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市場調查報告書
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2082632

次世代定序的靶向序列捕獲和樣品製備（2026）

Target Enrichment and Library Preparation for Next-Generation Sequencing, 2026
出版日期: | 出版商: Kalorama Information | 英文 136 Pages | 商品交期: 最快1-2個工作天內

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簡介目錄

Kalorama Information 發布的《次世代定序的靶向序列捕獲與樣品製備（2026）》報告對生命科學工具產業中最具技術活力和商業性價值的領域之一進行了全面且前瞻性的評估。隨著次世代定序在研究、臨床診斷、生物製藥藥物研發和應用市場的快速發展，包括 DNA 和 RNA樣品製備、靶向序列捕獲、片段化、大小分選和品管在內的上游樣品製備流程，是影響下游定序性能、資料品質和整體成本效益的關鍵因素。

本報告反映了市場正經歷積極變革時期期的現實情況。隨著基於NGS（次世代定序）的檢測方法在臨床上的應用不斷擴大，樣品製備和標靶富集領域正進入新階段，其特點是定序儀之間的競爭日益激烈、價格壓力持續存在、技術快速體學以及多組學工作流程的興起，這些都從根本上改變了樣本的製備方式。

本報告探討了這些因素如何共同作用，加上向臨床應用加速過渡、長讀定序的成熟以及人工智慧日益成長的影響，檢驗產品戰略、競爭定位和市場成長軌跡，直至2030年。

市場概況及成長要素

本報告分析了全球NGS樣品製備和靶向序列捕獲產品的市場，並依主要區域（包括北美、歐洲、亞太地區和世界其他地區）進行了分類，同時探討了各區域的需求模式和市場佔有率。市場成長主要得益於一系列結構性利好因素，具體包括：全球數千家實驗室持續擴大次世代定序儀的部署；NGS在精準腫瘤學、罕見疾病診斷和無創產前檢測領域的快速應用；大規模人群基因組分析舉措的拓展；以及向分散式和臨床定序的持續轉變，這些轉變需要更高的樣本處理能力和更快、更自動化的工作流程。

另一方面，隨著設備和耗材層面的競爭加劇，整個定序流程的價格下降趨勢將持續，這將對成長構成阻力。隨著定序成本本身的降低，上游工程製備成本正受到更嚴格的審查，實驗室也擴大評估試劑盒更換、流程整合和超高通量多重定序策略，以降低單一樣本的成本。供應商也紛紛推出創新產品，從無需PCR、室溫穩定的試劑盒到能夠在一次運行中處理數千個樣本的超高通量多重測序和索引策略，以應對這一挑戰。

影響市場的主要趨勢

本期內容詳細分析了重塑樣品製備和靶向序列捕獲的主要趨勢，包括以下幾點：

  • 自動化和工作流程簡化
  • 多體學工作流程的整合
  • 表觀遺傳學的成熟與主流化
  • 長讀長定定序對樣品製備提出了新的要求。
  • 在臨床環境中加速採用
  • 定序儀市場的轉型和平台的多樣化
  • 人工智慧驅動的產品設計和資料分析
  • 擺脫對低溫運輸的依賴，永續性

競爭格局

樣品製備與靶向序列捕獲市場由Illumina公司主導，Agilent Technologies、Twist Bioscience、IDT/Danaher、Thermo Fisher Scientific、Roche/KAPA、Qiagen等公司也名列主要供應商之列。此外，市場中相當一部分佔有率由眾多專業供應商瓜分，包括NEB、Oxford Nanopor、PacBio、Revvity/NEXTFLEX、Takara Bio、Watchmaker Genomics、MGI/BGI以及許多新興供應商。本報告提供了各公司詳細的市場佔有率估算。

Twist Bioscience憑藉其基於矽的DNA合成平台和雜合反應捕獲晶片（現已整合到Illumina自有品牌的EXOME富集產品中），已成為成長最快的耗材供應商之一。 IDT透過其xGen產品線建構了最廣泛的平台獨立產品組合之一，可相容於多種定序平台，並且透過收購Archer進一步豐富了其檢測產品組合。 Agilent的SureSelect系列在靶向序列捕獲領域仍處於領先地位，而NEB已確立了其作為Illumina的OEM供應商和樣品製備技術獨立創新者的地位。本報告對包括10X Genomics、Agilent、Illumina、IDT、NEB、Oxford Nanopore、PacBio、Qiagen、Revvity、Roche、Takara Bio、Thermo Fisher和Twist Bioscience在內的13家主要公司進行了詳細分析。

調查方法

本報告全面概述了全球NGS樣品製備和靶向序列捕獲市場，分析了北美、歐洲、亞太地區及其他地區的市場情況，並探討了各區域的需求模式和市場佔有率。報告還評估了法規結構的影響，例如FDA體外診斷試劑（IVD）批准、伴隨診斷核准、CMS償付決策、實驗室自建檢測（LDT）相關監管規定以及基於歐盟體外診斷醫療器械法規（EU IVDR）的國際核准流程，以及影響臨床應用的償付趨勢和證據要求。

本報告以製造商為單位，逐一提供市場估算與預測，以2025年為基準年，預測期至2030年。分析採用了多種研究方法，包括一手和二手研究、內部資料庫、美國證券交易委員會（SEC）文件、產品資料、公司網站、會議報告、科學期刊和行業出版物。本報告評估了許多成長要素，例如定序平台的擴展、臨床NGS技術的演進、長讀長定序技術的應用、多體學工作流程的開發以及重塑耗材市場的競爭趨勢。

報告範圍

本報告由以下七個章節組成：

  • 執行摘要- 市場概覽、主要成長要素和結構性趨勢
  • 趨勢 - 對影響市場的技術、工作流程、監管和競爭趨勢進行詳細分析。
  • 產品 - 與樣品製備、靶向序列捕獲和樣品製備相關的當前產品和技術的綜合列表，包括最近推出的產品。
  • 銷售收入 - 市場規模、多年預測、區域細分及主要供應商耗材銷售收入分析
  • 競爭分析 - 估算市場佔有率、競爭定位，並評估主要和新興供應商。
  • 交易趨勢 - NGS樣品製備和靶向序列捕獲市場中的部分重要合作、授權協議和收購
  • 公司概況 - 主要市場參與企業的詳細介紹，涵蓋策略、產品系列、收入、主要合作夥伴關係等。

目錄

第1章 執行摘要

第2章 市場與技術趨勢

  • 降低成本、提高生產效率、小型化和簡化。
    • 廣泛的交易和收購
    • 對 Illumina 地位的挑戰帶來了改變。
    • 多體學技術的整合
    • 新型表觀遺傳學技術的優勢
    • 速度、自動化和低輸入樣本的重要性。
    • 長鏈讀取技術的成熟
    • 人工智慧加速發展的影響
    • 價格下跌持續影響市場格局。
    • 與低溫運輸和永續性相關的產品特性
    • 跨多個平台的產品
    • 中國成為主要的市場參與者。
    • 臨床應用的批准和檢驗
    • 訴訟的和解或解決
    • 微生物學和病原體檢測的成功
    • 監管趨勢和公告

第3章 產品與技術

第4章 市場規模與收入分析

  • 收入預測
  • 2025-2030年收入
  • 依地區分類的收入
  • Illumina定序耗材的銷售額

第5章 競爭格局與市場佔有率

第6章 市場交易

第7章 公司簡介

  • 10X GENOMICS
  • AGILENT TECHNOLOGIES
  • ILLUMINA
  • INTEGRATED DNA TECHNOLOGIES（DANAHER）
  • NEW ENGLAND BIOLABS
  • OXFORD NANOPORE
  • PACIFIC BIOSCIENCES
  • QIAGEN
  • REVVITY
  • ROCHE
  • TAKARA BIO
  • THERMO FISHER SCIENTIFIC
  • TWIST BIOSCIENCE
簡介目錄
Product Code: 26-041KA

Kalorama Information’s Target Enrichment and Library Preparation for Next-Generation Sequencing, 2026 delivers a comprehensive, forward-looking evaluation of one of the most technically dynamic and commercially consequential segments of the life science tools industry. As next-generation sequencing continues its rapid expansion across research, clinical diagnostics, biopharma drug discovery, and applied markets, the upstream sample preparation workflow—encompassing DNA and RNA library preparation, target enrichment, fragmentation, size selection, and quality control—has become a critical enabler of downstream sequencing performance, data quality, and overall cost efficiency.

This report reflects a market in active transition. With sustained growth in clinical adoption of NGS-based assays, the library preparation and target enrichment segment is navigating a new phase defined by intensifying sequencer competition, continued price pressure, rapid technology diversification, and the emergence of multi-omic workflows that are fundamentally reshaping how samples are prepared.

The report examines how these converging forces—combined with the accelerating shift to clinical applications, the maturation of long-read sequencing, and the growing influence of artificial intelligence—are reshaping product strategies, competitive positioning, and market growth trajectories through 2030.

Market Overview and Growth Drivers

The global market for NGS library preparation and target enrichment products is analyzed across major geographies, including North America, Europe, Asia Pacific, and the rest of the world, with discussion of regional demand patterns and market shares. Growth is being driven by a confluence of structural tailwinds: the continued expansion of the installed base of next-generation sequencers across thousands of research and clinical laboratories worldwide; the rapid adoption of NGS in precision oncology, rare disease diagnostics, and non-invasive prenatal testing; expanding population-scale genomics initiatives; and the ongoing transition of sequencing into decentralized and clinical settings that demand higher sample throughput and faster, more automated workflows.

At the same time, growth will face headwinds from ongoing price compression across the sequencing workflow, as competition intensifies at both the instrument and consumables levels. The falling cost of sequencing itself is increasing scrutiny of upstream preparation costs, and labs are increasingly evaluating kit switching, workflow consolidation, and ultra-high-multiplexing strategies to lower per-sample expenditures. Vendors are responding with innovations ranging from PCR-free and room-temperature-stable kits to extreme-multiplexing indexing strategies that allow thousands of samples to be prepared in a single run.

Key Trends Shaping the Market

This edition provides in-depth analysis of the defining trends reshaping library preparation and target enrichment, including:

  • Automation and workflow simplification
  • Convergence of multi-omic workflows
  • Maturation and mainstreaming of epigenetics
  • Long-read sequencing driving new preparation requirements
  • Accelerating clinical adoption
  • Sequencer market disruption and platform diversification
  • AI-driven product design and data interpretation
  • Cold-chain independence and sustainability

Competitive Landscape

The library preparation and target enrichment market is led by Illumina, with Agilent Technologies, Twist Bioscience, IDT/Danaher, Thermo Fisher Scientific, Roche/KAPA, and Qiagen among the other major suppliers. A substantial portion of the market is distributed among a large and growing number of specialized suppliers, including NEB, Oxford Nanopore, PacBio, Revvity/NEXTFLEX, Takara Bio, Watchmaker Genomics, MGI/BGI, and numerous emerging vendors. Detailed market share estimates by company are provided within the report.

Twist Bioscience has emerged as one of the fastest-growing consumables suppliers, driven by its silicon-based DNA synthesis platform and hybridization-capture panels that are now embedded in Illumina’s own branded exome enrichment products. IDT has built one of the broadest platform-agnostic portfolios through its xGen product line, with compatibility across multiple sequencing platforms and an increasingly comprehensive assay portfolio following the Archer acquisition. Agilent’s SureSelect franchise remains a major force in target enrichment, while NEB occupies a distinctive position as both an OEM supplier to Illumina and an independent library preparation innovator. The report profiles thirteen major companies in depth, including 10X Genomics, Agilent, Illumina, IDT, NEB, Oxford Nanopore, PacBio, Qiagen, Revvity, Roche, Takara Bio, Thermo Fisher, and Twist Bioscience.

Scope and Methodology

The report provides global coverage of the NGS library preparation and target enrichment market, with analysis spanning North America, Europe, Asia Pacific, and rest-of-world regions, along with discussion of regional demand patterns and market shares. It evaluates the impact of regulatory frameworks—including FDA IVD clearances and companion diagnostic approvals, CMS reimbursement decisions, LDT-related oversight, and international approval processes under the EU IVDR—as well as reimbursement trends and evidence requirements shaping clinical adoption.

Market estimates are presented at the manufacturer level, with 2025 as the base year and forecasts through 2030. The analysis incorporates primary and secondary research, internal databases, SEC filings, product literature, corporate websites, conference presentations, scientific journals, and trade publications. The report assesses growth drivers such as sequencer platform expansion, the evolution of clinical NGS, adoption of long-read technologies, multi-omic workflow development, and the competitive dynamics reshaping the consumables landscape.

Report Coverage

The report is organized across seven chapters:

  • Executive Summary — market overview, key growth drivers, and structural trends
  • Trends — detailed analysis of technology, workflow, regulatory, and competitive trends shaping the market
  • Products — comprehensive listing of current library preparation, target enrichment, and sample preparation products and technologies, including recent product introductions
  • Revenues — market sizing, multi-year forecasts, regional breakouts, and analysis of leading supplier consumables revenues
  • Competitive Analysis — market share estimates, competitive positioning, and an assessment of leading and emerging suppliers
  • Deals — selected significant collaborations, licensing agreements, and acquisitions in the NGS library preparation and target enrichment market
  • Corporate Profiles — in-depth profiles of major market participants covering strategy, product portfolios, revenues, and key partnerships

Table of Contents

CHAPTER 1: EXECUTIVE SUMMARY

  • ABOUT KALORAMA INFORMATION
  • INTRODUCTION
    • Product Introductions, Indications of Price Pressure
    • Stability Yielding to Diversity and Potential Disruption
    • A Period of Rapid Adoption, But Lower Prices
    • High Likelihood of Longer-Term Challenges
  • SIZE AND GROWTH OF THE MARKET
  • SCOPE AND METHODOLOGY
    • Applications and Definitions

CHAPTER 2: MARKET AND TECHNOLOGY TRENDS

  • FALLING COSTS, IMPROVED OUTPUT, SMALLER AND SIMPLER
    • Broad Range of Deals and Acquisitions
    • Challenges to Illumina's Position Lead to Changes
    • Integration of Multi-Omic Techniques
    • New Epigenetics Techniques Bring Advantages
    • Importance of Speed, Automation, and Low-Input Samples
    • Long-Read Technologies Maturing
    • Accelerating Impact of AI
    • Decreasing Prices Continue Shaping the Market
    • Cold Chain and Sustainability Product Features
    • Products Across Multiple Platforms
    • China Becoming a Major Market Player
    • Acceptance and Validation of Clinical Applications
    • Settlement or Resolution of Litigation
    • Success in Microbiology and Pathogen Detection
    • Regulatory Trends and Announcements
      • Table 2-1: Regulatory, Reimbursement, and Other Announcements in the NGS Library Preparation and Target Enrichment Market, June 2021–April 2026

CHAPTER 3: PRODUCTS AND TECHNOLOGIES

  • Table 3-1: Selected Library Preparation and Target Enrichment Products and Technologies, May 2026
    • PRODUCT LAUNCHES
      • 2026 Products
      • 2025 Products
      • 2024 Products
      • 2023 Products
      • 2022 Products
      • 2021 Products

CHAPTER 4: MARKET SIZE AND REVENUE ANALYSIS

  • REVENUES FORECAST
    • Figure 4-1: Estimated Cost of Sequencing a Human Genome, 1990–2026 (US$)
  • Revenue 2025-2030
    • Table 4-1: NGS Library Preparation and Target Enrichment Market Revenues, 2025–2030 (US$ Millions)
    • Figure 4-2: NGS Library Preparation and Target Enrichment Market Revenues, 2025–2030 (US$ Millions)
    • Table 4-2: NGS Library Preparation and Target Enrichment Market Growth Rate, 2025–2030 (%)
    • Figure 4-3: NGS Library Preparation and Target Enrichment Market Growth Rate, 2026–2030 (%)
  • Revenues by Region
    • Table 4-3: Estimated NGS Sample Preparation Revenues, by Region, 2025 (US$ Millions, %)
    • Figure 4-4: Estimated NGS Sample Preparation Revenues, by Region, 2025 (US$ Millions)
    • Figure 4-5: NGS Sample Preparation Regional Market Share, 2025 (%)
  • Illumina Sequencing Consumables Revenues
    • Table 4-4: Illumina Quarterly Sequencing Consumables Revenues, Q1 2014–Q1 2026 (US$ Millions)
    • Figure 4-6: Illumina Quarterly Sequencing Consumables Revenues, Q1 2014–Q1 2026 (US$ Millions)
    • Table 4-5: Contribution of Consumables to Illumina Revenue, 2016–2025 (US$ Millions, %)
    • Figure 4-7: Contribution of Consumables to Illumina Revenue, 2016–2025 (US$ Millions, %)
    • Table 4-6: Illumina Sequencing Consumables Growth Rates, 2016-2025 (%)
    • Figure 4-8: Illumina Sequencing Consumables Growth Rates, 2016-2025 (%)

CHAPTER 5: COMPETITIVE LANDSCAPE AND MARKET SHARES

  • INTRODUCTION
    • Continued Growth and Technological Advances
    • Sequencer Competition Returning
    • Library Preparation and Target Enrichment Market
      • Table 5-1: Estimated Library Preparation and Target Enrichment Market Revenue and Shares, by Company, 2025 (US$ Millions, %)
      • Figure 5-1: Estimated Library Preparation and Target Enrichment Revenues, by Company, 2025 (US$ Millions)
      • Figure 5-2: Estimated Library Preparation and Target Enrichment Shares, by Company, 2025 (%)
    • Smaller Companies Experiencing Mixed Success

CHAPTER 6: MARKET DEALS

  • Table 6-1: Selected Significant Deals in the NGS Library Preparation and Target Enrichment Market, Recent Years

CHAPTER 7: CORPORATE PROFILES

  • 10X GENOMICS
  • AGILENT TECHNOLOGIES
  • ILLUMINA
  • INTEGRATED DNA TECHNOLOGIES (DANAHER)
  • NEW ENGLAND BIOLABS
  • OXFORD NANOPORE
  • PACIFIC BIOSCIENCES
  • QIAGEN
  • REVVITY
  • ROCHE
  • TAKARA BIO
  • THERMO FISHER SCIENTIFIC
  • TWIST BIOSCIENCE