市場調查報告書
商品編碼
1466427
基因合成市場:依產品、方法、基因型、應用和最終用途 - 2024-2030 年全球預測Gene Synthesis Market by Product (Hardware, Services, Software), Method (Chip-Based Synthesis, PCR-Based Enzyme Synthesis, Solid-Phase Synthesis), Gene Type, Application, End-use - Global Forecast 2024-2030 |
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預計2023年基因合成市場規模為42.4億美元,2024年達46.8億美元,2030年預計將達87億美元,複合年成長率為10.82%。
基因合成市場包括與研究、醫學、農業和生物技術等各行業透過化學方法人工創建 DNA 序列相關的技術、產品和服務。典型的最終用戶包括學術機構、製藥和生物技術公司、政府機構和委外研發機構(CRO)。全球人口中慢性病盛行率的不斷上升、對個人化藥物的需求不斷增加,以及基因組研究的進步正在推動這一市場的發展。此外,基因合成相對於傳統方法的優勢正在推動市場成長。然而,諸如規範基因改造作物開發和商業化的嚴格法規以及對合成基因的大小和複雜性的限制等技術挑戰限制了基因合成市場的成長。提高效率和精度的基因合成新技術以及基因合成在能源和農業領域的廣泛應用正在為市場創造巨大的成長機會。
主要市場統計 | |
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基準年[2023] | 42.4億美元 |
預測年份 [2024] | 46.8億美元 |
預測年份 [2030] | 87億美元 |
複合年成長率(%) | 10.82% |
擴大支持產品合成基因精確設計的軟體的使用
基因合成硬體,包括寡核苷酸合成器,是合成 DNA 和 RNA 短片段(稱為寡核苷酸)的專用設備。這些合成器在基因合成的早期階段至關重要,可以創建組裝成更長基因序列的構建塊。基因定序儀對於此目的至關重要,它提供高通量和準確的定序能力,以確保合成基因符合預期設計。自動液體處理系統用於在移液、稀釋和混合組裝和擴增步驟所需的試劑和寡核苷酸期間減少錯誤並提高通量。基因合成服務涉及生產可自訂的合成 DNA 序列,以滿足特定的研究或工業要求。這些服務對於蛋白質生產、抗體工程、疫苗開發和生質燃料研究等各種應用至關重要。對自訂基因的需求不斷成長,導致越來越多的服務供應商提供基因合成的端到端解決方案。該軟體解決方案專為合成基因設計和模擬而設計。這些工具使研究人員和生物技術人員能夠透過最佳化密碼子使用偏差、RNA 二級結構預測、GC 含量和限制性內切酶位點避免等因素來簡化他們的工作流程。此外,基因合成軟體可降低 DNA 從頭合成過程中出現錯誤的風險,有助於提高研究效率並最大限度地降低成本。
方法 提高大型計劃中基於晶片的合成的利用率
基於晶片的合成使用微陣列或生物晶片在小玻片上同時合成數千種寡核苷酸。這種高通量方法適用於需要多個基因的大型計劃或當成本效率很重要時。基於 PCR 的酵素合成使用 DNA聚合酵素等酶,透過連續幾輪的 PCR 擴增將短寡核苷酸組裝成全長基因。這種方法提供快速的周轉時間,非常適合專注於單一基因或基因變異的小型計劃。固相合成將核苷酸依序付加固定在撐體上的不斷生長的 DNA 鏈中。此方法保真度高,並且可以產生比其他方法錯誤更少的長 DNA 序列。基於晶片的綜合非常適合需要成本效率的大型計劃。基於 PCR 的酶合成非常適合專注於單基因或基因變異的小型計劃,其中快速週轉時間至關重要,而固相合成需要高保真度和長 DNA 序列時則首選。
基因型表現基因合成具有越來越大的潛力,為時間敏感的計劃提供快速獲取短基因的途徑。
複雜基因合成專注於創建包含挑戰性序列的合成基因,例如高 GC 含量、串聯重複序列和同聚物區域。疫苗開發、途徑工程和酵素最佳化等治療應用的高級研究需要這些基因。 Express Gene Synthesis 適合需要快速週轉時間進行小型計劃和概念驗證研究的科學家。與其他類型的基因合成相比,合成基因的長度短,傳遞時間短。標準基因合成使用多種技術,包括寡核苷酸組裝和糾錯,來合成高品質、無錯誤的 DNA 序列。此產品類型最常用於常規分子生物學計劃,包括克隆、表達分析和重組蛋白生產。
最終用途生物技術和製藥公司越來越關注創新藥物發現和治療方法開發。
學術機構和政府研究機構由於專注於基礎研究、治療開發和基因工程的進步,對基因合成市場的需求做出了重大貢獻。這些研究機構使用基因合成服務來產生自訂DNA 序列、設計生物途徑和目標基因修飾。生物技術和製藥公司嚴重依賴基因合成服務來推進藥物發現、治療方法開發和精準醫療。自訂基因促進蛋白質表現研究、新藥物標靶的鑑定以及疾病特異性動物模型的開發。受託研究機構已成為基因合成服務的重要最終用戶,為生物製藥和學術客戶提供基因庫建設、自訂克隆和蛋白質表現最佳化方面的支援。生物技術和製藥公司由於專注於創新藥物發現和治療開發而佔據最大佔有率。學術和政府研究機構也紛紛效仿,並專注於基因工程的基礎研究和進展。透過提供滿足各行業不同客戶需求的全面基因組學解決方案,CRO 正經歷快速成長。
基因型:越來越多的機會表達針對特定宿主生物體中高水平表達而最佳化的基因。
複雜基因的特徵是其核苷酸序列複雜,通常含有高GC含量、重複序列和容易產生二級結構的序列。這種複雜性可能會給合成過程和隨後的克隆帶來挑戰。具有長均聚物運作或編碼剪接位點的基因也可以被認為是複雜的。合成複雜的基因需要先進的技術和精心的設計,以確保最終產品的保真度和功能性。表達基因是指經最佳化以在特定宿主生物體中高水平表達的合成產生的DNA序列。這些基因變體通常會經歷密碼子最佳化,即更改密碼子以匹配表達系統的首選用途,並導致 mRNA 更有效地翻譯為蛋白質。此外,可以將強啟動子、增強子和其他調控元件付加到表達的基因中,以促進研究或工業酵素應用的蛋白質生產。標準基因是合成的 DNA 序列,是基因合成服務的基本產品。該基因不具有複雜基因中的複雜性,且未針對涉及表達基因的過度表現進行最佳化。相反,標準基因為研究人員提供了一種準確、可靠且經濟高效的方法來獲取反映天然 DNA 序列或包含微小修飾的 DNA 序列,以用於克隆和功能分析。標準基因是許多基因工程計劃的支柱,廣泛應用於生命科學的各個領域。
區域洞察
由於發達的醫療保健部門和支持性政府計劃的存在,美洲的基因合成市場高度發展。這是由於研發設施的改善、可支配收入的增加和經濟狀況的快速發展。此外,聯邦機構和當局還推出了多項舉措、計劃和計劃,以鼓勵該地區的基因治療研究,形成美洲基因合成的平台。印度、中國、新加坡和馬來西亞等新興國家由於醫療保健標準的提高而具有市場擴張的潛力。國內基因合成製造商在這些經濟體中佔有重要地位,有助於大型跨國企業快速滲透市場。慢性病的流行、技術的進步和醫療基礎設施的改善是推動歐洲、中東和非洲基因合成市場的關鍵原因。該地區各國政府繼續投資基因治療,從而擴大了各種基因合成的使用。 2022年2月,荷蘭政府投資5,504萬美元建造一座新的國家試點工廠,以推進有前景的細胞和基因療法的開發和製造。荷蘭政府的投資預計將為細胞和基因治療公司提供巨大的機會。
FPNV定位矩陣
FPNV定位矩陣對於評估基因合成市場至關重要。我們檢視與業務策略和產品滿意度相關的關鍵指標,以對供應商進行全面評估。這種深入的分析使用戶能夠根據自己的要求做出明智的決策。根據評估,供應商被分為四個成功程度不同的像限:前沿(F)、探路者(P)、利基(N)和重要(V)。
市場佔有率分析
市場佔有率分析是一種綜合工具,可以對基因合成市場供應商的現狀進行深入而深入的研究。全面比較和分析供應商在整體收益、基本客群和其他關鍵指標方面的貢獻,以便更好地了解公司的績效及其在爭奪市場佔有率時面臨的挑戰。此外,該分析還提供了對該行業競爭特徵的寶貴見解,包括在研究基準年觀察到的累積、分散主導地位和合併特徵等因素。詳細程度的提高使供應商能夠做出更明智的決策並制定有效的策略,從而在市場上獲得競爭優勢。
1. 市場滲透率:提供有關主要企業所服務的市場的全面資訊。
2. 市場開拓:我們深入研究利潤豐厚的新興市場,並分析其在成熟細分市場的滲透率。
3. 市場多元化:提供有關新產品發布、開拓地區、最新發展和投資的詳細資訊。
4. 競爭評估和情報:對主要企業的市場佔有率、策略、產品、認證、監管狀況、專利狀況和製造能力進行全面評估。
5. 產品開發與創新:提供對未來技術、研發活動和突破性產品開發的見解。
1. 基因合成市場的市場規模與預測是多少?
2.在基因合成市場的預測期間內,有哪些產品、細分市場、應用和領域需要考慮投資?
3.基因合成市場的技術趨勢與法規結構是什麼?
4.基因合成市場主要廠商的市場佔有率是多少?
5. 進入基因合成市場的合適型態和策略手段是什麼?
[181 Pages Report] The Gene Synthesis Market size was estimated at USD 4.24 billion in 2023 and expected to reach USD 4.68 billion in 2024, at a CAGR 10.82% to reach USD 8.70 billion by 2030.
The gene synthesis market comprises technologies, products, and services related to the artificial creation of DNA sequences through chemical methods in various industries such as research, medicine, agriculture, and biotechnology. Key end-users include academic institutions, pharmaceutical and biotechnology companies, government agencies, and contract research organizations (CROs). The growing prevalence of chronic conditions among the global population and rising demand for personalized medicines, along with advancements in genomics research, are driving this market. Moreover, the advantage of gene synthesis over traditional methods is fueling market growth. However, strict regulations governing the development and commercialization of GMOs and technical challenges such as limitations in size and complexity of synthetic genes limit the growth of the gene synthesis market. Emerging technologies in gene synthesis for efficiency and accuracy and the growing utilization of gene synthesis in energy and agriculture industries are creating significant growth opportunities in the market.
KEY MARKET STATISTICS | |
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Base Year [2023] | USD 4.24 billion |
Estimated Year [2024] | USD 4.68 billion |
Forecast Year [2030] | USD 8.70 billion |
CAGR (%) | 10.82% |
Product: Expanding usage of software that helps design synthetic genes accurately
Gene synthesis hardware, including oligonucleotide synthesizers, are specialized instruments used for the synthesis of short DNA or RNA fragments called oligonucleotides. These synthesizers are essential in the initial steps of gene synthesis, creating the building blocks that will be assembled into longer gene sequences. Gene sequencers are critical for this purpose, providing high-throughput and accurate sequencing capabilities to ensure the synthetic genes match the intended design. Automated liquid handling systems are employed to reduce errors and increase throughput during the pipetting, dilution, and mixing of reagents and oligonucleotides necessary for assembly and amplification steps. Gene synthesis services involve the production of synthetic DNA sequences that can be customized to cater to specific research or industrial requirements. These services are essential for various applications such as protein production, antibody engineering, vaccine development, and biofuel research. The growing demand for custom-made genes has led to an increase in service providers offering end-to-end solutions in gene synthesis. Software solutions are designed specifically for designing and simulating synthetic genes. These tools allow researchers and biotechnologists to streamline their workflow by optimizing factors such as codon usage bias, RNA secondary structure prediction, GC content, and restriction enzyme site avoidance. Moreover, gene synthesis software helps reduce the risk of errors during de novo DNA synthesis, thereby improving research efficiency and minimizing costs.
Method: Rising utilization of chip-based synthesis for large-scale projects
Chip-based synthesis uses microarrays or biochips to synthesize thousands of oligonucleotides simultaneously on a small glass slide. This high-throughput method is suitable for large-scale projects requiring multiple genes or when cost-efficiency is crucial. PCR-based enzyme synthesis involves using enzymes such as DNA polymerase to assemble short overlapping oligonucleotides into full-length genes through consecutive rounds of PCR amplification. This method offers quick turnaround times and is ideal for small-scale projects focusing on single genes or gene variants. Solid-phase synthesis involves sequentially adding nucleotides to a growing DNA chain immobilized on a solid support. This method offers high fidelity and can generate long DNA sequences with fewer errors than other methods. Chip-based synthesis is best suited for large-scale projects requiring cost efficiency. PCR-based enzyme synthesis is ideal when rapid turnaround times are essential for small-scale projects focusing on single genes or gene variants, while solid-phase synthesis is preferred when high fidelity and longer DNA sequences are required.
Gene Type: Growing potential for express gene synthesis that provides quick access to shorter genes for time-sensitive projects
Complex gene synthesis focuses on creating synthetic genes that contain challenging sequences, such as high GC content, tandem repeats, and homopolymeric regions. Scientists often require these genes for advanced research in therapeutic applications such as vaccine development, pathway engineering, and enzymatic optimization. Express gene synthesis caters to scientists who require fast turnaround times for small-scale projects or proof-of-concept studies. These synthesized genes are shorter in length and have a quicker turnaround time compared to other types of gene synthesis. Standard gene synthesis involves the synthesis of high-quality, error-free DNA sequences using a variety of techniques, including oligonucleotide assembly and error correction. This type is most commonly used in routine molecular biology projects involving cloning, expression analysis, and recombinant protein production.
End-use: Increasing focus on innovative drug discovery and therapeutic development across biotechnology and pharmaceutical companies
Academic and government research institutes significantly contribute to gene synthesis market demand because they focus on basic research, therapeutic development, and genetic engineering advancements. These institutes utilize gene synthesis services to generate custom DNA sequences, design biological pathways, and perform targeted gene modifications. Biotechnology and pharmaceutical companies rely heavily on gene synthesis services for drug discovery, therapeutic development, and precision medicine advancements. Custom genes facilitate protein expression studies, identification of novel drug targets, and development of disease-specific animal models. Contract research organizations have emerged as vital end-users of gene synthesis services, supporting biopharmaceutical and academic clients in gene library construction, custom cloning, and protein expression optimization. Biotechnology and pharmaceutical companies command the largest share due to their focus on innovative drug discovery and therapeutic development. Academic government research institutes follow closely, emphasizing fundamental research and genetic engineering advancements. CROs are experiencing rapid growth by offering comprehensive genomics solutions that cater to diverse client demands across industries.
Gene Type: Growing potential of express genes that are optimized for high levels of expression in specific host organisms
Complex genes are characterized by their intricate nucleotide sequences, which often include high GC content, repeated sequences, or sequences prone to secondary structures. Such complexities can pose challenges during the synthesis process and subsequent cloning. Genes with long homopolymeric runs or cryptic splice sites are also considered complex. Synthesizing complex genes requires advanced techniques and careful design to ensure the fidelity and functionality of the final product. Express genes refer to synthetically manufactured DNA sequences optimized for high levels of expression in specific host organisms. These gene variants usually undergo codon optimization, where codons are modified to match the preferred usage of the expression system, leading to more efficient translation of the mRNA into proteins. Additionally, express genes can be outfitted with strong promoters, enhancers, and other regulatory elements to boost protein production for research or industrial enzyme applications. Standard genes are synthetic DNA sequences that represent the basic offering in gene synthesis services. The genes do not possess the complexities found in complex genes and are not optimized for overexpression, including express genes. Instead, standard genes provide researchers with accurate, reliable, and cost-effective means to obtain DNA sequences that are reflective of the native DNA sequence or include slight modifications for cloning or functional analysis. Standard genes are the backbone of many genetic engineering projects and are widely used across different domains of life sciences.
Regional Insights
The gene synthesis market in the Americas is highly developing owing to the presence of a developed healthcare sector and supportive government programs, which has resulted in considerable product development and the commercialization of gene synthesis technologies in the United States and Canada. This is attributed to growing improvements in R&D facilities, available disposable income, and rapidly developing economic conditions. Moreover, federal agencies and authorities have launched several initiatives, programs, and schemes to encourage gene therapy research in the region, creating a platform for gene synthesis in the Americas. Emerging economies such as India, China, Singapore, and Malaysia are potential markets for market expansion due to improved healthcare standards. These economies have a considerable presence of domestic manufacturers of gene synthesis, which contributes to an upsurge in the market penetration of multinational giants. The growing prevalence of chronic diseases, increasing technological advancements, and improved healthcare infrastructure are the primary reasons driving the gene synthesis market in EMEA. Governments across the region have been continuously investing in gene therapies, thereby expanding the utilization of various gene syntheses. In February 2022, the Dutch government invested USD 55.04 million to build a new national pilot factory to advance the development and manufacturing of promising cell and gene therapies. The investment by the Dutch government is expected to provide excellent opportunities for cell and gene therapy companies.
FPNV Positioning Matrix
The FPNV Positioning Matrix is pivotal in evaluating the Gene Synthesis Market. It offers a comprehensive assessment of vendors, examining key metrics related to Business Strategy and Product Satisfaction. This in-depth analysis empowers users to make well-informed decisions aligned with their requirements. Based on the evaluation, the vendors are then categorized into four distinct quadrants representing varying levels of success: Forefront (F), Pathfinder (P), Niche (N), or Vital (V).
Market Share Analysis
The Market Share Analysis is a comprehensive tool that provides an insightful and in-depth examination of the current state of vendors in the Gene Synthesis Market. By meticulously comparing and analyzing vendor contributions in terms of overall revenue, customer base, and other key metrics, we can offer companies a greater understanding of their performance and the challenges they face when competing for market share. Additionally, this analysis provides valuable insights into the competitive nature of the sector, including factors such as accumulation, fragmentation dominance, and amalgamation traits observed over the base year period studied. With this expanded level of detail, vendors can make more informed decisions and devise effective strategies to gain a competitive edge in the market.
Key Company Profiles
The report delves into recent significant developments in the Gene Synthesis Market, highlighting leading vendors and their innovative profiles. These include Agilent Technologies, Inc., Ansa Biotechnologies, Inc., Applied Biological Materials Inc., AstraZeneca PLC, Azenta, Inc., Barcode Biosciences Private Limited, BGI Genomics by BGI Group, BioCat GmbH by AddLife AB, Biomatik Corporation, Bioneer Corporation, Biotage AB, Biotech Desk Pvt. Ltd., Boster Biological Technology, Brooks Automation Inc., Camena Bioscience, Charles River Laboratories International, Inc., Constructive Bio Ltd, Creative Biogene, Danaher Corporation, DNA TwoPointO Inc., Elabscience Biotechnology Inc., Elegen Corp., Eurofins Scientific SE, Evonetix Ltd., GenCefe Biotech Limited, Gene Universal, Inc., General Biosystems, Inc., GenScript Biotech Corporation, Ginkgo Bioworks Holdings, Inc., Macrogen, Inc., Merck KGaA, NZYTech, Lda., OriGene Technologies, Inc., ProMab Biotechnologies, Inc., ProteoGenix SAS, QIAGEN N.V., Synbio Technologies LLC, Telesis Bio Inc., Thermo Fisher Scientific Inc., and Twist Bioscience Corporation.
Market Segmentation & Coverage
1. Market Penetration: It presents comprehensive information on the market provided by key players.
2. Market Development: It delves deep into lucrative emerging markets and analyzes the penetration across mature market segments.
3. Market Diversification: It provides detailed information on new product launches, untapped geographic regions, recent developments, and investments.
4. Competitive Assessment & Intelligence: It conducts an exhaustive assessment of market shares, strategies, products, certifications, regulatory approvals, patent landscape, and manufacturing capabilities of the leading players.
5. Product Development & Innovation: It offers intelligent insights on future technologies, R&D activities, and breakthrough product developments.
1. What is the market size and forecast of the Gene Synthesis Market?
2. Which products, segments, applications, and areas should one consider investing in over the forecast period in the Gene Synthesis Market?
3. What are the technology trends and regulatory frameworks in the Gene Synthesis Market?
4. What is the market share of the leading vendors in the Gene Synthesis Market?
5. Which modes and strategic moves are suitable for entering the Gene Synthesis Market?