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市場調查報告書
商品編碼
1885393
全球成人史蒂爾病市場:按治療方法和地區分類的分析和預測(2025-2035 年)Adult-Onset Still Disease Market - A Global and Regional Analysis: Focus on Therapy and Region - Analysis and Forecast, 2025-2035 |
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全球成人史蒂爾病市場規模預計將從 2024 年的 3.231 億美元大幅成長至 2035 年的 4.552 億美元,2025 年至 2035 年的複合年成長率將達到 3.30%。
| 關鍵市場統計數據 | |
|---|---|
| 預測期 | 2025-2035 |
| 2025 年評估 | 3.29億美元 |
| 2035 年預測 | 4.552億美元 |
| 複合年成長率 | 3.3% |
成人斯蒂爾病市場正經歷穩步成長,主要促進因素包括臨床上對該疾病認知的提高、免疫發病機制研究的進展以及靶向關鍵炎症通路生物療法的廣泛應用。成人史蒂爾氏症是一種罕見的全身性自體發炎性疾病,其特徵是反覆發燒、關節炎和皮疹。由於診斷標準的改進以及風濕症醫師和免疫學家對該疾病的認知提高,其診斷率正在上升。此疾病的多種臨床表現常常導致診斷延遲,凸顯了對更有效、更特異性的生物標記和標靶治療的持續需求。
對這種疾病的細胞激素驅動機制,特別是白細胞介素(IL)-1、IL-6 和 IL-18 的作用機制的深入了解,激發了人們對靶向這些細胞因子的生物療法的興趣。 IL-1 和 IL-6 拮抗劑等細胞激素抑制劑的引入,透過改善症狀控制和減輕對傳統糖皮質激素和非類固醇消炎劑(NSAIDs) 無效患者的全身性炎症,徹底改變了疾病的治療方式。目前正在進行的評估新型藥物(包括 IL-18結合蛋白質和 Janus 激酶 (JAK) 抑制劑)的臨床研究,預計在未來幾年將進一步豐富治療選擇。
按治療方法,生物製藥主導。
按治療方法類型分類,生物製藥在全球市場佔據主導地位,預計2024年市佔率將達到70.39%。此領域對於治療難治性成人史蒂爾氏症至關重要,抑制IL-1、IL-6和IL-18等關鍵細胞激素是實現緩解和預防巨噬細胞活化症候群等併發症的關鍵。應用最廣泛的生物製藥包括IL-1抑制劑(如阿那白滯素和卡那單抗)以及IL-6抑制劑(如托珠單抗),這兩種藥物對於快速控制全身性發炎至關重要。阿那白滯素可在急性發作期每日給藥以發揮阻斷作用,而卡那單抗則允許延長給藥間隔,並被指南強烈推薦。隨著對精準自體發炎性疾病治療需求的不斷成長,這些生物製藥對於複雜的全身性疾病至關重要,在重症病例中展現出優於非類固醇消炎劑(NSAIDs)和糖皮質激素的療效。生物製藥的日益普及反映了其在重塑成人斯蒂爾病治療和推動市場持續擴張方面的核心作用。
按地區分類,預計北美將錄得最高的成長率
北美地區在全球成人史蒂爾病市場中主導,預計2024年將佔據約37%的市場。同時,亞太地區在預測期(2025-2035年)內預計將以5.36%的複合年成長率成長,這主要得益於醫療基礎設施的不斷完善、疾病認知度的提高以及對生物製藥療法投資的增加。亞太地區擁有多元化且快速發展的醫療體系,在成人斯蒂爾病的治療方面取得了顯著進展,尤其是在中國、日本、印度和韓國等國家,各國政府和私營機構都優先考慮罕見疾病研究和孤兒藥的取得。該地區龐大的人口規模,加上自體發炎性疾病盛行率的不斷上升,推動了對創新細胞激素抑制劑(如IL-1和IL-6抑制劑)的需求。此外,先進的診斷技術和生物相似藥的日益普及,提高了治療的可及性,預計也將推動成人斯蒂爾病市場的快速成長。
本報告檢視了全球成人史蒂爾病市場,並總結了關鍵趨勢、市場影響因素分析、法律制度、研發管線分析、市場規模趨勢和預測、按各個細分市場、地區/主要國家進行的詳細分析、競爭格局以及主要企業的概況。
範圍和定義
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Introduction of the Adult-Onset Still Disease Market
The global adult-onset still disease market, initially valued at $323.1 million in 2024, is projected to witness substantial growth, surging to $455.2 million by 2035, marking a remarkable compound annual growth rate (CAGR) of 3.30% over the period from 2025 to 2035.
| KEY MARKET STATISTICS | |
|---|---|
| Forecast Period | 2025 - 2035 |
| 2025 Evaluation | $329.0 Million |
| 2035 Forecast | $455.2 Million |
| CAGR | 3.3% |
The adult-onset still disease market has been witnessing gradual evolution, largely driven by growing clinical recognition of the condition, advances in immunopathogenesis research, and the expanding use of biologic therapies targeting key inflammatory pathways. Adult-onset still disease, a rare systemic autoinflammatory disorder characterized by recurrent fevers, arthritis, and skin rash, is increasingly being identified through improved diagnostic criteria and greater awareness among rheumatologists and immunologists. The disease's heterogeneous presentation often leads to diagnostic delays, which continue to underscore the need for more effective and specific biomarkers as well as targeted treatment options.
Rising understanding of the disease's underlying cytokine-driven mechanisms, particularly the roles of interleukin (IL)-1, IL-6, and IL-18, has catalyzed interest in targeted biologic therapies. The introduction of cytokine inhibitors such as IL-1 and IL-6 antagonists has transformed disease management, offering improved symptom control and reduction in systemic inflammation for patients refractory to conventional corticosteroids and nonsteroidal anti-inflammatory drugs (NSAIDs). Ongoing clinical investigations evaluating newer agents, including IL-18 binding proteins and Janus kinase (JAK) inhibitors, are expected to further diversify the therapeutic landscape over the coming years.
Market Introduction
The adult-onset still disease market has been undergoing steady transformation, propelled by advances in cytokine-targeted biologics and strengthened clinical guidelines for early intervention. Companies and researchers are prioritizing interleukin (IL)-1 and IL-6 inhibitors, alongside emerging IL-18 blockers, to address refractory cases and achieve sustained remission. Key developments include the FDA approval of canakinumab (Ilaris) for active still's disease encompassing adult-onset still's disease and tadekinig alfa's orphan drug status. These innovations underscore a shift toward first-line biologic therapy, reducing reliance on glucocorticoids and enhancing outcomes in this rare autoinflammatory condition. As focus intensifies on molecular diagnostics and combination regimens, adult-onset still's disease treatments are set to expand access and efficacy across global rheumatology practices.
Industrial Impact
The adult-onset still disease market has been experiencing a significant shift, driven by the increasing demand for cytokine-targeted biologics and the growing focus on early intervention in autoinflammatory disorders. Key players such as Novartis AG, F. Hoffmann-La Roche Ltd, and Swedish Orphan Biovitrum AB have been playing a central role in advancing adult-onset still's disease therapies, supporting the development of novel IL-1, IL-6, and IL-18 inhibitors beyond traditional corticosteroids. These innovations are crucial for managing refractory cases, systemic inflammation, and complications, including macrophage activation syndrome, enabling more efficient, targeted disease control with improved remission rates. By enhancing the speed and precision of therapeutic response, reducing glucocorticoid dependency, and facilitating global clinical collaborations, adult-onset still's disease treatment advancements are contributing to more effective, streamlined management. The market's impact is further amplified by its alignment with the global shift toward precision medicine, positioning biologics as a cornerstone of adult-onset still disease care.
Market Segmentation:
Segmentation 1: By Therapy
Biologics to Dominate the Adult-Onset Still Disease Market (by Therapy)
Based on the method, the global adult-onset still disease market was led by biologics, which held a 70.39% share in 2024. This segment is essential in managing refractory adult-onset still disease cases, where blocking key cytokines such as IL-1, IL-6, and IL-18 is critical for achieving remission and preventing complications such as macrophage activation syndrome. Among the most widely adopted biologics are IL-1 inhibitors, including anakinra and canakinumab, alongside IL-6 blockers, including tocilizumab, both of which are pivotal in rapidly controlling systemic inflammation. Anakinra provides daily blockade for acute flares, while canakinumab enables extended dosing intervals with strong guideline endorsement. As demand for precision autoinflammatory therapies grows, these biologics are crucial for complex systemic disorders, outpacing NSAIDs and corticosteroids in efficacy for severe presentations. The rising adoption of biologics reflects their central role in reshaping adult-onset still's disease treatment and driving sustained market expansion.
Segmentation 2: By Region
North America to Witness the Highest Growth in the Adult-Onset Still Disease Market (by Region)
The adult-onset still disease market in North America dominates globally, accounting for approximately 37% share in 2024. Meanwhile, the Asia-Pacific region is expected to witness a growth rate of 5.36% during the forecast period 2025-2035, driven by expanding healthcare infrastructure, rising disease awareness, and increased investments in biologic therapies. Asia-Pacific, with its diverse and rapidly evolving healthcare systems, is witnessing notable advancements in adult-onset still's disease management, particularly in countries including China, Japan, India, and South Korea, where governments and private entities are prioritizing rare disease research and orphan drug access. The region's large population, coupled with a growing burden of autoinflammatory conditions, has heightened demand for innovative cytokine inhibitors such as IL-1 and IL-6 blockers. Furthermore, increasing adoption of advanced diagnostics and biosimilars is enhancing treatment accessibility, positioning Asia-Pacific for accelerated expansion in the adult-onset still disease market.
Recent Developments in the Adult-Onset Still Disease Market
Demand - Drivers, Challenges, and Opportunities
Market Drivers:
Expansion of Diagnostic Capabilities: The advancement of diagnostic tools for adult-onset still's disease has played a crucial role in propelling market expansion by enabling earlier detection, precise differentiation from similar conditions, and personalized treatment strategies. Key biomarkers such as glycosylated ferritin and elevated serum ferritin levels (>500 ng/mL) are pivotal in distinguishing adult-onset still's disease from other inflammatory disorders. These developments, integrated into clinical guidelines in certain countries, including Japan, facilitate rapid initiation of targeted biologics such as IL-1 and IL-6 inhibitors, reducing misdiagnosis and improving patient outcomes in this rare autoinflammatory condition. Additionally, emerging AI and machine learning applications in systems biology models are optimizing therapy selection, validating early biologic intervention over conventional treatments, and supporting sustained remission. As diagnostic precision evolves alongside biomarker-driven monitoring and flare prediction, these innovations are addressing critical unmet needs, positioning advanced diagnostics as a cornerstone for adult-onset still disease market growth and enhanced disease management.
Market Challenges:
High Costs of Biologic Treatments: The high costs associated with biologic therapies for adult-onset still's disease present a significant challenge to market growth, limiting patient access and straining healthcare systems. Biologics such as anakinra (Kineret), tocilizumab (Actemra), and canakinumab (Ilaris), essential for managing refractory cases, require substantial investment in complex manufacturing, specialized facilities, and rigorous quality control, resulting in annual treatment expenses. The elevated prices, far exceeding traditional therapies, restrict affordability, particularly in low- and middle-income countries and among uninsured patients. Additionally, stringent eligibility for such financial aid programs leaves many underinsured individuals facing high out-of-pocket burdens, hindering widespread adoption. Overcoming these financial barriers through biosimilars, expanded insurance coverage, and enhanced access initiatives will be crucial for broadening adult-onset still's disease treatment reach and ensuring equitable care across diverse healthcare settings.
Market Opportunities:
Regulatory Incentives and Designations: Regulatory incentives, particularly Orphan Drug Designation and Breakthrough Therapy Designation, present a significant growth opportunity for the adult-onset still disease market, accelerating development timelines and providing essential financial and market exclusivity benefits. These designations, including FDA tax credits covering up to 50% of clinical trial costs, fee waivers, and seven years of U.S. market exclusivity alongside EMA's ten-year protection, are driving investment into rare disease therapies such as canakinumab and tadekinig alfa. In regions such as North America and Europe with robust regulatory frameworks, these incentives facilitate expedited approvals through intensive FDA guidance, rolling reviews, and priority evaluations. Additionally, collaborations between biopharma developers and regulatory bodies are enhancing adult-onset still's disease therapy pipelines, positioning these incentives as a cornerstone for broader market expansion and improved patient access.
How can this report add value to an organization?
Product/Innovation Strategy: The global adult-onset still disease market has been extensively segmented based on various categories, such as therapy and region. This can help readers get a clear overview of which segments account for the largest share and which ones are well-positioned to grow in the coming years.
Growth/Marketing Strategy: Regulatory approval has accounted for the majority of key developments, comprising nearly 85% of the total developments in the global adult-onset still disease market between January 2021 and October 2025.
Competitive Strategy: The global adult-onset still disease market has numerous established players with product portfolios. Key players in the global adult-onset still disease market, analyzed and profiled in the study, include established players offering therapies for adult-onset still's disease.
Methodology
Key Considerations and Assumptions in Market Engineering and Validation
Primary Research
The primary sources involve industry experts in adult-onset still's disease, including the market players offering therapies. Resources such as CEOs, vice presidents, marketing directors, and medical directors have been interviewed to obtain and verify both qualitative and quantitative aspects of this research study.
The key data points taken from the primary sources include:
Secondary Research
Open Sources
The key data points taken from the secondary sources include:
Key Market Players and Competition Synopsis
The companies profiled have been selected based on inputs gathered from an analysis of company coverage, product portfolio, and market penetration.
Some prominent names established in this market are:
Scope and Definition