Disorders
- Genetic Disorders
- Liver Disorders
- Rare Diseases
- Other Disorders
End-users
- Pharmaceutical/Biopharmaceutical Companies
- Academic And Research Institutes
- Hospitals
Company Size
- Small
- Mid-sized
- Large and Very Large
Key Geographical Regions
- North America
- Europe
- Asia-Pacific
- Rest of the World
Research Coverage:
- This chapter provides a comprehensive overview of oligonucleotides and their various types. It delves into the different steps involved in custom oligonucleotide synthesis, as well as the processes of chemical modification and purification of oligonucleotides. Additionally, the chapter discusses the challenges associated with oligonucleotide manufacturing, including regulatory hurdles and technical complexities, leading to the growing trend of outsourcing manufacturing operations. Furthermore, it examines the key growth drivers and barriers in oligonucleotide manufacturing, along with upcoming trends in the field. Through this discussion, readers gain a thorough understanding of the oligonucleotide manufacturing landscape and its evolving dynamics.
- This chapter conducts a comprehensive evaluation of oligonucleotide synthesis providers, considering various crucial parameters, such as the year of establishment, company size, location of headquarters, location of oligonucleotide synthesis facilities, and scale of operation. Additionally, the assessment covers the types of oligonucleotides synthesized, such as antisense oligonucleotides, aptamers, DNA oligonucleotides, oligonucleotide probes, primers, RNA oligonucleotides, and others. It also examines the type of products synthesized, including oligonucleotide APIs and finished dosage forms/drug products, as well as the application areas such as research, diagnostics, and therapeutics. Furthermore, the evaluation considers the additional services offered by these providers, encompassing process development/method validation, analytical testing, custom synthesis, sequencing, modification, purification, fill-finish, quality assurance and control, and regulatory support. Through this thorough assessment, readers gain insights into the capabilities and offerings of various oligonucleotide synthesis providers, aiding informed decision-making in selecting suitable partners or suppliers within the industry.
- This chapter undertakes an extensive competitiveness analysis of oligonucleotide synthesis providers, focusing on several key parameters, such as supplier strength, which is evaluated based on years of experience in the industry. Additionally, service strength is assessed, considering factors such as the scale of operation, types of oligonucleotides synthesized, application areas served, types of products synthesized, and the range of additional services offered. Moreover, the number of oligonucleotide synthesis facilities operated by each provider is considered a crucial factor in evaluating their competitiveness. Through this detailed analysis, readers gain insights into the competitive positioning of oligonucleotide synthesis providers, aiding informed decision-making in selecting suitable partners or suppliers within the industry.
- Detailed company profiles of prominent players (shortlisted based on our proprietary criteria) engaged in offering oligonucleotide synthesis services. Each profile features a brief overview of the company (including information on year of establishment, location of headquarters, number of employees and leadership team), financial information (if available), service portfolio, recent developments and an informed future outlook.
- This section presents an insightful make-versus-buy framework, examining the key indicators and factors affecting the developers' decision-making whether to outsource oligonucleotide manufacturing operations or set-up in-house capabilities. Through this framework, various critical factors such as cost analysis, technological expertise, regulatory compliance, scalability, timelines, and strategic alignment are examined in detail. By considering these factors, sponsors and developers can make informed decisions that align with their organizational goals, resources, and long-term strategies.
- Comprehensive analysis of completed, ongoing, and planned clinical studies evaluating various oligonucleotide therapeutics, based on several relevant parameters, such as trial registration year, trial status, trial phase, enrolled patient population, type of sponsor, most active industry players (in terms of number of trials conducted), study design, therapeutic area and key geographical regions.
- Elaborate assessment of the partnerships inked between stakeholders in this industry, since 2014, based on several parameters, such as year of partnership, type of partnership, type of oligonucleotide, therapeutic area, application area and the most active players (in terms of the number of partnerships signed). It also provides for the regional distribution of the companies involved in these agreements.
- Comprehensive assessment of expansion initiatives undertaken by oligonucleotide synthesis providers, during the period, since 2015, along with information on several relevant parameters, such as year of expansion, type of expansion, scale of operation, application area, amount invested, area of facility and location of expanded facility.
- Comprehensive review of the various oligonucleotide-focused manufacturing initiatives undertaken by top 13 big pharma players (shortlisted on the basis of 2022 revenues), highlighting trends across various parameters, such as number of initiatives, year of initiative, type of initiative, type of initiative, scale of operation, type of oligonucleotide manufactured, and amount invested.
- Elaborate insight on the overall installed capacity for manufacturing of oligonucleotides, based on information reported by various industry stakeholders in the public domain. The analysis highlights the distribution of the available capacity based on the company size (small, mid-sized, and large and very large firms) and key geographical regions (North America, Europe and, Asia-Pacific and Rest of the World).
- This chapter provides an informed estimate of the annual clinical demand for oligonucleotide therapeutics, considering the target patient population in ongoing and planned clinical trials sponsored by both industry and non-industry players. Additionally, we estimate the commercial demand for oligonucleotides by analyzing the top 12 oligonucleotide-based therapies and phase III drugs. This estimation takes into account various relevant parameters such as the target patient population, dosing frequency, and dose strength of the aforementioned products. Through this analysis, readers gain insights into the expected clinical and commercial demand for oligonucleotide therapeutics, aiding in strategic planning and decision-making within the industry.
- Comprehensive assessment of the factors that can impact the growth of oligonucleotide synthesis services market. It also features identification and analysis of key drivers, potential restraints, emerging opportunities, and existing challenges.
- This section presents a detailed forecast of the oligonucleotide synthesis market to estimate both the current market size and future opportunities over the next 11 years. Leveraging multiple parameters and anticipated adoption trends, we have provided an informed estimate of the market size during the forecast period from 2024 to 2035. These estimations are further validated through primary research and analysis to ensure accuracy and reliability. Through this forecast, readers gain insights into the expected growth trajectory and potential opportunities within the oligonucleotide synthesis market, aiding in strategic planning and decision-making for stakeholders in the industry.
- Comprehensive projections of the current and future opportunity within the oligo synthesis market across different application areas, such as research and diagnostics, and therapeutics.
- Elaborate projections of the current and future opportunity within the oligo synthesis market across different types of product synthesized, such as active pharmaceutical ingredients and finished dosage forms.
- Comprehensive projections of the current and future oligo synthesis market across different types of oligonucleotide synthesized, such as antisense, DNA, siRNA and other oligonucleotides.
- Detailed projections of the current and future opportunity within the oligonucleotide synthesis market across different scales of operation, such as clinical and commercial.
- Detailed projections of the current and future opportunity within the oligonucleotide synthesis industry across different therapeutic areas, such as cardiovascular disorders, genetic disorders, liver disorders, rare diseases, and other disorders.
- Detailed projections of the current and future opportunity within the field of oligonucleotide synthesis across different end-users, such as pharmaceutical / biopharmaceutical companies, academic and research institutes, and hospitals.
- Detailed projections of the current and future opportunity within the field of oligonucleotide synthesis across different company sizes, such as small, mid-sized, and large and very large.
- Detailed projections of the current and future opportunity within the oligonucleotide synthesis market across key geographical regions, such as North America, Europe, Asia-Pacific and Rest of the World.
Key Benefits of Buying this Report
- The report offers market leaders and newcomers valuable insights into revenue estimations for both the overall market and its sub-segments.
- Stakeholders can utilize the report to enhance their understanding of the competitive landscape, allowing for improved business positioning and more effective go-to-market strategies.
- The report provides stakeholders with a pulse on the Oligonucleotide Synthesis Market, furnishing them with essential information on significant market drivers, barriers, opportunities, and challenges.
Leading Market Companies
- Agilent Technologies
- Ajinomoto Bio-Pharma Services
- CordenPharma
- Creative Biolabs
- Ella Biotech
- Eurofins Genomics
- Future synthesis
- Integrated DNA Technologies
- Kaneka Eurogentec
- LGC Biosearch Technologies
- Merck
- Microsynth
- Nitto Avecia
- Ribo Biotechnology
- STA Pharmaceutical / Wuxi STA
- Sumitomo Chemical
- Thermo Fisher Scientific
- TriLink Biotechnologies
TABLE OF CONTENTS
Table Of Contents
1. PREFACE
- 1.1. Oligonucleotide Synthesis Market Overview
- 1.2. Market Share Insights
- 1.3. Key Market Insights
- 1.4. Report Coverage
- 1.5. Frequently Asked Questions
- 1.6. Chapter Outlines
2. RESEARCH METHODOLOGY
- 2.1. Chapter Overview
- 2.2. Research Assumptions
- 2.3. Project Methodology
- 2.4. Forecast Methodology
- 2.5. Robust Quality Control
- 2.6. Key Market Segmentations
- 2.7. Key Considerations
- 2.7.1. Demographics
- 2.7.2. Economic Factors
- 2.7.3. Government Regulations
- 2.7.4. Supply Chain
- 2.7.5. COVID Impact
- 2.7.6. Market Access
- 2.7.7. Healthcare Policies
- 2.7.8. Industry Consolidation
3. ECONOMIC AND OTHER PROJECT SPECIFIC CONSIDERATIONS
- 3.1. Chapter Overview
- 3.2. Market Dynamics
- 3.2.1. Time Period
- 3.2.1.1. Historical Trends
- 3.2.1.2. Current and Future Estimates
- 3.2.2. Currency Coverage and Foreign Exchange Rate
- 3.2.2.1. Major Currencies Affecting the Market
- 3.2.2.2. Factors Affecting Currency Fluctuations and Foreign Exchange Rates
- 3.2.2.3. Impact of Foreign Exchange Rate Volatility on the Market
- 3.2.2.4. Strategies for Mitigating Foreign Exchange Risk
- 3.2.3. Trade Policies
- 3.2.3.1. Impact of Trade Barriers on the Market
- 3.2.3.2. Strategies for Mitigating the Risks Associated with Trade Barriers
- 3.2.4. Recession
- 3.2.4.1. Historical Analysis of Past Recessions and Lessons Learnt
- 3.2.4.2. Assessment of Current Economic Conditions and Potential Impact on the Market
- 3.2.5. Inflation
- 3.2.5.1. Measurement and Analysis of Inflationary Pressures in the Economy
- 3.2.5.2. Potential Impact of Inflation on the Market Evolution
4. EXECUTIVE SUMMARY
5. INTRODUCTION
- 5.1. Chapter Overview
- 5.2. Oligonucleotide Structure
- 5.3. Types of Oligonucleotides
- 5.3.1. Antisense Oligonucleotides
- 5.3.2. Aptamers
- 5.3.3. miRNA
- 5.3.4. shRNA
- 5.3.5. siRNA
- 5.3.6. Other Oligonucleotides
- 5.4. Manufacturing of Oligonucleotides
- 5.4.1. Synthesis of Oligonucleotides
- 5.4.1.1. Process Development / Validation
- 5.4.1.2. Analytical Testing
- 5.4.1.3. Quality Control and Quality Assurance
- 5.4.2. Modification of Oligonucleotides
- 5.4.2.1. Backbone Modification
- 5.4.2.2. Sugar Ring Modification
- 5.4.3. Purification of Oligonucleotides
- 5.4.3.1. Cartridge Purification
- 5.4.3.2. Desalting
- 5.4.3.3. High Performance Liquid Chromatography
- 5.4.3.4. Polyacrylamide Gel Electrophoresis
- 5.4.4 Formulation of Oligonucleotides
- 5.5. Outsourcing Oligonucleotide Manufacturing
- 5.5.1. Need for Outsourcing
- 5.5.2. Advantages of Outsourcing Manufacturing Operations
- 5.6. Future Perspectives
6. MARKET LANDSCAPE
- 6.1. Chapter Overview
- 6.2. Oligonucleotide Synthesis Providers: Overall Market Landscape
- 6.2.1. Analysis by Year of Establishment
- 6.2.2. Analysis by Company Size
- 6.2.3. Analysis by Location of Headquarters
- 6.2.4. Analysis by Company Size and Location of Headquarters
- 6.2.5. Analysis by Location of Oligonucleotide Synthesis Facilities
- 6.2.6. Analysis by Scale of Operation
- 6.2.7. Analysis by Type of Oligonucleotide Synthesized
- 6.2.8. Analysis by Type of Oligonucleotide Product Synthesized
- 6.2.9. Analysis by Application Area
- 6.2.10. Analysis by Type of Additional Service Offered
7. COMPANY COMPETITIVENESS ANALYSIS
- 7.1. Chapter Overview
- 7.2. Assumptions and Key Parameters
- 7.3. Methodology
- 7.4. Oligonucleotide Synthesis Providers: Company Competitiveness Analysis
- 7.4.1. Oligonucleotide Synthesis Providers Based in North America
- 7.4.2. Oligonucleotide Synthesis Providers Based in Europe
- 7.4.3. Oligonucleotide Synthesis Providers Based in Asia- Pacific and Rest of the World
8. COMPANY PROFILES
- 8.1. Chapter Overview
- 8.2. Detailed Company Profiles of Leading Service Providers
- 8.2.1. Agilent Technologies
- 8.2.1.1. Company Overview
- 8.2.1.2. Financial Information
- 8.2.1.3. Service Portfolio
- 8.2.1.4. Recent Developments and Future Outlook
- 8.2.2. Ajinomoto Bio-Pharma Services
- 8.2.2.1. Company Overview
- 8.2.2.2. Financial Information
- 8.2.2.3. Service Portfolio
- 8.2.2.4. Recent Developments and Future Outlook
- 8.2.3. CordenPharma
- 8.2.3.1. Company Overview
- 8.2.3.2. Service Portfolio
- 8.2.3.3. Recent Developments and Future Outlook
- 8.2.4. Integrated DNA Technologies
- 8.2.4.1. Company Overview
- 8.2.4.2. Service Portfolio
- 8.2.4.3. Recent Developments and Future Outlook
- 8.2.5. Kaneka Eurogentec
- 8.2.5.1. Company Overview
- 8.2.5.2. Financial Information
- 8.2.5.3. Service Portfolio
- 8.2.5.4. Recent Developments and Future Outlook
- 8.2.6. LGC Biosearch Technologies
- 8.2.6.1. Company Overview
- 8.2.6.2. Financial Information
- 8.2.6.3. Service Portfolio
- 8.2.6.4. Recent Developments and Future Outlook
- 8.2.7. Microsynth
- 8.2.7.1. Company Overview
- 8.2.7.2. Service Portfolio
- 8.2.7.3. Recent Developments and Future Outlook
- 8.2.8. Merck
- 8.2.8.1. Company Overview
- 8.2.8.2. Financial Information
- 8.2.8.3. Service Portfolio
- 8.2.8.4. Recent Developments and Future Outlook
- 8.2.9. Nitto Avecia
- 8.2.9.1. Company Overview
- 8.2.9.2. Financial Information
- 8.2.9.3. Service Portfolio
- 8.2.9.4. Recent Developments and Future Outlook
- 8.2.10. Thermo Fisher Scientific
- 8.2.10.1. Company Overview
- 8.2.10.2. Financial Information
- 8.2.10.3. Service Portfolio
- 8.2.10.4. Recent Developments and Future Outlook
- 8.2.11. TriLink BioTechnologies
- 8.2.11.1. Company Overview
- 8.2.11.2. Service Portfolio
- 8.2.11.3. Recent Developments and Future Outlook
- 8.3. Short Company Profiles of Leading Service Providers
- 8.3.1. Creative Biolabs
- 8.3.1.1. Company Overview
- 8.3.1.2. Service Portfolio
- 8.3.2. Ella Biotech
- 8.3.2.1. Company Overview
- 8.3.2.2. Service Portfolio
- 8.3.3. Eurofins Genomics
- 8.3.3.1. Company Overview
- 8.3.3.2. Service Portfolio
- 8.3.4. Future Synthesis
- 8.3.4.1. Company Overview
- 8.3.4.2. Service Portfolio
- 8.3.5. Ribo Biotechnology
- 8.3.5.1. Company Overview
- 8.3.5.2. Service Portfolio
- 8.3.6. STA Pharmaceutical
- 8.3.6.1. Company Overview
- 8.3.6.2. Service Portfolio
- 8.3.7. Sumitomo Chemical
- 8.3.7.1. Company Overview
- 8.3.7.2. Service Portfolio
9. MAKE VERSUS BUY DECISION MAKING FRAMEWORK
- 9.1. Chapter Overview
- 9.2. Assumptions and Key Parameters
- 9.3. Oligonucleotide Synthesis: Make versus Buy Decision Making Framework
- 9.3.1. Scenario 1
- 9.3.2. Scenario 2
- 9.3.3. Scenario 3
- 9.3.4. Scenario 4
- 9.4. Concluding Remarks
10. CLINICAL TRIAL ANALYSIS
- 10.1. Chapter Overview
- 10.2. Scope and Methodology
- 10.3. Oligonucleotide Therapeutics: Clinical Trial Analysis
- 10.3.1. Analysis by Trial Registration Year
- 10.3.2. Analysis by Trial Status
- 10.3.3. Analysis by Trial Registration Year and Trial Status
- 10.3.4. Analysis by Trial Phase
- 10.3.5. Analysis by Trial Registration Year and Trial Phase
- 10.3.6. Analysis of Enrolled Patient Population by Trial Registration Year
- 10.3.7. Analysis of Enrolled Patient Population by Trial Phase
- 10.3.8. Analysis by Type of Oligonucleotide
- 10.3.9. Analysis by Therapeutic Area
- 10.3.10. Analysis by Study Design
- 10.3.11. Analysis by Type of Sponsor
- 10.3.12. Most Active Players: Analysis by Number of Registered Trials
- 10.3.13. Analysis of Number of Registered Trials by Geography
- 10.3.14. Analysis of Number of Registered Trials by Trial Status and Geography
- 10.3.15. Analysis of Enrolled Patient Population by Geography
- 10.3.16. Analysis of Enrolled Patient Population by Trial Status and Geography
11. PARTNERSHIPS AND COLLABORATIONS
- 11.1. Chapter Overview
- 11.2. Partnership Models
- 11.3. Oligonucleotide Synthesis: Partnerships and Collaborations
- 11.3.1. Analysis by Year of Partnership
- 11.3.2. Analysis by Type of Partnership
- 11.3.3. Analysis by Year and Type of Partnership
- 11.3.4. Analysis by Type of Oligonucleotide
- 11.3.5. Analysis by Therapeutic Area
- 11.3.6. Analysis by Application Area
- 11.3.7. Most Active Players: Analysis by Number of Partnerships
- 11.3.8. Analysis by Geography
- 11.3.8.1. Intracontinental and Intercontinental Agreements
- 11.3.8.2. Local and International Agreements
12. RECENT EXPANSIONS
- 12.1. Chapter Overview
- 12.2. Type of Expansion
- 12.3. Oligonucleotide Synthesis: Recent Expansions
- 12.3.1. Analysis by Year of Expansion
- 12.3.2. Analysis by Type of Expansion
- 12.3.3. Analysis by Year and Type of Expansion
- 12.3.4. Analysis by Location of Expanded Facility
- 12.3.5. Analysis by Type of Expansion and Location of Expanded Facility
- 12.3.6. Analysis by Area of Expanded Facility
- 12.3.7. Analysis by Scale of Operation
- 12.3.8. Analysis by Amount Invested
- 12.3.9. Most Active Players: Analysis by Number of Expansions
13. BIG PHARMA INITIATIVES
- 13.1. Chapter Overview
- 13.2. Oligonucleotide Related Initiatives by Big Pharmaceutical Players
- 13.2.1. Analysis by Number of Initiatives
- 13.2.2. Analysis by Year of Initiative
- 13.2.3. Analysis by Type of Initiative
- 13.2.3.1. Analysis by Type of Partnership
- 13.2.3.2. Analysis by Type of Expansion
- 13.2.4. Analysis by Year and Type of Initiative
- 13.2.5. Analysis by Scale of Operation
- 13.2.6. Analysis by Type of Oligonucleotide
- 13.2.7. Analysis by Amount Invested
14. CAPACITY ANALYSIS
- 14.1. Chapter Overview
- 14.2. Key Assumptions and Methodology
- 14.3. Oligonucleotide Synthesis: Global Installed Capacity
- 14.3.1. Analysis by Company Size
- 14.3.2. Analysis by Geography
- 14.3.2.1. Analysis of Oligonucleotide Synthesis Capacity in North America
- 14.3.2.2. Analysis of Oligonucleotide Synthesis Capacity in Europe
- 14.3.2.3. Analysis of Oligonucleotide Synthesis Capacity in Asia-Pacific and Rest of the World
- 14.3.3. Concluding Remarks
15. DEMAND ANALYSIS
- 15.1 Chapter Overview
- 15.2. Assumptions and Methodology
- 15.3. Overall Demand for Oligonucleotides
- 15.4. Global Clinical Demand for Oligonucleotides
- 15.4.1. Analysis by Type of Oligonucleotide
- 15.4.2. Analysis by Therapeutic Area
- 15.4.3. Analysis by Geography
- 15.5. Global Commercial Demand for Oligonucleotides
- 15.5.1. Analysis by Type of Oligonucleotide
- 15.5.2. Analysis by Therapeutic Area
- 15.5.3. Analysis by Geography
16. MARKET IMPACT ANALYSIS
- 16.1. Chapter Overview
- 16.2. Market Drivers
- 16.3. Market Restraints
- 16.4. Market Opportunities
- 16.5. Market Challenges
- 16.6. Conclusion
17. GLOBAL OLIGONUCLEOTIDE SYNTHESIS MARKET
- 17.1. Chapter Overview
- 17.2. Key Assumptions and Methodology
- 17.3. Global Oligonucleotide Synthesis Market, Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 17.3.1. Scenario Analysis
- 17.3.1.1. Conservative Scenario
- 17.3.1.2. Optimistic Scenario
- 17.4. Key Market Segmentations
18. OLIGONUCLEOTIDE SYNTHESIS MARKET, BY APPLICATION AREA
- 18.1. Chapter Overview
- 18.2. Key Assumptions and Methodology
- 18.3. Oligonucleotide Synthesis Market: Distribution by Application Area, 2018, 2024 and 2035
- 18.3.1. Research and Diagnostics: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 18.3.2. Therapeutics: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 18.4. Data Triangulation and Validation
19. OLIGONUCLEOTIDE SYNTHESIS MARKET, BY TYPE OF PRODUCT SYNTHESIZED
- 19.1. Chapter Overview
- 19.2. Key Assumptions and Methodology
- 19.3. Oligonucleotide Synthesis Market: Distribution by Type of Product Synthesized, 2018, 2024 and 2035
- 19.3.1. Active Pharmaceutical Ingredients: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 19.3.2. Finished Dosage Forms: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 19.4. Data Triangulation and Validation
20. OLIGONUCLEOTIDE SYNTHESIS MARKET, BY TYPE OF OLIGONUCLEOTIDE SYNTHESIZED
- 20.1. Chapter Overview
- 20.2. Key Assumptions and Methodology
- 20.3. Oligonucleotide Synthesis Market: Distribution by Type of Oligonucleotide Synthesized, 2018, 2024 and 2035
- 20.3.1. Antisense Oligonucleotides: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 20.3.2. DNA Oligonucleotides: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 20.3.3. siRNA Oligonucleotides: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 20.3.4. Other Oligonucleotides: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 20.4. Data Triangulation and Validation
21. OLIGONUCLEOTIDE SYNTHESIS MARKET, BY SCALE OF OPERATION
- 21.1. Chapter Overview
- 21.2. Key Assumptions and Methodology
- 21.3. Oligonucleotide Synthesis Market: Distribution by Scale of Operation, 2018, 2024 and 2035
- 21.3.1. Clinical Scale of Operation: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 21.3.2. Commercial Scale of Operation: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 21.4. Data Triangulation and Validation
22. OLIGONUCLEOTIDE SYNTHESIS MARKET, BY THERAPEUTIC AREA
- 22.1. Chapter Overview
- 22.2. Key Assumptions and Methodology
- 22.3. Oligonucleotide Synthesis Market: Distribution Therapeutic Area, 2018, 2024 and 2035
- 22.3.1. Cardiovascular Disorders: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 22.3.2. Genetic Disorders: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 22.3.3. Liver Disorders: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 22.3.4. Rare Diseases: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 22.3.5. Other Disorders: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 22.4. Data Triangulation and Validation
23. OLIGONUCLEOTIDE SYNTHESIS MARKET, BY END-USERS
- 23.1. Chapter Overview
- 23.2. Key Assumptions and Methodology
- 23.3. Oligonucleotide Synthesis Market: Distribution by End-users, 2018, 2024 and 2035
- 23.3.1. Pharmaceutical / Biopharmaceutical Companies: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 23.3.2. Academic and Research Institutes: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 23.3.3. Hospitals: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 23.4. Data Triangulation and Validation
24. OLIGONUCLEOTIDE SYNTHESIS MARKET, BY COMPANY SIZE
- 24.1. Chapter Overview
- 24.2. Key Assumptions and Methodology
- 24.3. Oligonucleotide Synthesis Market: Distribution by Company Size, 2018, 2024 and 2035
- 24.3.1. Small Companies: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 24.3.2. Mid-sized Companies: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 24.3.3. Large and Very Large Companies: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 24.4. Data Triangulation and Validation
25. OLIGONUCLEOTIDE SYNTHESIS MARKET: DISTRIBUTION BY KEY GEOGRAPHICAL REGIONS
- 25.1. Chapter Overview
- 25.2. Key Assumptions and Methodology
- 25.3. Oligonucleotide Synthesis Market: Distribution by Key Geographical Regions, 2018, 2024 and 2035
- 25.3.1. North America: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 25.3.1.1. US: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 25.3.1.2. Canada: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 25.3.2. Europe: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 25.3.2.1. Switzerland: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 25.3.2.2. Germany: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 25.3.2.3. Belgium: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 25.3.2.4. Rest of Europe: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 25.3.3. Asia-Pacific: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 25.3.3.1. China: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 25.3.3.2. South Korea: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 25.3.3.3. Japan: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 25.3.3.4. India: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 25.3.3.5. Rest of Asia-Pacific: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 25.3.4. Rest of the World: Historical Trends (2018-2023) and Future Estimates (2024-2035)
- 25.4. Data Triangulation and Validation
26. EXECUTIVE INSIGHTS
- 26.1. Chapter Overview
- 26.2. BianoGMP
- 26.2.1. Company Snapshot
- 26.2.2. Interview Transcript
- 26.3. Hanugen Therapeutics
- 26.3.1. Company Snapshot
- 26.3.2. Interview Transcript
- 26.4. IBA Life Sciences
- 26.4.1. Company Snapshot
- 26.4.2 Interview Transcript
- 26.5. Axolabs
- 26.5.1. Company Snapshot
- 26.5.2. Interview Transcript
- 26.6. SBS Genetech
- 26.6.1. Company Snapshot
- 26.6.2. Interview Transcript
- 26.7. Aptagen
- 26.7.1. Company Snapshot
- 26.7.2. Interview Transcript
- 26.8. Invitek Diagnostics
- 26.8.1. Company Snapshot
- 26.8.2. Interview Transcript
27. CONCLUDING REMARKS
28. APPENDIX I: TABULATED DATA
29. APPENDIX II: LIST OF COMPANIES AND ORGANIZATION