3-胺基磺酸鹽磺酸市場報告：趨勢、預測與競爭分析（至2031年）

全球3-胺基磺酸鹽磺酸市場未來很可能在生物緩衝液和塗料市場中看到機會。預計全球 3-胺基磺酸鹽磺酸市場從 2025 年到 2031 年的複合年成長率為 5.6%。該市場的主要驅動力是製藥行業需求的成長、生物製藥研究投資的增加、生物技術公司的擴張以及個人保健產品和化妝品需求的不斷成長。

• Lucintel 預測，按類型分類，99% 純度的電池預計在預測期內將出現高速成長。
• 根據應用，生物緩衝液預計將實現更高的成長。
• 根據地區來看，預計亞太地區將在預測期內實現最高成長。

3-胺基磺酸鹽磺酸市場的策略成長機會

3-胺基磺酸鹽磺酸市場為各個關鍵應用領域提供了各種策略成長機會。這些機會由技術進步和多個行業不斷成長的需求所驅動，為擴張和創新提供了途徑。

• 製藥應用：製藥業為 3-胺基磺酸鹽提供了巨大的成長機會。它作為緩衝劑的作用增強了藥物製劑的穩定性，隨著新治療方法的出現，推動了需求。
• 農藥：農業需求的不斷成長為 3-胺基磺酸鹽磺酸作為農藥性能增強劑的使用創造了機會。它能夠提高肥料和殺蟲劑的功效，這對製造商來說是一個有吸引力的選擇。
• 工業清洗劑：對有效工業清洗劑的需求不斷成長提供了成長機會。 3-胺基磺酸鹽可以提高配方的清洗能力，使其在廣泛的行業中具有吸引力。
• 電子製造：電子業在製造過程中擴大採用 3-胺基磺酸鹽。 3-胺基磺酸鹽的特性提高了電子元件的性能並開啟了新的應用。
• 個人保健產品：個人護理行業正在探索在配方中使用 3-胺基磺酸鹽來提高穩定性和功效。這一趨勢為製造商提供了實現產品多樣化的機會。

這些成長機會表明，3-胺基磺酸鹽磺酸市場的相關人員可以透過調整其策略和產業需求，在不同的應用領域中獲得成功。

3-胺基磺酸鹽磺酸市場促進因素與挑戰

3-胺基磺酸鹽磺酸市場受到技術進步、經濟狀況、法律規範等各種促進因素​​和挑戰的影響。這些因素對生產流程、市場需求和產業內的競爭動態有重大影響。了解這些促進因素和挑戰對於尋求應對不斷變化的情況、利用成長機會並解決潛在障礙的相關人員來說至關重要。

推動 3-胺基磺酸鹽磺酸市場發展的因素有：

• 藥品需求不斷增加：製藥業是胺基磺酸鹽磺酸市場的主要驅動力。用作藥物配方中的緩衝劑，以增加穩定性和功效。隨著新藥和治療方法的開發，對此類化合物等高品質中間體的需求預計會增加，從而為製造商創造成長機會。
• 合成技術的進步：合成技術的創新提高了3-胺基磺酸鹽的生產效率。改進的方法可提高產量並降低生產成本，對製造商具有吸引力。這些進步不僅提高了盈利，而且還滿足了各種應用中對高純度產品日益成長的需求。
• 農業用途的增加：肥料和殺蟲劑等農業化學品的擴大推動了對 3-胺基磺酸鹽磺酸的需求。 3-胺基磺酸鹽有助於增強這些產品的有效性，使其成為有價值的添加劑。隨著農業部門的持續成長，對有效化學解決方案的需求可能會增加，這將有利於市場。
• 法規遵循和品質標準：有關化學品安全和環境影響的更嚴格的法規促使製造商專注於高純度、環保的配方。遵守這些法規可以提高產品的吸引力和適銷性，特別是在品質標準至關重要的行業，例如製藥和農業。
• 全球市場的擴張：供應鏈的全球化為3-胺基磺酸鹽磺酸市場提供了新的機會。進入新興市場可以讓製造商實現客戶群多樣化並增加銷售。擴大地理覆蓋範圍使公司能夠利用全球不斷成長的工業需求。

3-胺基磺酸鹽磺酸市場的挑戰如下：

• 原物料價格波動：3-胺基磺酸鹽生產所用原物料價格的波動可能會對我們的利潤率產生不利影響。製造商必須仔細監控這些價格波動，因為成本增加將導致產品價格上漲和市場競爭力下降。
• 來自替代化學品的競爭：具有類似作用的替代化學品的出現對 3-環己氨基胺基磺酸鹽市場構成了挑戰。為了保持市場佔有率，製造商必須注重產品差異化，並展示其相對於其他產品的獨特優勢。
• 消費者偏好的變化：消費者對永續性和產品功效的偏好迅速變化，需要製造商不斷創新。密切關注市場趨勢和不斷變化的需求對您的成功至關重要。

這些市場促進因素和挑戰的相互作用極大地影響了 3-胺基磺酸鹽磺酸市場。雖然製藥和農業領域不斷成長的需求提供了充足的機會，但原料波動和競爭替代品等因素需要策略規劃和創新。相關人員需要謹慎掌握這些動態，以實現成長並降低風險。

目錄

第1章執行摘要

2. 全球3-胺基磺酸鹽磺酸市場：市場動態

• 簡介、背景和分類
• 供應鏈
• 產業驅動力與挑戰

第3章市場趨勢與預測分析（2019-2031）

• 宏觀經濟趨勢（2019-2024）及預測（2025-2031）
• 全球3-胺基磺酸鹽磺酸市場趨勢（2019-2024年）及預測（2025-2031年）
• 全球 3-胺基磺酸鹽磺酸市場（按類型）
  • 純度99%
  • 純度：99%以上
• 全球3-胺基磺酸鹽磺酸市場（依應用）
  • 生物緩衝液
  • 塗層
  • 其他

第4章區域市場趨勢與預測分析（2019-2031）

• 全球3-胺基磺酸鹽磺酸市場（按地區）
• 北美3-胺基磺酸鹽磺酸市場
• 歐洲3-胺基磺酸鹽磺酸市場
• 亞太地區3-胺基磺酸鹽磺酸市場
• 世界其他地區3-胺基磺酸鹽磺酸市場

第5章 競爭分析

• 產品系列分析
• 營運整合
• 波特五力分析

第6章 成長機會與策略分析

• 成長機會分析
  • 全球 3-胺基磺酸鹽磺酸市場成長機會（按類型）
  • 全球 3-胺基磺酸鹽磺酸市場成長機會（按應用）
  • 全球 3-胺基磺酸鹽磺酸市場成長機會（按地區）
• 全球3-胺基磺酸鹽磺酸市場的新趨勢
• 戰略分析
  • 新產品開發
  • 全球3-胺基磺酸鹽磺酸市場產能擴張
  • 全球 3-胺基磺酸鹽磺酸市場的企業合併
  • 認證和許可

第7章主要企業簡介

• Matrix Fine Chemicals
• Changshu Juhe Chemical
• Yeasen Biotechnology
• Suzhou Yacoo Science
• Changzhou Welton Chemical

The future of the global 3-cyclohexylaminopropane sulfonic acid market looks promising with opportunities in the biological buffer and coating markets. The global 3-cyclohexylaminopropane sulfonic acid market is expected to grow with a CAGR of 5.6% from 2025 to 2031. The major drivers for this market are the rising demand in the pharmaceuticals industry, growing investment in biopharmaceutical research, and the expansion of biotechnology companies, as well as, rising demand for personal care and cosmetics products.

• Lucintel forecasts that, within the type category, purity 99% is expected to witness higher growth over the forecast period.
• Within the application category, biological buffer is expected to witness higher growth.
• In terms of regions, APAC is expected to witness the highest growth over the forecast period.

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Emerging Trends in the 3-Cyclohexylaminopropane Sulfonic Acid Market

The 3-cyclohexylaminopropane sulfonic acid market is evolving with several emerging trends that reflect technological advancements and changing industry demands. These trends are reshaping the market landscape, highlighting the importance of sustainability, innovation, and regulatory compliance in product development.

• Sustainable Production Methods: There is a growing emphasis on developing sustainable production processes for 3-cyclohexylaminopropane sulfonic acid. Manufacturers are adopting greener chemistry techniques to minimize environmental impact, aligning with global sustainability goals and regulatory requirements.
• Technological Innovations: Advances in chemical synthesis and purification technologies are enhancing the efficiency and quality of 3-cyclohexylaminopropane sulfonic acid production. Innovations such as continuous flow synthesis are being explored to improve yields and reduce processing times.
• Regulatory Compliance and Quality Standards: Increased regulatory scrutiny is prompting manufacturers to focus on high-purity products. Meeting stringent quality standards is becoming essential, particularly in the pharmaceutical sector, where product efficacy and safety are paramount.
• Diversification of Applications: The use of 3-cyclohexylaminopropane sulfonic acid is expanding into new applications beyond traditional uses. Industries such as agriculture and electronics are exploring its potential, driving demand and fostering innovation in formulation development.
• Collaboration and Partnerships: Collaborations between chemical manufacturers and research institutions are promoting advancements in 3-cyclohexylaminopropane sulfonic acid applications. These partnerships facilitate knowledge sharing and accelerate the development of innovative solutions.

These trends are reshaping the 3-cyclohexylaminopropane sulfonic acid market, driving sustainability, innovation, and regulatory compliance while expanding its applications across various industries.

Recent Developments in the 3-Cyclohexylaminopropane Sulfonic Acid Market

Recent developments in the 3-cyclohexylaminopropane sulfonic acid market reflect ongoing innovations and adaptations to meet industry needs. These developments indicate a shift towards more sustainable practices, enhanced product quality, and increased application versatility, positioning the market for future growth.

• Eco-Friendly Synthesis: A major development is the introduction of eco-friendly synthesis methods for 3-cyclohexylaminopropane sulfonic acid. These methods reduce waste and energy consumption, aligning with sustainability goals and appealing to environmentally conscious consumers.
• Enhanced Purity Standards: Manufacturers are increasingly focusing on producing high-purity 3-cyclohexylaminopropane sulfonic acid to meet stringent regulatory requirements, particularly in the pharmaceutical industry. This shift ensures product efficacy and safety, expanding market opportunities.
• Research and Development Investments: Significant R&D investments are driving innovation in applications and formulations. Companies are exploring new uses for 3-cyclohexylaminopropane sulfonic acid in agriculture and electronics, broadening its market potential.
• Global Supply Chain Optimization: Manufacturers are optimizing supply chains to improve efficiency and reduce costs. This includes strategic partnerships with raw material suppliers, which enhance product availability and support market growth.
• Product Portfolio Diversification: Companies are diversifying their product portfolios to include various grades and formulations of 3-cyclohexylaminopropane sulfonic acid. This strategy allows them to cater to different industries and meet specific customer needs.

These developments are positively impacting the 3-cyclohexylaminopropane sulfonic acid market by promoting sustainability, enhancing product quality, and fostering innovation, positioning the industry for future expansion.

Strategic Growth Opportunities for 3-Cyclohexylaminopropane Sulfonic Acid Market

The 3-cyclohexylaminopropane sulfonic acid market offers various strategic growth opportunities across key applications. These opportunities are driven by technological advancements and increasing demand across multiple industries, providing avenues for expansion and innovation.

• Pharmaceutical Applications: The pharmaceutical sector represents a significant growth opportunity for 3-cyclohexylaminopropane sulfonic acid. Its role as a buffering agent enhances drug formulation stability, driving demand as new therapies emerge.
• Agricultural Chemicals: Increasing agricultural demands are creating opportunities for 3-cyclohexylaminopropane sulfonic acid as a performance enhancer in agrochemicals. Its ability to improve efficacy in fertilizers and pesticides makes it an attractive option for manufacturers.
• Industrial Cleaning Products: The rising demand for effective industrial cleaning solutions presents growth opportunities. 3-cyclohexylaminopropane sulfonic acid can enhance the cleaning power of formulations, appealing to a broad range of industries.
• Electronics Manufacturing: The electronics sector is increasingly adopting 3-cyclohexylaminopropane sulfonic acid in manufacturing processes. Its properties enhance the performance of electronic components, opening new avenues for application.
• Personal Care Products: The personal care industry is exploring the use of 3-cyclohexylaminopropane sulfonic acid in formulations for improved stability and effectiveness. This trend presents opportunities for manufacturers to diversify their product offerings.

These growth opportunities indicate that stakeholders in the 3-cyclohexylaminopropane sulfonic acid market can align their strategies with industry demands, positioning themselves for success in diverse applications.

3-Cyclohexylaminopropane Sulfonic Acid Market Driver and Challenges

The 3-cyclohexylaminopropane sulfonic acid market is influenced by a variety of drivers and challenges stemming from technological advancements, economic conditions, and regulatory frameworks. These factors significantly impact production processes, market demand, and competitive dynamics within the industry. Understanding these drivers and challenges is essential for stakeholders aiming to navigate the evolving landscape and capitalize on growth opportunities while addressing potential hurdles.

The factors responsible for driving the 3-cyclohexylaminopropane sulfonic acid market include:

• Growing Demand in Pharmaceuticals: The pharmaceutical industry is a significant driver of the 3-cyclohexylaminopropane sulfonic acid market. Its use as a buffering agent in drug formulations enhances stability and efficacy. As new medications and therapies are developed, the demand for high-quality intermediates like this compound is expected to rise, creating growth opportunities for manufacturers.
• Technological Advancements in Synthesis: Innovations in synthesis techniques are improving the production efficiency of 3-cyclohexylaminopropane sulfonic acid. Enhanced methods lead to higher yields and lower production costs, making it more attractive to manufacturers. These advancements not only boost profitability but also meet the growing demands for high-purity products in various applications.
• Increasing Agricultural Applications: The expansion of agricultural chemicals, such as fertilizers and pesticides, is driving the demand for 3-cyclohexylaminopropane sulfonic acid. Its ability to enhance the effectiveness of these products makes it a valuable additive. As the agricultural sector continues to grow, the need for effective chemical solutions is likely to increase, benefiting the market.
• Regulatory Compliance and Quality Standards: Stricter regulations regarding chemical safety and environmental impact are pushing manufacturers to focus on high-purity and eco-friendly formulations. Compliance with these regulations enhances product appeal and marketability, particularly in industries like pharmaceuticals and agriculture, where quality standards are paramount.
• Global Market Expansion: The globalization of supply chains offers new opportunities for the 3-cyclohexylaminopropane sulfonic acid market. Access to emerging markets allows manufacturers to diversify their customer base and increase sales. By expanding their geographic reach, companies can capitalize on growing industrial demands worldwide.

Challenges in the 3-cyclohexylaminopropane sulfonic acid market include:

• Raw Material Price Volatility: Fluctuations in the prices of raw materials used in the production of 3-cyclohexylaminopropane sulfonic acid can negatively impact profit margins. Manufacturers must navigate these price changes carefully, as increased costs can lead to higher product prices and reduced competitiveness in the market.
• Competition from Alternative Chemicals: The emergence of alternative chemicals that can fulfill similar roles poses a challenge to the 3-cyclohexylaminopropane sulfonic acid market. To maintain market share, manufacturers must focus on differentiating their products and demonstrating the unique benefits of their offerings compared to alternatives.
• Evolving Consumer Preferences: Rapid changes in consumer preferences towards sustainability and product efficacy require constant innovation from manufacturers. Staying attuned to market trends and evolving demands is essential for success, as companies that fail to adapt may lose market relevance.

The interplay of these drivers and challenges significantly shapes the 3-cyclohexylaminopropane sulfonic acid market. While growing demand in pharmaceuticals and agriculture presents ample opportunities, factors such as raw material volatility and competition from alternatives necessitate strategic planning and innovation. Stakeholders must navigate these dynamics carefully to capitalize on growth while mitigating risks.

List of 3-Cyclohexylaminopropane Sulfonic Acid Companies

Companies in the market compete on the basis of product quality offered. Major players in this market focus on expanding their manufacturing facilities, R&D investments, infrastructural development, and leverage integration opportunities across the value chain. Through these strategies 3-cyclohexylaminopropane sulfonic acid companies cater increasing demand, ensure competitive effectiveness, develop innovative products & technologies, reduce production costs, and expand their customer base. Some of the 3-cyclohexylaminopropane sulfonic acid companies profiled in this report include-

• Matrix Fine Chemicals
• Changshu Juhe Chemical
• Yeasen Biotechnology
• Suzhou Yacoo Science
• Changzhou Welton Chemical

3-Cyclohexylaminopropane Sulfonic Acid by Segment

The study includes a forecast for the global 3-cyclohexylaminopropane sulfonic acid market by type, application, and region.

3-Cyclohexylaminopropane Sulfonic Acid Market by Type [Analysis by Value from 2019 to 2031]:

• Purity99%
• Purity>99%

3-Cyclohexylaminopropane Sulfonic Acid Market by Application [Analysis by Value from 2019 to 2031]:

• Biological Buffer
• Coating
• Others

3-Cyclohexylaminopropane Sulfonic Acid Market by Region [Analysis by Value from 2019 to 2031]:

• North America
• Europe
• Asia Pacific
• The Rest of the World

Country Wise Outlook for the 3-Cyclohexylaminopropane Sulfonic Acid Market

The 3-cyclohexylaminopropane sulfonic acid market has seen significant advancements, driven by increasing demand across various applications such as pharmaceuticals, agriculture, and industrial processes. As a versatile chemical, it plays a crucial role in enhancing product performance and efficacy. Key regions like the United States, China, Germany, India, and Japan are experiencing notable developments influenced by local market dynamics, regulatory changes, and technological innovations, which are reshaping the market landscape.

• United States: In the U.S., the demand for 3-cyclohexylaminopropane sulfonic acid is on the rise, particularly in the pharmaceutical sector. Companies are focusing on developing more efficient synthesis methods to improve yields and reduce costs. Additionally, the growing emphasis on green chemistry is driving innovations in production techniques, aligning with environmental regulations and sustainability goals.
• China: China's market for 3-cyclohexylaminopropane sulfonic acid is expanding rapidly, fueled by industrial growth and increasing applications in agriculture and manufacturing. Local manufacturers are investing in technology to enhance production efficiency and product quality. The government's support for chemical industry upgrades is also encouraging advancements in formulation and application development.
• Germany: Germany is witnessing a shift towards high-purity 3-cyclohexylaminopropane sulfonic acid, driven by the pharmaceutical and chemical industries. The focus on regulatory compliance and sustainability is prompting manufacturers to adopt eco-friendly production methods. Research initiatives are also exploring innovative applications, which are expected to bolster market growth in the coming years.
• India: In India, the growth of the pharmaceutical and agrochemical sectors is significantly boosting the demand for 3-cyclohexylaminopropane sulfonic acid. Local manufacturers are enhancing their capabilities to produce high-quality products at competitive prices. Increased investments in research and development are fostering innovation, leading to new applications in various industries.
• Japan: Japan's market is characterized by a strong emphasis on quality and regulatory compliance. The demand for 3-cyclohexylaminopropane sulfonic acid in electronics and pharmaceuticals is driving manufacturers to improve product specifications and purity levels. Furthermore, collaborations between companies and research institutions are promoting advancements in formulation technologies and applications.

Features of the Global 3-Cyclohexylaminopropane Sulfonic Acid Market

Market Size Estimates: 3-cyclohexylaminopropane sulfonic acid market size estimation in terms of value ($B).

Trend and Forecast Analysis: Market trends (2019 to 2024) and forecast (2025 to 2031) by various segments and regions.

Segmentation Analysis: 3-cyclohexylaminopropane sulfonic acid market size by type, application, and region in terms of value ($B).

Regional Analysis: 3-cyclohexylaminopropane sulfonic acid market breakdown by North America, Europe, Asia Pacific, and Rest of the World.

Growth Opportunities: Analysis of growth opportunities in different types, applications, and regions for the 3-cyclohexylaminopropane sulfonic acid market.

Strategic Analysis: This includes M&A, new product development, and competitive landscape of the 3-cyclohexylaminopropane sulfonic acid market.

Analysis of competitive intensity of the industry based on Porter's Five Forces model.

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This report answers following 11 key questions:

• Q.1. What are some of the most promising, high-growth opportunities for the 3-cyclohexylaminopropane sulfonic acid market by type (purity99% and purity>99%), application (biological buffer, coating, and others), and region (North America, Europe, Asia Pacific, and the Rest of the World)?
• Q.2. Which segments will grow at a faster pace and why?
• Q.3. Which region will grow at a faster pace and why?
• Q.4. What are the key factors affecting market dynamics? What are the key challenges and business risks in this market?
• Q.5. What are the business risks and competitive threats in this market?
• Q.6. What are the emerging trends in this market and the reasons behind them?
• Q.7. What are some of the changing demands of customers in the market?
• Q.8. What are the new developments in the market? Which companies are leading these developments?
• Q.9. Who are the major players in this market? What strategic initiatives are key players pursuing for business growth?
• Q.10. What are some of the competing products in this market and how big of a threat do they pose for loss of market share by material or product substitution?
• Q.11. What M&A activity has occurred in the last 5 years and what has its impact been on the industry?

Table of Contents

1. Executive Summary

2. Global 3-Cyclohexylaminopropane Sulfonic Acid Market : Market Dynamics

• 2.1: Introduction, Background, and Classifications
• 2.2: Supply Chain
• 2.3: Industry Drivers and Challenges

3. Market Trends and Forecast Analysis from 2019 to 2031

• 3.1. Macroeconomic Trends (2019-2024) and Forecast (2025-2031)
• 3.2. Global 3-Cyclohexylaminopropane Sulfonic Acid Market Trends (2019-2024) and Forecast (2025-2031)
• 3.3: Global 3-Cyclohexylaminopropane Sulfonic Acid Market by Type
  • 3.3.1: Purity99%
  • 3.3.2: Purity>99%
• 3.4: Global 3-Cyclohexylaminopropane Sulfonic Acid Market by Application
  • 3.4.1: Biological Buffer
  • 3.4.2: Coating
  • 3.4.3: Others

4. Market Trends and Forecast Analysis by Region from 2019 to 2031

• 4.1: Global 3-Cyclohexylaminopropane Sulfonic Acid Market by Region
• 4.2: North American 3-Cyclohexylaminopropane Sulfonic Acid Market
  • 4.2.1: North American 3-Cyclohexylaminopropane Sulfonic Acid Market by Type: Purity99% and Purity>99%
  • 4.2.2: North American 3-Cyclohexylaminopropane Sulfonic Acid Market by Application: Biological Buffer, Coating, and Others
• 4.3: European 3-Cyclohexylaminopropane Sulfonic Acid Market
  • 4.3.1: European 3-Cyclohexylaminopropane Sulfonic Acid Market by Type: Purity99% and Purity>99%
  • 4.3.2: European 3-Cyclohexylaminopropane Sulfonic Acid Market by Application: Biological Buffer, Coating, and Others
• 4.4: APAC 3-Cyclohexylaminopropane Sulfonic Acid Market
  • 4.4.1: APAC 3-Cyclohexylaminopropane Sulfonic Acid Market by Type: Purity99% and Purity>99%
  • 4.4.2: APAC 3-Cyclohexylaminopropane Sulfonic Acid Market by Application: Biological Buffer, Coating, and Others
• 4.5: ROW 3-Cyclohexylaminopropane Sulfonic Acid Market
  • 4.5.1: ROW 3-Cyclohexylaminopropane Sulfonic Acid Market by Type: Purity99% and Purity>99%
  • 4.5.2: ROW 3-Cyclohexylaminopropane Sulfonic Acid Market by Application: Biological Buffer, Coating, and Others

5. Competitor Analysis

• 5.1: Product Portfolio Analysis
• 5.2: Operational Integration
• 5.3: Porter's Five Forces Analysis

6. Growth Opportunities and Strategic Analysis

• 6.1: Growth Opportunity Analysis
  • 6.1.1: Growth Opportunities for the Global 3-Cyclohexylaminopropane Sulfonic Acid Market by Type
  • 6.1.2: Growth Opportunities for the Global 3-Cyclohexylaminopropane Sulfonic Acid Market by Application
  • 6.1.3: Growth Opportunities for the Global 3-Cyclohexylaminopropane Sulfonic Acid Market by Region
• 6.2: Emerging Trends in the Global 3-Cyclohexylaminopropane Sulfonic Acid Market
• 6.3: Strategic Analysis
  • 6.3.1: New Product Development
  • 6.3.2: Capacity Expansion of the Global 3-Cyclohexylaminopropane Sulfonic Acid Market
  • 6.3.3: Mergers, Acquisitions, and Joint Ventures in the Global 3-Cyclohexylaminopropane Sulfonic Acid Market
  • 6.3.4: Certification and Licensing

7. Company Profiles of Leading Players

• 7.1: Matrix Fine Chemicals
• 7.2: Changshu Juhe Chemical
• 7.3: Yeasen Biotechnology
• 7.4: Suzhou Yacoo Science
• 7.5: Changzhou Welton Chemical