RNA 疫苗市場：進步和增長機會

RNA 療法和疫苗已經存在了一段時間，但 COVID-19 大流行將它們大量推向市場。 業內人士認為，為 COVID-19 開發的 mRNA 疫苗將有效減少 SARS-CoV-2 病毒對人群的影響。

本報告考察了全球 RNA 疫苗市場，並提供了市場概覽、戰略要務、增長機會等。

內容

戰略要務

• 為什麼增長越來越難？
• 戰略要務
• 三大戰略要務對 RNA 疫苗行業的影響
• 增長機會加速增長管道引擎

增長機會分析

• 分析範圍
• 細分
• 繼續開發 RNA 疫苗
• RNA 疫苗克服了傳統疫苗的局限性
• RNA 疫苗開發的世界趨勢
• 司機
• 抑制生長

創新研發場景

RNA 疫苗開發概況：預防性和治療性疫苗

利益相關者生態系統

• 展示 RNA 疫苗增長潛力的動態全球生態系統
• 開發創新疫苗製造單元並擴大產能
• RNA 疫苗開發人員之間的協作

成長機會

• 增長機會 1：RNA 疫苗製造和交付的全球基礎設施開發
• 增長機會 2：改變 RNA 和改進設計
• 增長機會 3：改進輸送系統和配方

附錄

下一步

Technology Innovations and Investments Bolster Next-generation Prophylactic and Therapeutic RNA Vaccines

RNA therapeutics and vaccines have been around for a long time, but the COVID-19 pandemic enabled their mass-market commercialization. Industry players saw mRNA vaccines developed for COVID-19 as effective for reducing the impact of the SARS-CoV-2 virus in populations. Moderna emerged as the first player to develop and commercialize an mRNA vaccine for COVID-19, followed by others such as Pfizer and BioNTech. mRNA is the first form of RNA vaccine to complete clinical trials and commercialization. Frost & Sullivan's analysis shows industry participants are developing mRNA vaccines for influenza, HIV, and cancer.

RNA vaccine development is research intensive, with newer RNA modifications giving rise to more unique forms like self-amplifying mRNA (saRNA) and circular RNA vaccines. RNA design and optimization are essential to obtain RNA forms that suit vaccine development and provide the expected outcomes. saRNA vaccines are considered the next-generation RNA vaccines with improved properties and more advantages over mRNA vaccines. Meanwhile, circular RNA vaccines are emerging due to enhanced properties such as stability and higher protein expressions. It is a new RNA vaccine with high potential in the early stages of R&D and clinical trials.

Apart from research on RNA forms, RNA vaccine delivery systems and route of administration are also deciding factors in their success. To achieve maximum potential, researchers should deliver RNA vaccines through effective delivery systems that retain their potency.

Increased global demands for COVID-19 vaccines led to the manufacturing of mRNA vaccines in a short time to cater to large populations. Vaccine developers adopted digital technologies, expanded manufacturing units and capabilities, and increased collaborations with contract development and manufacturing companies to achieve such humongous targets. Expanding RNA vaccine manufacturing will increase the vaccine capacity and reduce large-scale manufacturing costs. This will ensure that the vaccine is affordable and allow vaccine developers to provide them to developing countries at a subsidy.

This report includes the following:

• Reasons for RNA vaccines emerging as a promising category of therapeutics

• Technological developments

• Digital biomanufacturing-driven changes in RNA vaccine development

• Newer modes of delivery

• Progress of clinical trials since the approval of the first RNA vaccine

• Global adoption rate

• Prospects for RNA vaccine developers

Table of Contents

Strategic Imperatives

• Why Is It Increasingly Difficult to Grow?The Strategic Imperative 8™: Factors Creating Pressure on Growth
• The Strategic Imperative 8™
• The Impact of the Top 3 Strategic Imperatives on the Ribonucleic Acid (RNA) Vaccine Industry
• Growth Opportunities Fuel the Growth Pipeline Engine™
• Research Methodology

Growth Opportunity Analysis

• Scope of Analysis
• Segmentation
• A Growing Shift Toward Developing RNA Vaccines
• RNA Vaccines Overcome Limitations of Conventional Vaccines
• Global Trends in RNA Vaccine Development
• Growth Drivers
• Growth Restraints

Innovations and R&D Scenario

• Types of RNA Vaccines and Technology Readiness Level (TRL)
• Design and Modifications Improve Synthetic RNA Vaccine Production
• Industry Players with RNA Vaccine Modification Platforms
• Advanced Platforms Improve RNA Vaccine Designs and Processes to Produce High-quality Vaccines
• Industry Players with AI-based RNA Design Platforms
• The Lack of Well-developed Manufacturing Processes Slow RNA Vaccines Production Rates
• Overcoming RNA Vaccine Manufacturing Bottlenecks to Meet Increased Demand
• New Initiatives in RNA Vaccine Development and Manufacturing Platforms
• Digitalization Will Transform RNA Vaccine Manufacturing
• Developments in RNA Vaccine Delivery Systems
• Developments in RNA Vaccine Delivery Systems (continued)
• Industry Players Developing RNA Vaccine Delivery Platforms
• New Formulations Increase the Shelf-life and Maximize the Delivery Potential of the RNA Vaccine
• Newer Developments in RNA Vaccine Administration Routes
• Needle-free Vaccine Delivery Administration Routes for mRNA Vaccines

RNA Vaccines Development Landscape: Prophylactic and Therapeutic Vaccines

• RNA Vaccines Clinical Pipelines
• Increased RNA Vaccine Programs Globally
• Prophylactic RNA Vaccines
• Therapeutic RNA Vaccines
• mRNA Vaccines
• Ongoing Developments by mRNA Vaccine Developers
• saRNA Vaccines
• Ongoing Developments by saRNA Vaccine Developers
• Circular RNA Vaccines
• Priority Disease Areas for RNA Vaccine Developers
• Disease Focus Areas and Players Developing RNA Vaccines
• RNA Vaccine Development and Manufacturing Industry Players
• Future Opportunities for RNA Vaccines

Stakeholder Ecosystem

• A Dynamic Global Ecosystem Showcasing the Growth Potential of RNA Vaccines
• A Dynamic Global Ecosystem Showcasing the Growth Potential of RNA Vaccines (continued)
• Development of Innovative Vaccine Manufacturing Units and Capacity Expansion
• Collaborations Among RNA Vaccine Developers
• Collaborations Among RNA Vaccine Developers (continued)

Growth Opportunity Universe

• Growth Opportunity 1: Global Infrastructure Development for RNA Vaccine Manufacturing and Delivery
• Growth Opportunity 1: Global Infrastructure Development for RNA Vaccine Manufacturing and Delivery (continued)
• Growth Opportunity 2: RNA Modifications and Design Improvements
• Growth Opportunity 2: RNA Modifications and Design Improvements (continued)
• Growth Opportunity 3: Improving Delivery Systems and Formulations
• Growth Opportunity 3: Improving Delivery Systems and Formulations (continued)

Appendix

• Technology Readiness Levels (TRL): Explanation
• Active RNA Vaccine Pipelines
• Active RNA Vaccine Pipelines (continued)
• Active RNA Vaccine Pipelines (continued)
• Active RNA Vaccine Pipelines (continued)
• Active RNA Vaccine Pipelines (continued)
• Active RNA Vaccine Pipelines (continued)
• Active RNA Vaccine Pipelines (continued)
• Active RNA Vaccine Pipelines (continued)
• Overcoming Delivery Challenges in RNA Vaccines

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