市場調查報告書
商品編碼
1466258
DNA 定序市場:按產品和服務、技術、工作流程、應用分類 - 2024-2030 年全球預測DNA Sequencing Market by Product & Services (Consumables, Instruments, Services), Technology (Next-Generation Sequencing, Sanger Sequencing, Third Generation DNA Sequencing), Workflow, Application - Global Forecast 2024-2030 |
※ 本網頁內容可能與最新版本有所差異。詳細情況請與我們聯繫。
DNA定序市場規模預估2023年為603.9億美元,2024年達719.8億美元,預計2030年將達2,103.4億美元,複合年成長率為19.51%。
DNA 定序是一種實驗室技術,可確定單一 DNA 分子內的核苷酸或鹼基序列。 DNA 鹼基序列包含細胞用來發育和發揮功能的編碼生物訊息。 DNA 序列可用於多種目的,包括診斷和疾病治療、醫學研究和法醫分析。醫療專業人員可以使用定序來識別某些疾病的基因變化或突變。對遺傳疾病和癌症的研究數量不斷增加,以及對個人化醫療的需求不斷成長,主要推動了 DNA 定序的研究和發展。此外,與 DNA 定序相關的技術限制和定序平台的高成本也限制了 DNA 定序市場的成長。此外,複雜的資料分析和標準化通訊協定的缺乏導致 DNA 定序結果的變異性。此外,DNA定序在臨床和研究應用中的日益普及以及包括下一代定序在內的新定序技術的採用預計將為市場成長創造利潤豐厚的機會。基因組研究投資的增加正在促進市場成長。
主要市場統計 | |
---|---|
基準年[2023] | 603.9億美元 |
預測年份 [2024] | 719.8億美元 |
預測年份 [2030] | 2103.4億美元 |
複合年成長率(%) | 19.51% |
產品/服務:隨著生物資訊學和計算生物學的進步,整體服務的演變
耗材對於 DNA 定序至關重要,包括定序過程中使用的所有必需試劑、套件和化學物質。包括DNA製備套件、文庫製備套件、定序試劑等。耗材的品質和類型直接影響定序工作的準確性、效率和成本效益。耗材的持續創新對於提高定序性能、降低每個樣本的成本並使 DNA 定序可用於更廣泛的應用至關重要。儀器是 DNA 測序中使用的核心硬體,從能夠同時處理數千個基因組的高通量測序儀到專為快速現場分析而設計的小型可攜式儀器。設備選擇取決於所需序列的規模、所需的詳細程度和可用預算。該領域的創新著重於提高速度、降低成本以及提高定序結果的解析度和保真度。方便用戶使用的介面和更緊湊的設計的開拓也在新市場和應用中採用測序技術方面發揮關鍵作用。 DNA 定序服務涵蓋廣泛的服務,從服務到資料分析和諮詢。這些服務對於需要內部基礎設施或專業知識來執行定序的營業單位尤其重要。服務供應商描述複雜資料的定序以及有價值的分析和解釋,以提供可行的見解。隨著生物資訊學和計算生物學的進步擴大了從序列資料中獲得的見解的範圍和質量,這一領域正在迅速發展。
技術:次世代定序儀(NGS) 日益普及,可實現超高通量
新一代定序 (NGS) 技術是一種快速對 DNA 樣本中的鹼基對進行定序的高通量方法。 NGS 可以同時對多條 DNA 鏈進行定序,從而顯著減少基因組研究的時間和成本。標靶定序和重定序著重於對基因組內的特定感興趣區域進行定序,例如包含致病突變的區域。這提供了一種經濟高效的方法來分析目標區域的遺傳變異。全EXOME定序涉及對基因組中基因的所有蛋白質轉錄區進行定序。這些區域被稱為外顯子,約佔人類基因組的 1% 至 2%,包含約 85% 的已知與疾病相關的基因突變。全基因組定序(WGS)透過對整個基因組進行定序來概述生物體的整個基因組成,使研究人員能夠識別編碼和非編碼區域,並了解它們的潛在突變和變異。Sanger定序被認為是第一代定序技術,是一種確定DNA鹼基序列的方法。它在 DNA 定序技術的發展中發揮了關鍵作用,並且仍然是小規模 DNA 定序計劃的黃金標準。第三代 DNA 定序,也稱為長讀長定序,可以對單分子 DNA 進行即時定序。這項技術透過產生更長的讀數超越了先前的限制,這對於理解複雜的基因組區域至關重要。奈米定序是第三代定序儀的一種型態,可讓單條 DNA 鏈通過奈米尺寸的孔。鹼基序列是利用 DNA 通過時電導率的變化來確定的。此方法可以即時分析長 DNA 或 RNA 片段。單分子即時 (SMRT) 定序的特點是能夠高精度讀取單分子 DNA。此方法有利於檢測表觀遺傳修飾,並提供高品質的長讀長,從而可以全面了解基因組、轉錄組和表觀基因。
工作流程:越來越偏好滿足準確性要求的定序方法
預測序階段是 DNA 定序工作流程中關鍵的第一步,收集樣本、評估其品質並為定序過程做好準備。此步驟包括從樣本中提取 DNA,對其進行定量以確定存在多少 DNA,並可能將 DNA 打碎以將其分解成更小的片段。在此階段確保 DNA 的完整性和純度對於成功的定序結果至關重要。定序階段涉及 DNA 序列的實際確定。這可以透過多種技術來完成,包括短 DNA 鏈的Sanger定序和用於全面、大規模基因組研究的下一代定序 (NGS)。 NGS 技術允許對數百萬個 DNA 片段進行平行序列測定,並描述了一種高通量的基因組序列測定方法。在這個階段,會產生大量的原始序列資料,分析需要大量的計算工作。資料分析階段將原始序列資料轉換為可解釋的格式。這個過程通常被稱為生物資訊學,包括序列與參考基因組的比對、突變/突變的識別以及基因組特徵的註釋等任務。採用先進的計算工具和演算法來處理複雜的資料,使得從序列資訊中得出生物學結論成為可能。最終目標是深入了解序列測定基因組的遺傳結構、功能和變異。
應用:擴大DNA定序在臨床研究的應用,以準確診斷與了解遺傳疾病
農業基因組學利用基因組學見解來提高作物產量、抗病性和對環境變化的適應性,從而增強糧食安全和農業實踐。在法醫學領域,DNA定序有助於刑事調查、災難受害者身分識別、遺產鑑定等中的個人識別,大大提高了法醫分析的準確性。臨床試驗中的 DNA 定序可以實現對遺傳疾病的準確診斷、治療和理解。透過對個別基因組進行定序,醫療專業人員可以檢測致病突變,指導個人化治療計劃,預測疾病感受性,並徹底改變患者照護和預防醫學。消費者基因體學是 DNA 定序中成長最快的部分,可以深入了解個人的基因組成、血統、性狀和某些健康狀況的傾向。基因組資訊的民主化將促進採取知情和主動的方法來保護消費者的健康和保健。 HLA型檢測(DNA 序列中的人類白血球抗原分型)對於免疫系統監測至關重要,特別是在器官移植適宜性、疾病相關研究和藥物超敏反應方面。此應用確保了供體和受體之間的兼容性,降低了移植排斥的風險,並促進了標靶治療。總體基因體學和流行病學透過分析複雜微生物群落的遺傳物質,描述了微生物在生物多樣性、微生物生態學和人類健康中的作用的見解。這些知識有助於追蹤疾病爆發、了解病原體的傳播以及開發藥物。在藥物開發中,DNA 定序加速了新治療標靶和機制的發現,提高了新藥的功效和安全性。在腫瘤學領域,DNA定序能夠識別與癌症相關的基因突變,促進標靶治療和個人化醫療方法的開發,並透過更有效和毒性更低的治療來改善癌症患者的生活,其好處包括提高生存率和品質。
區域洞察
由於主要企業的持續技術進步、高額研發投資以及技術先進的醫療基礎設施的可用性,美洲在 DNA 定序市場中佔據關鍵地位,從而在預測期內帶來良好的市場成長。在美國和加拿大,政府支持藥物開發和癌症治療研究的舉措正在推動北美市場的強勁成長。在歐洲,由於實驗室中 DNA 定序的使用增加、研發活性化以及 DNA 定序技術的進步,該地區正在經歷顯著的發展。由於國際公司的策略性舉措,亞太地區的 DNA 定序市場規模正在擴大。
FPNV定位矩陣
FPNV定位矩陣對於評估DNA定序市場至關重要。我們檢視與業務策略和產品滿意度相關的關鍵指標,以對供應商進行全面評估。這種深入的分析使用戶能夠根據自己的要求做出明智的決策。根據評估,供應商被分為四個成功程度不同的像限。最前線 (F)、探路者 (P)、利基 (N) 和重要 (V)。
市場佔有率分析
市場佔有率分析是一種綜合工具,可對 DNA 定序市場中供應商的現況進行深入而詳細的研究。全面比較和分析供應商在整體收益、基本客群和其他關鍵指標方面的貢獻,以便更好地了解公司的績效及其在爭奪市場佔有率時面臨的挑戰。此外,該分析還提供了對該細分市場競爭特徵的寶貴見解,包括在研究基準年觀察到的累積、碎片化主導地位和合併特徵等因素。這種詳細程度的提高使供應商能夠做出更明智的決策並制定有效的策略,從而在市場上獲得競爭優勢。
1. 市場滲透率:提供有關主要企業所服務的市場的全面資訊。
2. 市場開拓:我們深入研究利潤豐厚的新興市場,並分析其在成熟細分市場的滲透率。
3. 市場多元化:包括新產品發布、開拓地區、最新發展和投資的詳細資訊。
4. 競爭評估和情報:對主要企業的市場佔有率、策略、產品、認證、監管狀況、專利狀況和製造能力進行全面評估。
5. 產品開發與創新:包括對未來技術、研發活動和突破性產品開發的見解。
1.DNA定序市場的市場規模與預測是多少?
2.在DNA定序市場的預測期間內,我們應該考慮投資哪些產品和應用?
3.DNA定序市場的技術趨勢和法規結構是什麼?
4.DNA定序市場主要廠商的市場佔有率是多少?
5.進入DNA定序市場的合適型態和策略手段是什麼?
[185 Pages Report] The DNA Sequencing Market size was estimated at USD 60.39 billion in 2023 and expected to reach USD 71.98 billion in 2024, at a CAGR 19.51% to reach USD 210.34 billion by 2030.
DNA sequencing is the laboratory technique determining the sequence of nucleotides or bases in a single DNA molecule. DNA base sequence contains the encoded biological information that cells use to develop and function. DNA sequencing is used for various purposes, including diagnosis & disease treatment, medical research, and forensic analysis. Healthcare professionals can use sequencing to identify gene alterations or mutations of a specific disease condition. Rising cases of genetic disorders & cancer and growing demand for personalized medicine primarily boosting the research & development for DNA sequencing. Furthermore, technical limitations associated with DNA sequencing and the high cost of the sequencing platform limit the DNA sequencing market growth. In addition, complex data analysis & lack of standardized protocols lead to variability in the results of DNA sequencing. Moreover, the increasing adoption of DNA sequencing in clinical and research applications and the adoption of novel sequencing technologies, including next-generation sequencing, are expected to create lucrative opportunities for market growth. The rising investments in genomics research contribute to market growth.
KEY MARKET STATISTICS | |
---|---|
Base Year [2023] | USD 60.39 billion |
Estimated Year [2024] | USD 71.98 billion |
Forecast Year [2030] | USD 210.34 billion |
CAGR (%) | 19.51% |
Product & Services: Evolution across services with advances in bioinformatics and computational biology
Consumables are integral to DNA sequencing, encompassing all the necessary reagents, kits, and chemicals used during sequencing. These include DNA preparation kits, library preparation kits, and sequencing reagents. The quality and type of consumables directly impact the sequencing operation's accuracy, efficiency, and cost-effectiveness. Continuous innovation in consumables is critical for enhancing sequencing performance and reducing the per-sample cost, thereby making DNA sequencing more accessible for a broader range of applications. Instruments are the core hardware used in DNA sequencing, which ranges from high-throughput sequencers capable of processing thousands of genomes simultaneously to smaller, more portable devices designed for rapid and on-site analysis. The choice of instrument depends on the scale of sequencing needed, the level of detail required, and the available budget. Innovations in this segment focus on improving speed, reducing costs, and enhancing the resolution and fidelity of the sequencing results. Developing user-friendly interfaces and more compact designs also plays a significant role in adopting sequencing technology in new markets and applications. Services in DNA sequencing encompass a wide array of offerings, from sequencing-as-a-service to data analysis and consulting. These services are particularly important for entities needing more in-house infrastructure or expertise to perform sequencing. Service providers offer sequencing and valuable analysis and interpretation of complex data to provide actionable insights. This segment is evolving rapidly, with advances in bioinformatics and computational biology enhancing the scope and quality of the insights that can be derived from sequencing data, thereby offering tailored solutions to meet the diverse needs of customers.
Technology: Growing popularity of next-generation sequencing (NGS) for ultra-high throughput
Next-generation sequencing (NGS) technology represents a high-throughput approach that helps rapidly sequence the base pairs in DNA samples. NGS allows for the sequencing of multiple DNA strands simultaneously, drastically reducing the time and cost of genomic research. Targeted sequencing & resequencing focuses on sequencing specific areas of interest within a genome, such as regions containing mutations contributing to disease. This provides a cost-effective way to analyze genetic variation in targeted regions. Whole exome sequencing involves sequencing all the protein-coding regions of genes in a genome. These regions, known as exons, comprise about 1%-2% of the human genome and contain about 85% of known genetic mutations linked to diseases. Whole Genome Sequencing (WGS) involves sequencing the entire genome that provides an overview of the entire genetic makeup of an organism, allowing researchers to understand both coding and non-coding regions and their potential mutations or variations. Sanger sequencing is regarded as the first-generation sequencing technique and is a method for determining DNA nucleotide sequences. It has been pivotal in the development of DNA sequencing technologies and remains a gold standard for small-scale DNA sequencing projects. Third-generation DNA sequencing, also known as long-read sequencing, allows for the sequencing of single molecules of DNA in real-time. This technology surpasses previous limitations by generating longer reads, critical for understanding complex genomic regions. Nanopore sequencing is a form of third-generation sequencing that involves threading single DNA strands through nanoscopic pores. As the DNA passes through, changes in the electrical conductivity are used to identify the base sequence; this method allows for real-time analysis of long DNA or RNA fragments. Single-molecule real-time (SMRT) sequencing is characterized by its ability to read single molecules of DNA with high accuracy. This method provides advantages in detecting epigenetic modifications and offers high-quality long reads, enabling comprehensive views of genomes, transcriptomes, and epigenomes.
Workflow: Rising preference for sequencing methods to meet accuracy requirements
The pre-sequencing phase is a critical first step in the DNA sequencing workflow, where samples are collected, assessed for quality, and prepared for the sequencing process. This stage involves DNA extraction from the sample material, quantification to determine the amount of DNA present, and sometimes fragmentation, where the DNA is broken down into smaller pieces. Ensuring the integrity and purity of the DNA at this stage is paramount for successful sequencing outcomes. During the sequencing phase, the actual determination of the DNA sequence takes place. This can be performed using various technologies, such as Sanger sequencing for shorter DNA strands or Next-Generation Sequencing (NGS) for comprehensive, large-scale genomic studies. NGS techniques allow for the parallel sequencing of millions of DNA fragments, providing a high-throughput approach to genome sequencing. This stage generates vast raw sequence data, requiring significant computational effort to analyze. The data analysis phase involves converting the raw sequencing data into an interpretable format. This process, often referred to as bioinformatics, includes tasks such as aligning the sequences against reference genomes, identifying variations/mutations, and annotating genomic features. Advanced computational tools and algorithms are employed to handle the complex data, making drawing biological conclusions from the sequence information possible. The end goal is to provide insights into the sequenced genome's genetic structure, function, and variations.
Application: Expanding application of DNA sequencing in clinical investigation for precise diagnosis and understanding of genetic disorders
Agrigenomics uses genomic insights to improve crop yield, disease resistance, and adaptability to environmental changes for enhanced food security and agricultural practices. In forensics, DNA sequencing facilitates the identification of individuals in criminal investigations, disaster victim identification, and heritage testing, significantly improving the accuracy of forensic analysis. DNA sequencing in clinical investigations enables precise diagnosis, treatment, and understanding of genetic disorders. By sequencing an individual's genome, healthcare professionals detect mutations responsible for diseases, guide personalized treatment plans, and predict disease susceptibility, revolutionizing patient care and preventive medicine. Consumer genomics, a burgeoning segment of DNA sequencing, gives individuals insights into their genetic makeup, ancestry, traits, and predispositions to certain health conditions. This democratization of genomic information fosters an informed and proactive approach to health and wellness among consumers. HLA typing, or human leukocyte antigen typing in DNA sequencing, is pivotal in immune system monitoring, particularly for organ transplantation suitability, disease association studies, and drug hypersensitivity reactions. This application ensures the compatibility between donors and recipients, mitigating the risk of transplant rejection and facilitating targeted therapies. Metagenomics and epidemiology involve the analysis of genetic material from complex microbial communities, offering insights into biodiversity, microbial ecology, and the role of microbes in human health. This knowledge is instrumental in tracking disease outbreaks, understanding pathogen spread, and developing drugs. In drug development, DNA sequencing accelerates the discovery of novel therapeutic targets and mechanisms, enhancing the efficacy and safety of new drugs. Oncology benefits significantly from DNA sequencing by enabling the identification of genetic mutations associated with cancer, which facilitates the development of targeted therapy and personalized medicine approaches, improving cancer patients' survival rates and quality of life through more effective and less toxic treatments.
Regional Insights
The Americas has a significant landscape in the DNA sequencing market owing to continuous technological developments by key players, high research and development investment, and availability of technologically advanced healthcare infrastructure, resulting in lucrative market growth in the forecasted period. Government initiatives in the U.S. and Canada supporting research in drug development and treatment of cancer have created significant market growth in North America. In Europe, the growing usage of DNA sequencing in laboratories, rising R&D, and increasing advancements in DNA sequencing technologies have created significant regional development. Asia-Pacific has a growing market in DNA sequencing due to strategic initiatives undertaken by international firms to expand their presence owing to the high customer base, which is expected to create market growth in the region.
FPNV Positioning Matrix
The FPNV Positioning Matrix is pivotal in evaluating the DNA Sequencing Market. It offers a comprehensive assessment of vendors, examining key metrics related to Business Strategy and Product Satisfaction. This in-depth analysis empowers users to make well-informed decisions aligned with their requirements. Based on the evaluation, the vendors are then categorized into four distinct quadrants representing varying levels of success: Forefront (F), Pathfinder (P), Niche (N), or Vital (V).
Market Share Analysis
The Market Share Analysis is a comprehensive tool that provides an insightful and in-depth examination of the current state of vendors in the DNA Sequencing Market. By meticulously comparing and analyzing vendor contributions in terms of overall revenue, customer base, and other key metrics, we can offer companies a greater understanding of their performance and the challenges they face when competing for market share. Additionally, this analysis provides valuable insights into the competitive nature of the sector, including factors such as accumulation, fragmentation dominance, and amalgamation traits observed over the base year period studied. With this expanded level of detail, vendors can make more informed decisions and devise effective strategies to gain a competitive edge in the market.
Key Company Profiles
The report delves into recent significant developments in the DNA Sequencing Market, highlighting leading vendors and their innovative profiles. These include 10x Genomics, Inc., Abbott Laboratories, AbbVie Inc., Agilent Technologies, Inc., Azenta, Inc., Becton, Dickinson and Company, BGI Genomics Co., Ltd., Bio-Rad Laboratories, Inc., BioChain Institute Inc., Charles River Laboratories International, Inc., Danaher Corporation, Dante Labs Inc., Eppendorf SE, Eurofins Scientific SE, F. Hoffmann-La Roche Ltd., Genomics England, Genscript Biotech Corporation, Illumina, Inc., Johnson & Johnson Services, Inc., Konica Minolta, Inc., Laboratory Corporation of America Holdings, Macrogen Inc., Merck KGaA, Novartis AG, Novogene Co, Ltd., Oxford Nanopore Technologies PLC, Pacific Biosciences of California, Inc., PerkinElmer, Inc., QIAGEN N.V., Sartorius AG, Shimadzu Corporation, SOPHiA GENETICS SA, Thermo Fisher Scientific Inc., Twist Bioscience Corporation, and Veritas Genetics Inc. by LetsGetChecked.
Market Segmentation & Coverage
1. Market Penetration: It presents comprehensive information on the market provided by key players.
2. Market Development: It delves deep into lucrative emerging markets and analyzes the penetration across mature market segments.
3. Market Diversification: It provides detailed information on new product launches, untapped geographic regions, recent developments, and investments.
4. Competitive Assessment & Intelligence: It conducts an exhaustive assessment of market shares, strategies, products, certifications, regulatory approvals, patent landscape, and manufacturing capabilities of the leading players.
5. Product Development & Innovation: It offers intelligent insights on future technologies, R&D activities, and breakthrough product developments.
1. What is the market size and forecast of the DNA Sequencing Market?
2. Which products, segments, applications, and areas should one consider investing in over the forecast period in the DNA Sequencing Market?
3. What are the technology trends and regulatory frameworks in the DNA Sequencing Market?
4. What is the market share of the leading vendors in the DNA Sequencing Market?
5. Which modes and strategic moves are suitable for entering the DNA Sequencing Market?