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數位 PCR 全球市場-2022-2029Global Digital PCR Market - 2022-2029 |
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數位 PCR 是一種終點 PCR 技術,用於準確量化和研究與相關大序列相比的小序列。 PCR是指聚合□鍊式反應。多次擴增 DNA 和 RNA 片段。您可以發現個體的基因變化和傳染病。
由於多種因素,預計全球數位 PCR 市場將擴大。其中一些是技術進步的提高、新產品的推出、傳染病事件的增加以及生物製藥公司研發活動的激增。
各主要參與者的研發活動激增是推動市場的主要因素。 PCR 診斷多種疾病,包括感染和基因改變。疾病的早□□期診斷是可能的,即使是微量抗體或癌細胞的存在也可以通過多次擴增 DNA 或 RNA 來檢測。數位 PCR (dPCR) 能夠準確和高靈敏度地測量核酸。常規PCR使用瓊脂糖凝膠電泳檢測擴增產物,使其成為半定量終點檢測。數位 PCR (dPCR) 主要分為三種亞型:束流式、液滴式和基於芯片的數位 PCR。
全球 PCR 市場的主要可能性之一是 d-PCR 分子診斷的研發支出增加。為了促進有效診斷,幾家生物技術和生命科學公司正在合作開發 d-PCR 在幾種疾病適應症中的診斷測試和治療用途,以提供良好的治療。
各大公司的新產品推出和PCR技術的技術突破正在推動市場的擴大。例如,一些市場進入者創造了自己的 d-PCR 產品,可以識別各種疾病或檢測各種基因異常。例如,2021 年 3 月,賽默飛宣布美國食品藥品監督管理局完成其實時 PCR 產品 QuantStudio 5 的上市,並將其推向市場。它可以幫助實驗室和開發人員滿足檢測需求。
主要的主要參與者正在開發具有新鮮創新和進步的最新產品和模型。大多數獲批產品正在推動市場增長。例如,賽默飛世爾在 2020 年創建了幾個 PCR 試劑盒和測試用於診斷和研究,以對抗 COVID-19 爆發。在獲得美國 FDA 對 SARS CoV 2 多重實時 PCR 測試的緊急使用授權 (EUA) 後,他們發布了 AcroMetrix 冠狀病毒 2019 (COVID-19) RNA Control。
PCR 的昂貴設備和技術限制預計會阻礙市場擴張。經典的 d-PCR 方法需要優化和驗證分析程序、在 PCR 擴增的指數生長期測量所有信號、由於存在反應修飾劑而難以檢測靶標以及需要 DNA 序列模板。具有各種技術限制,例如由於效率低下而無法識別生物分子。此外,還有一些程序限制不能用於基因組研究,例如使用致癌化學物質、d-PCR 試劑與 dsDNA 的化學結合以及無法評估 DNA 質量。
COVID-19 影響分析
COVID-19 疫情嚴重影響了醫療保健行業。 PCR 市場經歷了繁榮,其中診斷行業受到的影響最為嚴重。實時 PCR 和數位 PCR 的需求量很大,因為它們用於藥物發現研究和診斷。行業團體越來越重視創建液滴數位 PCR 試劑盒來測試 COVID-19。監管機構完全支持這些測試,以限制 COVID-19 大流行的影響。
預計 COVID-19 流行病將對全球 PCR 市場的增長產生積極影響,因為數位 PCR 技術被用於診斷 COVID-19 感染。隨著各種傳染病變得越來越普遍,市場正在增長。
該技術部分進一步細分為數位微滴 PCR、光束數位 PCR 和基於芯片的數位 PCR。由於產品推出的增加和各種新技術的進步,預計數位微滴 PCR 將佔據最大的市場份額。隨著數位 PCR 的發展,核酸分析可以以極高的靈敏度、精密度和準確度進行。它還可用於監測低豐度目標、等位基因變異 (SNP)、具有復雜背景的目標以及實時 PCR 無法檢測到的目標水平的細微變化。該技術現已獲准用於體外研究。
微滴式數位 PCR 使用水乳液微滴技術將 DNA 樣本分成 20,000 個微滴。然後每個液滴都經過模板的 PCR 複製,陽性液滴的定量使我們能夠推斷出確切的目標。液滴數位 PCR 提供絕對定量、精確度和靈敏度,從而實現更有用和更準確的分析。例如,2020 年,Bio-Rad 宣布其液滴數位 PCR SARS-CoV-2 檢測試劑盒獲得美國食品和藥物管理局的 COVID 檢測緊急使用授權。
由於慢性病的廣泛存在、數位 PCR 設備進步的主要參與者的存在以及區域滲透基礎的迅速增加,北美將在 2021 年獲得數位 PCR 市場的廣泛份額。並且由於其起落架,預計在未來幾年內將掩蓋全球市場。開發數位 PCR 產品的技術進步將刺激市場。有利的報銷政策和更好的醫療設施將推動市場增長。
該地區的主要參與者包括 Thermo Fisher Scientific、Bio-Rad Laboratories Inc.、Becton, Dickinson and Company 和 F. Hoffmann-La Roche, Ltd.,它們提供各種創新產品。所有這些公司都推出了各種創新的新產品。它還經歷了各種收購和合併,以推動該地區的市場增長,北美是最大的股東。
全球數位 PCR 市場與多個國際和區域市場競爭激烈。產品多樣化、收入安全和機會使市場更具競爭力。 Thermo Fisher Scientific、Bio-Rad Laboratories, Inc. 和 F. Hoffmann-La-Roche, Inc. 是全球數位 PCR 市場的三大主要參與者。其他知名企業包括安捷倫科技、雅培實驗室、Becton Dickinson and Company、丹納赫公司、Eppendorf、默克、Promega Corporation、Takara Bio、Enzo Life Sciences、Meridian Bioscience、Bioneer、QIAGEN N.V、ELITech Group、Genetron Holdings Limited。
公司正在尋求聯合研究、戰略合作夥伴關係、收購和合併,以擴大對數位 PCR 的需求並將其擴展到全球。公司還利用新產品發布、產品開發、市場擴張和技術進步等戰略來維持其在市場中的地位。例如:
概述 Samo Fisher Scientific 是一家致力於科學的醫療保健經銷商公司。我們製造和銷售試劑、科學儀器和設備、耗材、軟件和服務。成立於 1956 年,總部位於美國馬薩諸塞州沃爾瑟姆。
QuantStudio*6 和 7 Pro 實時 PCR 系統-一種高度靈活的 PCR 系統,可補充各種應用和有利條件。可以免提使用並最大限度減少污染的智能係統。您甚至可以使用手機來安排和監控您的跑步。 QuantStudio 6 和 7 Pro 系統包括一個 96 孔模塊,該模塊採用稱為 VeriFlex 的技術構建,用於特定的溫度控制。所有這些塊都分配到隔離區域,因此它們在一次運行中單獨循環,這是優化的理想選擇。
重大進展。 22022 年 2 月,Therma Fisher 啟動了一項快速 Renvo PCR 測試以對抗 COVID-19。這是我們病原體監測產品組合中的一種新型解決方案機載產品。該測試是對氣溶膠傳感採樣器收集的空氣樣本進行的。
The end-point PCR technique, digital PCR, is utilized for accurate quantification and studying small sequences compared to related large sequences. PCR stands for a polymerase chain reaction. It amplifies the DNA or RNA segments multiple times. Finds genetic changes or infections in any individual.
The global digital PCR market will expand due to several factors. Some of them are rising technological advancements, novel product launches, growing infectious disease incidents, and a surge in R&D activities by biopharma companies.
The surge in research and development activities by various major key players is a major factor in driving the market. PCR diagnoses various illnesses, such as infectious diseases and genetic changes. It can diagnose the disease in its earliest stage, and even if only minute amounts of antibodies or cancer cells are present, it can detect it by amplifying the DNA or RNA multiple times. Nucleic acid measurement is accurate and sensitive, thanks to digital PCR (dPCR). Traditional PCR uses agarose gel electrophoresis to detect the amplified product, making it a semi-quantitative end-point examination. The three main subtypes of digital PCR (dPCR) are beaming, droplet, and chip-based digital PCR.
One of the significant possibilities in the worldwide PCR market is the growth of R&D spending for d-PCR molecular diagnostics. To facilitate effective diagnosis, several biotechnologies and life sciences, businesses are collaborating on developing diagnostic tests and the therapeutic use of d-PCR in several illness indications to provide effective treatment.
Introducing new products by major companies and technological breakthroughs in PCR technologies fuel the market's expansion. For instance, some market participants have created unique d-PCR products that can recognize various diseases or detect various genetic abnormalities. For instance, in Mar 2021, Thermo Fisher announced United States Food and Drug Administration had completed the listing for QuantStudio 5, a real-time PCR and launched it in the market. It helps labs and developers fulfill the demands of testing.
Major key players develop the latest products or models with novel technological innovations and advancements. Most of the products receiving approval are driving the market's growth. For instance, in 2020, Thermo Fisher created several PCR kits and tests for diagnostic and research to fight the COVID-19 outbreak. They released AcroMetrix Coronavirus 2019 (COVID-19) RNA Control after receiving the US FDA's emergency use authorization (EUA) for the SARS CoV 2 multiplex real-time PCR test.
Costly equipment and PCR's technological limitations are predicted to impede market expansion. A classic d-PCR method is accompanied by a variety of technical limitations, including the need for assay procedure optimization and validation, the measurement of signals all through the exponential growth phase of the PCR amplification, difficulties in target detection caused by the existence of reaction modulators, and the inability to identify biomolecules due to the poor efficiency of the DNA sequence template. Additionally, the usage of carcinogenic chemicals, chemical binding of d-PCR reagent to dsDNA and inability to evaluate DNA quality are some of the procedural restrictions that prevent using these reagents in genomic research.
COVID-19 Impact Analysis
The COVID-19 outbreak severely impacted the healthcare industry. The PCR market has experienced a boom, and the diagnosis sector was most severely affected. Real-time and digital PCR are in high demand since they are used for drug research and diagnostic purposes. It is becoming increasingly important for industry entities to test COVID-19 by creating droplet digital PCR kits. The regulatory agencies have given these tests their full support to limit the COVID-19 pandemic's effects.
Since digital PCR techniques are utilized to diagnose COVID-19 infection, the COVID-19 epidemic is projected to affect the global PCR market's growth positively. The market is expanding because various infectious diseases are becoming more common.
The technology segment is further sub-segmented into digital droplet PCR, beaming digital PCR and chip-based digital PCR. Digital droplet PCR is expected to hold the largest market share due to the increasing number of product launches and various novel technological advances. Nucleic acid analysis can be done with extreme sensitivity, accuracy and exactness because of the development of digital PCR. It is also helpful for monitoring low-abundance targets, allelic variations (SNPs), targets with complicated backgrounds, and tiny changes in target levels that real-time PCR cannot pick up on. The use of this technology in in-vitro testing has now been authorized.
The droplet digital PCR divides the sample of DNA into 20,000 droplets using water-emulsion droplet technology. Every particular droplet then experiences PCR replication of the template and quantifying the positive droplets provides accurate target estimation. Absolute quantification, high precision and high sensitivity can be seen in droplet digital PCR so that it will be more helpful and accurate for analysis. For instance, in 2020, Bio-Rad announced that the droplet digital PCR SARS-CoV-2 test kit got emergency use permission from the United States Food and Drug Administration for COVID testing.
In 2021 North America reserve an extensive share in the digital PCR market, and it is estimated that it is also going to overshadow the global market in the coming years owing to the upsurge in widespread presence of chronic diseases, the existence of key players for the progress of digital PCR devices, and prevalent foundation and substructure in the region. The growing technological advancement for developing digital PCR products shall stimulate the market. Favorable reimbursement policies and better healthcare facilities shall fuel market growth.
Most of the key players in this region are Thermo Fisher Scientific, Bio-Rad Laboratories Inc., Becton, Dickinson and Company and F. Hoffmann-La Roche, Ltd. All of them are launching various innovative and novel products. Various acquisitions and merges are also taking place, fueling the market's growth in this region and making North America the largest shareholder.
The global digital PCR market is highly competitive with several international and local markets. Product diversification, revenue generation, and opportunities intensify the market competition. Thermo Fisher Scientific, Bio-Rad Laboratories Inc., and F. Hoffmann-La Roche, Ltd. are the three key players operating in the global digital PCR market. Other well-known players are Agilent Technologies, Abbott Laboratories, Becton Dickinson and Company, Danaher Corporation, Eppendorf, Merck, Promega Corporation, Takara Bio, Enzo Life Sciences, Meridian Bioscience, Bioneer, QIAGEN N.V, ELITech Group, Genetron Holdings Limited.
The companies are entering into collaborations, strategic partnerships, acquisitions and mergers to increase the demand for digital PCR and their global expansion. Companies are also using new product launches, product development, market expansion and technical advancement strategies to hold their market position. For instance,
Overview: Thermo Fisher Scientific is a healthcare distributor company that serves science. They manufacture and market reagents, scientific instruments & equipment, consumables and software services. It was established in 1956 and is based in Waltham, Massachusetts, United States.
QuantStudio*6 and 7 Pro Real-Time PCR Systems - These are PCR systems that are very flexible as they reinforce various kinds of applications and favorable conditions. The smartness of these systems is created to minimize contamination by making them run hands-free. Mobile phones can be used to schedule and even monitor the run. The QuantStudio 6 and 7 Pro systems contain 96-well blocks that comprise a technology known as VeriFlex that is used for specific temperature control. All these blocks are prorated into secluded zones, due to which there are separate cycling surrounding inside the one and same run that is ideal for optimization.
Key Developments: In Feb 2022, Therma Fisher launched its rapid Renvo PCR test to fight COVID-19. It is a novel solution in-air product that is included in its portfolio of pathogen surveillance. This test is done on the air samples collected by the aerosol sense sampler.
The digital PCR market report would provide access to an approx. 45+ market data table, 40+ figures and 180 pages.