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1198142

蛋白質穩定性分析市場 - COVID-19 的增長、趨勢、影響和預測 (2023-28)

Protein Stability Analysis Market - Growth, Trends, and Forecasts (2023-28)
出版日期: | 出版商: Mordor Intelligence | 英文 114 Pages | 商品交期: 2-3個工作天內

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簡介目錄

在預測期內，蛋白質穩定性分析市場預計將以 3.5% 的複合年增長率增長。

COVID-19 在其早期階段對蛋白質穩定性分析市場產生了重大影響，因為已經進行了蛋白質穩定性研究以極大地評估 COVID-19 病毒的結構和特性，這將有助於更好地幫助獲得理解並支持開發有效和高效的療法。 例如，2022 年 9 月在斯坦福大學醫學雜誌上發表的一篇論文發現，醫院 COVID-19 患者血液中病毒水平升高預示著呼吸道症狀惡化，並繼續暗示病毒複製。 在測試過程中，在患者血液中測量了來自導致 COVID-19 的病毒的蛋白質。 因此，蛋白質分析顯示與 COVID-19 相關的並發症可能會促進市場增長。

在後大流行時代出現了不同的 COVID-19 變體，並且仍在研究中。 自大流行開始以來，世衛組織描述了八個關注領域 (VOI)，即 Epsilon、Zeta、Eta、Theta、Iota、Kappa、Lambda 和 Mu。 目前正在進行研究以確定 omicron 變體是否會影響病毒特性、傳播速度、相關疾病的嚴重程度、疫苗性能或其他公共衛生和社會措施。因此，對蛋白質分析產品的需求預計會增加。 另一個要考慮的因素是 Sars-COV-2 庫存，預計在預測期內對市場產生積極影響。

製藥和生物製藥公司研發支出的增加、蛋白質組學和基因組學研究活動的增加以及重組蛋白療法和生物製品的增加等因素都是有助於蛋白質穩定性以證明研究成果的因素。由於根據評估的需要，預計將在預測期內推動市場增長。

例如，根據 EFPIA 2022 報告，2021 年歐洲將在藥物研發方面投入約 415 億歐元（約合 351.09 億美元）。 因此，巨大的研發投資將在預測期內推動蛋白質穩定性分析市場的增長。 此外，隨著研究人員尋求蛋白質穩定性研究的機會，預計基因組研究活動的投資和融資將推動市場發展。 例如，2022 年 9 月，隸屬於 NIH 的 NHGRI 將在五年內投資 335 萬美元啟動基因組學研究體驗，以吸引研究人員參與其基因組學增加多樣性 (GREAT) 計劃。計劃投資於 此外，2022 年 9 月，西澳大利亞大學與 Proteomics International 的合資企業獲得了 200 萬美元的資金，該公司是一家在蛋白質醫學、環境和農業測試方面提供基本服務的公司。 這筆資金將使 WA Proteomics Facility 能夠升級其自動化工具和員工，並將其輸出能力提高到數百個樣本。

由於製藥和生物製藥公司研發支出的增加以及蛋白質組學和基因組學研究活動的增加，預計蛋白質穩定性分析市場在預測期內將會增長。 然而，蛋白質穩定性分析系統的高成本預計將在一定程度上抑制該市場的增長。

蛋白質穩定性分析的市場趨勢

差示掃描量熱法 (DSC) 預計在預測期內將佔很大份額

差示掃描量熱法通過測量某些生物分子（如蛋白質）變性所需的熱量，已廣泛用於評估天然形式的蛋白質穩定性。稻田。 通過這種技術，具有較高中點熱轉變的分子被確定為比具有較低熱轉變中點的分子更穩定。 該技術廣泛用於研發和藥物發現。 由於 DSC 可用於觀察材料轉變的簡便性和速度等廣泛優勢，預計 DSC 領域將在預測期內增長。 由於這些原因，DSC 優於其他蛋白質掃描和鑑定技術。

使用差示掃描量熱法在蛋白質穩定性領域的研發正在推動市場增長，因為它證明了 DSC 在研究中的簡便性和速度。 根據 2022 年 6 月發表在《生物傳感器》雜誌上的一篇文章，有一項研究展示了使用基於微機電系統 (MEMS) 的新型差示掃描量熱儀 (DSC) 對蛋白質樣品進行直接熱表徵。 這種 MEMS 量熱儀可以根據許多治療性蛋白質的轉變溫度以高通量篩選其構象穩定性。 因此，與蛋白質分析相關的 DSC 的這種進步可能會在預測期內推動市場增長。 該行業的累計研發支出證明了研發 (R&D) 在製藥行業的重要性。 研發支出每年都在增加，據觀察，一些製藥和生物技術公司專注於加強其研發設施，這最終促進了市場的增長。 美國最近看到各種製藥公司和政府組織增加了研發支出，預計這將在預測期內推動市場增長。 例如，根據 EFPIA 的 2022 年報告，2021 年北美將佔全球藥品銷售額的 49.1%，而歐洲為 23.4%。 研發支出和銷售增長預計將增加對 DSC 等蛋白質穩定性分析技術的需求，從而推動市場增長。

北美有望在預測期內主導市場

在該地區，知名研發機構的存在及其高額投資將在預測期內推動市場增長，因為研究計劃預計將利用蛋白質穩定性研究來獲得準確的結果。 例如，根據加拿大統計局 2022 年 6 月的一份報告，2021 年內部研發支出預計將增長 3.5%，達到 234 億美元。 公司預計 2022 年內部研發支出增長將放緩，總研發支出預計將增長 1.7% 至 238 億美元。

此外，政府和私營公司對基因組學和蛋白□□質組學研究的投資預計將推動北美地區的市場增長。 例如，2021 年 2 月，總部位於西雅圖的 Nautilus Biotechnology 將通過合併進入股票市場，獲得 3.5 億美元，用於加速開髮用於藥物發現和診斷應用的蛋白質分析技術。 此外，斯坦福大學質譜蛋白質組學種子基金將於 2022 年 9 月向尋求新質譜項目和新方法的研究人員提供 10,000 美元的研究資助，以利用最近增加的研究儀器的功能。

此外，北美地區的基因組學和蛋白□□質組學研究將推動市場增長，因為它認識到蛋白質穩定性研究的必要性，並利用與穩定性研究相關的試劑和儀器。 例如，MDPI 在墨西哥國家呼吸疾病研究所 Ismael Cosio Villegas 的支持下於 2022 年 5 月發表的一篇論文發現，蛋白質組學能夠識別可用於血清學診斷的新型過敏原，1 研究結果已經宣布，它現在可以在一次分析中分析數千種蛋白質。

蛋白質穩定性分析市場競爭者分析

由於多家公司在全球和區域運營，蛋白質穩定性分析市場在本質上是分散的。 競爭格局包括對具有市場份額的幾家知名國際和地區公司的分析。 其中包括 Agilent Technologies Inc、NanoTemper Technologies、Shimadzu Corporation、Thermo Fisher Scientific 和 Spectris PLC (Malvern Panalytical Ltd)。

其他福利。

  • Excel 格式的市場預測 (ME) 表
  • 3 個月的分析師支持

內容

第一章介紹

  • 研究假設和市場定義
  • 調查範圍

第二章研究方法論

第 3 章執行摘要

第四章市場動態

  • 市場概覽
  • 市場驅動力
    • 製藥和生物製藥公司的研發支出增加
    • 增加蛋白質組學和基因組學方面的研究活動
    • 重組蛋白療法和生物製劑的數量增加
  • 市場製約因素
    • 蛋白質穩定性分析儀成本高
  • 波特的五力分析
    • 供應商的議價能力
    • 買方/消費者議價能力
    • 新進入者的威脅
    • 替代品的威脅
    • 競爭公司之間的敵對關係

第 5 章市場細分（基於價值的市場規模：100 萬美元）

  • 按產品分類
    • 試劑和檢測試劑盒
    • 樂器
    • 耗材/配件
    • 其他產品
  • 按技術
    • 色譜法
    • 光譜學
    • 表面等離子體共振
    • 差示掃描量熱儀
    • 差示掃描熒光法
    • 其他技術
  • 最終用戶
    • 製藥和生物技術公司
    • 學術和研究機構
  • 按地區
    • 北美
      • 美國
      • 加拿大
      • 墨西哥
    • 歐洲
      • 德國
      • 英國
      • 法國
      • 意大利
      • 西班牙
      • 其他歐洲地區
    • 亞太地區
      • 中國
      • 日本
      • 印度
      • 澳大利亞
      • 韓國
      • 其他亞太地區
    • 中東
      • 海灣合作委員會
      • 南非
      • 其他中東地區
    • 南美洲地區
      • 巴西
      • 阿根廷
      • 其他南美洲

第六章競爭格局

  • 公司簡介
    • Agilent Technologies, Inc.
    • NanoTemper Technologies
    • Horiba, Ltd
    • Perkinelmer, Inc.
    • Setaram Instrumentation
    • Shimadzu Corporation
    • Spectris PLC
    • Thermo Fisher Scientific
    • Unchained Labs
    • Danaher Corporation（Molecular Devices）
    • Spectris PLC（Malvern Panalytical Ltd）
    • Bruker Corporation

第七章市場機會與未來趨勢

簡介目錄
Product Code: 67630

The protein stability analysis market is expected to register a CAGR of 3.5% during the forecast period.

COVID-19 had a significant impact on the protein stability analysis market in the initial phase since protein stability studies were conducted to assess the structure and nature of the COVID-19 virus to a great extent which helps gain a better understanding of the virus and supports the development of effective and efficient therapeutics. For instance, as per the article published in September 2022 in Stanford Medicine, elevated virus levels in the blood of COVID-19 patients in hospitals predicted the worsening of respiratory symptoms and suggest ongoing viral replication in advanced disease stages. A protein of the virus that causes COVID-19 was measured in the patient's blood during the test. Hence, such analysis showing the complications associated with COVID-19 through protein analysis will likely boost the market growth.

In the post-pandemic era, studies are still being conducted due to the emergence of different COVID-19 mutants. Since the beginning of the pandemic, the WHO has described eight variants of interest (VOIs), namely Epsilon, Zeta, Eta, Theta, Iota, Kappa, Lambda, and Mu. Currently, studies are being conducted to determine whether mutants of Omicron variants affect the virus's properties, speed of spreading, the severity of the associated disease, the performance of vaccines, or other public health and social measures and hence, the demand for protein analysis products is expected to increase. Another factor to account for are the Sars-COV-2 strains which are expected to have a positive impact on the market over the forecast period.

Factors such as rising research and development expenditure of pharmaceutical and biopharmaceutical companies, increasing proteomics and genomics research activities, and an increasing number of recombinant protein therapeutics and biologics are expected to drive the market growth over the forecast period since research studies require protein stability assessments to substantiate the results.

For instance, as per the EFPIA 2022 report, in 2021, Europe invested an estimated EUR 41,500 million (about USD 35,109 million) in pharmaceutical R&D. Thus, huge investments in R&D drive the growth of the protein stability analysis market during the forecast period. Furthermore, investments and financing in genomic research activities are projected to fuel the market as researchers seek opportunities in protein stability studies. For instance, in September 2022 NHGRI, part of the NIH, planned to fund USD 3.35 million over five years to launch the Genome Research Experiences to attract researchers into the Genomics Field to Enhance Diversity (GREAT) program. Moreover, in September 2022, a joint venture by the University of Western Australia and Proteomics International, which conducts vital work in medical, environmental, and agricultural testing of proteins received a funding of USD 2 million . The money is likely to enable the WA Proteomics Facility to upgrade its automated tools and staff, increasing output capacity to hundreds of samples.

As a result of the increase in pharmaceutical and biopharmaceutical companies' R&D expenditures, as well as the increase in the number of proteomics and genomics research activities, the protein stability analysis market is anticipated to witness growth over the forecast period. However, the high cost of protein stability analysis systems is expected to restrain the growth of this market to a certain extent.

Protein Stability Analysis Market Trends

Differential Scanning Calorimetry (DSC) is Expected to Hold a Significant Share Over the Forecast Period

The differential scanning calorimetry technique has been widely used in characterizing the stability of proteins in their native form by measuring the heat required to denature a particular biomolecule, like a protein. This technique determines molecules with higher thermal transition midpoints, which are considered more stable than those with lower transition midpoints. This technique is widely used in research & development and drug discovery. The DSC segment is likely to witness growth over the forecast period due to the wide advantages of DSC such as the ease and speed with which it can be used to see transitions in materials. Due to this reason, DSC is preferred over other techniques to scan and identify proteins.

The research and development in the field of protein stability using differential scanning calorimetry are driving the market growth as it showcases the ease and speed of DSC for research. According to an article published in June 2022 in the Biosensors journal, a study demonstrated the direct thermal characterization of protein samples using a new micro-electromechanical system (MEMS)-based differential scanning calorimeter (DSC). With high throughput, the MEMS calorimeter could screen many therapeutic proteins for conformational stability based on transition temperature. Hence, such advancements in DSC associated with protein analysis are likely to boost market growth over the forecast period. The importance of research and development (R&D) for the pharmaceutical industry is evidenced by the cumulative R&D expenditure in the sector. It has been observed that R&D spending is increasing each year and several pharma and biotech companies are focusing on strengthening their R&D facilities which are ultimately driving the growth of the market studied. The spending on research and development (R&D) by various pharmaceutical companies and government organizations has been increasing recently in the United States, which is anticipated to drive market growth over the forecast period. For instance, as per the 2022 report from EFPIA, in 2021 North America accounted for 49.1% of world pharmaceutical sales compared with 23.4% for Europe. As the R&D expenditure and sales increase, the demand for protein stability analysis techniques like DSC is expected to increase thereby boosting the market growth.

North America is Expected to Dominate the Market During the Forecast Period

The presence of well-established research and development institutions and their high investment in the region is driving market growth over the forecast period since the research initiatives are likely to utilize protein stability studies for accurate results. For instance, as per the Statistics Canada June 2022 report, in-house spending on R&D in 2021 was expected to grow by 3.5%, reaching USD 23.4 billion. Companies expect more modest growth in their in-house R&D spending in 2022, with total R&D spending anticipated to increase by 1.7% to USD 23.8 billion.

Furthermore, investments by the government and private companies in genomic and proteomic research are likely to drive market growth in the North American region. For instance, in February 2021, through a merger, Seattle-based Nautilus Biotechnology entered the public market and received USD 350 million to accelerate the development of its protein analysis technology for drug discovery and diagnostic applications. Moreover, in September 2022, Stanford University Mass Spectrometry Proteomics Seed Grants provided a research grant of USD 10,000 to researchers aiming for new mass spectrometry projects and new methodologies taking advantage of the capabilities of recently added research instrumentation.

Additionally, genomic as well as proteomic research works in the North American region promote market growth since they identify the need for protein stability study and utilize the reagents and equipment associated with stability studies. For instance, as per the article published in May 2022 by MDPI which was supported by the National Institute of Respiratory Diseases "Ismael Cosio Villegas," Mexico, a study showed that proteomics has enabled the identification of novel allergens that can be used in serodiagnosis and has made it possible to analyze thousands of proteins in a single analysis.

Protein Stability Analysis Market Competitor Analysis

The protein stability analysis market is fragmented in nature due to the presence of several companies operating globally as well as regionally. The competitive landscape includes an analysis of a few international and local companies that hold market shares and are well-known. These include Agilent Technologies Inc, NanoTemper Technologies, Shimadzu Corporation, Thermo Fisher Scientific, and Spectris PLC (Malvern Panalytical Ltd).

Additional Benefits:

  • The market estimate (ME) sheet in Excel format
  • 3 months of analyst support

TABLE OF CONTENTS

1 INTRODUCTION

  • 1.1 Study Assumptions and Market Definition
  • 1.2 Scope of the Study

2 RESEARCH METHODOLOGY

3 EXECUTIVE SUMMARY

4 MARKET DYNAMICS

  • 4.1 Market Overview
  • 4.2 Market Drivers
    • 4.2.1 Rising Research and Development Expenditure of Pharmaceutical and Biopharmaceutical Companies
    • 4.2.2 Increasing Proteomics and Genomics Research Activities
    • 4.2.3 Increasing Number of Recombinant Protein Therapeutics and Biologics
  • 4.3 Market Restraints
    • 4.3.1 High Cost of Protein Stability Analysis Instruments
  • 4.4 Porter's Five Forces Analysis
    • 4.4.1 Bargaining Power of Suppliers
    • 4.4.2 Bargaining Power of Buyers/Consumers
    • 4.4.3 Threat of New Entrants
    • 4.4.4 Threat of Substitute Products
    • 4.4.5 Intensity of Competitive Rivalry

5 MARKET SEGMENTATION (Market Size by Value - USD Million)

  • 5.1 By Product
    • 5.1.1 Reagents and Assay Kits
    • 5.1.2 Instruments
    • 5.1.3 Consumables and Accessories
    • 5.1.4 Other Products
  • 5.2 By Technique
    • 5.2.1 Chromatography
    • 5.2.2 Spectroscopy
    • 5.2.3 Surface Plasmon Resonance
    • 5.2.4 Differential Scanning Calorimetry
    • 5.2.5 Differential Scanning Fluorimetry
    • 5.2.6 Other Techniques
  • 5.3 By End-User
    • 5.3.1 Pharmaceutical & Biotechnology Companies
    • 5.3.2 Academic and Research Organizations
  • 5.4 Geography
    • 5.4.1 North America
      • 5.4.1.1 United States
      • 5.4.1.2 Canada
      • 5.4.1.3 Mexico
    • 5.4.2 Europe
      • 5.4.2.1 Germany
      • 5.4.2.2 United Kingdom
      • 5.4.2.3 France
      • 5.4.2.4 Italy
      • 5.4.2.5 Spain
      • 5.4.2.6 Rest of Europe
    • 5.4.3 Asia-Pacific
      • 5.4.3.1 China
      • 5.4.3.2 Japan
      • 5.4.3.3 India
      • 5.4.3.4 Australia
      • 5.4.3.5 South Korea
      • 5.4.3.6 Rest of Asia-Pacific
    • 5.4.4 Middle East
      • 5.4.4.1 GCC
      • 5.4.4.2 South Africa
      • 5.4.4.3 Rest of Middle East
    • 5.4.5 South America
      • 5.4.5.1 Brazil
      • 5.4.5.2 Argentina
      • 5.4.5.3 Rest of South America

6 COMPETITIVE LANDSCAPE

  • 6.1 Company Profiles
    • 6.1.1 Agilent Technologies, Inc.
    • 6.1.2 NanoTemper Technologies
    • 6.1.3 Horiba, Ltd
    • 6.1.4 Perkinelmer, Inc.
    • 6.1.5 Setaram Instrumentation
    • 6.1.6 Shimadzu Corporation
    • 6.1.7 Spectris PLC
    • 6.1.8 Thermo Fisher Scientific
    • 6.1.9 Unchained Labs
    • 6.1.10 Danaher Corporation (Molecular Devices)
    • 6.1.11 Spectris PLC (Malvern Panalytical Ltd)
    • 6.1.12 Bruker Corporation

7 MARKET OPPORTUNITIES AND FUTURE TRENDS