![]() |
市場調查報告書
商品編碼
2023561
至 2035 年患者來源異種移植模型市場分析和預測:按類型、產品、服務、技術、應用、最終用戶和鼠模型分類。Patient-Derived Xenograft Model Market Analysis and Forecast to 2035: Type, Product, Services, Technology, Application, End User, Mice Model |
||||||
全球患者來源異種移植(PDX)模型市場預計將從2025年的4億美元成長到2035年的11億美元,複合年成長率(CAGR)為12.1%。政府和私人機構對癌症研究投入的增加正在加速PDX模型在全球的應用。 2024年10月,英國國家健康研究所(NIHR)和生命科學辦公室(OLS)投資1,401萬美元,用於支持包括PDX在內的先進臨床前模型的六個癌症研究計畫。同樣,中國也在增加對免疫腫瘤學的投資,利用PDX模型研究腫瘤與免疫系統的相互作用,並開發CAR-T療法。生物技術和製藥行業的成長也進一步推動了市場需求。 2025年10月,日本國立癌症中心推出了“J-PDX庫”,旨在加強轉化腫瘤學研究和精準醫療主導的藥物舉措。
臨床前研究中的腫瘤類型涵蓋了多種惡性腫瘤,旨在了解疾病進展和治療反應。消化器官系統腫瘤有助於深入了解大腸直腸癌和胃癌,婦科腫瘤則專注於卵巢癌和子宮癌。呼吸系統腫瘤包括肺癌模型,中樞神經系統腫瘤則以膠質母細胞瘤及相關腦瘤為研究對象。骨髓惡性腫瘤包括白血病和淋巴瘤,皮膚腫瘤則研究黑色素瘤等皮膚癌。其他固態腫瘤則代表了未包含在上述類別中的多種癌症。結合這些分類,研究人員能夠模擬人類疾病的生物學特徵,並評估針對多種癌症適應症的新治療方法。
| 市場區隔 | |
|---|---|
| 類型 | 胃腸道腫瘤、婦科腫瘤、呼吸系統腫瘤、中樞神經系統腫瘤、骨髓惡性腫瘤、皮膚腫瘤和其他固態腫瘤。 |
| 產品 | 小鼠模型、大鼠模型 |
| 服務 | 模型創建與增殖、模型表徵、冷凍保存及其他服務 |
| 科技 | 異位(皮下)移植,原位移植 |
| 目的 | 臨床前研究、生物標記分析、轉化研究、生物銀行 |
| 最終用戶 | 製藥和生物技術公司、合約研究組織 (CRO) 和合約開發生產組織 (CDMO)、學術和研究機構 |
| 小鼠模型 | 裸鼠(Achimic)、NOD/SCID、NSG、人源化小鼠 |
動物模型是腫瘤學研究中不可或缺的工具,它們為研究腫瘤生物學和治療性介入提供了可控的系統。小鼠模型因其易於進行基因操作、繁殖週期短以及可獲得免疫力缺乏品系(從而能夠進行人類腫瘤的異種移植)而被廣泛應用。體型較大的大鼠模型則提供了互補的視角,能夠進行更複雜的外科手術和藥理研究。這兩種模型均可作為藥物療效測試、生物標記發現和轉化研究的平台。這些模型的使用彌合了體外實驗和臨床試驗之間的鴻溝,確保候選治療方法在進入人體試驗之前能夠進行體內評估。
預計到2025年,北美將引領病患來源異種移植(PDX)模型市場,佔48.2%的市佔率。這主要得益於癌症發病率的上升以及對可預測的、與患者相關的臨床前模型日益成長的需求。該地區強大的研究基礎設施和高額的醫療費用支出也進一步推動了市場成長。預計到2024年,美國將新增約2,001,140例癌症病例和611,720例死亡病例,創歷史新高。這一成長歸因於人口老化、診斷能力的提高以及篩檢的增加,所有這些因素都推動了對PDX等先進腫瘤研究模型的需求,以促進有效的藥物研發和精準醫療。
亞太地區是患者來源異質骨移植(PDX)模型市場成長最快的地區,預計在預測期內將以14.8%的複合年成長率成長。這一成長主要得益於全部區域癌症負擔的不斷加重以及腫瘤研究能力的不斷提升。根據輝瑞公司統計,亞洲主要國家約有360萬癌症患者,其中女性患者約400萬,光是中國就有160萬男性和150萬女性患者。在中國,已建立了涵蓋胃腸道癌、肺癌、肝癌和食道癌的大規模PDX模型庫,保留了腫瘤的組織學特徵和藥物反應,從而支持了先進的臨床前研究、精準醫療和加速抗癌藥物的研發。
利用 CRISPR 技術擴大人源化 PDX 模型的應用
利用CRISPR技術建構人源化患者來源異種移植(PDX)模型正日益成為全球市場的重要趨勢,其驅動力源自於免疫腫瘤學和標靶治療研究中對臨床相關平台的需求。這些先進的模型將患者腫瘤組織與人源化免疫系統結合,從而能夠更準確地評估治療反應。產業公司正在加速基因編輯PDX平台的商業化,以增強其服務能力。例如,百奧賽圖製藥公司(Biocytogen Pharmaceuticals)正在擴展其BioMice®平台,利用精準的基因編輯技術開發基因修飾和免疫人源化小鼠模型,從而提高其在腫瘤學研發和免疫療法開發中模擬人類生理和病理條件的能力。
PDX模型外包給CRO的趨勢日益明顯,正在加速市場擴張。
隨著製藥和生物技術公司越來越依賴外部合作夥伴進行專業的臨床前腫瘤學研究,將患者來源的異種移植(PDX)模型外包給合約研究組織(CRO)的做法日益增多,加速了市場擴張。不斷擴充的藥物研發管線和有限的內部資源促使贊助公司轉向擁有先進PDX專業知識的CRO。外包服務能夠提供專業的設施、技術能力和可擴展的動物飼養設施,同時降低營運成本並縮短轉化研究週期。例如,InnoSer利用PDX小鼠模型提供全面的腫瘤學CRO服務,使贊助公司能夠在體內精確複製腫瘤異質性和治療反應,從而評估治療效果並支持高效的藥物開發流程。
The global Patient-Derived Xenograft (PDX) Model Market is projected to grow from $0.4 billion in 2025 to $1.1 billion by 2035, at a compound annual growth rate (CAGR) of 12.1%. Rising government and private funding for cancer research is accelerating the adoption of Patient-Derived Xenograft (PDX) models globally. In October 2024, the UK National Institute for Health Research (NIHR) and the Office for Life Sciences (OLS) invested USD 14.01 million in six cancer research projects supporting advanced preclinical models, including PDX. Similarly, China is expanding investments in immuno-oncology, leveraging PDX models for tumor-immune interaction studies and CAR-T development. Growth in biotechnology and pharmaceutical sectors further drives demand. In October 2025, Japan's National Cancer Center launched the J-PDX Library, strengthening translational oncology research and precision medicine-driven drug development initiatives.
Tumor types in preclinical research encompass a wide range of malignancies studied to understand disease progression and therapeutic response. Gastro-intestinal tumors provide insights into colorectal and gastric cancers, while gynecological tumors focus on ovarian and uterine malignancies. Respiratory tumors include lung cancer models, and central nervous system tumors address glioblastoma and related brain cancers. Hematological malignancies cover leukemias and lymphomas, whereas dermatological tumors explore skin cancers such as melanoma. Other solid tumors represent diverse cancers outside these categories. Together, these classifications enable researchers to replicate human disease biology and evaluate novel therapies across multiple cancer indications.
| Market Segmentation | |
|---|---|
| Type | Gastro-Intestinal Tumors, Gynecological Tumors, Respiratory Tumors, Central Nervous System Tumors, Hematological Malignancies, Dermatological Tumors, Other Solid Tumors |
| Product | Mice Models, Rat Models |
| Services | Model Creation & Expansion, Model Characterization, Cryopreservation, Other Services |
| Technology | Heterotopic (Subcutaneous) Implantation, Orthotopic Implantation |
| Application | Preclinical Research, Biomarker Analysis, Translational Research, Biobanking |
| End User | Pharma & Biotechnology Companies, CROs & CDMOs, Academics & Research Institutes |
| Mice Model | Nude (Athymic), NOD/SCID, NSG, Humanized Mice |
Animal models are essential tools in oncology research, providing controlled systems to study tumor biology and therapeutic interventions. Mice models are widely used due to their genetic manipulability, short reproductive cycles, and availability of immunodeficient strains that support human tumor xenografts. Rat models, larger in size, allow for more complex surgical procedures and pharmacological studies, offering complementary insights. Both models serve as platforms for drug efficacy testing, biomarker discovery, and translational research. Their use bridges the gap between in vitro experiments and clinical trials, ensuring that candidate therapies are evaluated in living systems before advancing to human studies.
North America dominated the Patient-Derived Xenograft (PDX) model market with a 48.2% share in 2025, driven by the rising cancer burden and increasing demand for predictive, patient-relevant preclinical models. The region's strong research infrastructure and high healthcare spending further support market expansion. In 2024, the United States is projected to record approximately 2,001,140 new cancer cases and 611,720 deaths, marking a record-high incidence. This growth is attributed to population aging, improved diagnostic capabilities, and wider screening adoption, all of which are intensifying the need for advanced oncology research models like PDX for effective drug development and precision medicine.
Asia-Pacific is the fastest-growing region in the Patient-Derived Xenograft (PDX) model market, with a CAGR of 14.8% during the forecast period. Growth is driven by a high and rising cancer burden alongside expanding oncology research capabilities across the region. According to Pfizer, major Asian countries account for approximately 3.6 million male and 4.0 million female cancer patients, with China alone representing 1.6 million males and 1.5 million females. China has developed extensive PDX libraries covering gastrointestinal, lung, liver, and esophageal cancers, preserving tumor histology and drug response, thereby supporting advanced preclinical research, precision medicine, and accelerated oncology drug development.
Rising Adoption of CRISPR-Engineered Humanized PDX Models
Rising adoption of CRISPR-engineered humanized Patient-Derived Xenograft (PDX) models is emerging as a key trend in the global market, driven by the need for more translationally relevant platforms in immuno-oncology and targeted therapy research. These advanced models combine patient tumor tissues with humanized immune systems, enabling more accurate evaluation of therapeutic responses. Industry players are increasingly commercializing gene-edited PDX platforms to strengthen their offerings. For instance, Biocytogen Pharmaceuticals has expanded its BioMice(R) platform with genetically engineered and immune-humanized mouse models developed using precise gene editing, enhancing the ability to replicate human physiological and pathological conditions for oncology research and immunotherapy development.
Rising Outsourcing of PDX Models to CROs Accelerates Market Expansion
Rising outsourcing of Patient-Derived Xenograft (PDX) models to contract research organizations (CROs) is accelerating market expansion, as pharmaceutical and biotechnology companies increasingly rely on external partners for specialized preclinical oncology research. Expanding drug pipelines and limited in-house capacities are driving sponsors toward CROs with advanced PDX expertise. Outsourcing enables access to specialized infrastructure, technical capabilities, and scalable vivarium facilities, while reducing operational costs and accelerating translational timelines. For instance, InnoSer offers comprehensive oncology CRO services with PDX mouse models that allow sponsors to evaluate therapeutic efficacy by accurately replicating tumor heterogeneity and treatment responses in vivo, supporting efficient drug development processes.
Our research scope provides comprehensive market data, insights, and analysis across a variety of critical areas. We cover Local Market Analysis, assessing consumer demographics, purchasing behaviors, and market size within specific regions to identify growth opportunities. Our Local Competition Review offers a detailed evaluation of competitors, including their strengths, weaknesses, and market positioning. We also conduct Local Regulatory Reviews to ensure businesses comply with relevant laws and regulations. Industry Analysis provides an in-depth look at market dynamics, key players, and trends. Additionally, we offer Cross-Segmental Analysis to identify synergies between different market segments, as well as Production-Consumption and Demand-Supply Analysis to optimize supply chain efficiency. Our Import-Export Analysis helps businesses navigate global trade environments by evaluating trade flows and policies. These insights empower clients to make informed strategic decisions, mitigate risks, and capitalize on market opportunities.