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市場調查報告書
商品編碼
1887170
镥-177 (Lu-177) 市場規模、佔有率、成長及全球產業分析:依類型、應用和地區劃分的洞察與預測 (2024-2032)Lutetium-177 Market Size, Share, Growth and Global Industry Analysis By Type & Application, Regional Insights and Forecast to 2024-2032 |
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隨著標靶放射性核種療法在癌症治療中日益重要,全球镥-177 (Lu-177) 市場正在快速擴張。根據最新評估,預計2024年市場規模將達到21.5億美元,2025年達到27.3億美元,到2032年將達到108.4億美元。這意味著2025年至2032年的複合年增長率(CAGR)為21.8%。這一快速增長主要受癌症發病率上升、標靶治療的日益普及以及新一代Lu-177放射性藥物供應量增加的推動。
市場概覽
镥-177是一種β射線放射性同位素,用於標靶放射性核種治療,特別適用於神經內分泌腫瘤(NETs)和攝護腺癌,這兩種腫瘤的發生率在全球範圍內均呈上升趨勢。镥-177能夠特異性地與腫瘤受體結合,例如NETs中的生長抑素受體和前列腺癌中的PSMA(前列腺特異性抗原受體),從而實現將輻射精準地輸送到癌細胞,同時保護健康組織。主要市場參與者包括諾華製藥(Novartis AG)、蘭特斯控股公司(Lantheus Holdings, Inc.)、泰利克斯製藥公司(Telix Pharmaceuticals, Inc.)和雷迪製藥診斷公司(Radiopharm Theranostics, Inc.),這些公司都在積極拓展其镥-177 (Lu-177)。
全球精準腫瘤學的興起也推動了市場發展,放射性配體療法 (RLT) 已成為傳統療法無效患者的重要治療選擇。
主要地區市場規模及趨勢
2024年,北美在全球市場佔主導地位,市佔率高達82.79%。這主要得益於該地區較高的癌症發生率、完善的醫保報銷系統以及先進的放射性藥物生產設施。預計到 2024 年,該地區的收入將達到 17.8 億美元,其中美國憑藉 SHINE Technologies 位於簡斯維爾的 Lu-177 工廠(北美最大的 Lu-177 工廠)等關鍵設施,引領著生產市場。
歐洲在 2024 年佔第二大市場佔有率,這得益於其強大的臨床基礎設施和標靶療法的日益普及。英國薩頓核醫治療中心的啟用進一步增強了該地區提供 Lu-177 PSMA 療法的能力。
亞太地區預計將成為成長最快的地區,這主要得益於癌症病例的增加、臨床試驗的擴展以及各項合作計畫的支持。 Radiopharm Theranostics 與 ANSTO 達成協議,供應未摻雜的釕-177,這凸顯了對先進放射性藥物的持續投資。
市場驅動因素
前列腺癌、神經內分泌腫瘤和其他惡性腫瘤的發生率不斷上升是推動市場成長的關鍵因素。僅在美國,預計到 2025 年將新增 313,780 例前列腺癌病例。镥-177 能夠靶向輸送 β 射線,使其成為晚期和難治性癌症的首選治療方法。
標靶放射性核素治療可減少副作用並改善治療效果。 Lutathera(釕-177 多肽)和 Plavicto(釕-177 維匹博肽四環素)等產品的日益普及持續推動著市場成長。
市場限制因子
高額的治療費用限制了中低收入國家的採用。單次注射 Pluvicto 的價格根據地區不同,從 5,000 美元到 12,000 美元不等,平均療程需要六次注射。放射治療基礎設施的匱乏和不完善的報銷體系進一步阻礙了其在全球的推廣應用。
市場機會
推進臨床研究帶來了巨大的機會。在髓母細胞瘤、乳癌、膠質母細胞瘤和非小細胞肺癌 (NSCLC) 領域,使用鎔-177 進行的臨床試驗數量不斷增加,這正在擴大治療範圍。諸如 177Lu-omburtamab-DTPA 獲得 RPDD(監管優先開發認定)等批准,正在拓展兒科腫瘤領域的治療選擇。
市場趨勢
聯合療法
將釕-177與免疫療法、DNA修復抑制劑和化療合併應用正成為一大趨勢。 Telix Pharmaceuticals 的 STARSTRUCK I 期臨床試驗(TLX250 與 peposertib 合併用藥)代表治療方案向協同增效方向的轉變。
依藥物分類
依年齡組
依應用領域
依最終使用者
The global Lutetium-177 (Lu-177) market is experiencing rapid expansion as targeted radionuclide therapy gains global prominence in cancer treatment. According to the latest assessment, the market was valued at USD 2.15 billion in 2024, is projected to rise to USD 2.73 billion in 2025, and is expected to reach USD 10.84 billion by 2032, registering a strong CAGR of 21.8% during 2025-2032. This accelerated growth is driven by increasing cancer prevalence, expanding adoption of targeted therapies, and the growing availability of next-generation Lu-177 radiopharmaceuticals.
Market Overview
Lutetium-177 is a beta-emitting radioisotope used in targeted radionuclide therapy, particularly for neuroendocrine tumors (NETs) and prostate cancer, two cancer types with rising global incidence. Its unique ability to bind to tumor receptors-such as somatostatin receptors in NETs and PSMA in prostate cancer-allows precise delivery of radiation directly to cancer cells while preserving healthy tissues. Key market players include Novartis AG, Lantheus Holdings, Inc., Telix Pharmaceuticals, and Radiopharm Theranostics, all actively expanding their Lu-177 portfolios and production capabilities.
The market is also supported by the global shift toward precision oncology, where radioligand therapy (RLT) is emerging as a vital treatment option for patients who fail conventional therapies.
Market Size & Key Regional Insights
North America dominated the global market in 2024, holding a substantial 82.79% share, driven by high cancer prevalence, strong reimbursement frameworks, and the presence of advanced radiopharmaceutical manufacturing facilities. Regional revenue reached USD 1.78 billion in 2024, with the U.S. leading production due to major facilities like SHINE Technologies' Lu-177 plant in Janesville, the largest in North America.
Europe accounted for the second-largest market share in 2024, supported by robust clinical infrastructure and rising adoption of targeted therapies. The launch of the Nuclear Medicine Therapy Centre in Sutton, U.K., further strengthened the region's capabilities in administering Lu-177 PSMA therapy.
Asia Pacific is projected to be the fastest-growing region, driven by rising cancer cases, expanding clinical trials, and supportive collaboration initiatives. Partnerships such as Radiopharm Theranostics' agreement with ANSTO to supply non-carrier-added Lu-177 highlight ongoing investments in advanced radiopharmaceuticals.
Market Drivers
The increasing incidence of prostate cancer, neuroendocrine tumors, and other malignancies is a primary growth driver. In the U.S. alone, 313,780 new prostate cancer cases are estimated for 2025. Lu-177's ability to deliver targeted beta radiation makes it a preferred therapy for advanced and treatment-resistant cancers.
Targeted radionuclide therapy reduces side effects and improves treatment outcomes. Increasing adoption of products like LUTATHERA (Lu-177 dotatate) and PLUVICTO (Lu-177 vipivotide tetraxetan) continues to fuel market expansion.
Market Restraints
High treatment costs restrict adoption in lower-middle-income countries. A single dose of Pluvicto can cost USD 5,000-12,000 depending on the region, with an average treatment regimen requiring six doses. Limited radiotherapy infrastructure and insufficient reimbursement policies further challenge global adoption.
Market Opportunities
Growing clinical research presents significant opportunities. Increasing numbers of clinical trials on Lu-177 for medulloblastoma, breast cancer, glioblastoma, and NSCLC are widening the therapeutic scope. Regulatory approvals-such as the RPDD for 177Lu-omburtamab-DTPA-are expanding treatment options into pediatric oncology.
Market Trends
Combination Therapy Integration
Combining Lu-177 with immunotherapy, DNA-repair inhibitors, and chemotherapy is emerging as a key trend. Telix Pharmaceuticals' STARSTRUCK Phase I trial combining TLX250 with peposertib exemplifies this shift toward synergistic treatment options.
By Drug
By Age Group
By Application
By End-User
Conclusion
With its market value rising from USD 2.15 billion in 2024 to USD 10.84 billion by 2032, the Lutetium-177 market is poised for transformational growth. Increasing cancer incidence, expanding radioligand therapy approvals, and strong regional production capabilities position Lu-177 as a cornerstone in the future of precision oncology.
Segmentation By Drug
By Age Group
By Application
By End-User
By Region
Figure 46: Global Lutetium-177 Market Share (%), By Company, 2024