市場調查報告書
商品編碼
1465974
胚胎著床前基因檢測市場:按技術、產品、程序類型、應用、最終用戶 - 2024-2030 年全球預測Preimplantation Genetic Testing Market by Technology, Offering, Procedure Type, Application, End User - Global Forecast 2024-2030 |
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預計2023年胚胎著床前基因檢測市場規模為7.284億美元,2024年將達8.2906億美元,2030年將達18.8628億美元,複合年成長率為14.56%。
胚胎著床前基因檢測(PGT)是指在胚胎著床前檢測影響胚胎的染色體異常的技術。 PGT是一項重要服務,能夠在體外受精(IVF)方法中及早發現胚胎著床前胚胎的遺傳異常,顯著降低將遺傳性疾病傳給後代的風險並提高成功率。 PGT 的主要應用領域包括識別單發疾病、染色體異常、粒線體疾病以及潛在兄弟姐妹的人類白血球抗原 (HLA) 匹配。由於生活方式的改變以及夫妻選擇生育的延遲導致不孕率不斷上升,因此需要開發PGT技術。政府促進體外受精治療的措施正在創造許多擴張機會。然而,與 IVF 治療和 PGT 程序相關的高成本可能是潛在最終用戶的主要阻礙力。圍繞 PGT 的倫理問題和 IVF 治療的有限保險範圍阻礙了 PGT 服務的採用。領先的生物技術公司正在迅速加強應對道德和監管挑戰,創造考慮道德和倫理因素的技術。次世代定序(NGS)和非侵入性胚胎著床前測試等新方法是新興技術,為該技術的發展提供了巨大潛力。
主要市場統計 | |
---|---|
基準年[2023] | 7.284 億美元 |
預測年份 [2024] | 82906萬美元 |
預測年份 [2030] | 18.8628億美元 |
複合年成長率(%) | 14.56% |
檢測染色體異常和單基因疾病的下一代定序技術取得進展
比較基因組雜合反應(CGH) 已被用來比較兩個樣本的 DNA 來檢測染色體失衡。檢測胚胎著床前胚胎的染色體異常,有助於選擇健康胚胎進行體外受精。螢光原位雜合反應(FISH) 是一種使用螢光探針來視覺化和繪製細胞內染色體上特定 DNA 序列的技術。可以檢測染色體異常,包括非整倍體和易位。次世代定序(NGS) 能夠快速且準確地對大量 DNA序列測定,因此成為胚胎著床前基因檢測的強大工具。聚合酵素鏈鎖反應(PCR) 是一種廣泛使用的分子生物學技術,可擴增特定的 DNA 序列以進行分析和檢測單基因疾病。單核苷酸多態性(SNP)評估基因組中單核苷酸水平的變異,用於識別遺傳疾病的攜帶者並評估多因素疾病(包括癌症)的風險。
提供:利用多樣化的產品來最佳化製程條件並獲得準確的結果
該設備在 PGT 過程中發揮重要作用,因為它可以對胚胎進行準確、高效的基因篩檢。關鍵設備包括次世代定序儀(NGS)、定量 PCR (qPCR) 系統和螢光原位雜合反應(FISH) 分析儀。 NGS具有高通量定序能力和廣泛的檢測範圍,適合檢測單基因和染色體異常。 PGT使用的試劑和耗材由基因檢測所需的各種套件、探針、緩衝液、酵素、溶液等組成。探針對於檢測特定染色體異常至關重要,緩衝液為最佳擴增條件提供了適當的條件。軟體和服務是 PGT 不可或缺的一部分,因為它們可確保基因檢測結果的可靠資料管理、分析、解釋和報告。偏好圍繞著使用者友善的介面、準確的變異檢測演算法、用於變異註釋的綜合資料庫、安全的資料儲存選項等。
胚胎著床前遺傳學診斷(PGD)程序變得普及,降低了遺傳疾病的風險。
胚胎著床前遺傳學診斷(PGD)是一種專門的程序,可以在植入或懷孕前診斷出胚胎中的基因突變和染色體異常。 PGD 的主要目的是降低某些遺傳疾病的風險,如囊腫纖維化、亨廷頓舞蹈症和肌肉萎縮症。胚胎著床前遺傳學篩檢(PGS),也稱為非整倍體染色體胚胎著床前遺傳學檢測(PGT-A),是在胚胎著床前胚胎中染色體非整倍性或不平衡的情況。透過識別具有正確染色體數量的胚胎,PGS旨在降低流產、死產、唐氏症和其他染色體異常的風險,並增加成功懷孕的機會。
廣泛使用胚胎著床前基因檢測來治療應用性非整倍體疾病
非整倍體是一種由於細胞內染色體數量異常而導致唐氏症、愛德華茲氏症候群和帕陶氏症等遺傳性疾病的疾病。胚胎著床前非整倍體基因檢測(PGT-A)可在胚胎著床前辨識出染色體異常的胚胎,進而增加成功懷孕的機會。透過胚胎著床前基因檢測進行性別鑑定,讓夫婦選擇孩子的性別,以平衡家庭並避免與性別相關的疾病。人類白血球抗原 (HLA) 分型可在幹細胞和器官移植過程中匹配供體和受體的組織類型。胚胎著床前HLA型檢測可以識別組織學相容的胚胎,並促進患有血液疾病或免疫系統缺陷的兄弟姐妹的成功植入。染色體結構異常涉及染色體結構的變化,包括缺失、重複和重排。此外,X連鎖疾病是由X染色體上的基因突變引起的,對男性的影響比女性更嚴重。
最終用戶:醫療研究機構擴大採用 PGT,以實現準確診斷和有效治療
胚胎著床前基因檢測廣泛應用於各種醫療機構,並在臨床研究中取得了成功。合約研究和製造組織 (CRMO) 是在產品開發、製造和商業化中發揮關鍵作用的關鍵組織。這些組織更喜歡外包服務,以確保品管、遵守監管標準和成本效率,同時專注於核心能力。同樣,冷凍庫是在極低的溫度下儲存精子、卵子和胚胎等生物樣本以供將來使用的機構。胚胎著床前基因檢測對於冷凍銀行至關重要,可確保在體外受精和顯微授精等移植程序之前儲存樣本的遺傳活力。醫院、診斷實驗室和服務供應商正在利用胚胎著床前基因檢測技術透過準確的診斷和有效的治療為患者護理做出貢獻。研究機構和學術機構透過尖端研究、技術開發和跨學科合作,在推動胚胎著床前基因檢測的創新和進步方面發揮關鍵作用。這些機構專注於開發下一代定序(NGS)等新技術,以提高胚胎著床前基因檢測方法的準確性。
區域洞察
在美洲,由於生活方式的改變和基因檢測意識的增強導致不孕率上升,因此對胚胎著床前基因檢測(PGT)的需求很高。改善的醫療基礎設施和優惠的報銷政策使美洲尋求不孕症治療的夫婦更容易獲得 PGT 服務。該地區企業擁有強大的研發能力,政府支持支持該領域的創新。亞洲是 PGT 的主要市場,因為 PGT 服務改善了 IVF 等先進生育技術的提供,擴大了醫療旅遊業,並吸引了尋求具有成本效益的治療選擇的外國患者。由於政府對醫療保健研究的資助增加以及 IVF 在歐洲國家普及等因素,歐洲對全球 PGT 市場做出了巨大貢獻。此外,圍繞基因檢測的嚴格法律規範確保了在進行 PGT 服務時的品管和道德考慮。該地區的主要企業正在為胚胎著床前基因檢測實踐的技術進步做出重大貢獻。
FPNV定位矩陣
FPNV定位矩陣對於評估胚胎著床前基因檢測市場至關重要。我們檢視與業務策略和產品滿意度相關的關鍵指標,以對供應商進行全面評估。這種深入的分析使用戶能夠根據自己的要求做出明智的決策。根據評估,供應商被分為四個成功程度不同的像限:前沿(F)、探路者(P)、利基(N)和重要(V)。
市場佔有率分析
市場佔有率分析是一種綜合工具,可以對胚胎著床前基因測試市場供應商的現狀進行深入而深入的研究。全面比較和分析供應商在整體收益、基本客群和其他關鍵指標方面的貢獻,以便更好地了解公司的績效及其在爭奪市場佔有率時面臨的挑戰。此外,該分析還提供了對該行業競爭特徵的寶貴見解,包括在研究基準年觀察到的累積、分散主導地位和合併特徵等因素。詳細程度的提高使供應商能夠做出更明智的決策並制定有效的策略,從而在市場上獲得競爭優勢。
1. 市場滲透率:提供有關主要企業所服務的市場的全面資訊。
2. 市場開拓:我們深入研究利潤豐厚的新興市場,並分析其在成熟細分市場的滲透率。
3. 市場多元化:提供有關新產品發布、開拓地區、最新發展和投資的詳細資訊。
4. 競爭評估和情報:對主要企業的市場佔有率、策略、產品、認證、監管狀況、專利狀況和製造能力進行全面評估。
5. 產品開發與創新:提供對未來技術、研發活動和突破性產品開發的見解。
1.胚胎著床前基因檢測市場規模及預測為何?
2.在胚胎著床前基因檢測市場的預測期間內,有哪些產品、細分市場、應用和領域需要考慮投資?
3.胚胎著床前基因檢測市場的技術趨勢和法規結構是什麼?
4.胚胎著床前基因檢測市場主要廠商的市場佔有率如何?
5. 進入胚胎著床前基因檢測市場的合適型態和策略性手段是什麼?
[192 Pages Report] The Preimplantation Genetic Testing Market size was estimated at USD 728.40 million in 2023 and expected to reach USD 829.06 million in 2024, at a CAGR 14.56% to reach USD 1,886.28 million by 2030.
Preimplantation genetic testing (PGT) refers to technologies used to detect chromosomal abnormalities affecting the embryos before implantation. PGT is a crucial service that allows for early detection of genetic abnormalities in embryos before implantation during in-vitro fertilization (IVF) procedures, significantly reducing the risk of passing on inheritable diseases to offspring and improving IVF success rates. The primary application areas for PGT include identifying monogenic disorders, chromosomal abnormalities, mitochondrial diseases, and human leukocyte antigen (HLA) matching for potential siblings. The rising infertility rates due to lifestyle changes and delayed parenthood choices among couples have necessitated the development of PGT technologies. Government initiatives promoting IVF treatments create numerous expansion opportunities. However, high costs associated with IVF treatments and PGT procedures can be a major deterrent to potential end-users. Ethical concerns surrounding PGT and limited insurance coverage for IVF treatments hinder the adoption of PGT services. Major biotechnology companies are rapidly expanding efforts to combat ethical and regulatory challenges and creating technologies that take moral and ethical issues under consideration. New approaches such as next-generation sequencing (NGS) and non-invasive preimplantation testing are emerging technologies that offer significant potential for the growth of the technology.
KEY MARKET STATISTICS | |
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Base Year [2023] | USD 728.40 million |
Estimated Year [2024] | USD 829.06 million |
Forecast Year [2030] | USD 1,886.28 million |
CAGR (%) | 14.56% |
Technology: Advancements in next-generation sequencing to detect chromosomal abnormalities and single-gene disorders
Comparative genomic hybridization (CGH) is adopted for detecting chromosomal imbalances by comparing the DNA of two samples. It can detect chromosomal abnormalities in embryos before implantation and help select healthy embryos for IVF. Fluorescence in situ hybridization (FISH) is a technique that uses fluorescent probes to visualize and map specific DNA sequences on chromosomes within cells. It can detect numerical chromosomal abnormalities, including aneuploidy or translocations. Next-generation sequencing (NGS) is a robust tool for preimplantation genetic testing owing to its ability to sequence large amounts of DNA quickly and accurately. Polymerase chain reaction (PCR) is a widely used molecular biology technique that amplifies specific DNA sequences for analysis and can detect monogenic diseases. Single-nucleotide polymorphism (SNP) evaluates variations at the single-nucleotide level within the genome and is used to identify carriers of inherited diseases or assess the risk of multifactorial disorders, including cancer.
Offering: Utilization of diverse offerings to optimize process conditions and derive accurate results
Instruments play a critical role in the PGT process as they enable accurate and efficient genetic screening of embryos. Key instruments include next-generation sequencers (NGS), quantitative PCR (qPCR) systems, and fluorescence in situ hybridization (FISH) analyzers. NGS offers high-throughput sequencing capabilities and a broader detection range, making it suitable for detecting single-gene disorders and chromosomal abnormalities. Reagents and consumables used for PGT consist of various kits, probes, buffers, enzymes, and solutions necessary for genetic testing procedures. Probes are vital in detecting specific chromosomal aberrations, and buffers provide appropriate conditions for optimal amplification conditions. Software and services are essential components of PGT, as they ensure reliable data management, analysis, interpretation, and reporting for genetic testing results. Need-based preferences revolve around user-friendly interfaces, accurate algorithms for variant detection, comprehensive databases for variant annotation, and secure data storage options.
Procedure: Increasing deployment of preimplantation genetic diagnosis (PGD) procedures to reduce the risk of genetic disorders
Preimplantation genetic diagnosis (PGD) is a specialized procedure that allows the identification of genetic mutations or chromosomal abnormalities in embryos diagnosed before implantation and pregnancy. The primary goal of PGD is to reduce the risk of developing specific genetic disorders such as cystic fibrosis, Huntington's disease, and muscular dystrophy. Preimplantation genetic screening (PGS), referred to as preimplantation genetic testing for aneuploidies (PGT-A), detects chromosomal aneuploidies or imbalances in embryos before implantation. PGS aims to improve the chances of successful pregnancies by identifying embryos with the correct number of chromosomes, reducing the risk of miscarriage, stillbirth, or having a child affected by Down syndrome or other chromosomal abnormalities.
Application: Wide use of preimplantation genetic testing for aneuploidy disorder
Aneuploidy is a disorder in which an abnormal number of chromosomes in a cell leads to genetic disorders, including Down syndrome, Edwards syndrome, and Patau syndrome. Preimplantation of genetic testing for aneuploidy (PGT-A) identifies embryos with chromosomal abnormalities before implantation, increasing the chances of a successful pregnancy outcome. Gender identification through preimplantation genetic testing allows couples to choose the gender of their child for family balancing or to avoid sex-linked disorders. Human leukocyte antigen (HLA) typing matches tissue types between donor and recipient for stem cell or organ transplantation procedures. Preimplantation HLA typing identifies embryos with compatible tissue types, potentially facilitating successful transplants in siblings with blood disorders or immune system deficiencies. Structural chromosomal abnormalities involve alterations in chromosome structure, including deletions, duplications, and rearrangements. In addition, X-linked diseases are caused by mutations in genes on the X chromosome, affecting males more severely than females.
End User: Increasing adoption of PGT in healthcare research organizations for accurate diagnosis and effective treatments
Preimplantation genetics testing is widely used in various healthcare facilities, providing successful outcomes in clinical research. Contract research and manufacturing organizations (CRMOs) are primary organizations that play a crucial role in developing, manufacturing, and commercializing preimplantation genetic testing products. These organizations prefer outsourcing their services to ensure quality control, compliance with regulatory standards, and cost efficiency while focusing on their core competencies. Similarly, cryobanks are institutions that store biological samples such as sperm, eggs, and embryos at extremely low temperatures for future use. Preimplantation genetic testing is crucial for cryobanks to ensure the genetic viability of stored samples before implantation procedures like IVF or ICSI. Hospitals, diagnostic labs, and service providers contribute to patient care through accurate diagnosis and effective treatments using preimplantation genetic testing technologies. Research laboratories and academic institutes play a vital role in driving innovation and advancements in preimplantation genetic testing through cutting-edge research, technological developments, and interdisciplinary collaborations. These institutions focus on developing novel techniques like next-generation sequencing (NGS) to enhance the accuracy of preimplantation genetic testing methods.
Regional Insights
The Americas exhibit a high need for preimplantation genetic testing (PGT) owing to rising infertility rates caused by lifestyle changes and increasing awareness regarding genetic testing. Well-established healthcare infrastructure facilities and favorable reimbursement policies have made PGT services more accessible to couples seeking infertility treatments in the Americas. Companies in the region have strong R&D capabilities and government support that drive innovation in the field. Asia is emerging as a big and opportunistic market for PGT owing to improved provision of advanced fertility techniques such as IVF with PGT services and growing medical tourism, attracting international patients seeking cost-effective treatment options. Europe contributes significantly to the global PGT market due to factors such as increased government funding for healthcare research and widespread adoption of IVF procedures across various European countries. Moreover, stringent regulatory frameworks surrounding genetic testing ensure quality control and ethical considerations when implementing PGT services. Key players within this region contribute significantly to technological advancements in preimplantation genetic testing practices.
FPNV Positioning Matrix
The FPNV Positioning Matrix is pivotal in evaluating the Preimplantation Genetic Testing Market. It offers a comprehensive assessment of vendors, examining key metrics related to Business Strategy and Product Satisfaction. This in-depth analysis empowers users to make well-informed decisions aligned with their requirements. Based on the evaluation, the vendors are then categorized into four distinct quadrants representing varying levels of success: Forefront (F), Pathfinder (P), Niche (N), or Vital (V).
Market Share Analysis
The Market Share Analysis is a comprehensive tool that provides an insightful and in-depth examination of the current state of vendors in the Preimplantation Genetic Testing Market. By meticulously comparing and analyzing vendor contributions in terms of overall revenue, customer base, and other key metrics, we can offer companies a greater understanding of their performance and the challenges they face when competing for market share. Additionally, this analysis provides valuable insights into the competitive nature of the sector, including factors such as accumulation, fragmentation dominance, and amalgamation traits observed over the base year period studied. With this expanded level of detail, vendors can make more informed decisions and devise effective strategies to gain a competitive edge in the market.
Key Company Profiles
The report delves into recent significant developments in the Preimplantation Genetic Testing Market, highlighting leading vendors and their innovative profiles. These include Abbott Laboratories, Agilent Technologies, Inc., Bio-Rad Laboratories, Inc., Bio-Techne Corporation, Bioarray S.L., EUROPE IVF International s.r.o., F. Hoffmann-La Roche AG, Genea Limited, GENETiKS, Illumina, Inc., Invicta Genetics, Invitae Corporation, Juno Genetics, US Inc., Laboratory Corporation of America Holdings, MedGenome Labs Ltd., Merck KGaA, Natera, Inc., NextGen Genetics Holdings, LLC, Ovation Fertility, PacGenomics, PerkinElmer, Inc., Progyny, Inc., Qiagen N.V., Quest Diagnostics Incorporated, Reproductive Genetic Innovations, LLC, SEQUENCE46, LLC, Sysmex Corporation, Takara Bio Inc., The Cooper Companies Inc., Thermo Fisher Scientific Inc., Vitrolife Sweden AB, and Yikon Genomics (Shanghai) Co., Ltd..
Market Segmentation & Coverage
1. Market Penetration: It presents comprehensive information on the market provided by key players.
2. Market Development: It delves deep into lucrative emerging markets and analyzes the penetration across mature market segments.
3. Market Diversification: It provides detailed information on new product launches, untapped geographic regions, recent developments, and investments.
4. Competitive Assessment & Intelligence: It conducts an exhaustive assessment of market shares, strategies, products, certifications, regulatory approvals, patent landscape, and manufacturing capabilities of the leading players.
5. Product Development & Innovation: It offers intelligent insights on future technologies, R&D activities, and breakthrough product developments.
1. What is the market size and forecast of the Preimplantation Genetic Testing Market?
2. Which products, segments, applications, and areas should one consider investing in over the forecast period in the Preimplantation Genetic Testing Market?
3. What are the technology trends and regulatory frameworks in the Preimplantation Genetic Testing Market?
4. What is the market share of the leading vendors in the Preimplantation Genetic Testing Market?
5. Which modes and strategic moves are suitable for entering the Preimplantation Genetic Testing Market?